Sandbox 80 - Revision history

http://52.214.119.220/wiki/index.php?action=history&feed=atom&title=Sandbox_80 Sandbox 80 - Revision history 2026-04-10T08:56:10Z Revision history for this page on the wiki MediaWiki 1.11.2 http://52.214.119.220/wiki/index.php?title=Sandbox_80&diff=1203571&oldid=prev Student at 16:29, 11 March 2011 2011-03-11T16:29:31Z

<p></p> <table style="background-color: white; color:black;"> <col class='diff-marker' /> <col class='diff-content' /> <col class='diff-marker' /> <col class='diff-content' /> <tr> <td colspan='2' style="background-color: white; color:black;">←Older revision</td> <td colspan='2' style="background-color: white; color:black;">Revision as of 16:29, 11 March 2011</td> </tr> <tr><td colspan="2" class="diff-lineno">Line 3:</td> <td colspan="2" class="diff-lineno">Line 3:</td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>This is an antiviral drug used to treat HIV by inhibiting proteases in the virus. This inhibition causes the spread of the virus to decrease significantly. The <scene name='Sandbox_80/Protease/1'>protease</scene> is an enzyme that the virus uses to produce the proteins necessary to assemble more viruses. </div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>This is an antiviral drug used to treat HIV by inhibiting proteases in the virus. This inhibition causes the spread of the virus to decrease significantly. The <scene name='Sandbox_80/Protease/1'>protease</scene> is an enzyme that the virus uses to produce the proteins necessary to assemble more viruses. </div></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>The common name for saqinavir is fortovase. It functions as peptide-like analogue that binds to <scene name='Sandbox_80/Ac_1/1'>active site 1</scene> of the protein and causes inhibition by preventing the protease from cleaving polyproteins which in turn causes the virus to create non-infectious virus particles. </div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>The common name for saqinavir is fortovase. It functions as peptide-like analogue that binds to <scene name='Sandbox_80/Ac_1/1'>active site 1</scene> of the protein and causes inhibition by preventing the protease from cleaving polyproteins which in turn causes the virus to create non-infectious virus particles<ins style="color: red; font-weight: bold; text-decoration: none;">. This drug is often used in combination with other HIV medications to produce a more potent effect</ins>. </div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> <tr><td colspan="2" class="diff-lineno">Line 14:</td> <td colspan="2" class="diff-lineno">Line 14:</td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>==Protein and Drug interations==</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>==Protein and Drug interations==</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>intermolecular forces that cause the drug to bind in the active site of the protease are prodominantly H-bonds to </div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>intermolecular forces that cause the drug to bind in the active site of the protease are prodominantly H-bonds to </div></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div><scene name='Sandbox_80/Hydrophilic/1'>hydrophilic groups</scene></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><scene name='Sandbox_80/Hydrophilic/1'>hydrophilic groups</scene><ins style="color: red; font-weight: bold; text-decoration: none;">. The carboxylic acid group in the <scene name='Sandbox_80/Asp_25/1'>Aspartic Acid</scene> residue 25 binds with the hydroxyl group of Saquinavir.</ins></div></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div><del style="color: red; font-weight: bold; text-decoration: none;">attraction </del></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div> </div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>==References==</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>==References==</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0000973</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0000973</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=60934&loc=ec_rcs#pharmaction</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=60934&loc=ec_rcs#pharmaction</div></td></tr> </table>

Student http://52.214.119.220/wiki/index.php?title=Sandbox_80&diff=1203570&oldid=prev Student at 16:21, 11 March 2011 2011-03-11T16:21:42Z

<p></p> <table style="background-color: white; color:black;"> <col class='diff-marker' /> <col class='diff-content' /> <col class='diff-marker' /> <col class='diff-content' /> <tr> <td colspan='2' style="background-color: white; color:black;">←Older revision</td> <td colspan='2' style="background-color: white; color:black;">Revision as of 16:21, 11 March 2011</td> </tr> <tr><td colspan="2" class="diff-lineno">Line 11:</td> <td colspan="2" class="diff-lineno">Line 11:</td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>The chemical formula of <scene name='Sandbox_80/Stickwireframe/1'>Saquinavir</scene> is (C39)(H54)(N6)(O8)S and the molecular weight is 766.94 g/mol.There are 5 aromatic rings, two of which are heterocyclic. One hydroxyl group near the center of the compound that plays an important role in active site binding. The amino groups cause the protease to recognize the drug as a natural substrate with amino acid groups which are recognized by the active sites. </div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>The chemical formula of <scene name='Sandbox_80/Stickwireframe/1'>Saquinavir</scene> is (C39)(H54)(N6)(O8)S and the molecular weight is 766.94 g/mol.There are 5 aromatic rings, two of which are heterocyclic. One hydroxyl group near the center of the compound that plays an important role in active site binding. The amino groups cause the protease to recognize the drug as a natural substrate with amino acid groups which are recognized by the active sites. </div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"></td><td colspan="2"> </td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>{{STRUCTURE_3oxc | PDB=3oxc | SCENE= }}</div></td><td colspan="2"> </td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>==Protein and Drug interations==</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>==Protein and Drug interations==</div></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>intermolecular forces</div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>intermolecular forces <ins style="color: red; font-weight: bold; text-decoration: none;">that cause the drug to bind in the active site of the protease are prodominantly H-bonds to </ins></div></td></tr> <tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;"><scene name='Sandbox_80/Hydrophilic/1'>hydrophilic groups</scene></ins></div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>attraction </div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>attraction </div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> </table>

Student http://52.214.119.220/wiki/index.php?title=Sandbox_80&diff=1203569&oldid=prev Student at 16:13, 11 March 2011 2011-03-11T16:13:23Z

<p></p> <table style="background-color: white; color:black;"> <col class='diff-marker' /> <col class='diff-content' /> <col class='diff-marker' /> <col class='diff-content' /> <tr> <td colspan='2' style="background-color: white; color:black;">←Older revision</td> <td colspan='2' style="background-color: white; color:black;">Revision as of 16:13, 11 March 2011</td> </tr> <tr><td colspan="2" class="diff-lineno">Line 9:</td> <td colspan="2" class="diff-lineno">Line 9:</td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>==Structure==</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>==Structure==</div></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>The chemical formula of <scene name='Sandbox_80/Stickwireframe/1'>Saquinavir</scene> is (C39)(H54)(N6)(O8)S and the molecular weight is 766.94 g/mol.</div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>The chemical formula of <scene name='Sandbox_80/Stickwireframe/1'>Saquinavir</scene> is (C39)(H54)(N6)(O8)S and the molecular weight is 766.94 g/mol.<ins style="color: red; font-weight: bold; text-decoration: none;">There are 5 aromatic rings, two of which are heterocyclic. One hydroxyl group near the center of the compound that plays an important role in active site binding. The amino groups cause the protease to recognize the drug as a natural substrate with amino acid groups which are recognized by the active sites. </ins></div></td></tr> <tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div> </div></td></tr> <tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div> </div></td></tr> <tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">{{STRUCTURE_3oxc | PDB=3oxc | SCENE= }}</ins></div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>==Protein and Drug interations==</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>==Protein and Drug interations==</div></td></tr> </table>

Student http://52.214.119.220/wiki/index.php?title=Sandbox_80&diff=1203529&oldid=prev Student at 09:59, 11 March 2011 2011-03-11T09:59:04Z

<p></p> <table style="background-color: white; color:black;"> <col class='diff-marker' /> <col class='diff-content' /> <col class='diff-marker' /> <col class='diff-content' /> <tr> <td colspan='2' style="background-color: white; color:black;">←Older revision</td> <td colspan='2' style="background-color: white; color:black;">Revision as of 09:59, 11 March 2011</td> </tr> <tr><td colspan="2" class="diff-lineno">Line 9:</td> <td colspan="2" class="diff-lineno">Line 9:</td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>==Structure==</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>==Structure==</div></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>The chemical formula of <scene name='Sandbox_80/Stickwireframe/1'>Saquinavir</scene> is (C39)(H54)(N6)(O8)S and the molecular weight is 766.94 g/mol. <del style="color: red; font-weight: bold; text-decoration: none;">This compound is</del></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>The chemical formula of <scene name='Sandbox_80/Stickwireframe/1'>Saquinavir</scene> is (C39)(H54)(N6)(O8)S and the molecular weight is 766.94 g/mol.</div></td></tr> <tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div> </div></td></tr> <tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">==Protein and Drug interations==</ins></div></td></tr> <tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">intermolecular forces</ins></div></td></tr> <tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">attraction </ins></div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>==References==</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>==References==</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0000973</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0000973</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=60934&loc=ec_rcs#pharmaction</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=60934&loc=ec_rcs#pharmaction</div></td></tr> </table>

Student http://52.214.119.220/wiki/index.php?title=Sandbox_80&diff=1203522&oldid=prev Student: /* Saquinavir */ 2011-03-11T09:28:59Z

<p><span class="autocomment">Saquinavir</span></p> <table style="background-color: white; color:black;"> <col class='diff-marker' /> <col class='diff-content' /> <col class='diff-marker' /> <col class='diff-content' /> <tr> <td colspan='2' style="background-color: white; color:black;">←Older revision</td> <td colspan='2' style="background-color: white; color:black;">Revision as of 09:28, 11 March 2011</td> </tr> <tr><td colspan="2" class="diff-lineno">Line 4:</td> <td colspan="2" class="diff-lineno">Line 4:</td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>This is an antiviral drug used to treat HIV by inhibiting proteases in the virus. This inhibition causes the spread of the virus to decrease significantly. The <scene name='Sandbox_80/Protease/1'>protease</scene> is an enzyme that the virus uses to produce the proteins necessary to assemble more viruses. </div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>This is an antiviral drug used to treat HIV by inhibiting proteases in the virus. This inhibition causes the spread of the virus to decrease significantly. The <scene name='Sandbox_80/Protease/1'>protease</scene> is an enzyme that the virus uses to produce the proteins necessary to assemble more viruses. </div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>The common name for saqinavir is fortovase. It functions as peptide-like analogue that binds to <scene name='Sandbox_80/Ac_1/1'>active site 1</scene> of the protein and causes inhibition by preventing the protease from cleaving polyproteins which in turn causes the virus to create non-infectious virus particles. </div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>The common name for saqinavir is fortovase. It functions as peptide-like analogue that binds to <scene name='Sandbox_80/Ac_1/1'>active site 1</scene> of the protein and causes inhibition by preventing the protease from cleaving polyproteins which in turn causes the virus to create non-infectious virus particles. </div></td></tr> <tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>{{STRUCTURE_3oxc | PDB=3oxc | SCENE= }}</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>{{STRUCTURE_3oxc | PDB=3oxc | SCENE= }}</div></td></tr> </table>

Student http://52.214.119.220/wiki/index.php?title=Sandbox_80&diff=1203520&oldid=prev Student at 09:07, 11 March 2011 2011-03-11T09:07:47Z

<p></p> <table style="background-color: white; color:black;"> <col class='diff-marker' /> <col class='diff-content' /> <col class='diff-marker' /> <col class='diff-content' /> <tr> <td colspan='2' style="background-color: white; color:black;">←Older revision</td> <td colspan='2' style="background-color: white; color:black;">Revision as of 09:07, 11 March 2011</td> </tr> <tr><td colspan="2" class="diff-lineno">Line 3:</td> <td colspan="2" class="diff-lineno">Line 3:</td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>This is an antiviral drug used to treat HIV by inhibiting proteases in the virus. This inhibition causes the spread of the virus to decrease significantly. The <scene name='Sandbox_80/Protease/1'>protease</scene> is an enzyme that the virus uses to produce the proteins necessary to assemble more viruses. </div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>This is an antiviral drug used to treat HIV by inhibiting proteases in the virus. This inhibition causes the spread of the virus to decrease significantly. The <scene name='Sandbox_80/Protease/1'>protease</scene> is an enzyme that the virus uses to produce the proteins necessary to assemble more viruses. </div></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>The common name for saqinavir is fortovase. It functions as peptide-like analogue that binds to the protein and causes inhibition by preventing the protease from cleaving polyproteins which in turn causes the virus to create non-infectious virus particles. </div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>The common name for saqinavir is fortovase. It functions as peptide-like analogue that binds to <ins style="color: red; font-weight: bold; text-decoration: none;"><scene name='Sandbox_80/Ac_1/1'>active site 1</scene> of </ins>the protein and causes inhibition by preventing the protease from cleaving polyproteins which in turn causes the virus to create non-infectious virus particles. </div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>{{STRUCTURE_3oxc | PDB=3oxc | SCENE= }}</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>{{STRUCTURE_3oxc | PDB=3oxc | SCENE= }}</div></td></tr> </table>

Student http://52.214.119.220/wiki/index.php?title=Sandbox_80&diff=1203519&oldid=prev Student: /* References */ 2011-03-11T08:52:37Z

<p><span class="autocomment">References</span></p> <table style="background-color: white; color:black;"> <col class='diff-marker' /> <col class='diff-content' /> <col class='diff-marker' /> <col class='diff-content' /> <tr> <td colspan='2' style="background-color: white; color:black;">←Older revision</td> <td colspan='2' style="background-color: white; color:black;">Revision as of 08:52, 11 March 2011</td> </tr> <tr><td colspan="2" class="diff-lineno">Line 12:</td> <td colspan="2" class="diff-lineno">Line 12:</td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>==References==</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>==References==</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0000973</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0000973</div></td></tr> <tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=60934&loc=ec_rcs#pharmaction</div></td></tr> </table>

Student http://52.214.119.220/wiki/index.php?title=Sandbox_80&diff=1203518&oldid=prev Student: /* Saquinavir */ 2011-03-11T08:51:05Z

<p><span class="autocomment">Saquinavir</span></p> <table style="background-color: white; color:black;"> <col class='diff-marker' /> <col class='diff-content' /> <col class='diff-marker' /> <col class='diff-content' /> <tr> <td colspan='2' style="background-color: white; color:black;">←Older revision</td> <td colspan='2' style="background-color: white; color:black;">Revision as of 08:51, 11 March 2011</td> </tr> <tr><td colspan="2" class="diff-lineno">Line 3:</td> <td colspan="2" class="diff-lineno">Line 3:</td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>This is an antiviral drug used to treat HIV by inhibiting proteases in the virus. This inhibition causes the spread of the virus to decrease significantly. The <scene name='Sandbox_80/Protease/1'>protease</scene> is an enzyme that the virus uses to produce the proteins necessary to assemble more viruses. </div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>This is an antiviral drug used to treat HIV by inhibiting proteases in the virus. This inhibition causes the spread of the virus to decrease significantly. The <scene name='Sandbox_80/Protease/1'>protease</scene> is an enzyme that the virus uses to produce the proteins necessary to assemble more viruses. </div></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div> </div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">The common name for saqinavir is fortovase. It functions as peptide-like analogue that binds to the protein and causes inhibition by preventing the protease from cleaving polyproteins which in turn causes the virus to create non-infectious virus particles. </ins></div></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div> </div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div></div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>{{STRUCTURE_3oxc | PDB=3oxc | SCENE= }}</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>{{STRUCTURE_3oxc | PDB=3oxc | SCENE= }}</div></td></tr> </table>

Student http://52.214.119.220/wiki/index.php?title=Sandbox_80&diff=1203517&oldid=prev Student at 08:26, 11 March 2011 2011-03-11T08:26:41Z

<p></p> <table style="background-color: white; color:black;"> <col class='diff-marker' /> <col class='diff-content' /> <col class='diff-marker' /> <col class='diff-content' /> <tr> <td colspan='2' style="background-color: white; color:black;">←Older revision</td> <td colspan='2' style="background-color: white; color:black;">Revision as of 08:26, 11 March 2011</td> </tr> <tr><td colspan="2" class="diff-lineno">Line 2:</td> <td colspan="2" class="diff-lineno">Line 2:</td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>=Saquinavir=</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>=Saquinavir=</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>This is an antiviral drug used to treat HIV by inhibiting proteases in the virus. This inhibition causes the spread of the virus to decrease significantly. The protease </div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>This is an antiviral drug used to treat HIV by inhibiting proteases in the virus. This inhibition causes the spread of the virus to decrease significantly. The <ins style="color: red; font-weight: bold; text-decoration: none;"><scene name='Sandbox_80/Protease/1'></ins>protease<ins style="color: red; font-weight: bold; text-decoration: none;"></scene> is an enzyme that the virus uses to produce the proteins necessary to assemble more viruses. </ins></div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> </table>

Student http://52.214.119.220/wiki/index.php?title=Sandbox_80&diff=1203515&oldid=prev Student at 08:16, 11 March 2011 2011-03-11T08:16:28Z

<p></p> <table style="background-color: white; color:black;"> <col class='diff-marker' /> <col class='diff-content' /> <col class='diff-marker' /> <col class='diff-content' /> <tr> <td colspan='2' style="background-color: white; color:black;">←Older revision</td> <td colspan='2' style="background-color: white; color:black;">Revision as of 08:16, 11 March 2011</td> </tr> <tr><td colspan="2" class="diff-lineno">Line 1:</td> <td colspan="2" class="diff-lineno">Line 1:</td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>{{Template:Tims Sandbox Reservation}}</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>{{Template:Tims Sandbox Reservation}}</div></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div><del style="color: red; font-weight: bold; text-decoration: none;">=</del>=Saquinavir<del style="color: red; font-weight: bold; text-decoration: none;">=</del>=</div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>=Saquinavir=</div></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>This is <del style="color: red; font-weight: bold; text-decoration: none;">a placeholder text </del>to <del style="color: red; font-weight: bold; text-decoration: none;">help you get started </del>in </div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div> </div></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div><del style="color: red; font-weight: bold; text-decoration: none;">placing a Jmol applet on your page</del>. <del style="color: red; font-weight: bold; text-decoration: none;">At any time, click</del></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>This is <ins style="color: red; font-weight: bold; text-decoration: none;">an antiviral drug used </ins>to <ins style="color: red; font-weight: bold; text-decoration: none;">treat HIV by inhibiting proteases </ins>in <ins style="color: red; font-weight: bold; text-decoration: none;">the virus</ins>. <ins style="color: red; font-weight: bold; text-decoration: none;">This inhibition causes </ins>the <ins style="color: red; font-weight: bold; text-decoration: none;">spread </ins>of <ins style="color: red; font-weight: bold; text-decoration: none;">the virus </ins>to <ins style="color: red; font-weight: bold; text-decoration: none;">decrease significantly</ins>. <ins style="color: red; font-weight: bold; text-decoration: none;">The protease </ins></div></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div><del style="color: red; font-weight: bold; text-decoration: none;">"Show Preview" at </del>the <del style="color: red; font-weight: bold; text-decoration: none;">bottom </del>of <del style="color: red; font-weight: bold; text-decoration: none;">this page </del>to <del style="color: red; font-weight: bold; text-decoration: none;">see how it goes</del>.</div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div> </div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>Replace the PDB id (use lowercase!) after the STRUCTURE_ and after PDB= to load </div></td><td colspan="2"> </td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>and display another structure.</div></td><td colspan="2"> </td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>{{STRUCTURE_3oxc | PDB=3oxc | SCENE= }}</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>{{STRUCTURE_3oxc | PDB=3oxc | SCENE= }}</div></td></tr> <tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"></td></tr> <tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>==Structure==</div></td></tr> <tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>The chemical formula of <scene name='Sandbox_80/Stickwireframe/1'>Saquinavir</scene> is (C39)(H54)(N6)(O8)S and the molecular weight is 766.94 g/mol. This compound is</div></td></tr> <tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"></td></tr> <tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>==References==</div></td></tr> <tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0000973</div></td></tr> </table>

Student