Rifampicin - Revision history

http://52.214.119.220/wiki/index.php?action=history&feed=atom&title=Rifampicin Rifampicin - Revision history 2026-04-04T03:35:49Z Revision history for this page on the wiki MediaWiki 1.11.2 http://52.214.119.220/wiki/index.php?title=Rifampicin&diff=4012927&oldid=prev Alexander Berchansky at 14:57, 4 January 2024 2024-01-04T14:57:17Z

<p></p> <table style="background-color: white; color:black;"> <col class='diff-marker' /> <col class='diff-content' /> <col class='diff-marker' /> <col class='diff-content' /> <tr> <td colspan='2' style="background-color: white; color:black;">←Older revision</td> <td colspan='2' style="background-color: white; color:black;">Revision as of 14:57, 4 January 2024</td> </tr> <tr><td colspan="2" class="diff-lineno">Line 6:</td> <td colspan="2" class="diff-lineno">Line 6:</td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>Crystal structure data and biochemical data suggest that <scene name='10/1022377/Cv/4'>rifampicin binds to the pocket of the RNA polymerase β subunit</scene> within the DNA/RNA channel, but away from the active site.<ref name="a39">PMID:11290327</ref> The inhibitor prevents RNA synthesis by physically blocking elongation, and thus preventing synthesis of host bacterial proteins. By this "steric-occlusion" mechanism, rifampicin blocks synthesis of the second or third phosphodiester bond between the nucleotides in the RNA backbone, preventing elongation of the 5' end of the RNA transcript past more than 2 or 3 nucleotides.<ref name="a39">PMID:11290327</ref><ref name="a49">PMID:18787125</ref></div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>Crystal structure data and biochemical data suggest that <scene name='10/1022377/Cv/4'>rifampicin binds to the pocket of the RNA polymerase β subunit</scene> within the DNA/RNA channel, but away from the active site.<ref name="a39">PMID:11290327</ref> The inhibitor prevents RNA synthesis by physically blocking elongation, and thus preventing synthesis of host bacterial proteins. By this "steric-occlusion" mechanism, rifampicin blocks synthesis of the second or third phosphodiester bond between the nucleotides in the RNA backbone, preventing elongation of the 5' end of the RNA transcript past more than 2 or 3 nucleotides.<ref name="a39">PMID:11290327</ref><ref name="a49">PMID:18787125</ref></div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>In a recent study Rifampicin was shown to bind to [[NADPH-Cytochrome P450 Reductase|cytochrome P450 reductase]] and alter its conformation as well as activity towards supporting metabolism of progesterone via CYP21A2.<ref name="a50">PMID:33859207</ref></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>In a recent study Rifampicin was shown to bind to [[NADPH-Cytochrome P450 Reductase|cytochrome P450 reductase]] and alter its conformation as well as activity towards supporting metabolism of <ins style="color: red; font-weight: bold; text-decoration: none;">[[</ins>progesterone<ins style="color: red; font-weight: bold; text-decoration: none;">]] </ins>via CYP21A2.<ref name="a50">PMID:33859207</ref></div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div></StructureSection></div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div></StructureSection></div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>== References ==</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>== References ==</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div><references/></div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div><references/></div></td></tr> </table>

Alexander Berchansky http://52.214.119.220/wiki/index.php?title=Rifampicin&diff=4012926&oldid=prev Alexander Berchansky at 14:56, 4 January 2024 2024-01-04T14:56:41Z

<p></p> <table style="background-color: white; color:black;"> <col class='diff-marker' /> <col class='diff-content' /> <col class='diff-marker' /> <col class='diff-content' /> <tr> <td colspan='2' style="background-color: white; color:black;">←Older revision</td> <td colspan='2' style="background-color: white; color:black;">Revision as of 14:56, 4 January 2024</td> </tr> <tr><td colspan="2" class="diff-lineno">Line 6:</td> <td colspan="2" class="diff-lineno">Line 6:</td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>Crystal structure data and biochemical data suggest that <scene name='10/1022377/Cv/4'>rifampicin binds to the pocket of the RNA polymerase β subunit</scene> within the DNA/RNA channel, but away from the active site.<ref name="a39">PMID:11290327</ref> The inhibitor prevents RNA synthesis by physically blocking elongation, and thus preventing synthesis of host bacterial proteins. By this "steric-occlusion" mechanism, rifampicin blocks synthesis of the second or third phosphodiester bond between the nucleotides in the RNA backbone, preventing elongation of the 5' end of the RNA transcript past more than 2 or 3 nucleotides.<ref name="a39">PMID:11290327</ref><ref name="a49">PMID:18787125</ref></div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>Crystal structure data and biochemical data suggest that <scene name='10/1022377/Cv/4'>rifampicin binds to the pocket of the RNA polymerase β subunit</scene> within the DNA/RNA channel, but away from the active site.<ref name="a39">PMID:11290327</ref> The inhibitor prevents RNA synthesis by physically blocking elongation, and thus preventing synthesis of host bacterial proteins. By this "steric-occlusion" mechanism, rifampicin blocks synthesis of the second or third phosphodiester bond between the nucleotides in the RNA backbone, preventing elongation of the 5' end of the RNA transcript past more than 2 or 3 nucleotides.<ref name="a39">PMID:11290327</ref><ref name="a49">PMID:18787125</ref></div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>In a recent study Rifampicin was shown to bind to cytochrome P450 reductase and alter its conformation as well as activity towards supporting metabolism of progesterone via CYP21A2.<ref name="a50">PMID:33859207</ref></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>In a recent study Rifampicin was shown to bind to <ins style="color: red; font-weight: bold; text-decoration: none;">[[NADPH-Cytochrome P450 Reductase|</ins>cytochrome P450 reductase<ins style="color: red; font-weight: bold; text-decoration: none;">]] </ins>and alter its conformation as well as activity towards supporting metabolism of progesterone via CYP21A2.<ref name="a50">PMID:33859207</ref></div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div></StructureSection></div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div></StructureSection></div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>== References ==</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>== References ==</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div><references/></div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div><references/></div></td></tr> </table>

Alexander Berchansky http://52.214.119.220/wiki/index.php?title=Rifampicin&diff=4012925&oldid=prev Alexander Berchansky at 14:54, 4 January 2024 2024-01-04T14:54:32Z

<p></p> <table style="background-color: white; color:black;"> <col class='diff-marker' /> <col class='diff-content' /> <col class='diff-marker' /> <col class='diff-content' /> <tr> <td colspan='2' style="background-color: white; color:black;">←Older revision</td> <td colspan='2' style="background-color: white; color:black;">Revision as of 14:54, 4 January 2024</td> </tr> <tr><td colspan="2" class="diff-lineno">Line 2:</td> <td colspan="2" class="diff-lineno">Line 2:</td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>Rifampicin, also known as rifampin, is an ansamycin antibiotic used to treat several types of bacterial infections, including tuberculosis (TB), Mycobacterium avium complex, leprosy, and Legionnaires' disease.<ref name="a2">[https://www.drugs.com/monograph/rifampin.html "Rifampin".] The American Society of Health-System Pharmacists. Archived from the original on 2015-09-07. Retrieved Aug 1, 2015.</ref> It is almost always used together with other antibiotics with two notable exceptions: when given as a "preferred treatment that is strongly recommended"<ref name="a3">PMID:32053584</ref> for latent TB infection; and when used as post-exposure prophylaxis to prevent Haemophilus influenzae type b and meningococcal disease in people who have been exposed to those bacteria. Before treating a person for a long period of time, measurements of liver enzymes and blood counts are recommended.<ref name="a2">[https://www.drugs.com/monograph/rifampin.html "Rifampin".] The American Society of Health-System Pharmacists. Archived from the original on 2015-09-07. Retrieved Aug 1, 2015.</ref> See also [https://en.wikipedia.org/wiki/Rifampicin Rifampicin].</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>Rifampicin, also known as rifampin, is an ansamycin antibiotic used to treat several types of bacterial infections, including tuberculosis (TB), Mycobacterium avium complex, leprosy, and Legionnaires' disease.<ref name="a2">[https://www.drugs.com/monograph/rifampin.html "Rifampin".] The American Society of Health-System Pharmacists. Archived from the original on 2015-09-07. Retrieved Aug 1, 2015.</ref> It is almost always used together with other antibiotics with two notable exceptions: when given as a "preferred treatment that is strongly recommended"<ref name="a3">PMID:32053584</ref> for latent TB infection; and when used as post-exposure prophylaxis to prevent Haemophilus influenzae type b and meningococcal disease in people who have been exposed to those bacteria. Before treating a person for a long period of time, measurements of liver enzymes and blood counts are recommended.<ref name="a2">[https://www.drugs.com/monograph/rifampin.html "Rifampin".] The American Society of Health-System Pharmacists. Archived from the original on 2015-09-07. Retrieved Aug 1, 2015.</ref> See also [https://en.wikipedia.org/wiki/Rifampicin Rifampicin].</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>Rifampicin inhibits bacterial DNA-dependent RNA synthesis by inhibiting bacterial DNA-dependent RNA polymerase.<ref name="a48">PMID:4957347</ref> <scene name='10/1022377/Cv/2'>THERMUS AQUATICUS CORE RNA POLYMERASE-RIFAMPICIN COMPLEX</scene> ([[1i6v]]).</div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>Rifampicin inhibits bacterial DNA-dependent RNA synthesis by inhibiting bacterial DNA-dependent <ins style="color: red; font-weight: bold; text-decoration: none;">[[</ins>RNA polymerase<ins style="color: red; font-weight: bold; text-decoration: none;">]]</ins>.<ref name="a48">PMID:4957347</ref> <scene name='10/1022377/Cv/2'>THERMUS AQUATICUS CORE RNA POLYMERASE-RIFAMPICIN COMPLEX</scene> ([[1i6v]]).</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>Crystal structure data and biochemical data suggest that <scene name='10/1022377/Cv/4'>rifampicin binds to the pocket of the RNA polymerase β subunit</scene> within the DNA/RNA channel, but away from the active site.<ref name="a39">PMID:11290327</ref> The inhibitor prevents RNA synthesis by physically blocking elongation, and thus preventing synthesis of host bacterial proteins. By this "steric-occlusion" mechanism, rifampicin blocks synthesis of the second or third phosphodiester bond between the nucleotides in the RNA backbone, preventing elongation of the 5' end of the RNA transcript past more than 2 or 3 nucleotides.<ref name="a39">PMID:11290327</ref><ref name="a49">PMID:18787125</ref></div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>Crystal structure data and biochemical data suggest that <scene name='10/1022377/Cv/4'>rifampicin binds to the pocket of the RNA polymerase β subunit</scene> within the DNA/RNA channel, but away from the active site.<ref name="a39">PMID:11290327</ref> The inhibitor prevents RNA synthesis by physically blocking elongation, and thus preventing synthesis of host bacterial proteins. By this "steric-occlusion" mechanism, rifampicin blocks synthesis of the second or third phosphodiester bond between the nucleotides in the RNA backbone, preventing elongation of the 5' end of the RNA transcript past more than 2 or 3 nucleotides.<ref name="a39">PMID:11290327</ref><ref name="a49">PMID:18787125</ref></div></td></tr> </table>

Alexander Berchansky http://52.214.119.220/wiki/index.php?title=Rifampicin&diff=4012921&oldid=prev Alexander Berchansky at 14:13, 4 January 2024 2024-01-04T14:13:29Z

<p></p> <table style="background-color: white; color:black;"> <col class='diff-marker' /> <col class='diff-content' /> <col class='diff-marker' /> <col class='diff-content' /> <tr> <td colspan='2' style="background-color: white; color:black;">←Older revision</td> <td colspan='2' style="background-color: white; color:black;">Revision as of 14:13, 4 January 2024</td> </tr> <tr><td colspan="2" class="diff-lineno">Line 2:</td> <td colspan="2" class="diff-lineno">Line 2:</td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>Rifampicin, also known as rifampin, is an ansamycin antibiotic used to treat several types of bacterial infections, including tuberculosis (TB), Mycobacterium avium complex, leprosy, and Legionnaires' disease.<ref name="a2">[https://www.drugs.com/monograph/rifampin.html "Rifampin".] The American Society of Health-System Pharmacists. Archived from the original on 2015-09-07. Retrieved Aug 1, 2015.</ref> It is almost always used together with other antibiotics with two notable exceptions: when given as a "preferred treatment that is strongly recommended"<ref name="a3">PMID:32053584</ref> for latent TB infection; and when used as post-exposure prophylaxis to prevent Haemophilus influenzae type b and meningococcal disease in people who have been exposed to those bacteria. Before treating a person for a long period of time, measurements of liver enzymes and blood counts are recommended.<ref name="a2">[https://www.drugs.com/monograph/rifampin.html "Rifampin".] The American Society of Health-System Pharmacists. Archived from the original on 2015-09-07. Retrieved Aug 1, 2015.</ref> See also [https://en.wikipedia.org/wiki/Rifampicin Rifampicin].</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>Rifampicin, also known as rifampin, is an ansamycin antibiotic used to treat several types of bacterial infections, including tuberculosis (TB), Mycobacterium avium complex, leprosy, and Legionnaires' disease.<ref name="a2">[https://www.drugs.com/monograph/rifampin.html "Rifampin".] The American Society of Health-System Pharmacists. Archived from the original on 2015-09-07. Retrieved Aug 1, 2015.</ref> It is almost always used together with other antibiotics with two notable exceptions: when given as a "preferred treatment that is strongly recommended"<ref name="a3">PMID:32053584</ref> for latent TB infection; and when used as post-exposure prophylaxis to prevent Haemophilus influenzae type b and meningococcal disease in people who have been exposed to those bacteria. Before treating a person for a long period of time, measurements of liver enzymes and blood counts are recommended.<ref name="a2">[https://www.drugs.com/monograph/rifampin.html "Rifampin".] The American Society of Health-System Pharmacists. Archived from the original on 2015-09-07. Retrieved Aug 1, 2015.</ref> See also [https://en.wikipedia.org/wiki/Rifampicin Rifampicin].</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>Rifampicin inhibits bacterial DNA-dependent RNA synthesis by inhibiting bacterial DNA-dependent RNA polymerase.<ref name="a48">PMID:4957347</ref></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>Rifampicin inhibits bacterial DNA-dependent RNA synthesis by inhibiting bacterial DNA-dependent RNA polymerase.<ref name="a48">PMID:4957347</ref> <ins style="color: red; font-weight: bold; text-decoration: none;"><scene name='10/1022377/Cv/2'>THERMUS AQUATICUS CORE RNA POLYMERASE-RIFAMPICIN COMPLEX</scene> ([[1i6v]]).</ins></div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>Crystal structure data and biochemical data suggest that rifampicin binds to the pocket of the RNA polymerase β subunit within the DNA/RNA channel, but away from the active site.<ref name="a39">PMID:11290327</ref> The inhibitor prevents RNA synthesis by physically blocking elongation, and thus preventing synthesis of host bacterial proteins. By this "steric-occlusion" mechanism, rifampicin blocks synthesis of the second or third phosphodiester bond between the nucleotides in the RNA backbone, preventing elongation of the 5' end of the RNA transcript past more than 2 or 3 nucleotides.<ref name="a39">PMID:11290327</ref><ref name="a49">PMID:18787125</ref></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>Crystal structure data and biochemical data suggest that <ins style="color: red; font-weight: bold; text-decoration: none;"><scene name='10/1022377/Cv/4'></ins>rifampicin binds to the pocket of the RNA polymerase β subunit<ins style="color: red; font-weight: bold; text-decoration: none;"></scene> </ins>within the DNA/RNA channel, but away from the active site.<ref name="a39">PMID:11290327</ref> The inhibitor prevents RNA synthesis by physically blocking elongation, and thus preventing synthesis of host bacterial proteins. By this "steric-occlusion" mechanism, rifampicin blocks synthesis of the second or third phosphodiester bond between the nucleotides in the RNA backbone, preventing elongation of the 5' end of the RNA transcript past more than 2 or 3 nucleotides.<ref name="a39">PMID:11290327</ref><ref name="a49">PMID:18787125</ref></div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>In a recent study Rifampicin was shown to bind to cytochrome P450 reductase and alter its conformation as well as activity towards supporting metabolism of progesterone via CYP21A2.<ref name="a50">PMID:33859207</ref></div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>In a recent study Rifampicin was shown to bind to cytochrome P450 reductase and alter its conformation as well as activity towards supporting metabolism of progesterone via CYP21A2.<ref name="a50">PMID:33859207</ref></div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div><scene name='10/1022377/Cv/2'>THERMUS AQUATICUS CORE RNA POLYMERASE-RIFAMPICIN COMPLEX</scene> ([[1i6v]]).</div></td><td colspan="2"> </td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"></td><td colspan="2"> </td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div><scene name='10/1022377/Cv/3'>Rifampicin binding site</scene>.</div></td><td colspan="2"> </td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div></StructureSection></div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div></StructureSection></div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>== References ==</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>== References ==</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div><references/></div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div><references/></div></td></tr> </table>

Alexander Berchansky http://52.214.119.220/wiki/index.php?title=Rifampicin&diff=4012920&oldid=prev Alexander Berchansky at 14:05, 4 January 2024 2024-01-04T14:05:10Z

<p></p> <table style="background-color: white; color:black;"> <col class='diff-marker' /> <col class='diff-content' /> <col class='diff-marker' /> <col class='diff-content' /> <tr> <td colspan='2' style="background-color: white; color:black;">←Older revision</td> <td colspan='2' style="background-color: white; color:black;">Revision as of 14:05, 4 January 2024</td> </tr> <tr><td colspan="2" class="diff-lineno">Line 1:</td> <td colspan="2" class="diff-lineno">Line 1:</td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div><StructureSection load='' size='340' side='right' caption='Caption for this structure' scene='10/1022377/Cv/1'></div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div><StructureSection load='' size='340' side='right' caption='Caption for this structure' scene='10/1022377/Cv/1'></div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>Rifampicin, also known as rifampin, is an ansamycin antibiotic used to treat several types of bacterial infections, including tuberculosis (TB), Mycobacterium avium complex, leprosy, and Legionnaires' disease.<ref name="a2">[https://www.drugs.com/monograph/rifampin.html "Rifampin".] The American Society of Health-System Pharmacists. Archived from the original on 2015-09-07. Retrieved Aug 1, 2015.</ref> It is almost always used together with other antibiotics with two notable exceptions: when given as a "preferred treatment that is strongly recommended"<ref name="a3">PMID:32053584</ref> for latent TB infection; and when used as post-exposure prophylaxis to prevent Haemophilus influenzae type b and meningococcal disease in people who have been exposed to those bacteria. Before treating a person for a long period of time, measurements of liver enzymes and blood counts are recommended.<ref name="a2">[https://www.drugs.com/monograph/rifampin.html "Rifampin".] The American Society of Health-System Pharmacists. Archived from the original on 2015-09-07. Retrieved Aug 1, 2015.</ref> See also [https://en.wikipedia.org/wiki/Rifampicin Rifampicin].</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>Rifampicin, also known as rifampin, is an ansamycin antibiotic used to treat several types of bacterial infections, including tuberculosis (TB), Mycobacterium avium complex, leprosy, and Legionnaires' disease.<ref name="a2">[https://www.drugs.com/monograph/rifampin.html "Rifampin".] The American Society of Health-System Pharmacists. Archived from the original on 2015-09-07. Retrieved Aug 1, 2015.</ref> It is almost always used together with other antibiotics with two notable exceptions: when given as a "preferred treatment that is strongly recommended"<ref name="a3">PMID:32053584</ref> for latent TB infection; and when used as post-exposure prophylaxis to prevent Haemophilus influenzae type b and meningococcal disease in people who have been exposed to those bacteria. Before treating a person for a long period of time, measurements of liver enzymes and blood counts are recommended.<ref name="a2">[https://www.drugs.com/monograph/rifampin.html "Rifampin".] The American Society of Health-System Pharmacists. Archived from the original on 2015-09-07. Retrieved Aug 1, 2015.</ref> See also [https://en.wikipedia.org/wiki/Rifampicin Rifampicin].</div></td></tr> <tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"></td></tr> <tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>Rifampicin inhibits bacterial DNA-dependent RNA synthesis by inhibiting bacterial DNA-dependent RNA polymerase.<ref name="a48">PMID:4957347</ref></div></td></tr> <tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"></td></tr> <tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>Crystal structure data and biochemical data suggest that rifampicin binds to the pocket of the RNA polymerase β subunit within the DNA/RNA channel, but away from the active site.<ref name="a39">PMID:11290327</ref> The inhibitor prevents RNA synthesis by physically blocking elongation, and thus preventing synthesis of host bacterial proteins. By this "steric-occlusion" mechanism, rifampicin blocks synthesis of the second or third phosphodiester bond between the nucleotides in the RNA backbone, preventing elongation of the 5' end of the RNA transcript past more than 2 or 3 nucleotides.<ref name="a39">PMID:11290327</ref><ref name="a49">PMID:18787125</ref></div></td></tr> <tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"></td></tr> <tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>In a recent study Rifampicin was shown to bind to cytochrome P450 reductase and alter its conformation as well as activity towards supporting metabolism of progesterone via CYP21A2.<ref name="a50">PMID:33859207</ref></div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div><scene name='10/1022377/Cv/2'>THERMUS AQUATICUS CORE RNA POLYMERASE-RIFAMPICIN COMPLEX</scene> ([[1i6v]]).</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div><scene name='10/1022377/Cv/2'>THERMUS AQUATICUS CORE RNA POLYMERASE-RIFAMPICIN COMPLEX</scene> ([[1i6v]]).</div></td></tr> </table>

Alexander Berchansky http://52.214.119.220/wiki/index.php?title=Rifampicin&diff=4012919&oldid=prev Alexander Berchansky at 13:58, 4 January 2024 2024-01-04T13:58:43Z

<p></p> <table style="background-color: white; color:black;"> <col class='diff-marker' /> <col class='diff-content' /> <col class='diff-marker' /> <col class='diff-content' /> <tr> <td colspan='2' style="background-color: white; color:black;">←Older revision</td> <td colspan='2' style="background-color: white; color:black;">Revision as of 13:58, 4 January 2024</td> </tr> <tr><td colspan="2" class="diff-lineno">Line 3:</td> <td colspan="2" class="diff-lineno">Line 3:</td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div><scene name='10/1022377/Cv/2'>THERMUS AQUATICUS CORE RNA POLYMERASE-RIFAMPICIN COMPLEX</scene> ([[1i6v]]).</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div><scene name='10/1022377/Cv/2'>THERMUS AQUATICUS CORE RNA POLYMERASE-RIFAMPICIN COMPLEX</scene> ([[1i6v]]).</div></td></tr> <tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"></td></tr> <tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><scene name='10/1022377/Cv/3'>Rifampicin binding site</scene>.</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div></StructureSection></div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div></StructureSection></div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>== References ==</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>== References ==</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div><references/></div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div><references/></div></td></tr> </table>

Alexander Berchansky http://52.214.119.220/wiki/index.php?title=Rifampicin&diff=4012918&oldid=prev Alexander Berchansky at 13:39, 4 January 2024 2024-01-04T13:39:13Z

<p></p> <table style="background-color: white; color:black;"> <col class='diff-marker' /> <col class='diff-content' /> <col class='diff-marker' /> <col class='diff-content' /> <tr> <td colspan='2' style="background-color: white; color:black;">←Older revision</td> <td colspan='2' style="background-color: white; color:black;">Revision as of 13:39, 4 January 2024</td> </tr> <tr><td colspan="2" class="diff-lineno">Line 2:</td> <td colspan="2" class="diff-lineno">Line 2:</td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>Rifampicin, also known as rifampin, is an ansamycin antibiotic used to treat several types of bacterial infections, including tuberculosis (TB), Mycobacterium avium complex, leprosy, and Legionnaires' disease.<ref name="a2">[https://www.drugs.com/monograph/rifampin.html "Rifampin".] The American Society of Health-System Pharmacists. Archived from the original on 2015-09-07. Retrieved Aug 1, 2015.</ref> It is almost always used together with other antibiotics with two notable exceptions: when given as a "preferred treatment that is strongly recommended"<ref name="a3">PMID:32053584</ref> for latent TB infection; and when used as post-exposure prophylaxis to prevent Haemophilus influenzae type b and meningococcal disease in people who have been exposed to those bacteria. Before treating a person for a long period of time, measurements of liver enzymes and blood counts are recommended.<ref name="a2">[https://www.drugs.com/monograph/rifampin.html "Rifampin".] The American Society of Health-System Pharmacists. Archived from the original on 2015-09-07. Retrieved Aug 1, 2015.</ref> See also [https://en.wikipedia.org/wiki/Rifampicin Rifampicin].</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>Rifampicin, also known as rifampin, is an ansamycin antibiotic used to treat several types of bacterial infections, including tuberculosis (TB), Mycobacterium avium complex, leprosy, and Legionnaires' disease.<ref name="a2">[https://www.drugs.com/monograph/rifampin.html "Rifampin".] The American Society of Health-System Pharmacists. Archived from the original on 2015-09-07. Retrieved Aug 1, 2015.</ref> It is almost always used together with other antibiotics with two notable exceptions: when given as a "preferred treatment that is strongly recommended"<ref name="a3">PMID:32053584</ref> for latent TB infection; and when used as post-exposure prophylaxis to prevent Haemophilus influenzae type b and meningococcal disease in people who have been exposed to those bacteria. Before treating a person for a long period of time, measurements of liver enzymes and blood counts are recommended.<ref name="a2">[https://www.drugs.com/monograph/rifampin.html "Rifampin".] The American Society of Health-System Pharmacists. Archived from the original on 2015-09-07. Retrieved Aug 1, 2015.</ref> See also [https://en.wikipedia.org/wiki/Rifampicin Rifampicin].</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>[[1i6v]]</div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;"><scene name='10/1022377/Cv/2'>THERMUS AQUATICUS CORE RNA POLYMERASE-RIFAMPICIN COMPLEX</scene> (</ins>[[1i6v]]<ins style="color: red; font-weight: bold; text-decoration: none;">).</ins></div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div></StructureSection></div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div></StructureSection></div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>== References ==</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>== References ==</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div><references/></div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div><references/></div></td></tr> </table>

Alexander Berchansky http://52.214.119.220/wiki/index.php?title=Rifampicin&diff=4012910&oldid=prev Alexander Berchansky at 14:20, 3 January 2024 2024-01-03T14:20:22Z

<p></p> <table style="background-color: white; color:black;"> <col class='diff-marker' /> <col class='diff-content' /> <col class='diff-marker' /> <col class='diff-content' /> <tr> <td colspan='2' style="background-color: white; color:black;">←Older revision</td> <td colspan='2' style="background-color: white; color:black;">Revision as of 14:20, 3 January 2024</td> </tr> <tr><td colspan="2" class="diff-lineno">Line 1:</td> <td colspan="2" class="diff-lineno">Line 1:</td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div><StructureSection load='' size='340' side='right' caption='Caption for this structure' scene=''></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><StructureSection load='' size='340' side='right' caption='Caption for this structure' scene='<ins style="color: red; font-weight: bold; text-decoration: none;">10/1022377/Cv/1</ins>'></div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>Rifampicin, also known as rifampin, is an ansamycin antibiotic used to treat several types of bacterial infections, including tuberculosis (TB), Mycobacterium avium complex, leprosy, and Legionnaires' disease.<ref name="a2">[https://www.drugs.com/monograph/rifampin.html "Rifampin".] The American Society of Health-System Pharmacists. Archived from the original on 2015-09-07. Retrieved Aug 1, 2015.</ref> It is almost always used together with other antibiotics with two notable exceptions: when given as a "preferred treatment that is strongly recommended"<ref name="a3">PMID:32053584</ref> for latent TB infection; and when used as post-exposure prophylaxis to prevent Haemophilus influenzae type b and meningococcal disease in people who have been exposed to those bacteria. Before treating a person for a long period of time, measurements of liver enzymes and blood counts are recommended.<ref name="a2">[https://www.drugs.com/monograph/rifampin.html "Rifampin".] The American Society of Health-System Pharmacists. Archived from the original on 2015-09-07. Retrieved Aug 1, 2015.</ref> See also [https://en.wikipedia.org/wiki/Rifampicin Rifampicin].</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>Rifampicin, also known as rifampin, is an ansamycin antibiotic used to treat several types of bacterial infections, including tuberculosis (TB), Mycobacterium avium complex, leprosy, and Legionnaires' disease.<ref name="a2">[https://www.drugs.com/monograph/rifampin.html "Rifampin".] The American Society of Health-System Pharmacists. Archived from the original on 2015-09-07. Retrieved Aug 1, 2015.</ref> It is almost always used together with other antibiotics with two notable exceptions: when given as a "preferred treatment that is strongly recommended"<ref name="a3">PMID:32053584</ref> for latent TB infection; and when used as post-exposure prophylaxis to prevent Haemophilus influenzae type b and meningococcal disease in people who have been exposed to those bacteria. Before treating a person for a long period of time, measurements of liver enzymes and blood counts are recommended.<ref name="a2">[https://www.drugs.com/monograph/rifampin.html "Rifampin".] The American Society of Health-System Pharmacists. Archived from the original on 2015-09-07. Retrieved Aug 1, 2015.</ref> See also [https://en.wikipedia.org/wiki/Rifampicin Rifampicin].</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> </table>

Alexander Berchansky http://52.214.119.220/wiki/index.php?title=Rifampicin&diff=4012908&oldid=prev Alexander Berchansky at 14:17, 3 January 2024 2024-01-03T14:17:13Z

<p></p> <table style="background-color: white; color:black;"> <col class='diff-marker' /> <col class='diff-content' /> <col class='diff-marker' /> <col class='diff-content' /> <tr> <td colspan='2' style="background-color: white; color:black;">←Older revision</td> <td colspan='2' style="background-color: white; color:black;">Revision as of 14:17, 3 January 2024</td> </tr> <tr><td colspan="2" class="diff-lineno">Line 1:</td> <td colspan="2" class="diff-lineno">Line 1:</td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div><StructureSection load='' size='340' side='right' caption='Caption for this structure' scene=''></div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div><StructureSection load='' size='340' side='right' caption='Caption for this structure' scene=''></div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>Rifampicin, also known as rifampin, is an ansamycin antibiotic used to treat several types of bacterial infections, including tuberculosis (TB), Mycobacterium avium complex, leprosy, and Legionnaires' disease.<ref name="a2">[https://www.drugs.com/monograph/rifampin.html "Rifampin".] The American Society of Health-System Pharmacists. Archived from the original on 2015-09-07. Retrieved Aug 1, 2015.</ref> It is almost always used together with other antibiotics with two notable exceptions: when given as a "preferred treatment that is strongly recommended"<ref name="a3">PMID:32053584</ref> for latent TB infection; and when used as post-exposure prophylaxis to prevent Haemophilus influenzae type b and meningococcal disease in people who have been exposed to those bacteria. Before treating a person for a long period of time, measurements of liver enzymes and blood counts are recommended.<ref name="a2">[https://www.drugs.com/monograph/rifampin.html "Rifampin".] The American Society of Health-System Pharmacists. Archived from the original on 2015-09-07. Retrieved Aug 1, 2015.</ref> See also [https://en.wikipedia.org/wiki/Rifampicin Rifampicin].</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>Rifampicin, also known as rifampin, is an ansamycin antibiotic used to treat several types of bacterial infections, including tuberculosis (TB), Mycobacterium avium complex, leprosy, and Legionnaires' disease.<ref name="a2">[https://www.drugs.com/monograph/rifampin.html "Rifampin".] The American Society of Health-System Pharmacists. Archived from the original on 2015-09-07. Retrieved Aug 1, 2015.</ref> It is almost always used together with other antibiotics with two notable exceptions: when given as a "preferred treatment that is strongly recommended"<ref name="a3">PMID:32053584</ref> for latent TB infection; and when used as post-exposure prophylaxis to prevent Haemophilus influenzae type b and meningococcal disease in people who have been exposed to those bacteria. Before treating a person for a long period of time, measurements of liver enzymes and blood counts are recommended.<ref name="a2">[https://www.drugs.com/monograph/rifampin.html "Rifampin".] The American Society of Health-System Pharmacists. Archived from the original on 2015-09-07. Retrieved Aug 1, 2015.</ref> See also [https://en.wikipedia.org/wiki/Rifampicin Rifampicin].</div></td></tr> <tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"></td></tr> <tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>[[1i6v]]</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div></StructureSection></div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div></StructureSection></div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>== References ==</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>== References ==</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div><references/></div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div><references/></div></td></tr> </table>

Alexander Berchansky http://52.214.119.220/wiki/index.php?title=Rifampicin&diff=4012907&oldid=prev Alexander Berchansky at 14:16, 3 January 2024 2024-01-03T14:16:27Z

<p></p> <table style="background-color: white; color:black;"> <col class='diff-marker' /> <col class='diff-content' /> <col class='diff-marker' /> <col class='diff-content' /> <tr> <td colspan='2' style="background-color: white; color:black;">←Older revision</td> <td colspan='2' style="background-color: white; color:black;">Revision as of 14:16, 3 January 2024</td> </tr> <tr><td colspan="2" class="diff-lineno">Line 1:</td> <td colspan="2" class="diff-lineno">Line 1:</td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div><StructureSection load='' size='340' side='right' caption='Caption for this structure' scene=''></div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div><StructureSection load='' size='340' side='right' caption='Caption for this structure' scene=''></div></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>Rifampicin, also known as rifampin, is an ansamycin antibiotic used to treat several types of bacterial infections, including tuberculosis (TB), Mycobacterium avium complex, leprosy, and Legionnaires' disease.<ref name="a2">[https://www.drugs.com/monograph/rifampin.html "Rifampin".] The American Society of Health-System Pharmacists. Archived from the original on 2015-09-07. Retrieved Aug 1, 2015.</ref> It is almost always used together with other antibiotics with two notable exceptions: when given as a "preferred treatment that is strongly recommended"<ref name="a3">PMID:32053584</ref> for latent TB infection; and when used as post-exposure prophylaxis to prevent Haemophilus influenzae type b and meningococcal disease in people who have been exposed to those bacteria. Before treating a person for a long period of time, measurements of liver enzymes and blood counts are recommended.<ref name="a2">[https://www.drugs.com/monograph/rifampin.html "Rifampin".] The American Society of Health-System Pharmacists. Archived from the original on 2015-09-07. Retrieved Aug 1, 2015.</ref> See also <del style="color: red; font-weight: bold; text-decoration: none;">[</del>[https://en.wikipedia.org/wiki/Rifampicin Rifampicin<del style="color: red; font-weight: bold; text-decoration: none;">]</del>].</div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>Rifampicin, also known as rifampin, is an ansamycin antibiotic used to treat several types of bacterial infections, including tuberculosis (TB), Mycobacterium avium complex, leprosy, and Legionnaires' disease.<ref name="a2">[https://www.drugs.com/monograph/rifampin.html "Rifampin".] The American Society of Health-System Pharmacists. Archived from the original on 2015-09-07. Retrieved Aug 1, 2015.</ref> It is almost always used together with other antibiotics with two notable exceptions: when given as a "preferred treatment that is strongly recommended"<ref name="a3">PMID:32053584</ref> for latent TB infection; and when used as post-exposure prophylaxis to prevent Haemophilus influenzae type b and meningococcal disease in people who have been exposed to those bacteria. Before treating a person for a long period of time, measurements of liver enzymes and blood counts are recommended.<ref name="a2">[https://www.drugs.com/monograph/rifampin.html "Rifampin".] The American Society of Health-System Pharmacists. Archived from the original on 2015-09-07. Retrieved Aug 1, 2015.</ref> See also [https://en.wikipedia.org/wiki/Rifampicin Rifampicin].</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div></StructureSection></div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div></StructureSection></div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>== References ==</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>== References ==</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div><references/></div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div><references/></div></td></tr> </table>

Alexander Berchansky