Quinone reductase - Revision history

Michal Harel at 10:07, 5 October 2023

2023-10-05T10:07:57Z

←Older revision		Revision as of 10:07, 5 October 2023
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	[[Quinone reductase 3D structures]]		[[Quinone reductase 3D structures]]
-
-	Updated on {{REVISIONDAY2}}-{{MONTHNAME\|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
-	{{#tree:id=OrganizedByTopic\|openlevels=0\|
-
-	*Quinone reductase type 1
-
-	**[[3jsx]] – hQR1 + coumarine derivative<br />
-	**[[2f1o]] – hQR1 + dicoumarol<br />
-	**[[1kbo]], [[1kbq]] – hQR1 + indole derivative<br />
-
-	*Quinone reductase type 2 or ribosyldihydronicotinamide dehydrogenase [quinone]
-
-	**[[4qod]] – hNQO2 - human<br />
-	**[[4qof]] – hNQO2 + FMN<br />
-	**[[1qr2]], [[3fw1]], [[4qoe]] – hNQO2 + FAD<br />
-	**[[3o2n]], [[3g5m]], [[3gam]] – hNQO2 + FAD + PET agent<br />
-	**[[3ovm]], [[3owh]], [[3owx]] – hNQO2 + FAD + carbamate derivative<br />
-	**[[3ox1]], [[2qx4]], [[2qx6]], [[2qx8]], [[2qx9]], [[2qwx]] – hNQO2 + FAD + acetamide derivative<br />
-	**[[3ox2]], [[4xdh]], [[4xdg]] - hNQO2 + FAD + indole derivative<br />
-	**[[3ox3]] - hNQO2 + FAD + carboxamide derivative<br />
-	**[[4u7f]], [[4u7g]], [[4u7h]] - hNQO2 + FAD + imidazole derivative<br />
-	**[[4zvk]], [[5buc]] - hNQO2 + FAD + ethidium<br />
-	**[[4zvm]] - hNQO2 + FAD + doxorubicin<br />
-	**[[2qmy]] – hNQO2 + FAD + adrenochrome<br />
-	**[[2qr2]] – hNQO2 + FAD + menadione<br />
-	**[[2qmz]] – hNQO2 + FAD + dopamine<br />
-	**[[4qog]] – hNQO2 + FAD + melatonin<br />
-	**[[1sg0]], [[4qoh]] – hNQO2 + FAD + resveratol<br />
-	**[[4qoj]] – hNQO2 + FMN + resveratol<br />
-	**[[4qoi]] – hNQO2 + FMN + melatonin<br />
-	**[[3nhu]], [[3nhs]], [[3nhr]], [[3nhp]], [[3nhl]], [[3nhk]], [[3nhj]], [[3nhf]], [[3nfr]], [[3nhw]], [[3nhy]], [[3uxe]], [[3uxh]] - hNQO2 + FAD + quinoline derivative<br />
-	**[[3te7]], [[3tem]], [[4zvl]], [[4zvn]], [[3tzb]] – hNQO2 + FAD + acridine derivative<br />
-	**[[2bzs]], [[1xi2]], [[1zx1]], [[3o73]], [[5lbw]], [[5lbz]], [[5lby]] – hNQO2 + FAD + anti-cancer prodrug<br />
-	**[[4fgj]], [[4fgk]], [[4fgl]] – hNQO2 + FAD + anti-malaria drug<br />
-	**[[5lbt]], [[5lbu]] – hNQO2 + FAD + anti-wart drug<br />
-	**[[4gqi]], [[4gr9]] – hNQO2 + FAD + ligand<br />
-
-	*Sulfide-quinone reductase or Sulfide-quinone oxidoreductase
-
-	**[[6mo6]], [[6mp5]], [[6oi5]] – hSQR + FAD<br />
-	**[[6oic]], [[6oib]], [[6oi6]], [[6wh6]] – hSQR + FAD + CoQ<br />
-	**[[3hyv]] – AaSQR + FAD – ''Aquifex aeolicus''<br />
-	**[[3hyw]] – AaSQR + FAD + decylubiquinone<br />
-	**[[3hyx]] – AaSQR + FAD + Aurachin C<br />
-	**[[3h8l]], [[3h8i]] – AaSQR + FAD + trisulfane<br />
-	**[[3t0k]] – AfSQR + FAD + trisulfide + decylubiquinone - ''Acidithiobacillus ferrooxidabs''<br />
-	**[[3t14]] – AfSQR + FAD + disulfide<br />
-	**[[3t2y]] – AfSQR (mutant) + FAD + disulfide<br />
-	**[[3t2k]], [[3t2z]] – AfSQR + FAD + trisulfane<br />
-	**[[3t31]] – AfSQR + FAD + decylubiquinone<br />
-
-	*NADPH-quinone reductase or NADPH-quinone oxidoreductase or NADP dehydrogenase [quinone]
-
-	**[[1d4a]], [[5ea2]] - hNQO1 + FAD<br />
-	**[[5a4k]] - hNQO1 (mutant) + FAD<br />
-	**[[3jsx]] – hNQO1 + FAD + chromen derivative<br />
-	**[[6fy4]] – hNQO1 + FAD + pyrrolidine derivative<br />
-	**[[2f1O]], [[4cet]] – hNQO1 + FAD + dicoumarol<br />
-	**[[5fuq]] – hNQO1 (mutant) + FAD + dicoumarol<br />
-	**[[4cf6]] – hNQO1 (mutant) + FAD + cibacron<br />
-	**[[1yb5]] – hNQO1 + NADP<br />
-	**[[1gg5]], [[1h66]], [[1h69]], [[1qbg]] - hNQRO1 + FAD + anti-cancer prodrug<br />
-	**[[1dxo]] - hNQO1 + FAD + quinone derivative<br />
-	**[[1kbo]], [[1kbq]] - hNQO1 + FAD + indole derivative<br />
-	**[[1dxq]] - mNQO1 + FAD - mouse<br />
-	**[[3ha2]] – NQO1 – ''Pediococcus pentosaceus''<br />
-
-	*Quinone reductase
-
-	**[[1qrd]] – QR + bicarbon blue + duroquinone - rat<br />
-
-	*Na(+)-translocating NADH-quinone reductase
-
-	**[[8a1t]], [[8a1x]], [[8acw]], [[8acy]] – VcNTNQD subunit a-f + FMN + riboflavin + FAD – Vibrio cholera – Cryo EM<br />
-	**[[8a1v]], [[8a1w]] – VcNTNQD subunit a-f + FMN + riboflavin + ubiquinone + FAD – Cryo EM<br />
-	**[[8ew3]] – VcNTNQD subunit a-f + FMN + riboflavin + ubiquinone – Cryo EM<br />
-	**[[8a1y]] – VcNTNQD subunit a-f + FMN + riboflavin + quinoline inhibitor + FAD – Cryo EM<br />
-	**[[7xk3]], [[7xk4]], [[7xk5]] – VcNTNQD subunit a-f + FMN + riboflavin + DOPE + FAD – Cryo EM<br />
-	[[7xk6]], [[7xk7]] – VcNTNQD subunit a-f + FMN + riboflavin + DOPE + FAD + antibiotic – Cryo EM<br />
-	**[[8a1u]] – VcNTNQD subunit a-f + FMN + riboflavin + ubiquinone + FAD + NADH – Cryo EM<br />
-	**[[8acw]] – VcNTNQD subunit f + NADH + FAD <br />
-	**[[4u9q]] – VcNTNQD subunit a<br />
-	**[[4u9u]] – VcNTNQD subunit f FAD-binding domain 130-407 + FAD <br />
-	**[[8ad3]], [[8ad5]] – VcNTNQD subunit f FAD-binding domain 130-407 (mutant) + FAD <br />
-	**[[7qu3]], [[7qu5]] – NTNQD subunit f FAD-binding domain 130-407 + FAD – Pseudomonas aeruginosa <br />
-	**[[7qty]], [[7qu0]] – KpNTNQD subunit f FAD-binding domain 130-407 + FAD - Klebsiella pneumoniae <br />

	==References==		==References==

Michal Harel at 10:04, 5 October 2023

2023-10-05T10:04:32Z

←Older revision		Revision as of 10:04, 5 October 2023
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	{{Clear}}		{{Clear}}
	The quinone ES936 causes irreversible inhibition of the NQO1. <scene name='2f1o/Align2/5'>Alignment</scene> of the hNQO1 dimer in complex with <font color='red'><b>ES936 (red)</b></font> ([[1kbq]]) with the hNQO1−dicoumarol complex ([[2f1o]]) yields 0.45Å RMSD for the 546 Cα atoms. The ES936 causes structural change only in the position of Phe 232. The movement of this residue is smaller than that caused by dicoumarol. The <scene name='2f1o/Align2/6'>distance</scene> between Tyr 128 and Phe 232 in the hNQO1−ES936 complex is only ~7 Å, while in the hNQO1−dicoumarol complex it is ~12 Å.		The quinone ES936 causes irreversible inhibition of the NQO1. <scene name='2f1o/Align2/5'>Alignment</scene> of the hNQO1 dimer in complex with <font color='red'><b>ES936 (red)</b></font> ([[1kbq]]) with the hNQO1−dicoumarol complex ([[2f1o]]) yields 0.45Å RMSD for the 546 Cα atoms. The ES936 causes structural change only in the position of Phe 232. The movement of this residue is smaller than that caused by dicoumarol. The <scene name='2f1o/Align2/6'>distance</scene> between Tyr 128 and Phe 232 in the hNQO1−ES936 complex is only ~7 Å, while in the hNQO1−dicoumarol complex it is ~12 Å.
-	</StructureSection>

	== 3D Structures of Quinone reductase ==		== 3D Structures of Quinone reductase ==
		+
		+	[[Quinone reductase 3D structures]]

	Updated on {{REVISIONDAY2}}-{{MONTHNAME\|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}		Updated on {{REVISIONDAY2}}-{{MONTHNAME\|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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	**[[1qrd]] – QR + bicarbon blue + duroquinone - rat<br />		**[[1qrd]] – QR + bicarbon blue + duroquinone - rat<br />
-	**[[~~4gi5~~]] – QR + FAD – ''Klebsiella pneumoniae''	+
-	}}	+	*Na(+)-translocating NADH-quinone reductase
		+
		+	**[[8a1t]], [[8a1x]], [[8acw]], [[8acy]] – VcNTNQD subunit a-f + FMN + riboflavin + FAD – Vibrio cholera – Cryo EM<br />
		+	**[[8a1v]], [[8a1w]] – VcNTNQD subunit a-f + FMN + riboflavin + ubiquinone + FAD – Cryo EM<br />
		+	**[[8ew3]] – VcNTNQD subunit a-f + FMN + riboflavin + ubiquinone – Cryo EM<br />
		+	**[[8a1y]] – VcNTNQD subunit a-f + FMN + riboflavin + quinoline inhibitor + FAD – Cryo EM<br />
		+	**[[7xk3]], [[7xk4]], [[7xk5]] – VcNTNQD subunit a-f + FMN + riboflavin + DOPE + FAD – Cryo EM<br />
		+	[[7xk6]], [[7xk7]] – VcNTNQD subunit a-f + FMN + riboflavin + DOPE + FAD + antibiotic – Cryo EM<br />
		+	**[[8a1u]] – VcNTNQD subunit a-f + FMN + riboflavin + ubiquinone + FAD + NADH – Cryo EM<br />
		+	**[[8acw]] – VcNTNQD subunit f + NADH + FAD <br />
		+	**[[4u9q]] – VcNTNQD subunit a<br />
		+	**[[4u9u]] – VcNTNQD subunit f FAD-binding domain 130-407 + FAD <br />
		+	**[[8ad3]], [[8ad5]] – VcNTNQD subunit f FAD-binding domain 130-407 (mutant) + FAD <br />
		+	**[[7qu3]], [[7qu5]] – NTNQD subunit f FAD-binding domain 130-407 + FAD – Pseudomonas aeruginosa <br />
		+	**[[7qty]], [[7qu0]] – KpNTNQD subunit f FAD-binding domain 130-407 + FAD - Klebsiella pneumoniae <br />
		+
	==References==		==References==
	<ref group="xtra">PMID:10706635</ref> <ref group="xtra">PMID:16700548</ref> <references group="xtra"/>		<ref group="xtra">PMID:10706635</ref> <ref group="xtra">PMID:16700548</ref> <references group="xtra"/>
-		+	</StructureSection>
	[[Category:Topic Page]]		[[Category:Topic Page]]

Michal Harel at 09:44, 9 February 2022

2022-02-09T09:44:19Z

←Older revision		Revision as of 09:44, 9 February 2022
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	**[[6mo6]], [[6mp5]], [[6oi5]] – hSQR + FAD<br />		**[[6mo6]], [[6mp5]], [[6oi5]] – hSQR + FAD<br />
-	**[[6oic]], [[6oib]], [[6oi6]] – hSQR + FAD + CoQ<br />	+	**[[6oic]], [[6oib]], [[6oi6]], [[6wh6]] – hSQR + FAD + CoQ<br />
	**[[3hyv]] – AaSQR + FAD – ''Aquifex aeolicus''<br />		**[[3hyv]] – AaSQR + FAD – ''Aquifex aeolicus''<br />
	**[[3hyw]] – AaSQR + FAD + decylubiquinone<br />		**[[3hyw]] – AaSQR + FAD + decylubiquinone<br />

Michal Harel at 09:28, 9 February 2022

2022-02-09T09:28:23Z

←Older revision		Revision as of 09:28, 9 February 2022
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	__TOC__		__TOC__
	==Function==		==Function==
-	'''Quinone reductase type 1 (QR1)''' reduces quinines to the non-toxic hydroquinone. '''Quinone reductase type 2 (QR2)''' catalyzes the reduction of adrenochrome. The '''sulfide-quinone reductase (SQR)''' reduces sulfide and thus provides electrons for phototropic processes in bacteria. '''NADPH-quinone reductase (NQR)''' catalyzes the reduction of quinone to semiquinone. See [[Electron Transport & Oxidative Phosphorylation]].	+	'''Quinone reductase type 1 (QR1)''' reduces quinines to the non-toxic hydroquinone. '''Quinone reductase type 2 (QR2)''' or '''ribosyldihydronicotinamide dehydrogenase [quinone]''' catalyzes the reduction of adrenochrome. The '''sulfide-quinone reductase (SQR)''' reduces sulfide and thus provides electrons for phototropic processes in bacteria. '''NADPH-quinone reductase (NQR)''' catalyzes the reduction of quinone to semiquinone. See [[Electron Transport & Oxidative Phosphorylation]].

	== NADH Quinone oxidoreductase type 1 (NQO1) in complex with its potent inhibitor dicoumarol ==		== NADH Quinone oxidoreductase type 1 (NQO1) in complex with its potent inhibitor dicoumarol ==

Michal Harel at 09:46, 14 October 2020

2020-10-14T09:46:38Z

←Older revision		Revision as of 09:46, 14 October 2020
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	*Quinone reductase type 2 or ribosyldihydronicotinamide dehydrogenase [quinone]		*Quinone reductase type 2 or ribosyldihydronicotinamide dehydrogenase [quinone]

-	**[[4qod]] – ~~hQR2~~ - human<br />	+	**[[4qod]] – hNQO2 - human<br />
-	**[[4qof]] – ~~hQR2~~ + FMN<br />	+	**[[4qof]] – hNQO2 + FMN<br />
-	**[[1qr2]], [[3fw1]], [[4qoe]] – ~~hQR2~~ + FAD<br />	+	**[[1qr2]], [[3fw1]], [[4qoe]] – hNQO2 + FAD<br />
-	**[[3o2n]], [[3g5m]], [[3gam]] – ~~hQR2~~ + FAD + PET agent<br />	+	**[[3o2n]], [[3g5m]], [[3gam]] – hNQO2 + FAD + PET agent<br />
-	**[[3ovm]], [[3owh]], [[3owx]] – ~~hQR2~~ + FAD + carbamate derivative<br />	+	**[[3ovm]], [[3owh]], [[3owx]] – hNQO2 + FAD + carbamate derivative<br />
-	**[[3ox1]], [[2qx4]], [[2qx6]], [[2qx8]], [[2qx9]], [[2qwx]] – ~~hQR2~~ + FAD + acetamide derivative<br />	+	**[[3ox1]], [[2qx4]], [[2qx6]], [[2qx8]], [[2qx9]], [[2qwx]] – hNQO2 + FAD + acetamide derivative<br />
-	**[[3ox2]], [[4xdh]], [[4xdg]] - ~~hQR2~~ + FAD + indole derivative<br />	+	**[[3ox2]], [[4xdh]], [[4xdg]] - hNQO2 + FAD + indole derivative<br />
-	**[[3ox3]] - ~~hQR2~~ + FAD + carboxamide derivative<br />	+	**[[3ox3]] - hNQO2 + FAD + carboxamide derivative<br />
-	**[[4u7f]], [[4u7g]], [[4u7h]] - ~~hQR2~~ + FAD + imidazole derivative<br />	+	**[[4u7f]], [[4u7g]], [[4u7h]] - hNQO2 + FAD + imidazole derivative<br />
-	**[[4zvk]], [[5buc]] - ~~hQR2~~ + FAD + ethidium<br />	+	**[[4zvk]], [[5buc]] - hNQO2 + FAD + ethidium<br />
-	**[[4zvm]] - ~~hQR2~~ + FAD + doxorubicin<br />	+	**[[4zvm]] - hNQO2 + FAD + doxorubicin<br />
-	**[[2qmy]] – ~~hQR2~~ + FAD + adrenochrome<br />	+	**[[2qmy]] – hNQO2 + FAD + adrenochrome<br />
-	**[[2qr2]] – ~~hQR2~~ + FAD + menadione<br />	+	**[[2qr2]] – hNQO2 + FAD + menadione<br />
-	**[[2qmz]] – ~~hQR2~~ + FAD + dopamine<br />	+	**[[2qmz]] – hNQO2 + FAD + dopamine<br />
-	**[[4qog]] – ~~hQR2~~ + FAD + melatonin<br />	+	**[[4qog]] – hNQO2 + FAD + melatonin<br />
-	**[[1sg0]], [[4qoh]] – ~~hQR2~~ + FAD + resveratol<br />	+	**[[1sg0]], [[4qoh]] – hNQO2 + FAD + resveratol<br />
-	**[[4qoj]] – ~~hQR2~~ + FMN + resveratol<br />	+	**[[4qoj]] – hNQO2 + FMN + resveratol<br />
-	**[[4qoi]] – ~~hQR2~~ + FMN + melatonin<br />	+	**[[4qoi]] – hNQO2 + FMN + melatonin<br />
-	**[[3nhu]], [[3nhs]], [[3nhr]], [[3nhp]], [[3nhl]], [[3nhk]], [[3nhj]], [[3nhf]], [[3nfr]], [[3nhw]], [[3nhy]], [[3uxe]], [[3uxh]] - ~~hQR2~~ + FAD + quinoline derivative<br />	+	**[[3nhu]], [[3nhs]], [[3nhr]], [[3nhp]], [[3nhl]], [[3nhk]], [[3nhj]], [[3nhf]], [[3nfr]], [[3nhw]], [[3nhy]], [[3uxe]], [[3uxh]] - hNQO2 + FAD + quinoline derivative<br />
-	**[[3te7]], [[3tem]], [[4zvl]], [[4zvn]] ~~– hNQO2 + FAD + acridine derivative<br />~~	+	**[[3te7]], [[3tem]], [[4zvl]], [[4zvn]], [[3tzb]] – hNQO2 + FAD + acridine derivative<br />
-	**[[3tzb]] – ~~hNQ2~~ + FAD + acridine derivative<br />	+
	**[[2bzs]], [[1xi2]], [[1zx1]], [[3o73]], [[5lbw]], [[5lbz]], [[5lby]] – hNQO2 + FAD + anti-cancer prodrug<br />		**[[2bzs]], [[1xi2]], [[1zx1]], [[3o73]], [[5lbw]], [[5lbz]], [[5lby]] – hNQO2 + FAD + anti-cancer prodrug<br />
-	**[[4fgj]], [[4fgk]], [[4fgl]] – ~~hQR2~~ + FAD + anti-malaria drug<br />	+	**[[4fgj]], [[4fgk]], [[4fgl]] – hNQO2 + FAD + anti-malaria drug<br />
	**[[5lbt]], [[5lbu]] – hNQO2 + FAD + anti-wart drug<br />		**[[5lbt]], [[5lbu]] – hNQO2 + FAD + anti-wart drug<br />
-	**[[4gqi]], [[4gr9]] – ~~hQR2~~ + FAD + ligand<br />	+	**[[4gqi]], [[4gr9]] – hNQO2 + FAD + ligand<br />

	*Sulfide-quinone reductase or Sulfide-quinone oxidoreductase		*Sulfide-quinone reductase or Sulfide-quinone oxidoreductase
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	*NADPH-quinone reductase or NADPH-quinone oxidoreductase or NADP dehydrogenase [quinone]		*NADPH-quinone reductase or NADPH-quinone oxidoreductase or NADP dehydrogenase [quinone]

-	**[[1d4a]], [[5ea2]] - ~~hNQR~~ + FAD<br />	+	**[[1d4a]], [[5ea2]] - hNQO1 + FAD<br />
-	**[[5a4k]] - ~~hNQR~~ (mutant) + FAD<br />	+	**[[5a4k]] - hNQO1 (mutant) + FAD<br />
	**[[3jsx]] – hNQO1 + FAD + chromen derivative<br />		**[[3jsx]] – hNQO1 + FAD + chromen derivative<br />
	**[[6fy4]] – hNQO1 + FAD + pyrrolidine derivative<br />		**[[6fy4]] – hNQO1 + FAD + pyrrolidine derivative<br />
-	**[[2f1O]] – hNQO1 + FAD + dicoumarol<br />	+	**[[2f1O]], [[4cet]] – hNQO1 + FAD + dicoumarol<br />
-	**[[1yb5]] – ~~hNQR~~ + NADP<br />	+	**[[5fuq]] – hNQO1 (mutant) + FAD + dicoumarol<br />
-	**[[1gg5]], [[1h66]], [[1h69]], [[1qbg]] - ~~hNQR~~ + FAD + anti-cancer prodrug<br />	+	**[[4cf6]] – hNQO1 (mutant) + FAD + cibacron<br />
-	**[[1dxo]] - ~~hNQR~~ + FAD + quinone derivative<br />	+	**[[1yb5]] – hNQO1 + NADP<br />
-	**[[1kbo]], [[1kbq]] - ~~hNQR~~ + FAD + indole derivative<br />	+	**[[1gg5]], [[1h66]], [[1h69]], [[1qbg]] - hNQRO1 + FAD + anti-cancer prodrug<br />
-	**[[1dxq]] - ~~mNQR~~ + FAD - mouse<br />	+	**[[1dxo]] - hNQO1 + FAD + quinone derivative<br />
-	**[[3ha2]] – ~~NQR~~ – ''Pediococcus pentosaceus''<br />	+	**[[1kbo]], [[1kbq]] - hNQO1 + FAD + indole derivative<br />
		+	**[[1dxq]] - mNQO1 + FAD - mouse<br />
		+	**[[3ha2]] – NQO1 – ''Pediococcus pentosaceus''<br />

	*Quinone reductase		*Quinone reductase

Michal Harel at 09:29, 14 October 2020

2020-10-14T09:29:06Z

←Older revision		Revision as of 09:29, 14 October 2020
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	**[[4qoi]] – hQR2 + FMN + melatonin<br />		**[[4qoi]] – hQR2 + FMN + melatonin<br />
	**[[3nhu]], [[3nhs]], [[3nhr]], [[3nhp]], [[3nhl]], [[3nhk]], [[3nhj]], [[3nhf]], [[3nfr]], [[3nhw]], [[3nhy]], [[3uxe]], [[3uxh]] - hQR2 + FAD + quinoline derivative<br />		**[[3nhu]], [[3nhs]], [[3nhr]], [[3nhp]], [[3nhl]], [[3nhk]], [[3nhj]], [[3nhf]], [[3nfr]], [[3nhw]], [[3nhy]], [[3uxe]], [[3uxh]] - hQR2 + FAD + quinoline derivative<br />
-	**[[3te7]], [[3tem]], [[~~3tzb~~]], [[~~4zvl~~]], [[~~4zvn~~]] – ~~hQR2~~ + FAD + acridine derivative<br />	+	**[[3te7]], [[3tem]], [[4zvl]], [[4zvn]] – hNQO2 + FAD + acridine derivative<br />
-	**[[2bzs]], [[1xi2]], [[1zx1]], [[3o73]], [[5lbw]], [[5lbz]], [[5lby]] – ~~hQR2~~ + FAD + anti-cancer prodrug<br />	+	**[[3tzb]] – hNQ2 + FAD + acridine derivative<br />
		+	**[[2bzs]], [[1xi2]], [[1zx1]], [[3o73]], [[5lbw]], [[5lbz]], [[5lby]] – hNQO2 + FAD + anti-cancer prodrug<br />
	**[[4fgj]], [[4fgk]], [[4fgl]] – hQR2 + FAD + anti-malaria drug<br />		**[[4fgj]], [[4fgk]], [[4fgl]] – hQR2 + FAD + anti-malaria drug<br />
-	**[[5lbt]], [[5lbu]] – ~~hQR2~~ + FAD + anti-wart drug<br />	+	**[[5lbt]], [[5lbu]] – hNQO2 + FAD + anti-wart drug<br />
	**[[4gqi]], [[4gr9]] – hQR2 + FAD + ligand<br />		**[[4gqi]], [[4gr9]] – hQR2 + FAD + ligand<br />

-	*Sulfide-quinone reductase	+	*Sulfide-quinone reductase or Sulfide-quinone oxidoreductase

-	**[[3hyv]] – AaSQR – ''Aquifex aeolicus''<br />	+	**[[6mo6]], [[6mp5]], [[6oi5]] – hSQR + FAD<br />
-	**[[3hyw]] – AaSQR + decylubiquinone<br />	+	**[[6oic]], [[6oib]], [[6oi6]] – hSQR + FAD + CoQ<br />
-	**[[3hyx]] – AaSQR + Aurachin C<br />	+	**[[3hyv]] – AaSQR + FAD – ''Aquifex aeolicus''<br />
		+	**[[3hyw]] – AaSQR + FAD + decylubiquinone<br />
		+	**[[3hyx]] – AaSQR + FAD + Aurachin C<br />
		+	**[[3h8l]], [[3h8i]] – AaSQR + FAD + trisulfane<br />
		+	**[[3t0k]] – AfSQR + FAD + trisulfide + decylubiquinone - ''Acidithiobacillus ferrooxidabs''<br />
		+	**[[3t14]] – AfSQR + FAD + disulfide<br />
		+	**[[3t2y]] – AfSQR (mutant) + FAD + disulfide<br />
		+	**[[3t2k]], [[3t2z]] – AfSQR + FAD + trisulfane<br />
		+	**[[3t31]] – AfSQR + FAD + decylubiquinone<br />

-	*NADPH-quinone reductase	+	*NADPH-quinone reductase or NADPH-quinone oxidoreductase or NADP dehydrogenase [quinone]

-	**[[~~3ha2~~]] – ~~NQR – ''Pediococcus pentosaceus''~~<br />	+	**[[1d4a]], [[5ea2]] - hNQR + FAD<br />
-	**[[~~1dxq~~]], [[~~1d4a~~]] ~~- hNQR~~<br />	+	**[[5a4k]] - hNQR (mutant) + FAD<br />
		+	**[[3jsx]] – hNQO1 + FAD + chromen derivative<br />
		+	**[[6fy4]] – hNQO1 + FAD + pyrrolidine derivative<br />
		+	**[[2f1O]] – hNQO1 + FAD + dicoumarol<br />
	**[[1yb5]] – hNQR + NADP<br />		**[[1yb5]] – hNQR + NADP<br />
-	**[[1gg5]], [[1h66]], [[1h69]], [[1qbg]] - hNQR + anti-cancer prodrug<br />	+	**[[1gg5]], [[1h66]], [[1h69]], [[1qbg]] - hNQR + FAD + anti-cancer prodrug<br />
-	**[[1dxo]] - hNQR + quinone derivative<br />	+	**[[1dxo]] - hNQR + FAD + quinone derivative<br />
		+	**[[1kbo]], [[1kbq]] - hNQR + FAD + indole derivative<br />
		+	**[[1dxq]] - mNQR + FAD - mouse<br />
		+	**[[3ha2]] – NQR – ''Pediococcus pentosaceus''<br />

	*Quinone reductase		*Quinone reductase

Michal Harel at 08:28, 14 October 2020

2020-10-14T08:28:53Z

←Older revision		Revision as of 08:28, 14 October 2020
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	<StructureSection load='' size='350' scene='2f1o/Com_view/2' caption='NADPH dehydrogenase complex with FAD (red) and dicoumarol (blue) [[2f1o]]'>		<StructureSection load='' size='350' scene='2f1o/Com_view/2' caption='NADPH dehydrogenase complex with FAD (red) and dicoumarol (blue) [[2f1o]]'>
	{{Clear}}		{{Clear}}
		+	__TOC__
		+	==Function==
	'''Quinone reductase type 1 (QR1)''' reduces quinines to the non-toxic hydroquinone. '''Quinone reductase type 2 (QR2)''' catalyzes the reduction of adrenochrome. The '''sulfide-quinone reductase (SQR)''' reduces sulfide and thus provides electrons for phototropic processes in bacteria. '''NADPH-quinone reductase (NQR)''' catalyzes the reduction of quinone to semiquinone. See [[Electron Transport & Oxidative Phosphorylation]].		'''Quinone reductase type 1 (QR1)''' reduces quinines to the non-toxic hydroquinone. '''Quinone reductase type 2 (QR2)''' catalyzes the reduction of adrenochrome. The '''sulfide-quinone reductase (SQR)''' reduces sulfide and thus provides electrons for phototropic processes in bacteria. '''NADPH-quinone reductase (NQR)''' catalyzes the reduction of quinone to semiquinone. See [[Electron Transport & Oxidative Phosphorylation]].

Line 32:		Line 34:
	**[[1kbo]], [[1kbq]] – hQR1 + indole derivative<br />		**[[1kbo]], [[1kbq]] – hQR1 + indole derivative<br />

-	*Quinone reductase type 2	+	*Quinone reductase type 2 or ribosyldihydronicotinamide dehydrogenase [quinone]

-	**[[3fw1]], [[~~1qr2~~]] – hQR2 ~~- human~~<br />	+	**[[4qod]] – hQR2 - human<br />
-	**[[3o2n]], [[3g5m]], [[3gam]] – hQR2 + PET agent<br />	+	**[[4qof]] – hQR2 + FMN<br />
-	**[[3ovm]], [[3owh]], [[3owx]] – hQR2 + carbamate derivative<br />	+	**[[1qr2]], [[3fw1]], [[4qoe]] – hQR2 + FAD<br />
-	**[[3ox1]], [[2qx4]], [[2qx6]], [[2qx8]], [[2qx9]], [[2qwx]] – hQR2 + acetamide derivative<br />	+	**[[3o2n]], [[3g5m]], [[3gam]] – hQR2 + FAD + PET agent<br />
-	**[[3ox2]] - hQR2 + indole derivative<br />	+	**[[3ovm]], [[3owh]], [[3owx]] – hQR2 + FAD + carbamate derivative<br />
-	**[[3ox3]] - hQR2 + carboxamide derivative<br />	+	**[[3ox1]], [[2qx4]], [[2qx6]], [[2qx8]], [[2qx9]], [[2qwx]] – hQR2 + FAD + acetamide derivative<br />
-	**[[2qmy]] – hQR2 + adrenochrome<br />	+	**[[3ox2]], [[4xdh]], [[4xdg]] - hQR2 + FAD + indole derivative<br />
-	**[[2qr2]] – hQR2 + menadione<br />	+	**[[3ox3]] - hQR2 + FAD + carboxamide derivative<br />
-	**[[2qmz]] – hQR2 + dopamine<br />	+	**[[4u7f]], [[4u7g]], [[4u7h]] - hQR2 + FAD + imidazole derivative<br />
-	**[[1sg0]] – hQR2 + resveratol<br />	+	**[[4zvk]], [[5buc]] - hQR2 + FAD + ethidium<br />
-	**[[3nhu]], [[3nhs]], [[3nhr]], [[3nhp]], [[3nhl]], [[3nhk]], [[3nhj]], [[3nhf]], [[3nfr]], [[3nhw]], [[3nhy]], [[3uxe]], [[3uxh]] - hQR2 + quinoline derivative<br />	+	**[[4zvm]] - hQR2 + FAD + doxorubicin<br />
-	**[[3te7]], [[3tem]], [[3tzb]] – hQR2 + acridine derivative<br />	+	**[[2qmy]] – hQR2 + FAD + adrenochrome<br />
-	**[[2bzs]], [[1xi2]], [[1zx1]], [[3o73]] – hQR2 + anti-cancer prodrug<br />	+	**[[2qr2]] – hQR2 + FAD + menadione<br />
-	**[[4fgj]], [[4fgk]], [[4fgl]] – hQR2 + anti-malaria drug<br />	+	**[[2qmz]] – hQR2 + FAD + dopamine<br />
-	**[[4gqi]], [[4gr9]] – hQR2 + ligand<br />	+	**[[4qog]] – hQR2 + FAD + melatonin<br />
		+	**[[1sg0]], [[4qoh]] – hQR2 + FAD + resveratol<br />
		+	**[[4qoj]] – hQR2 + FMN + resveratol<br />
		+	**[[4qoi]] – hQR2 + FMN + melatonin<br />
		+	**[[3nhu]], [[3nhs]], [[3nhr]], [[3nhp]], [[3nhl]], [[3nhk]], [[3nhj]], [[3nhf]], [[3nfr]], [[3nhw]], [[3nhy]], [[3uxe]], [[3uxh]] - hQR2 + FAD + quinoline derivative<br />
		+	**[[3te7]], [[3tem]], [[3tzb]], [[4zvl]], [[4zvn]] – hQR2 + FAD + acridine derivative<br />
		+	**[[2bzs]], [[1xi2]], [[1zx1]], [[3o73]], [[5lbw]], [[5lbz]], [[5lby]] – hQR2 + FAD + anti-cancer prodrug<br />
		+	**[[4fgj]], [[4fgk]], [[4fgl]] – hQR2 + FAD + anti-malaria drug<br />
		+	**[[5lbt]], [[5lbu]] – hQR2 + FAD + anti-wart drug<br />
		+	**[[4gqi]], [[4gr9]] – hQR2 + FAD + ligand<br />

	*Sulfide-quinone reductase		*Sulfide-quinone reductase

Joel L. Sussman at 18:38, 21 October 2017

2017-10-21T18:38:49Z

←Older revision		Revision as of 18:38, 21 October 2017
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-	<StructureSection load='~~2f1o.pdb~~' size='350' scene='2f1o/Com_view/2' caption='NADPH dehydrogenase complex with FAD (red) and dicoumarol (blue) [[2f1o]]'>	+	<StructureSection load='' size='350' scene='2f1o/Com_view/2' caption='NADPH dehydrogenase complex with FAD (red) and dicoumarol (blue) [[2f1o]]'>
	{{Clear}}		{{Clear}}
	'''Quinone reductase type 1 (QR1)''' reduces quinines to the non-toxic hydroquinone. '''Quinone reductase type 2 (QR2)''' catalyzes the reduction of adrenochrome. The '''sulfide-quinone reductase (SQR)''' reduces sulfide and thus provides electrons for phototropic processes in bacteria. '''NADPH-quinone reductase (NQR)''' catalyzes the reduction of quinone to semiquinone. See [[Electron Transport & Oxidative Phosphorylation]].		'''Quinone reductase type 1 (QR1)''' reduces quinines to the non-toxic hydroquinone. '''Quinone reductase type 2 (QR2)''' catalyzes the reduction of adrenochrome. The '''sulfide-quinone reductase (SQR)''' reduces sulfide and thus provides electrons for phototropic processes in bacteria. '''NADPH-quinone reductase (NQR)''' catalyzes the reduction of quinone to semiquinone. See [[Electron Transport & Oxidative Phosphorylation]].

Michal Harel at 06:49, 3 August 2016

2016-08-03T06:49:00Z

←Older revision		Revision as of 06:49, 3 August 2016
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	Certain [http://en.wikipedia.org/wiki/Coumarin coumarins], [http://en.wikipedia.org/wiki/Flavones flavones] and the reactive dye cibacron blue are [http://en.wikipedia.org/wiki/Competitive_inhibition competitive inhibitors] of NQO1 activity, which compete with NAD(P)H for binding to NQO1. [[Dicoumarol]] (3-3’–methylene-bis (4-hydroxycoumarin)),		Certain [http://en.wikipedia.org/wiki/Coumarin coumarins], [http://en.wikipedia.org/wiki/Flavones flavones] and the reactive dye cibacron blue are [http://en.wikipedia.org/wiki/Competitive_inhibition competitive inhibitors] of NQO1 activity, which compete with NAD(P)H for binding to NQO1. [[Dicoumarol]] (3-3’–methylene-bis (4-hydroxycoumarin)),
	is the most potent competitive inhibitor of NQO1. Dicoumarol competes with NAD(P)H for binding to NQO1 and prevents the [http://en.wikipedia.org/wiki/Electron_transfer electron transfer] to FAD.		is the most potent competitive inhibitor of NQO1. Dicoumarol competes with NAD(P)H for binding to NQO1 and prevents the [http://en.wikipedia.org/wiki/Electron_transfer electron transfer] to FAD.
-	In addition to its role in the detoxification of quinones, NQO1 is also a 20S proteasome-associated protein that plays an important role in the stability of the [http://en.wikipedia.org/wiki/Tumor_suppressor_gene tumor suppressor] p53 and several other short-lived proteins including [[p73α]] and ornithine decarboxylase (ODC, ''i.e.'' [[7odc]]). NQO1 binds and stabilizes [[p53]], protecting p53 from [http://en.wikipedia.org/wiki/Proteasome#Ubiquitin-independent_degradation ubiquitin-independent 20S proteasomal degradation]. Dicoumarol and several other inhibitors of NQO1 activity, which compete with NADH for binding to NQO1, disrupt the binding of NQO1 to p53 and induce ubiquitin-independent p53 degradation.	+	In addition to its role in the detoxification of quinones, NQO1 is also a 20S proteasome-associated protein that plays an important role in the stability of the [http://en.wikipedia.org/wiki/Tumor_suppressor_gene tumor suppressor] p53 and several other short-lived proteins including p73α and ornithine decarboxylase (ODC, ''i.e.'' [[7odc]]). NQO1 binds and stabilizes [[p53]], protecting p53 from [http://en.wikipedia.org/wiki/Proteasome#Ubiquitin-independent_degradation ubiquitin-independent 20S proteasomal degradation]. Dicoumarol and several other inhibitors of NQO1 activity, which compete with NADH for binding to NQO1, disrupt the binding of NQO1 to p53 and induce ubiquitin-independent p53 degradation.

	{{Clear}}		{{Clear}}

Michal Harel at 09:03, 2 February 2016

2016-02-02T09:03:09Z

←Older revision		Revision as of 09:03, 2 February 2016
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-	<StructureSection load='2f1o.pdb' size='~~450~~' scene='2f1o/Com_view/2' caption='NADPH dehydrogenase complex with FAD (red) and dicoumarol (blue) [[2f1o]]'>	+	<StructureSection load='2f1o.pdb' size='350' scene='2f1o/Com_view/2' caption='NADPH dehydrogenase complex with FAD (red) and dicoumarol (blue) [[2f1o]]'>
	{{Clear}}		{{Clear}}
-	'''Quinone reductase type 1 (QR1)''' reduces quinines to the non-toxic hydroquinone. '''Quinone reductase type 2 (QR2)''' catalyzes the reduction of adrenochrome. The '''sulfide-quinone reductase (SQR)''' reduces sulfide and thus provides electrons for phototropic processes in bacteria. '''NADPH-quinone reductase (NQR)''' catalyzes the reduction of quinone to semiquinone. ~~The images at the left and at the right correspond to one representative Quinone reductase, ''i.e.'' the crystal structure of NADH quinone oxidoreductase (NQO1) with inhibitor dicoumarol (~~[[~~2f1o~~]]).	+	'''Quinone reductase type 1 (QR1)''' reduces quinines to the non-toxic hydroquinone. '''Quinone reductase type 2 (QR2)''' catalyzes the reduction of adrenochrome. The '''sulfide-quinone reductase (SQR)''' reduces sulfide and thus provides electrons for phototropic processes in bacteria. '''NADPH-quinone reductase (NQR)''' catalyzes the reduction of quinone to semiquinone. See [[Electron Transport & Oxidative Phosphorylation]].

	== NADH Quinone oxidoreductase type 1 (NQO1) in complex with its potent inhibitor dicoumarol ==		== NADH Quinone oxidoreductase type 1 (NQO1) in complex with its potent inhibitor dicoumarol ==