Ras-related protein Rab - Revision history

Michal Harel at 11:02, 26 October 2020

2020-10-26T11:02:02Z

←Older revision		Revision as of 11:02, 26 October 2020
Line 13:		Line 13:
	Rab-11A undergoes a conformation change of <scene name='80/804492/Cv/2'>two switch regions</scene> between its inactive GDP-bound structure and its active GTP-bound structure. <scene name='80/804492/Cv/8'>GDP forms numerous interactions at the active site</scene> located at the surface of the protein<ref>PMID:14699104</ref>. Water molecules are shown as red spheres.		Rab-11A undergoes a conformation change of <scene name='80/804492/Cv/2'>two switch regions</scene> between its inactive GDP-bound structure and its active GTP-bound structure. <scene name='80/804492/Cv/8'>GDP forms numerous interactions at the active site</scene> located at the surface of the protein<ref>PMID:14699104</ref>. Water molecules are shown as red spheres.

-	[[~~3D structures of~~ Ras-related protein Rab]]	+	[[Ras-related protein Rab 3D structures]]

	</StructureSection>		</StructureSection>

Michal Harel at 08:22, 18 October 2020

2020-10-18T08:22:30Z

←Older revision		Revision as of 08:22, 18 October 2020
Line 16:		Line 16:

	</StructureSection>		</StructureSection>
-
-	==3D structures of Ras-related protein Rab==
-
-	Updated on {{REVISIONDAY2}}-{{MONTHNAME\|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
-	{{#tree:id=OrganizedByTopic\|openlevels=0\|
-
-	*Rab-1 GTPase domain 1-178
-
-	**[[2fol]] – hRab-1 + GDP - human<br />
-	**[[6sku]] – hRab-1 + AnkX + GDP<br />
-	**[[5szh]], [[5szk]] – hRab-1 + Mical-cL + GNP<br />
-	**[[4i1o]] – hRab-1 + LepB + GDP<br />
-	**[[4fmb]] – hRab-1 + VirA + GDP<br />
-	**[[3tkl]] – hRab-1 + LidA + GTP<br />
-	**[[3sfv]] – hRab-1 (mutant) + LidA + GDP<br />
-	**[[3nkv]] – hRab-1 + GNP + AMP<br />
-	**[[3jza]], [[2wwx]], [[3l0i]] – hRab-1 + DrrA <br />
-	**[[5o74]] – hRab-1 + DrrA + GDP <br />
-
-	*Rab-2
-
-	**[[2a5j]] – hRab-2 + GDP<br />
-
-	*Rab-3
-
-	**[[2gf9]] – hRab-3 + GDP <br />
-	**[[3rab]] – Rab-3 + GNP - rat<br />
-	**[[4rkf]] – DmRab-3 + GDP - ''Drosophila melanogaster''<br />
-
-	*Rab-4
-
-	**[[2o52]] – hRab-4 + GDP<br />
-	**[[1yu9]] – hRab-4 + GNP<br />
-
-	*Rab-5C
-
-	**[[4kyi]] – hRab-5C + VipD + GNP<br />
-	**[[1z02]] – mRab-5C (mutant) + GNP - mouse<br />
-	**[[1z0d]], [[1z0a]] – mRab-5C + GDP <br />
-	**[[1huq]] – mRab-5C + GNP <br />
-
-	*Rab-6
-
-	**[[2e9s]], [[2fe4]], [[4dkx]] – hRab-6 + GDP <br />
-	**[[2ffq]] – hRab-6 + GSP <br />
-	**[[2gil]] – hRab-6 + GTP <br />
-	**[[1yzq]] – hRab-6 + GNP <br />
-	**[[3bbp]] – hRab-6 + GCC185 + GTP <br />
-	**[[3cwz]] – mRab-6 + R6IP1 + GTP <br />
-	**[[5lef]] – mRab-6 + KIF20A + GTP <br />
-	**[[2y8e]] – DmRab-5C + GNP <br />
-
-	*Rab-7L1
-
-	**[[6hh2]] – hRab-7L1 + GDP <br />
-
-	*Rab-8
-
-	**[[6sq2]] – hRab-8 + GTP<br />
-	**[[6stg]], [[4lhw]] – hRab-8 + GNP<br />
-	**[[6stf]], [[4lhv]] – hRab-8 + GDP<br />
-
-	*Rab-9
-
-	**[[1wms]] – hRab-9 + GDP<br />
-	**[[2ocb]] – hRab-9 + GNP<br />
-	**[[1s8f]] – Rab-9 + GDP - dog<br />
-	**[[1yzl]] – mRab-9 + GNP<br />
-	**[[4qxa]] – mRab-9 + RUTBC2 + GTP<br />
-
-	*Rab-11A complex with nucleotide
-
-	**[[1oiv]], [[6yi1]] – hRab-11A + GDP<br />
-	**[[1oix]] – hRab-11A (mutant) + GDP <br />
-	**[[5ez5]] – hRab-11A (mutant) + GTP <br />
-	**[[1yzk]] – hRab-11A + GppNHp<br />
-	**[[1oiw]] – hRab-11A (mutant) + GTPγS <br />
-	**[[3bfk]] – Rab-11A + GDP – ''Plasmodium falciparum''<br />
-	**[[5xr4]] – AtRab-11A + GDP – ''Arabidopsis thaliana''<br />
-	**[[5xr7]] – AtRab-11A (mutant) + GTP <br />
-	**[[5xr6]] – AtRab-11A + GppNHp<br />
-
-	*Rab-11A other complexes
-
-	**[[4c4p]] – hRab-11A + Rab11 family-interacting protein 2 <br />
-	**[[2gzd]], [[2gzh]] – hRab-11A (mutant) + Rab11 family-interacting protein 2 <br />
-	**[[2hv8]], [[2d7c]] – hRab-11A (mutant) + Rab11 family-interacting protein 3<br />
-	**[[4d0m]] – hRab-11A (mutant) + Rab11 family-interacting protein 3 + PI4KB<br />
-	**[[4uj5]] – hRab-11A (mutant) + Rab-3A interacting protein 3<br />
-	**[[4uj3]], [[4uj4]] – hRab-11A (mutant) + Rab11 family-interacting protein 3 + Rab-3A interacting protein 3<br />
-	**[[5jcz]] – hRab-11A + unconventional myosin-Va<br />
-	**[[4lwz]], [[4lx0]] – hRab-11A + unconventional myosin-Vb<br />
-	**[[4fmd]] – hRab-11A + EspG + GDP<br />
-	**[[6djl]] – hRab-11A (mutant) + SH3 domain-binding protein 5<br />
-	**[[5fbl]], [[5fbq]], [[5fbr]], [[5fbv]], [[5fbw]] – hRab-11A + PI4KB + inhibitor<br />
-	**[[5c46]] – hRab-11A (mutant) + PI4KB + GDPγS<br />
-	**[[5c4g]], [[5euq]], [[4d0l]] – hRab-11A (mutant) + PI4KB + GDPγS + inhibitor<br />
-
-	*Rab-11B
-
-	**[[2f9l]] – hRab-11B + GDP <br />
-	**[[2f9m]] – hRab-11B + GNP <br />
-
-	*Rab-12
-
-	**[[2il1]] – hRab-12 + GDP <br />
-
-	*Rab-14
-
-	**[[4d0g]] – hRab-14 (mutant) + Rab11 family-interacting protein 1 <br />
-	**[[4drz]], [[1z0f]] – hRab-14 + GDP <br />
-
-	*Rab-18
-
-	**[[1x3s]] – hRab-18 + GNP <br />
-
-	*Rab-22
-
-	**[[1yvd]] – mRab-22 + GNP <br />
-	**[[1z0j]] – mRab-22 (mutant) + rabenosyn-5 + GTP <br />
-
-	*Rab-23
-
-	**[[1z22]], [[1z2a]] – mRab-23 + GDP<br />
-
-	*Rab-25
-
-	**[[2oil]] – hRab-25 + GDP <br />
-	**[[3tso]] – hRab-25 + Rab11 family-interacting protein 2 <br />
-
-	*Rab-26
-
-	**[[2g6b]] – hRab-26 + GNP <br />
-
-	*Rab-27
-
-	**[[2f7s]] – hRab-27 + GDP <br />
-	**[[2iey]], [[2iez]], [[2if0]] – mRab-27 + GDP <br />
-	**[[2zet]] – mRab-27 + melanophilin + GDP <br />
-
-	*Rab-28
-
-	**[[2hxs]] – hRab-28 + G3D <br />
-	**[[3e5h]] – hRab-28 + GND <br />
-
-	*Rab-30
-
-	**[[2ew1]] – hRab-30 + GNP <br />
-
-	*Rab-31
-
-	**[[2fg5]] – hRab-31 + GNP <br />
-
-	*Rab-32
-
-	**[[6ff8]] – hRab-32 + GTP <br />
-	**[[5oed]], [[5oec]] – hRab-32 + GtgE + GDP <br />
-
-	*Rab-33
-
-	**[[1z06]] – mRab-33 + Gyp1 + GDP <br />
-	**[[2g77]] – mRab-33 + GNP <br />
-	**[[6zay]] – mRab-33 + Atg16L + GDP <br />
-	**[[6y09]], [[6sur]] – mRab-33 + Atg16L + GTP <br />
-
-	*Rab-35
-
-	**[[6if2]] – hRab-35 + GTP <br />
-	**[[6if3]] – hRab-35 + ACAP2 + GTP <br />
-	**[[6ekk]] – hRab-35 + DENDD 1A + GDP <br />
-	**[[3tw8]] – hRab-35 + DENDD 1B <br />
-
-	*Rab-38
-
-	**[[6s5h]], [[6hdu]] – hRab-38 + GTP <br />
-
-	*Rab-39B
-
-	**[[6s5f]] – hRab-39B + GMPPNP <br />
-
-	*Rab-43
-
-	**[[2hup]] – hRab-43 + GDP <br />
-	}}

	== References ==		== References ==

Michal Harel at 08:20, 18 October 2020

2020-10-18T08:20:24Z

←Older revision		Revision as of 08:20, 18 October 2020
Line 12:		Line 12:

	Rab-11A undergoes a conformation change of <scene name='80/804492/Cv/2'>two switch regions</scene> between its inactive GDP-bound structure and its active GTP-bound structure. <scene name='80/804492/Cv/8'>GDP forms numerous interactions at the active site</scene> located at the surface of the protein<ref>PMID:14699104</ref>. Water molecules are shown as red spheres.		Rab-11A undergoes a conformation change of <scene name='80/804492/Cv/2'>two switch regions</scene> between its inactive GDP-bound structure and its active GTP-bound structure. <scene name='80/804492/Cv/8'>GDP forms numerous interactions at the active site</scene> located at the surface of the protein<ref>PMID:14699104</ref>. Water molecules are shown as red spheres.
		+
		+	[[3D structures of Ras-related protein Rab]]

	</StructureSection>		</StructureSection>
Line 20:		Line 22:
	{{#tree:id=OrganizedByTopic\|openlevels=0\|		{{#tree:id=OrganizedByTopic\|openlevels=0\|

-	*Rab-1	+	*Rab-1 GTPase domain 1-178

	**[[2fol]] – hRab-1 + GDP - human<br />		**[[2fol]] – hRab-1 + GDP - human<br />
Line 30:		Line 32:
	**[[3sfv]] – hRab-1 (mutant) + LidA + GDP<br />		**[[3sfv]] – hRab-1 (mutant) + LidA + GDP<br />
	**[[3nkv]] – hRab-1 + GNP + AMP<br />		**[[3nkv]] – hRab-1 + GNP + AMP<br />
-	**[[3jza]] – hRab-1 + DrrA <br />	+	**[[3jza]], [[2wwx]], [[3l0i]] – hRab-1 + DrrA <br />
	**[[5o74]] – hRab-1 + DrrA + GDP <br />		**[[5o74]] – hRab-1 + DrrA + GDP <br />

Line 40:		Line 42:

	**[[2gf9]] – hRab-3 + GDP <br />		**[[2gf9]] – hRab-3 + GDP <br />
-	**[[~~4rkf~~]] – Rab-3 + GDP - ''Drosophila melanogaster''<br />	+	**[[3rab]] – Rab-3 + GNP - rat<br />
		+	**[[4rkf]] – DmRab-3 + GDP - ''Drosophila melanogaster''<br />

	*Rab-4		*Rab-4

	**[[2o52]] – hRab-4 + GDP<br />		**[[2o52]] – hRab-4 + GDP<br />
		+	**[[1yu9]] – hRab-4 + GNP<br />

	*Rab-5C		*Rab-5C
Line 51:		Line 55:
	**[[1z02]] – mRab-5C (mutant) + GNP - mouse<br />		**[[1z02]] – mRab-5C (mutant) + GNP - mouse<br />
	**[[1z0d]], [[1z0a]] – mRab-5C + GDP <br />		**[[1z0d]], [[1z0a]] – mRab-5C + GDP <br />
		+	**[[1huq]] – mRab-5C + GNP <br />

	*Rab-6		*Rab-6
Line 57:		Line 62:
	**[[2ffq]] – hRab-6 + GSP <br />		**[[2ffq]] – hRab-6 + GSP <br />
	**[[2gil]] – hRab-6 + GTP <br />		**[[2gil]] – hRab-6 + GTP <br />
		+	**[[1yzq]] – hRab-6 + GNP <br />
	**[[3bbp]] – hRab-6 + GCC185 + GTP <br />		**[[3bbp]] – hRab-6 + GCC185 + GTP <br />
	**[[3cwz]] – mRab-6 + R6IP1 + GTP <br />		**[[3cwz]] – mRab-6 + R6IP1 + GTP <br />
	**[[5lef]] – mRab-6 + KIF20A + GTP <br />		**[[5lef]] – mRab-6 + KIF20A + GTP <br />
		+	**[[2y8e]] – DmRab-5C + GNP <br />

	*Rab-7L1		*Rab-7L1
Line 106:		Line 113:
	**[[5c46]] – hRab-11A (mutant) + PI4KB + GDPγS<br />		**[[5c46]] – hRab-11A (mutant) + PI4KB + GDPγS<br />
	**[[5c4g]], [[5euq]], [[4d0l]] – hRab-11A (mutant) + PI4KB + GDPγS + inhibitor<br />		**[[5c4g]], [[5euq]], [[4d0l]] – hRab-11A (mutant) + PI4KB + GDPγS + inhibitor<br />
		+
		+	*Rab-11B
		+
		+	**[[2f9l]] – hRab-11B + GDP <br />
		+	**[[2f9m]] – hRab-11B + GNP <br />
		+
		+	*Rab-12
		+
		+	**[[2il1]] – hRab-12 + GDP <br />

	*Rab-14		*Rab-14

	**[[4d0g]] – hRab-14 (mutant) + Rab11 family-interacting protein 1 <br />		**[[4d0g]] – hRab-14 (mutant) + Rab11 family-interacting protein 1 <br />
-	**[[4drz]] – hRab-14 + GDP <br />	+	**[[4drz]], [[1z0f]] – hRab-14 + GDP <br />

	*Rab-18		*Rab-18
Line 160:		Line 176:
	*Rab-33		*Rab-33

-	**[[1z06]] – mRab-33 + Gyp1	+	**[[1z06]] – mRab-33 + Gyp1 + GDP <br />
-	GDP <br />	+
	**[[2g77]] – mRab-33 + GNP <br />		**[[2g77]] – mRab-33 + GNP <br />
	**[[6zay]] – mRab-33 + Atg16L + GDP <br />		**[[6zay]] – mRab-33 + Atg16L + GDP <br />

Michal Harel at 09:15, 17 October 2020

2020-10-17T09:15:06Z

←Older revision		Revision as of 09:15, 17 October 2020
Line 19:		Line 19:
	Updated on {{REVISIONDAY2}}-{{MONTHNAME\|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}		Updated on {{REVISIONDAY2}}-{{MONTHNAME\|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
	{{#tree:id=OrganizedByTopic\|openlevels=0\|		{{#tree:id=OrganizedByTopic\|openlevels=0\|
		+
		+	*Rab-1
		+
		+	**[[2fol]] – hRab-1 + GDP - human<br />
		+	**[[6sku]] – hRab-1 + AnkX + GDP<br />
		+	**[[5szh]], [[5szk]] – hRab-1 + Mical-cL + GNP<br />
		+	**[[4i1o]] – hRab-1 + LepB + GDP<br />
		+	**[[4fmb]] – hRab-1 + VirA + GDP<br />
		+	**[[3tkl]] – hRab-1 + LidA + GTP<br />
		+	**[[3sfv]] – hRab-1 (mutant) + LidA + GDP<br />
		+	**[[3nkv]] – hRab-1 + GNP + AMP<br />
		+	**[[3jza]] – hRab-1 + DrrA <br />
		+	**[[5o74]] – hRab-1 + DrrA + GDP <br />

	*Rab-2		*Rab-2

-	**[[2a5j]] – hRab-2 + GDP - ~~human~~<br />	+	**[[2a5j]] – hRab-2 + GDP<br />
		+
		+	*Rab-3
		+
		+	**[[2gf9]] – hRab-3 + GDP <br />
		+	**[[4rkf]] – Rab-3 + GDP - ''Drosophila melanogaster''<br />
		+
		+	*Rab-4
		+
		+	**[[2o52]] – hRab-4 + GDP<br />

-	*Rab-3D	+	*Rab-5C

-	**[[~~2gf9~~]] – hRab-3D + GDP <br />	+	**[[4kyi]] – hRab-5C + VipD + GNP<br />
		+	**[[1z02]] – mRab-5C (mutant) + GNP - mouse<br />
		+	**[[1z0d]], [[1z0a]] – mRab-5C + GDP <br />

	*Rab-6		*Rab-6

-	**[[2e9s]], [[2fe4]] – hRab-6 + GDP <br />	+	**[[2e9s]], [[2fe4]], [[4dkx]] – hRab-6 + GDP <br />
	**[[2ffq]] – hRab-6 + GSP <br />		**[[2ffq]] – hRab-6 + GSP <br />
	**[[2gil]] – hRab-6 + GTP <br />		**[[2gil]] – hRab-6 + GTP <br />
		+	**[[3bbp]] – hRab-6 + GCC185 + GTP <br />
		+	**[[3cwz]] – mRab-6 + R6IP1 + GTP <br />
		+	**[[5lef]] – mRab-6 + KIF20A + GTP <br />

	*Rab-7L1		*Rab-7L1

	**[[6hh2]] – hRab-7L1 + GDP <br />		**[[6hh2]] – hRab-7L1 + GDP <br />
		+
		+	*Rab-8
		+
		+	**[[6sq2]] – hRab-8 + GTP<br />
		+	**[[6stg]], [[4lhw]] – hRab-8 + GNP<br />
		+	**[[6stf]], [[4lhv]] – hRab-8 + GDP<br />

	*Rab-9		*Rab-9

-	**[[1yzl]] – mRab-9 + GNP - ~~mouse~~<br />	+	**[[1wms]] – hRab-9 + GDP<br />
		+	**[[2ocb]] – hRab-9 + GNP<br />
		+	**[[1s8f]] – Rab-9 + GDP - dog<br />
		+	**[[1yzl]] – mRab-9 + GNP<br />
		+	**[[4qxa]] – mRab-9 + RUTBC2 + GTP<br />

	*Rab-11A complex with nucleotide		*Rab-11A complex with nucleotide
Line 73:		Line 110:

	**[[4d0g]] – hRab-14 (mutant) + Rab11 family-interacting protein 1 <br />		**[[4d0g]] – hRab-14 (mutant) + Rab11 family-interacting protein 1 <br />
		+	**[[4drz]] – hRab-14 + GDP <br />

	*Rab-18		*Rab-18
Line 81:		Line 119:

	**[[1yvd]] – mRab-22 + GNP <br />		**[[1yvd]] – mRab-22 + GNP <br />
		+	**[[1z0j]] – mRab-22 (mutant) + rabenosyn-5 + GTP <br />

	*Rab-23		*Rab-23
Line 94:		Line 133:

	**[[2g6b]] – hRab-26 + GNP <br />		**[[2g6b]] – hRab-26 + GNP <br />
		+
		+	*Rab-27
		+
		+	**[[2f7s]] – hRab-27 + GDP <br />
		+	**[[2iey]], [[2iez]], [[2if0]] – mRab-27 + GDP <br />
		+	**[[2zet]] – mRab-27 + melanophilin + GDP <br />

	*Rab-28		*Rab-28

	**[[2hxs]] – hRab-28 + G3D <br />		**[[2hxs]] – hRab-28 + G3D <br />
		+	**[[3e5h]] – hRab-28 + GND <br />

	*Rab-30		*Rab-30
Line 110:		Line 156:

	**[[6ff8]] – hRab-32 + GTP <br />		**[[6ff8]] – hRab-32 + GTP <br />
		+	**[[5oed]], [[5oec]] – hRab-32 + GtgE + GDP <br />
		+
		+	*Rab-33
		+
		+	**[[1z06]] – mRab-33 + Gyp1
		+	GDP <br />
		+	**[[2g77]] – mRab-33 + GNP <br />
		+	**[[6zay]] – mRab-33 + Atg16L + GDP <br />
		+	**[[6y09]], [[6sur]] – mRab-33 + Atg16L + GTP <br />

	*Rab-35		*Rab-35
Line 120:		Line 175:
	*Rab-38		*Rab-38

-	**[[6s5h]] – hRab-38 + GTP <br />	+	**[[6s5h]], [[6hdu]] – hRab-38 + GTP <br />

	*Rab-39B		*Rab-39B

Michal Harel at 08:20, 17 October 2020

2020-10-17T08:20:18Z

←Older revision		Revision as of 08:20, 17 October 2020
Line 19:		Line 19:
	Updated on {{REVISIONDAY2}}-{{MONTHNAME\|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}		Updated on {{REVISIONDAY2}}-{{MONTHNAME\|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
	{{#tree:id=OrganizedByTopic\|openlevels=0\|		{{#tree:id=OrganizedByTopic\|openlevels=0\|
		+
		+	*Rab-2
		+
		+	**[[2a5j]] – hRab-2 + GDP - human<br />
		+
		+	*Rab-3D
		+
		+	**[[2gf9]] – hRab-3D + GDP <br />
		+
		+	*Rab-6
		+
		+	**[[2e9s]], [[2fe4]] – hRab-6 + GDP <br />
		+	**[[2ffq]] – hRab-6 + GSP <br />
		+	**[[2gil]] – hRab-6 + GTP <br />
		+
		+	*Rab-7L1
		+
		+	**[[6hh2]] – hRab-7L1 + GDP <br />
		+
		+	*Rab-9
		+
		+	**[[1yzl]] – mRab-9 + GNP - mouse<br />

	*Rab-11A complex with nucleotide		*Rab-11A complex with nucleotide

-	**[[1oiv]] – hRab-11A + GDP ~~- human~~<br />	+	**[[1oiv]], [[6yi1]] – hRab-11A + GDP<br />
	**[[1oix]] – hRab-11A (mutant) + GDP <br />		**[[1oix]] – hRab-11A (mutant) + GDP <br />
	**[[5ez5]] – hRab-11A (mutant) + GTP <br />		**[[5ez5]] – hRab-11A (mutant) + GTP <br />
Line 42:		Line 64:
	**[[5jcz]] – hRab-11A + unconventional myosin-Va<br />		**[[5jcz]] – hRab-11A + unconventional myosin-Va<br />
	**[[4lwz]], [[4lx0]] – hRab-11A + unconventional myosin-Vb<br />		**[[4lwz]], [[4lx0]] – hRab-11A + unconventional myosin-Vb<br />
		+	**[[4fmd]] – hRab-11A + EspG + GDP<br />
	**[[6djl]] – hRab-11A (mutant) + SH3 domain-binding protein 5<br />		**[[6djl]] – hRab-11A (mutant) + SH3 domain-binding protein 5<br />
	**[[5fbl]], [[5fbq]], [[5fbr]], [[5fbv]], [[5fbw]] – hRab-11A + PI4KB + inhibitor<br />		**[[5fbl]], [[5fbq]], [[5fbr]], [[5fbv]], [[5fbw]] – hRab-11A + PI4KB + inhibitor<br />
Line 50:		Line 73:

	**[[4d0g]] – hRab-14 (mutant) + Rab11 family-interacting protein 1 <br />		**[[4d0g]] – hRab-14 (mutant) + Rab11 family-interacting protein 1 <br />
		+
		+	*Rab-18
		+
		+	**[[1x3s]] – hRab-18 + GNP <br />
		+
		+	*Rab-22
		+
		+	**[[1yvd]] – mRab-22 + GNP <br />
		+
		+	*Rab-23
		+
		+	**[[1z22]], [[1z2a]] – mRab-23 + GDP<br />

	*Rab-25		*Rab-25

		+	**[[2oil]] – hRab-25 + GDP <br />
	**[[3tso]] – hRab-25 + Rab11 family-interacting protein 2 <br />		**[[3tso]] – hRab-25 + Rab11 family-interacting protein 2 <br />
		+
		+	*Rab-26
		+
		+	**[[2g6b]] – hRab-26 + GNP <br />
		+
		+	*Rab-28
		+
		+	**[[2hxs]] – hRab-28 + G3D <br />
		+
		+	*Rab-30
		+
		+	**[[2ew1]] – hRab-30 + GNP <br />
		+
		+	*Rab-31
		+
		+	**[[2fg5]] – hRab-31 + GNP <br />
		+
		+	*Rab-32
		+
		+	**[[6ff8]] – hRab-32 + GTP <br />
		+
		+	*Rab-35
		+
		+	**[[6if2]] – hRab-35 + GTP <br />
		+	**[[6if3]] – hRab-35 + ACAP2 + GTP <br />
		+	**[[6ekk]] – hRab-35 + DENDD 1A + GDP <br />
		+	**[[3tw8]] – hRab-35 + DENDD 1B <br />
		+
		+	*Rab-38
		+
		+	**[[6s5h]] – hRab-38 + GTP <br />
		+
		+	*Rab-39B
		+
		+	**[[6s5f]] – hRab-39B + GMPPNP <br />
		+
		+	*Rab-43
		+
		+	**[[2hup]] – hRab-43 + GDP <br />
	}}		}}

Alexander Berchansky at 12:18, 19 December 2018

2018-12-19T12:18:40Z

←Older revision		Revision as of 12:18, 19 December 2018
Line 11:		Line 11:
	== Structural highlights ==		== Structural highlights ==

-	Rab-11A undergoes a conformation change of <scene name='80/804492/Cv/2'>two switch regions</scene> between its inactive GDP-bound structure and its active GTP-bound structure. <scene name='80/804492/Cv/7'>GDP forms numerous interactions at the active site</scene> located at the surface of the protein<ref>PMID:14699104</ref>. Water molecules are shown as red spheres.	+	Rab-11A undergoes a conformation change of <scene name='80/804492/Cv/2'>two switch regions</scene> between its inactive GDP-bound structure and its active GTP-bound structure. <scene name='80/804492/Cv/8'>GDP forms numerous interactions at the active site</scene> located at the surface of the protein<ref>PMID:14699104</ref>. Water molecules are shown as red spheres.

	</StructureSection>		</StructureSection>

Alexander Berchansky at 12:17, 19 December 2018

2018-12-19T12:17:01Z

←Older revision		Revision as of 12:17, 19 December 2018
Line 11:		Line 11:
	== Structural highlights ==		== Structural highlights ==

-	Rab-11A undergoes a conformation change of <scene name='80/804492/Cv/2'>two switch regions</scene>~~two switch regions~~ between its inactive GDP-bound structure and its active GTP-bound structure. <scene name='80/804492/Cv/7'>GDP forms numerous interactions at the active site</scene> located at the surface of the protein<ref>PMID:14699104</ref>. Water molecules are shown as red spheres.	+	Rab-11A undergoes a conformation change of <scene name='80/804492/Cv/2'>two switch regions</scene> between its inactive GDP-bound structure and its active GTP-bound structure. <scene name='80/804492/Cv/7'>GDP forms numerous interactions at the active site</scene> located at the surface of the protein<ref>PMID:14699104</ref>. Water molecules are shown as red spheres.

	</StructureSection>		</StructureSection>

Alexander Berchansky at 12:16, 19 December 2018

2018-12-19T12:16:42Z

←Older revision		Revision as of 12:16, 19 December 2018
Line 11:		Line 11:
	== Structural highlights ==		== Structural highlights ==

-	Rab-11A undergoes a conformation change of <scene name='80/804492/Cv/2'>two switch regions</scene>two switch regions between its inactive GDP-bound structure and its active GTP-bound structure. GDP forms numerous interactions at the active site located at the surface of the protein<ref>PMID:14699104</ref>.	+	Rab-11A undergoes a conformation change of <scene name='80/804492/Cv/2'>two switch regions</scene>two switch regions between its inactive GDP-bound structure and its active GTP-bound structure. <scene name='80/804492/Cv/7'>GDP forms numerous interactions at the active site</scene> located at the surface of the protein<ref>PMID:14699104</ref>. Water molecules are shown as red spheres.

	</StructureSection>		</StructureSection>

Alexander Berchansky at 11:48, 19 December 2018

2018-12-19T11:48:53Z

←Older revision		Revision as of 11:48, 19 December 2018
Line 11:		Line 11:
	== Structural highlights ==		== Structural highlights ==

-	Rab-11A undergoes a conformation change of two switch regions between its inactive GDP-bound structure and its active GTP-bound structure. GDP forms numerous interactions at the active site located at the surface of the protein<ref>PMID:14699104</ref>.	+	Rab-11A undergoes a conformation change of <scene name='80/804492/Cv/2'>two switch regions</scene>two switch regions between its inactive GDP-bound structure and its active GTP-bound structure. GDP forms numerous interactions at the active site located at the surface of the protein<ref>PMID:14699104</ref>.

	</StructureSection>		</StructureSection>

Alexander Berchansky at 11:45, 19 December 2018

2018-12-19T11:45:35Z

←Older revision		Revision as of 11:45, 19 December 2018
Line 1:		Line 1:
-	<StructureSection load='1oix' size='340' side='right' caption='Human Rab-11A complex with GDP, phosphate and Mg+2 ion (green) (PDB code [[1oix]])' scene=''>	+	<StructureSection load='1oix' size='340' side='right' caption='Human Rab-11A complex with GDP, phosphate and Mg+2 ion (green) (PDB code [[1oix]])' scene='80/804492/Cv/1'>

	== Function ==		== Function ==