Purine nucleoside phosphorylase - Revision history

Michal Harel at 10:27, 5 December 2019

2019-12-05T10:27:57Z

←Older revision		Revision as of 10:27, 5 December 2019
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	</StructureSection>		</StructureSection>

-	==3D structures of purine nucleoside phosphorylase==
-
-	Updated on {{REVISIONDAY2}}-{{MONTHNAME\|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
-	{{#tree:id=OrganizedByTopic\|openlevels=0\|
-
-	*'''Purine nucleoside phosphorylase'''
-
-	**[[1ula]], [[1m73]] – hPNP – human<br />
-	**[[1pbn]] – bPNP – bovine<br />
-	**[[1odk]], [[1odl]] – TtPNP – ''Thermus thermophilus'' <br />
-	**[[1z33]] – TvPNP – ''Trichomonas vaginalis''<br />
-	**[[1tcv]], [[1td1]], [[5cxs]], [[5cxq]] – SmPNP – ''Schistosoma mansoni''<br />
-	**[[2b94]] – PNP – ''Plasmodium knowlesi'' <br />
-	**[[4mar]] – MrPNP – ''Meiothermus ruber''<br />
-	**[[1ecp]], [[1oty]], [[1ou4]], [[1yqq]], [[1yqu]], [[1yr3]], [[3onv]], [[4rj2]], [[4ts3]], [[4ts9]] – EcPNP – ''Escherichia coli'' <br />
-	**[[1otx]], [[1oum]], [[1ov6]], [[3opv]], [[4tta]], [[4tti]], [[4ttj]] – EcPNP (mutant)<br />
-	**[[1vhj]] – VcPNP – ''Vibrio cholerae''<br />
-	**[[1xe3]] – PNP – ''Bacillus anthracis''<br />
-	**[[4d8v]], [[4d8x]], [[4d8y]], [[4d98]] – BsPNP – ''Bacillus subtilis''<br />
-	**[[3tl6]] – EhPNP – ''Entamoeba histolica''<br />
-	**[[3uav]] – BcPNP – ''Bacillus cereus''<br />
-	**[[4lkr]] – PNP – ''Shewanella oneidensis''<br />
-	**[[4tym]] – PNP – ''Streptococcus agalactiae'' <br />
-
-	*Purine nucleoside phosphorylase binary complex with phosphate
-
-	**[[4gka]] – hPNP (mutant) + phosphate<br />
-	**[[1a9o]], [[3pnp]], [[4pnp]] – bPNP + phosphate<br />
-	**[[1qe5]] – CePNP + phosphate - ''Cellulomonas''<br />
-	**[[1tcu]] – SmPNP + phosphate <br />
-	**[[3khs]] – PNP + phosphate – grouper iridovirus<br />
-	**[[4m3n]] – MrPNP + phosphate <br />
-	**[[3ooe]], [[3ooh]] – EcPNP + phosphate <br />
-	**[[4ldn]] – PNP + phosphate – ''Vibrio fischeri''<br />
-	**[[4m7w]] – PNP + phosphate – ''Leptotrichia buccalis''<br />
-	**[[5mx4]], [[5mx6]], [[5mx8]], [[5lu0]] - HpPNP + phosphate - ''Helicobacter pylori''<br />
-	**[[6aqu]] – PfPNP + phosphate – ''Plasmodium falciparum''<br />
-
-	*Purine nucleoside phosphorylase complex with guanine and guanine derivatives
-
-	**[[1ulb]], [[1v2h]] – hPNP + guanine<br />
-	**[[4ece]] – hPNP (mutant) + guanine<br />
-	**[[1rfg]] – hPNP + guanosine<br />
-	**[[1yry]], [[3iny]] – hPNP + guanine derivative <br />
-	**[[1pwy]], [[1v41]], [[1v45]] – hPNP + antiviral drug <br />
-	**[[1v48]], [[2ai1]], [[2ai3]], [[3fuc]] – bPNP + guanine derivative <br />
-	**[[1b8n]] – bPNP + guanine derivative + phosphate<br />
-	**[[3e9z]] – SmPNP + guanine derivative <br />
-	**[[3iex]] – SmPNP + guanosine<br />
-	**[[1odj]] – TtPNP + guanosine<br />
-	**[[4da0]], [[4da8]], [[4dae]] – BsPNP + guanosine derivative<br />
-	**[[1vmk]] – PNP + guanine – ''Thermotoga maritima'' <br />
-	**[[3iom]] – MtPNP + guanine derivative - ''Mycobacterium tuberculosis'' <br />
-	**[[5i3c]] - EcPNP + guanine derivative <br />
-	**[[1c3x]] – CePNP + guanine derivative + phosphate<br />
-
-	*Purine nucleoside phosphorylase complex with inosine and inosine derivatives
-
-	**[[1rct]] – hPNP + inosine <br />
-	**[[1v3q]] – hPNP + anti HIV drug <br />
-	**[[1a9q]], [[1a9s]] – bPNP + inosine <br />
-	**[[2ai2]] – bPNP + inosine derivative <br />
-	**[[1a9t]], [[1a9p]], [[4pnp]] – bPNP + deazainosine + phosphate<br />
-	**[[3faz]] – SmPNP + inosine <br />
-	**[[5tbv]] – SmPNP + tubercidine <br />
-	**[[5tbt]] – SmPNP + cytidine <br />
-	**[[1z38]] – TvPNP + inosine <br />
-	**[[3uax]] – BcPNP + inosine <br />
-	**[[2bsx]] – PfPNP + inosine <br />
-	**[[1z39]] – TvPNP + deoxyinosine <br />
-	**[[1pr0]] - EcPNP + inosine + phosphate<br />
-
-	*Purine nucleoside phosphorylase complex with xanthine and xanthine derivatives
-
-	**[[1pf7]], [[1rr6]], [[1rsz]], [[1rt9]], [[3k8o]], [[3k8q]] – hPNP + transition state analog <br />
-	**[[2on6]] – hPNP (mutant) + transition state analog <br />
-	**[[2a0w]], [[2a0x]], [[2a0y]], [[2oc4]], [[2oc9]] – hPNP (mutant) + hypoxanthine derivative <br />
-	**[[2q7o]], [[3phb]] – hPNP + transition state analog + phosphate<br />
-	**[[4ear]], [[4eb8]] – hPNP (mutant) + transition state analog + phosphate<br />
-	**[[1vfn]], [[1a9r]] – bPNP + hypoxanthine<br />
-	**[[1b8o]], [[1g2o]] – bPNP + hypoxanthine derivative + phosphate<br />
-	**[[3bgs]] – bPNP + transition state analog + phosphate<br />
-	**[[3fnq]], [[5tbu]] – SmPNP + hypoxanthine<br />
-	**[[4dab]] – BsPNP + hypoxanthine<br />
-	**[[4uc0]] – PNP + hypoxanthine – ''Agrobacterium vitis''<br />
-	**[[5ifk]] - PNP + hypoxanthine - ''Kluyveromyces lactis''<br />
-	**[[3enz]] – PfPNP + hypoxanthine + ribose + arsenate<br />
-	**[[5iu6]] - EcPNP + hypoxanthine derivative<br />
-	**[[3odg]] – YpPNP + xanthine – ''Yersinia pseudotuberculosis''<br />
-	**[[3mb8]] – PNP + transition state analog + phosphate – ''Toxoplasma gondii''<br />
-	**[[3scz]] – MtPNP + hypoxanthine<br />
-	**[[1n3i]] – MtPNP + deazahypoxanthine + phosphate <br />
-	**[[1i80]] – MtPNP + iminoribitol + deazahypoxanthine + phosphate <br />
-
-	*Purine nucleoside phosphorylase complex with adenine and adenine derivatives
-
-	**[[3ggs]] – hPNP (mutant) + adenosine derivative <br />
-	**[[1odi]] – TtPNP + adenosine <br />
-	**[[1z34]], [[1z35]], [[1z37]] – TvPNP + adenosine derivative <br />
-	**[[4ns1]] – PgPNP + adenosine derivative – ''Porphyromonas gingivalis''<br />
-	**[[4nsn]] – PgPNP + adenine <br />
-	**[[3e9r]], [[5tbs]] – SmPNP + adenine <br />
-	**[[3f8w]] – SmPNP + adenosine <br />
-	**[[4dao]] – BsPNP + adenine <br />
-	**[[1vhw]] – VcPNP + adenosine <br />
-	**[[3u40]] – EhPNP + adenosine <br />
-	**[[4d9h]] – BsPNP + adenosine <br />
-	**[[4dan]] – BsPNP + adenosine derivative<br />
-	**[[2ac7]], [[3uaw]] – BcPNP + adenosine <br />
-	**[[3uay]], [[3uaz]] – BcPNP (mutant) + adenosine <br />
-	**[[4m1e]] – PNP + adenine – ''Planctomyces limnophilus''<br />
-	**[[4lna]] – PNP + adenine + phosphate – ''Spirosoma linguale''<br />
-	**[[1pk7]] - EcPNP + adenosine + phosphate<br />
-	**[[1pk9]], [[1pke]], [[1pr5]], [[1pr6]], [[1pw7]] - EcPNP + adenosine derivative + phosphate<br />
-
-	*Purine nucleoside phosphorylase complex with purine and purine derivatives
-
-	**[[3gb9]] – hPNP (mutant) + purine derivative <br />
-	**[[1lv8]], [[1lvu]], [[2qpl]] – bPNP + purine derivative <br />
-	**[[1fxu]] – bPNP + purine derivative + phosphate<br />
-	**[[1ovg]] - EcPNP (mutant) + purine derivative <br />
-	**[[1pr2]], [[1pr4]] – EcPNP + purine derivative + phosphate<br />
-
-	*Other purine nucleoside phosphorylase complexes
-
-	**[[3d1v]] – hPNP + mercapto-quinazolinone<br />
-	**[[5etj]], [[5ugf]] - hPNP (mutant) + inhibitor + phosphate<br />
-	**[[1z36]] – TvPNP + antibiotic<br />
-	**[[2i4t]], [[2isc]] – TvPNP + inhibitor + phosphate<br />
-	**[[3djf]] – SmPNP + inhibitor<br />
-	**[[3e0q]] – SmPNP + pyrimidine derivative<br />
-	**[[3fb1]] – SmPNP + ribose-1-phosphate <br />
-	**[[6awe]], [[6axa]], [[6b2l]], [[6b37]], [[6b3l]], [[6b4q]], [[6b4t]], [[6b56]], [[6b6k]], [[6b71]], [[6b7i]], [[6bb7]], [[6bfv]], [[6bhb]], [[6bi1]], [[6bi9]], [[6bif]], [[6bj6]], [[6bj7]] – SmPNP + inhibitor <br />
-	**[[5ko5]] - SmPNP + cytosine<br />
-	**[[5ko6]] - SmPNP + cytosine + ribose-1-phosphate<br />
-	**[[1a69]], [[1pr1]] – EcPNP + formycin <br />
-	**[[1k9s]], [[3ut6]] – EcPNP + formycin derivative + phosphate<br />
-	**[[6aqs]]]] – PfPNP (mutant) + inhibitor + phosphate<br />
-	**[[3phc]] – PfPNP + inhibitor + phosphate<br />
-	**[[2p4s]] – PNP + inhibitor + phosphate – ''Anopheles gambiae''<br />
-	**[[3occ]] – YpPNP + inhibitor + phosphate<br />
-	**[[3of3]] – VcPNP + inhibitor + phosphate<br />
-	**[[4da6]], [[4da7]], [[4dar]] – BsPNP + drug<br />
-
-	*PNP DeoD-type
-
-	**[[6f5a]], [[6f5i]], [[6g7x]] – HpPNP <br />
-	**[[6f4w]], [[6f4x]], [[6f52]] – HpPNP + formycin <br />
-	}}
	== References ==		== References ==
	<references/>		<references/>
	[[Category:Topic Page]]		[[Category:Topic Page]]

Michal Harel at 10:26, 5 December 2019

2019-12-05T10:26:57Z

←Older revision		Revision as of 10:26, 5 December 2019
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	<scene name='57/573714/Cv/5'>Residues 241-265 of PNP act as a gate that opens upon substrate binding</scene>. The ribose binding site is composed of mostly hydrophobic side chains<ref>PMID:14680831</ref>. <scene name='57/573714/Cv/6'>Active site</scene>.		<scene name='57/573714/Cv/5'>Residues 241-265 of PNP act as a gate that opens upon substrate binding</scene>. The ribose binding site is composed of mostly hydrophobic side chains<ref>PMID:14680831</ref>. <scene name='57/573714/Cv/6'>Active site</scene>.
		+
		+	==3D structures of purine nucleoside phosphorylase==
		+	[[Purine nucleoside phosphorylase 3D structures]]
		+
	</StructureSection>		</StructureSection>

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	*Purine nucleoside phosphorylase binary complex with phosphate		*Purine nucleoside phosphorylase binary complex with phosphate

		+	**[[4gka]] – hPNP (mutant) + phosphate<br />
	**[[1a9o]], [[3pnp]], [[4pnp]] – bPNP + phosphate<br />		**[[1a9o]], [[3pnp]], [[4pnp]] – bPNP + phosphate<br />
	**[[1qe5]] – CePNP + phosphate - ''Cellulomonas''<br />		**[[1qe5]] – CePNP + phosphate - ''Cellulomonas''<br />
	**[[1tcu]] – SmPNP + phosphate <br />		**[[1tcu]] – SmPNP + phosphate <br />
	**[[3khs]] – PNP + phosphate – grouper iridovirus<br />		**[[3khs]] – PNP + phosphate – grouper iridovirus<br />
-	**[[4gka]] – hPNP (mutant) + phosphate<br />
	**[[4m3n]] – MrPNP + phosphate <br />		**[[4m3n]] – MrPNP + phosphate <br />
	**[[3ooe]], [[3ooh]] – EcPNP + phosphate <br />		**[[3ooe]], [[3ooh]] – EcPNP + phosphate <br />
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	**[[1rfg]] – hPNP + guanosine<br />		**[[1rfg]] – hPNP + guanosine<br />
	**[[1yry]], [[3iny]] – hPNP + guanine derivative <br />		**[[1yry]], [[3iny]] – hPNP + guanine derivative <br />
		+	**[[1pwy]], [[1v41]], [[1v45]] – hPNP + antiviral drug <br />
	**[[1v48]], [[2ai1]], [[2ai3]], [[3fuc]] – bPNP + guanine derivative <br />		**[[1v48]], [[2ai1]], [[2ai3]], [[3fuc]] – bPNP + guanine derivative <br />
		+	**[[1b8n]] – bPNP + guanine derivative + phosphate<br />
	**[[3e9z]] – SmPNP + guanine derivative <br />		**[[3e9z]] – SmPNP + guanine derivative <br />
	**[[3iex]] – SmPNP + guanosine<br />		**[[3iex]] – SmPNP + guanosine<br />
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	**[[3iom]] – MtPNP + guanine derivative - ''Mycobacterium tuberculosis'' <br />		**[[3iom]] – MtPNP + guanine derivative - ''Mycobacterium tuberculosis'' <br />
	**[[5i3c]] - EcPNP + guanine derivative <br />		**[[5i3c]] - EcPNP + guanine derivative <br />
-	**[[1b8n]] – bPNP + guanine derivative + phosphate<br />
	**[[1c3x]] – CePNP + guanine derivative + phosphate<br />		**[[1c3x]] – CePNP + guanine derivative + phosphate<br />
-	**[[1pwy]], [[1v41]], [[1v45]] – hPNP + antiviral drug <br />

	*Purine nucleoside phosphorylase complex with inosine and inosine derivatives		*Purine nucleoside phosphorylase complex with inosine and inosine derivatives

	**[[1rct]] – hPNP + inosine <br />		**[[1rct]] – hPNP + inosine <br />
		+	**[[1v3q]] – hPNP + anti HIV drug <br />
	**[[1a9q]], [[1a9s]] – bPNP + inosine <br />		**[[1a9q]], [[1a9s]] – bPNP + inosine <br />
		+	**[[2ai2]] – bPNP + inosine derivative <br />
		+	**[[1a9t]], [[1a9p]], [[4pnp]] – bPNP + deazainosine + phosphate<br />
	**[[3faz]] – SmPNP + inosine <br />		**[[3faz]] – SmPNP + inosine <br />
	**[[5tbv]] – SmPNP + tubercidine <br />		**[[5tbv]] – SmPNP + tubercidine <br />
	**[[5tbt]] – SmPNP + cytidine <br />		**[[5tbt]] – SmPNP + cytidine <br />
-	**[[2ai2]] – bPNP + inosine derivative <br />
	**[[1z38]] – TvPNP + inosine <br />		**[[1z38]] – TvPNP + inosine <br />
	**[[3uax]] – BcPNP + inosine <br />		**[[3uax]] – BcPNP + inosine <br />
	**[[2bsx]] – PfPNP + inosine <br />		**[[2bsx]] – PfPNP + inosine <br />
	**[[1z39]] – TvPNP + deoxyinosine <br />		**[[1z39]] – TvPNP + deoxyinosine <br />
-	**[[1a9t]], [[1a9p]], [[4pnp]] – bPNP + deazainosine + phosphate<br />
	**[[1pr0]] - EcPNP + inosine + phosphate<br />		**[[1pr0]] - EcPNP + inosine + phosphate<br />
-	**[[1v3q]] – hPNP + anti HIV drug <br />

	*Purine nucleoside phosphorylase complex with xanthine and xanthine derivatives		*Purine nucleoside phosphorylase complex with xanthine and xanthine derivatives
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	**[[1pf7]], [[1rr6]], [[1rsz]], [[1rt9]], [[3k8o]], [[3k8q]] – hPNP + transition state analog <br />		**[[1pf7]], [[1rr6]], [[1rsz]], [[1rt9]], [[3k8o]], [[3k8q]] – hPNP + transition state analog <br />
	**[[2on6]] – hPNP (mutant) + transition state analog <br />		**[[2on6]] – hPNP (mutant) + transition state analog <br />
		+	**[[2a0w]], [[2a0x]], [[2a0y]], [[2oc4]], [[2oc9]] – hPNP (mutant) + hypoxanthine derivative <br />
		+	**[[2q7o]], [[3phb]] – hPNP + transition state analog + phosphate<br />
		+	**[[4ear]], [[4eb8]] – hPNP (mutant) + transition state analog + phosphate<br />
	**[[1vfn]], [[1a9r]] – bPNP + hypoxanthine<br />		**[[1vfn]], [[1a9r]] – bPNP + hypoxanthine<br />
		+	**[[1b8o]], [[1g2o]] – bPNP + hypoxanthine derivative + phosphate<br />
		+	**[[3bgs]] – bPNP + transition state analog + phosphate<br />
	**[[3fnq]], [[5tbu]] – SmPNP + hypoxanthine<br />		**[[3fnq]], [[5tbu]] – SmPNP + hypoxanthine<br />
-	**[[3scz]] – MtPNP + hypoxanthine<br />
	**[[4dab]] – BsPNP + hypoxanthine<br />		**[[4dab]] – BsPNP + hypoxanthine<br />
	**[[4uc0]] – PNP + hypoxanthine – ''Agrobacterium vitis''<br />		**[[4uc0]] – PNP + hypoxanthine – ''Agrobacterium vitis''<br />
	**[[5ifk]] - PNP + hypoxanthine - ''Kluyveromyces lactis''<br />		**[[5ifk]] - PNP + hypoxanthine - ''Kluyveromyces lactis''<br />
	**[[3enz]] – PfPNP + hypoxanthine + ribose + arsenate<br />		**[[3enz]] – PfPNP + hypoxanthine + ribose + arsenate<br />
-	**[[2a0w]], [[2a0x]], [[2a0y]], [[2oc4]], [[2oc9]] – hPNP (mutant) + hypoxanthine derivative <br />
	**[[5iu6]] - EcPNP + hypoxanthine derivative<br />		**[[5iu6]] - EcPNP + hypoxanthine derivative<br />
	**[[3odg]] – YpPNP + xanthine – ''Yersinia pseudotuberculosis''<br />		**[[3odg]] – YpPNP + xanthine – ''Yersinia pseudotuberculosis''<br />
-	**[[1b8o]], [[1g2o]] – bPNP + hypoxanthine derivative + phosphate<br />
-	**[[3bgs]] – bPNP + transition state analog + phosphate<br />
-	**[[2q7o]], [[3phb]] – hPNP + transition state analog + phosphate<br />
-	**[[4ear]], [[4eb8]] – hPNP (mutant) + transition state analog + phosphate<br />
	**[[3mb8]] – PNP + transition state analog + phosphate – ''Toxoplasma gondii''<br />		**[[3mb8]] – PNP + transition state analog + phosphate – ''Toxoplasma gondii''<br />
		+	**[[3scz]] – MtPNP + hypoxanthine<br />
	**[[1n3i]] – MtPNP + deazahypoxanthine + phosphate <br />		**[[1n3i]] – MtPNP + deazahypoxanthine + phosphate <br />
	**[[1i80]] – MtPNP + iminoribitol + deazahypoxanthine + phosphate <br />		**[[1i80]] – MtPNP + iminoribitol + deazahypoxanthine + phosphate <br />
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	*Purine nucleoside phosphorylase complex with adenine and adenine derivatives		*Purine nucleoside phosphorylase complex with adenine and adenine derivatives

		+	**[[3ggs]] – hPNP (mutant) + adenosine derivative <br />
	**[[1odi]] – TtPNP + adenosine <br />		**[[1odi]] – TtPNP + adenosine <br />
-	**[[1z34]], [[1z35]] – TvPNP + adenosine derivative <br />	+	**[[1z34]], [[1z35]], [[1z37]] – TvPNP + adenosine derivative <br />
	**[[4ns1]] – PgPNP + adenosine derivative – ''Porphyromonas gingivalis''<br />		**[[4ns1]] – PgPNP + adenosine derivative – ''Porphyromonas gingivalis''<br />
	**[[4nsn]] – PgPNP + adenine <br />		**[[4nsn]] – PgPNP + adenine <br />
-	**[[3ggs]] – hPNP (mutant) + adenosine derivative <br />
-	**[[1z37]] – TvPNP + adenosine <br />
	**[[3e9r]], [[5tbs]] – SmPNP + adenine <br />		**[[3e9r]], [[5tbs]] – SmPNP + adenine <br />
		+	**[[3f8w]] – SmPNP + adenosine <br />
	**[[4dao]] – BsPNP + adenine <br />		**[[4dao]] – BsPNP + adenine <br />
-	**[[3f8w]] – SmPNP + adenosine <br />
	**[[1vhw]] – VcPNP + adenosine <br />		**[[1vhw]] – VcPNP + adenosine <br />
	**[[3u40]] – EhPNP + adenosine <br />		**[[3u40]] – EhPNP + adenosine <br />
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	*Purine nucleoside phosphorylase complex with purine and purine derivatives		*Purine nucleoside phosphorylase complex with purine and purine derivatives

-	**[[1lv8]], [[1lvu]], [[2qpl]] – bPNP + purine derivative <br />
	**[[3gb9]] – hPNP (mutant) + purine derivative <br />		**[[3gb9]] – hPNP (mutant) + purine derivative <br />
		+	**[[1lv8]], [[1lvu]], [[2qpl]] – bPNP + purine derivative <br />
	**[[1fxu]] – bPNP + purine derivative + phosphate<br />		**[[1fxu]] – bPNP + purine derivative + phosphate<br />
	**[[1ovg]] - EcPNP (mutant) + purine derivative <br />		**[[1ovg]] - EcPNP (mutant) + purine derivative <br />
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	**[[5etj]], [[5ugf]] - hPNP (mutant) + inhibitor + phosphate<br />		**[[5etj]], [[5ugf]] - hPNP (mutant) + inhibitor + phosphate<br />
	**[[1z36]] – TvPNP + antibiotic<br />		**[[1z36]] – TvPNP + antibiotic<br />
		+	**[[2i4t]], [[2isc]] – TvPNP + inhibitor + phosphate<br />
	**[[3djf]] – SmPNP + inhibitor<br />		**[[3djf]] – SmPNP + inhibitor<br />
	**[[3e0q]] – SmPNP + pyrimidine derivative<br />		**[[3e0q]] – SmPNP + pyrimidine derivative<br />
	**[[3fb1]] – SmPNP + ribose-1-phosphate <br />		**[[3fb1]] – SmPNP + ribose-1-phosphate <br />
		+	**[[6awe]], [[6axa]], [[6b2l]], [[6b37]], [[6b3l]], [[6b4q]], [[6b4t]], [[6b56]], [[6b6k]], [[6b71]], [[6b7i]], [[6bb7]], [[6bfv]], [[6bhb]], [[6bi1]], [[6bi9]], [[6bif]], [[6bj6]], [[6bj7]] – SmPNP + inhibitor <br />
	**[[5ko5]] - SmPNP + cytosine<br />		**[[5ko5]] - SmPNP + cytosine<br />
	**[[5ko6]] - SmPNP + cytosine + ribose-1-phosphate<br />		**[[5ko6]] - SmPNP + cytosine + ribose-1-phosphate<br />
	**[[1a69]], [[1pr1]] – EcPNP + formycin <br />		**[[1a69]], [[1pr1]] – EcPNP + formycin <br />
	**[[1k9s]], [[3ut6]] – EcPNP + formycin derivative + phosphate<br />		**[[1k9s]], [[3ut6]] – EcPNP + formycin derivative + phosphate<br />
-	**[[2i4t]], [[2isc]] – TvPNP + inhibitor + phosphate<br />
	**[[6aqs]]]] – PfPNP (mutant) + inhibitor + phosphate<br />		**[[6aqs]]]] – PfPNP (mutant) + inhibitor + phosphate<br />
		+	**[[3phc]] – PfPNP + inhibitor + phosphate<br />
	**[[2p4s]] – PNP + inhibitor + phosphate – ''Anopheles gambiae''<br />		**[[2p4s]] – PNP + inhibitor + phosphate – ''Anopheles gambiae''<br />
	**[[3occ]] – YpPNP + inhibitor + phosphate<br />		**[[3occ]] – YpPNP + inhibitor + phosphate<br />
	**[[3of3]] – VcPNP + inhibitor + phosphate<br />		**[[3of3]] – VcPNP + inhibitor + phosphate<br />
-	**[[3phc]] – PfPNP + inhibitor + phosphate<br />
	**[[4da6]], [[4da7]], [[4dar]] – BsPNP + drug<br />		**[[4da6]], [[4da7]], [[4dar]] – BsPNP + drug<br />

Alexander Berchansky at 13:35, 20 August 2019

2019-08-20T13:35:26Z

←Older revision		Revision as of 13:35, 20 August 2019
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	== Structural highlights ==		== Structural highlights ==

-	<scene name='57/573714/Cv/2'>Residues 241-265 of PNP act as a gate that opens upon substrate binding</scene>. The ribose binding site is composed of mostly hydrophobic side chains<ref>PMID:14680831</ref>. <scene name='57/573714/Cv/4'>Active site</scene>.	+	<scene name='57/573714/Cv/5'>Residues 241-265 of PNP act as a gate that opens upon substrate binding</scene>. The ribose binding site is composed of mostly hydrophobic side chains<ref>PMID:14680831</ref>. <scene name='57/573714/Cv/6'>Active site</scene>.
	</StructureSection>		</StructureSection>

Michal Harel at 10:10, 29 August 2018

2018-08-29T10:10:26Z

←Older revision		Revision as of 10:10, 29 August 2018
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	**[[1odk]], [[1odl]] – TtPNP – ''Thermus thermophilus'' <br />		**[[1odk]], [[1odl]] – TtPNP – ''Thermus thermophilus'' <br />
	**[[1z33]] – TvPNP – ''Trichomonas vaginalis''<br />		**[[1z33]] – TvPNP – ''Trichomonas vaginalis''<br />
-	**[[1tcv]], [[1td1]], [[5cxs]] – SmPNP – ''Schistosoma ~~masoni~~''<br />	+	**[[1tcv]], [[1td1]], [[5cxs]], [[5cxq]] – SmPNP – ''Schistosoma mansoni''<br />
	**[[2b94]] – PNP – ''Plasmodium knowlesi'' <br />		**[[2b94]] – PNP – ''Plasmodium knowlesi'' <br />
	**[[4mar]] – MrPNP – ''Meiothermus ruber''<br />		**[[4mar]] – MrPNP – ''Meiothermus ruber''<br />
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	**[[4ldn]] – PNP + phosphate – ''Vibrio fischeri''<br />		**[[4ldn]] – PNP + phosphate – ''Vibrio fischeri''<br />
	**[[4m7w]] – PNP + phosphate – ''Leptotrichia buccalis''<br />		**[[4m7w]] – PNP + phosphate – ''Leptotrichia buccalis''<br />
-	**[[5mx4]], [[5mx6]], [[5mx8]], [[5lu0]] - ~~PNP~~ + phosphate - ''Helicobacter pylori''<br />	+	**[[5mx4]], [[5mx6]], [[5mx8]], [[5lu0]] - HpPNP + phosphate - ''Helicobacter pylori''<br />
		+	**[[6aqu]] – PfPNP + phosphate – ''Plasmodium falciparum''<br />

	*Purine nucleoside phosphorylase complex with guanine and guanine derivatives		*Purine nucleoside phosphorylase complex with guanine and guanine derivatives
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	**[[1a9q]], [[1a9s]] – bPNP + inosine <br />		**[[1a9q]], [[1a9s]] – bPNP + inosine <br />
	**[[3faz]] – SmPNP + inosine <br />		**[[3faz]] – SmPNP + inosine <br />
		+	**[[5tbv]] – SmPNP + tubercidine <br />
		+	**[[5tbt]] – SmPNP + cytidine <br />
	**[[2ai2]] – bPNP + inosine derivative <br />		**[[2ai2]] – bPNP + inosine derivative <br />
	**[[1z38]] – TvPNP + inosine <br />		**[[1z38]] – TvPNP + inosine <br />
	**[[3uax]] – BcPNP + inosine <br />		**[[3uax]] – BcPNP + inosine <br />
-	**[[2bsx]] – PfPNP + inosine ~~– ''Plasmodium falciparum''~~<br />	+	**[[2bsx]] – PfPNP + inosine <br />
	**[[1z39]] – TvPNP + deoxyinosine <br />		**[[1z39]] – TvPNP + deoxyinosine <br />
	**[[1a9t]], [[1a9p]], [[4pnp]] – bPNP + deazainosine + phosphate<br />		**[[1a9t]], [[1a9p]], [[4pnp]] – bPNP + deazainosine + phosphate<br />
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	**[[2on6]] – hPNP (mutant) + transition state analog <br />		**[[2on6]] – hPNP (mutant) + transition state analog <br />
	**[[1vfn]], [[1a9r]] – bPNP + hypoxanthine<br />		**[[1vfn]], [[1a9r]] – bPNP + hypoxanthine<br />
-	**[[3fnq]] – SmPNP + hypoxanthine<br />	+	**[[3fnq]], [[5tbu]] – SmPNP + hypoxanthine<br />
	**[[3scz]] – MtPNP + hypoxanthine<br />		**[[3scz]] – MtPNP + hypoxanthine<br />
	**[[4dab]] – BsPNP + hypoxanthine<br />		**[[4dab]] – BsPNP + hypoxanthine<br />
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	**[[3ggs]] – hPNP (mutant) + adenosine derivative <br />		**[[3ggs]] – hPNP (mutant) + adenosine derivative <br />
	**[[1z37]] – TvPNP + adenosine <br />		**[[1z37]] – TvPNP + adenosine <br />
-	**[[3e9r]] – SmPNP + adenine <br />	+	**[[3e9r]], [[5tbs]] – SmPNP + adenine <br />
	**[[4dao]] – BsPNP + adenine <br />		**[[4dao]] – BsPNP + adenine <br />
	**[[3f8w]] – SmPNP + adenosine <br />		**[[3f8w]] – SmPNP + adenosine <br />
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	**[[1k9s]], [[3ut6]] – EcPNP + formycin derivative + phosphate<br />		**[[1k9s]], [[3ut6]] – EcPNP + formycin derivative + phosphate<br />
	**[[2i4t]], [[2isc]] – TvPNP + inhibitor + phosphate<br />		**[[2i4t]], [[2isc]] – TvPNP + inhibitor + phosphate<br />
		+	**[[6aqs]]]] – PfPNP (mutant) + inhibitor + phosphate<br />
	**[[2p4s]] – PNP + inhibitor + phosphate – ''Anopheles gambiae''<br />		**[[2p4s]] – PNP + inhibitor + phosphate – ''Anopheles gambiae''<br />
	**[[3occ]] – YpPNP + inhibitor + phosphate<br />		**[[3occ]] – YpPNP + inhibitor + phosphate<br />
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	**[[3phc]] – PfPNP + inhibitor + phosphate<br />		**[[3phc]] – PfPNP + inhibitor + phosphate<br />
	**[[4da6]], [[4da7]], [[4dar]] – BsPNP + drug<br />		**[[4da6]], [[4da7]], [[4dar]] – BsPNP + drug<br />
		+
		+	*PNP DeoD-type
		+
		+	**[[6f5a]], [[6f5i]], [[6g7x]] – HpPNP <br />
		+	**[[6f4w]], [[6f4x]], [[6f52]] – HpPNP + formycin <br />
	}}		}}
	== References ==		== References ==
	<references/>		<references/>
	[[Category:Topic Page]]		[[Category:Topic Page]]

Michal Harel at 09:38, 29 August 2018

2018-08-29T09:38:37Z

←Older revision		Revision as of 09:38, 29 August 2018
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-	<StructureSection load='' size='~~450~~' side='right' caption='Human purine nucleoside phosphorylase complex with guanine and sulfate (PDB entry [[1v2h]])' scene='57/573714/Cv/1'>	+	<StructureSection load='' size='350' side='right' caption='Human purine nucleoside phosphorylase complex with guanine and sulfate (PDB entry [[1v2h]])' scene='57/573714/Cv/1'>
	== Function ==		== Function ==
	'''Purine nucleoside phosphorylase''' (PNP) cleaves nucleosides by phosphorylating ribose to produce ribose-1-phosphate. PNP metabolizes adenosine, inosine and guanosine<ref>PMID:11337031</ref>. PNP metabolizes the waste molecules deoxyinosine and deoxyguanosine which are formed when DNA breaks down.		'''Purine nucleoside phosphorylase''' (PNP) cleaves nucleosides by phosphorylating ribose to produce ribose-1-phosphate. PNP metabolizes adenosine, inosine and guanosine<ref>PMID:11337031</ref>. PNP metabolizes the waste molecules deoxyinosine and deoxyguanosine which are formed when DNA breaks down.

Joel L. Sussman at 14:06, 23 September 2017

2017-09-23T14:06:28Z

←Older revision		Revision as of 14:06, 23 September 2017
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-	<StructureSection load='~~1v2h~~' size='450' side='right' caption='Human purine nucleoside phosphorylase complex with guanine and sulfate (PDB entry [[1v2h]])' scene='57/573714/Cv/1'>	+	<StructureSection load='' size='450' side='right' caption='Human purine nucleoside phosphorylase complex with guanine and sulfate (PDB entry [[1v2h]])' scene='57/573714/Cv/1'>
	== Function ==		== Function ==
	'''Purine nucleoside phosphorylase''' (PNP) cleaves nucleosides by phosphorylating ribose to produce ribose-1-phosphate. PNP metabolizes adenosine, inosine and guanosine<ref>PMID:11337031</ref>. PNP metabolizes the waste molecules deoxyinosine and deoxyguanosine which are formed when DNA breaks down.		'''Purine nucleoside phosphorylase''' (PNP) cleaves nucleosides by phosphorylating ribose to produce ribose-1-phosphate. PNP metabolizes adenosine, inosine and guanosine<ref>PMID:11337031</ref>. PNP metabolizes the waste molecules deoxyinosine and deoxyguanosine which are formed when DNA breaks down.

Michal Harel at 21:59, 21 September 2017

2017-09-21T21:59:52Z

Alexander Berchansky at 10:20, 31 July 2016

2016-07-31T10:20:28Z

←Older revision		Revision as of 10:20, 31 July 2016
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	== Structural highlights ==		== Structural highlights ==

-	<scene name='57/573714/Cv/2'>Residues 241-265 of PNP act as a gate that opens upon substrate binding</scene>. The ribose binding site is composed of mostly hydrophobic side chains<ref>PMID:14680831</ref>.	+	<scene name='57/573714/Cv/2'>Residues 241-265 of PNP act as a gate that opens upon substrate binding</scene>. The ribose binding site is composed of mostly hydrophobic side chains<ref>PMID:14680831</ref>. <scene name='57/573714/Cv/4'>Active site</scene>.
	</StructureSection>		</StructureSection>

Alexander Berchansky at 09:54, 31 July 2016

2016-07-31T09:54:29Z

←Older revision		Revision as of 09:54, 31 July 2016
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-	<StructureSection load='1v2h' size='~~350~~' side='right' caption='Human purine nucleoside phosphorylase complex with guanine and sulfate (PDB entry [[1v2h]])' scene='57/573714/Cv/1'>	+	<StructureSection load='1v2h' size='450' side='right' caption='Human purine nucleoside phosphorylase complex with guanine and sulfate (PDB entry [[1v2h]])' scene='57/573714/Cv/1'>
	== Function ==		== Function ==
	'''Purine nucleoside phosphorylase''' (PNP) cleaves nucleosides by phosphorylating ribose to produce ribose-1-phosphate. PNP metabolizes adenosine, inosine and guanosine<ref>PMID:11337031</ref>. PNP metabolizes the waste molecules deoxyinosine and deoxyguanosine which are formed when DNA breaks down.		'''Purine nucleoside phosphorylase''' (PNP) cleaves nucleosides by phosphorylating ribose to produce ribose-1-phosphate. PNP metabolizes adenosine, inosine and guanosine<ref>PMID:11337031</ref>. PNP metabolizes the waste molecules deoxyinosine and deoxyguanosine which are formed when DNA breaks down.
Line 8:		Line 8:
	== Structural highlights ==		== Structural highlights ==

-	Residues 241-265 of PNP act as a gate that opens upon substrate binding. The ribose binding site is composed of mostly hydrophobic side chains<ref>PMID:14680831</ref>.	+	<scene name='57/573714/Cv/2'>Residues 241-265 of PNP act as a gate that opens upon substrate binding</scene>. The ribose binding site is composed of mostly hydrophobic side chains<ref>PMID:14680831</ref>.
	</StructureSection>		</StructureSection>

Alexander Berchansky at 09:45, 31 July 2016

2016-07-31T09:45:53Z

←Older revision		Revision as of 09:45, 31 July 2016
Line 1:		Line 1:
-	<StructureSection load='1v2h' size='350' side='right' caption='Human purine nucleoside phosphorylase complex with guanine and sulfate (PDB entry [[1v2h]])' scene=''>	+	<StructureSection load='1v2h' size='350' side='right' caption='Human purine nucleoside phosphorylase complex with guanine and sulfate (PDB entry [[1v2h]])' scene='57/573714/Cv/1'>
	== Function ==		== Function ==
	'''Purine nucleoside phosphorylase''' (PNP) cleaves nucleosides by phosphorylating ribose to produce ribose-1-phosphate. PNP metabolizes adenosine, inosine and guanosine<ref>PMID:11337031</ref>. PNP metabolizes the waste molecules deoxyinosine and deoxyguanosine which are formed when DNA breaks down.		'''Purine nucleoside phosphorylase''' (PNP) cleaves nucleosides by phosphorylating ribose to produce ribose-1-phosphate. PNP metabolizes adenosine, inosine and guanosine<ref>PMID:11337031</ref>. PNP metabolizes the waste molecules deoxyinosine and deoxyguanosine which are formed when DNA breaks down.

←Older revision		Revision as of 21:59, 21 September 2017
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	**[[1odk]], [[1odl]] – TtPNP – ''Thermus thermophilus'' <br />		**[[1odk]], [[1odl]] – TtPNP – ''Thermus thermophilus'' <br />
	**[[1z33]] – TvPNP – ''Trichomonas vaginalis''<br />		**[[1z33]] – TvPNP – ''Trichomonas vaginalis''<br />
-	**[[1tcv]], [[1td1]] – SmPNP – ''Schistosoma masoni''<br />	+	**[[1tcv]], [[1td1]], [[5cxs]] – SmPNP – ''Schistosoma masoni''<br />
	**[[2b94]] – PNP – ''Plasmodium knowlesi'' <br />		**[[2b94]] – PNP – ''Plasmodium knowlesi'' <br />
	**[[4mar]] – MrPNP – ''Meiothermus ruber''<br />		**[[4mar]] – MrPNP – ''Meiothermus ruber''<br />
-	**[[1ecp]], [[1oty]], [[1ou4]], [[1yqq]], [[1yqu]], [[1yr3]], [[3onv]], [[4rj2]] – EcPNP – ''Escherichia coli'' <br />	+	**[[1ecp]], [[1oty]], [[1ou4]], [[1yqq]], [[1yqu]], [[1yr3]], [[3onv]], [[4rj2]], [[4ts3]], [[4ts9]] – EcPNP – ''Escherichia coli'' <br />
-	**[[1otx]], [[1oum]], [[1ov6]], [[3opv]] – EcPNP (mutant)<br />	+	**[[1otx]], [[1oum]], [[1ov6]], [[3opv]], [[4tta]], [[4tti]], [[4ttj]] – EcPNP (mutant)<br />
	**[[1vhj]] – VcPNP – ''Vibrio cholerae''<br />		**[[1vhj]] – VcPNP – ''Vibrio cholerae''<br />
	**[[1xe3]] – PNP – ''Bacillus anthracis''<br />		**[[1xe3]] – PNP – ''Bacillus anthracis''<br />
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	**[[4ldn]] – PNP + phosphate – ''Vibrio fischeri''<br />		**[[4ldn]] – PNP + phosphate – ''Vibrio fischeri''<br />
	**[[4m7w]] – PNP + phosphate – ''Leptotrichia buccalis''<br />		**[[4m7w]] – PNP + phosphate – ''Leptotrichia buccalis''<br />
		+	**[[5mx4]], [[5mx6]], [[5mx8]], [[5lu0]] - PNP + phosphate - ''Helicobacter pylori''<br />

	*Purine nucleoside phosphorylase complex with guanine and guanine derivatives		*Purine nucleoside phosphorylase complex with guanine and guanine derivatives
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	**[[1vmk]] – PNP + guanine – ''Thermotoga maritima'' <br />		**[[1vmk]] – PNP + guanine – ''Thermotoga maritima'' <br />
	**[[3iom]] – MtPNP + guanine derivative - ''Mycobacterium tuberculosis'' <br />		**[[3iom]] – MtPNP + guanine derivative - ''Mycobacterium tuberculosis'' <br />
		+	**[[5i3c]] - EcPNP + guanine derivative <br />
	**[[1b8n]] – bPNP + guanine derivative + phosphate<br />		**[[1b8n]] – bPNP + guanine derivative + phosphate<br />
	**[[1c3x]] – CePNP + guanine derivative + phosphate<br />		**[[1c3x]] – CePNP + guanine derivative + phosphate<br />
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	**[[2bsx]] – PfPNP + inosine – ''Plasmodium falciparum''<br />		**[[2bsx]] – PfPNP + inosine – ''Plasmodium falciparum''<br />
	**[[1z39]] – TvPNP + deoxyinosine <br />		**[[1z39]] – TvPNP + deoxyinosine <br />
-	**[[1a9t]], [[1a9p]] – bPNP + deazainosine + phosphate<br />	+	**[[1a9t]], [[1a9p]], [[4pnp]] – bPNP + deazainosine + phosphate<br />
	**[[1pr0]] - EcPNP + inosine + phosphate<br />		**[[1pr0]] - EcPNP + inosine + phosphate<br />
	**[[1v3q]] – hPNP + anti HIV drug <br />		**[[1v3q]] – hPNP + anti HIV drug <br />
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	**[[4dab]] – BsPNP + hypoxanthine<br />		**[[4dab]] – BsPNP + hypoxanthine<br />
	**[[4uc0]] – PNP + hypoxanthine – ''Agrobacterium vitis''<br />		**[[4uc0]] – PNP + hypoxanthine – ''Agrobacterium vitis''<br />
		+	**[[5ifk]] - PNP + hypoxanthine - ''Kluyveromyces lactis''<br />
	**[[3enz]] – PfPNP + hypoxanthine + ribose + arsenate<br />		**[[3enz]] – PfPNP + hypoxanthine + ribose + arsenate<br />
	**[[2a0w]], [[2a0x]], [[2a0y]], [[2oc4]], [[2oc9]] – hPNP (mutant) + hypoxanthine derivative <br />		**[[2a0w]], [[2a0x]], [[2a0y]], [[2oc4]], [[2oc9]] – hPNP (mutant) + hypoxanthine derivative <br />
		+	**[[5iu6]] - EcPNP + hypoxanthine derivative<br />
	**[[3odg]] – YpPNP + xanthine – ''Yersinia pseudotuberculosis''<br />		**[[3odg]] – YpPNP + xanthine – ''Yersinia pseudotuberculosis''<br />
	**[[1b8o]], [[1g2o]] – bPNP + hypoxanthine derivative + phosphate<br />		**[[1b8o]], [[1g2o]] – bPNP + hypoxanthine derivative + phosphate<br />
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	**[[3d1v]] – hPNP + mercapto-quinazolinone<br />		**[[3d1v]] – hPNP + mercapto-quinazolinone<br />
		+	**[[5etj]], [[5ugf]] - hPNP (mutant) + inhibitor + phosphate<br />
	**[[1z36]] – TvPNP + antibiotic<br />		**[[1z36]] – TvPNP + antibiotic<br />
	**[[3djf]] – SmPNP + inhibitor<br />		**[[3djf]] – SmPNP + inhibitor<br />
	**[[3e0q]] – SmPNP + pyrimidine derivative<br />		**[[3e0q]] – SmPNP + pyrimidine derivative<br />
	**[[3fb1]] – SmPNP + ribose-1-phosphate <br />		**[[3fb1]] – SmPNP + ribose-1-phosphate <br />
		+	**[[5ko5]] - SmPNP + cytosine<br />
		+	**[[5ko6]] - SmPNP + cytosine + ribose-1-phosphate<br />
	**[[1a69]], [[1pr1]] – EcPNP + formycin <br />		**[[1a69]], [[1pr1]] – EcPNP + formycin <br />
	**[[1k9s]], [[3ut6]] – EcPNP + formycin derivative + phosphate<br />		**[[1k9s]], [[3ut6]] – EcPNP + formycin derivative + phosphate<br />