RNA uridylyltransferase - Revision history

Michal Harel at 08:06, 9 March 2022

2022-03-09T08:06:04Z

←Older revision		Revision as of 08:06, 9 March 2022
Line 14:		Line 14:
	*RNA uridylyltransferase-1		*RNA uridylyltransferase-1

-	**[[2e5g]] – ~~hRNAU~~-1 RNA recognition motif – human – NMR<br />	+	*RNA uridylyltransferase-1
-	**[[3pq1]] – ~~hRNAU~~-1 (mutant)<br />	+
-	**[[6l3f]] – ~~AtRNAU~~-1 (mutant) – ''Arabidopsis thaliana''<br />	+	**[[2e5g]] – hTUT-1 RNA recognition motif – human – NMR<br />
-	**[[6l8k]] – ~~AtRNAU~~-1 + UTP<br />	+	**[[3pq1]] – hTUT-1 (mutant)<br />
		+	**[[6l3f]] – AtTUT-1 (mutant) – ''Arabidopsis thaliana''<br />
		+	**[[6l8k]] – AtTUT-1 + UTP<br />
		+	**[[2b51]], [[5hcd]] – TbTUT-1 – ''Trypanosoma brucei''<br />
		+	**[[5ido]] – TbTUT-1 + UTP <br />
		+	**[[5i49]] – TbTUT-1 + UMPNPP <br />

	*RNA uridylyltransferase-4		*RNA uridylyltransferase-4

-	**[[2q0c]], [[2q0d]], [[2q0e]], [[2q0f]], [[2q0g]], [[2ikf]], [[2nom]], [[5kal]] – ~~TbRNAU~~-4 + nucleotide – ''~~Trypanosoma brucei~~''<br />	+	**[[6iw6]] – hTUT-4 253-723<br />
		+	**[[2q0c]], [[2q0d]], [[2q0e]], [[2q0f]], [[2q0g]], [[2ikf]], [[2nom]], [[5kal]] – TbTUT-4 + nucleotide <br />
		+
		+	*RNA uridylyltransferase-7
		+
		+	**[[5w0b]] – hTUT-7 catalytic module<br />
		+	**[[5w0m]] – hTUT-7 + U5 ssRNA <br />
		+	**[[5w0o]] – hTUT-7 + dsRNA + UTPbr />
		+	**[[5w0n]] – hTUT-7 + U2 ssRNA + UMPNPP<br />
		+
		+	*TUTase Tailor
		+
		+	**[[5z4c]] – DmTUTT – ''Drosophila melanogaster'' <br />
		+	**[[5z4a]], [[5z4d]], [[5z4j]], [[6i0t]], [[6i0u]], [[6i0v]] – DmTUTT + RNA <br />
		+	**[[5z4m]] – DmTUTT (mutant) + UTP <br />
		+
	}}		}}
	== References ==		== References ==
	<references/>		<references/>
	[[Category:Topic Page]]		[[Category:Topic Page]]

Michal Harel at 08:03, 9 March 2022

2022-03-09T08:03:48Z

←Older revision		Revision as of 08:03, 9 March 2022
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	<StructureSection load='' size='350' side='right' caption='RNA uridylyltransferase-4 complex with UTP, UMP and Mg+2 ions (green) (PDB entry [[2q0f]])' scene='53/536705/Cv/1'>		<StructureSection load='' size='350' side='right' caption='RNA uridylyltransferase-4 complex with UTP, UMP and Mg+2 ions (green) (PDB entry [[2q0f]])' scene='53/536705/Cv/1'>
	== Function ==		== Function ==
-	'''RNA uridylyltransferase''' or '''terminal uridylyltransferase''' (~~RNAU~~) catalyzes the addition of uridine to RNA. ~~RNAU~~ acts as a suppressor of microRNA synthesis by mediating its terminal uridylation<ref>PMID:17189640</ref>. For additional details on ~~RNAU~~-4 see [[Terminal Uridylyl Transferase]].	+	'''RNA uridylyltransferase''' or '''terminal uridylyltransferase''' or '''TUTase''' (TUT) catalyzes the addition of uridine to RNA. TUT acts as a suppressor of microRNA synthesis by mediating its terminal uridylation<ref>PMID:17189640</ref>. For additional details on TUT-4 see [[Terminal Uridylyl Transferase]]. ''Drosophila melanogaster'' TUTase is called '''TUTase Tailor''' <ref>PMID:26145174</ref>.

	== Structural highlights ==		== Structural highlights ==
-	<scene name='53/536705/Cv/5'>~~RNAU~~-4 active site contains UTP, UMP and Mg+2 ions</scene><ref>PMID:17785418</ref>. Water molecules are shown as red spheres. <scene name='53/536705/Cv/6'>Mg coordination site</scene>.	+	<scene name='53/536705/Cv/5'>TUT-4 active site contains UTP, UMP and Mg+2 ions</scene><ref>PMID:17785418</ref>. Water molecules are shown as red spheres. <scene name='53/536705/Cv/6'>Mg coordination site</scene>.

	</StructureSection>		</StructureSection>

Michal Harel at 11:05, 8 March 2022

2022-03-08T11:05:27Z

←Older revision		Revision as of 11:05, 8 March 2022
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	<StructureSection load='' size='350' side='right' caption='RNA uridylyltransferase-4 complex with UTP, UMP and Mg+2 ions (green) (PDB entry [[2q0f]])' scene='53/536705/Cv/1'>		<StructureSection load='' size='350' side='right' caption='RNA uridylyltransferase-4 complex with UTP, UMP and Mg+2 ions (green) (PDB entry [[2q0f]])' scene='53/536705/Cv/1'>
	== Function ==		== Function ==
-	'''RNA uridylyltransferase''' (RNAU) catalyzes the addition of uridine to RNA. RNAU acts as a suppressor of microRNA synthesis by mediating its terminal uridylation<ref>PMID:17189640</ref>. For additional details on RNAU-4 see [[Terminal Uridylyl Transferase]].	+	'''RNA uridylyltransferase''' or '''terminal uridylyltransferase''' (RNAU) catalyzes the addition of uridine to RNA. RNAU acts as a suppressor of microRNA synthesis by mediating its terminal uridylation<ref>PMID:17189640</ref>. For additional details on RNAU-4 see [[Terminal Uridylyl Transferase]].

	== Structural highlights ==		== Structural highlights ==

Michal Harel at 07:54, 27 October 2020

2020-10-27T07:54:32Z

←Older revision		Revision as of 07:54, 27 October 2020
Line 16:		Line 16:
	**[[2e5g]] – hRNAU-1 RNA recognition motif – human – NMR<br />		**[[2e5g]] – hRNAU-1 RNA recognition motif – human – NMR<br />
	**[[3pq1]] – hRNAU-1 (mutant)<br />		**[[3pq1]] – hRNAU-1 (mutant)<br />
		+	**[[6l3f]] – AtRNAU-1 (mutant) – ''Arabidopsis thaliana''<br />
		+	**[[6l8k]] – AtRNAU-1 + UTP<br />

	*RNA uridylyltransferase-4		*RNA uridylyltransferase-4

Alexander Berchansky at 12:24, 1 September 2019

2019-09-01T12:24:32Z

←Older revision		Revision as of 12:24, 1 September 2019
Line 4:		Line 4:

	== Structural highlights ==		== Structural highlights ==
-	<scene name='53/536705/Cv/3'>RNAU-4 active site contains UTP, UMP and Mg+2 ions</scene><ref>PMID:17785418</ref>. Water molecules shown as red spheres. <scene name='53/536705/Cv/4'>Mg coordination site</scene>.	+	<scene name='53/536705/Cv/5'>RNAU-4 active site contains UTP, UMP and Mg+2 ions</scene><ref>PMID:17785418</ref>. Water molecules are shown as red spheres. <scene name='53/536705/Cv/6'>Mg coordination site</scene>.

	</StructureSection>		</StructureSection>

Michal Harel at 21:29, 14 September 2018

2018-09-14T21:29:55Z

←Older revision		Revision as of 21:29, 14 September 2018
Line 1:		Line 1:
-	<StructureSection load='' size='~~450~~' side='right' caption='RNA uridylyltransferase-4 complex with UTP, UMP and Mg+2 ions (green) (PDB entry [[2q0f]])' scene='53/536705/Cv/1'>	+	<StructureSection load='' size='350' side='right' caption='RNA uridylyltransferase-4 complex with UTP, UMP and Mg+2 ions (green) (PDB entry [[2q0f]])' scene='53/536705/Cv/1'>
	== Function ==		== Function ==
	'''RNA uridylyltransferase''' (RNAU) catalyzes the addition of uridine to RNA. RNAU acts as a suppressor of microRNA synthesis by mediating its terminal uridylation<ref>PMID:17189640</ref>. For additional details on RNAU-4 see [[Terminal Uridylyl Transferase]].		'''RNA uridylyltransferase''' (RNAU) catalyzes the addition of uridine to RNA. RNAU acts as a suppressor of microRNA synthesis by mediating its terminal uridylation<ref>PMID:17189640</ref>. For additional details on RNAU-4 see [[Terminal Uridylyl Transferase]].

Joel L. Sussman at 05:52, 3 October 2017

2017-10-03T05:52:32Z

←Older revision		Revision as of 05:52, 3 October 2017
Line 1:		Line 1:
-	<StructureSection load='~~2q0f~~' size='450' side='right' caption='RNA uridylyltransferase-4 complex with UTP, UMP and Mg+2 ions (green) (PDB entry [[2q0f]])' scene='53/536705/Cv/1'>	+	<StructureSection load='' size='450' side='right' caption='RNA uridylyltransferase-4 complex with UTP, UMP and Mg+2 ions (green) (PDB entry [[2q0f]])' scene='53/536705/Cv/1'>
	== Function ==		== Function ==
	'''RNA uridylyltransferase''' (RNAU) catalyzes the addition of uridine to RNA. RNAU acts as a suppressor of microRNA synthesis by mediating its terminal uridylation<ref>PMID:17189640</ref>. For additional details on RNAU-4 see [[Terminal Uridylyl Transferase]].		'''RNA uridylyltransferase''' (RNAU) catalyzes the addition of uridine to RNA. RNAU acts as a suppressor of microRNA synthesis by mediating its terminal uridylation<ref>PMID:17189640</ref>. For additional details on RNAU-4 see [[Terminal Uridylyl Transferase]].

Michal Harel at 18:04, 2 October 2017

2017-10-02T18:04:10Z

←Older revision		Revision as of 18:04, 2 October 2017
Line 19:		Line 19:
	*RNA uridylyltransferase-4		*RNA uridylyltransferase-4

-	**[[2q0c]], [[2q0d]], [[2q0e]], [[2q0f]], [[2q0g]], [[2ikf]], [[2nom]] – TbRNAU-4 + nucleotide – ''Trypanosoma brucei''<br />	+	**[[2q0c]], [[2q0d]], [[2q0e]], [[2q0f]], [[2q0g]], [[2ikf]], [[2nom]], [[5kal]] – TbRNAU-4 + nucleotide – ''Trypanosoma brucei''<br />
	}}		}}
	== References ==		== References ==
	<references/>		<references/>
	[[Category:Topic Page]]		[[Category:Topic Page]]

Alexander Berchansky at 08:46, 21 August 2016

2016-08-21T08:46:15Z

←Older revision		Revision as of 08:46, 21 August 2016
Line 4:		Line 4:

	== Structural highlights ==		== Structural highlights ==
-	RNAU-4 active site contains UTP, UMP and Mg+2 ions<ref>PMID:17785418</ref>.	+	<scene name='53/536705/Cv/3'>RNAU-4 active site contains UTP, UMP and Mg+2 ions</scene><ref>PMID:17785418</ref>. Water molecules shown as red spheres. <scene name='53/536705/Cv/4'>Mg coordination site</scene>.

	</StructureSection>		</StructureSection>

Alexander Berchansky at 08:09, 21 August 2016

2016-08-21T08:09:58Z

←Older revision		Revision as of 08:09, 21 August 2016
Line 1:		Line 1:
-	<StructureSection load='2q0f' size='~~350~~' side='right' caption='RNA uridylyltransferase-4 complex with UTP ~~(stick model)~~, UMP ~~(stick model)~~ and Mg+2 ions (green) (PDB entry [[2q0f]])' scene=''>	+	<StructureSection load='2q0f' size='450' side='right' caption='RNA uridylyltransferase-4 complex with UTP, UMP and Mg+2 ions (green) (PDB entry [[2q0f]])' scene='53/536705/Cv/1'>
	== Function ==		== Function ==
	'''RNA uridylyltransferase''' (RNAU) catalyzes the addition of uridine to RNA. RNAU acts as a suppressor of microRNA synthesis by mediating its terminal uridylation<ref>PMID:17189640</ref>. For additional details on RNAU-4 see [[Terminal Uridylyl Transferase]].		'''RNA uridylyltransferase''' (RNAU) catalyzes the addition of uridine to RNA. RNAU acts as a suppressor of microRNA synthesis by mediating its terminal uridylation<ref>PMID:17189640</ref>. For additional details on RNAU-4 see [[Terminal Uridylyl Transferase]].