Sandbox GGC1 - Revision history

Student at 19:13, 28 April 2021

2021-04-28T19:13:14Z

←Older revision		Revision as of 19:13, 28 April 2021
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	</StructureSection>		</StructureSection>
	== References ==		== References ==
		+	#file:///C:/Users/Muna/Desktop/Spring%202021/Advanced%20Biochem/pcbi.1003329.pdf
		+	#https://www.ncbi.nlm.nih.gov/books/NBK22572/#:~:text=Kinesins%20moving%20along%20microtubules%20usually,surfaces%20of%20some%20eukaryotic%20cells.
		+	#https://www.ninds.nih.gov/Disorders/Patient-Caregiver-Education/Fact-Sheets/Charcot-Marie-Tooth-Disease-Fact-Sheet
	<references/>		<references/>

Student at 19:01, 28 April 2021

2021-04-28T19:01:09Z

←Older revision		Revision as of 19:01, 28 April 2021
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	==Kinesin Motor Domain==		==Kinesin Motor Domain==
	<StructureSection load='1bg2' size='340' side='right' caption='Kinesin Protein' scene=''>		<StructureSection load='1bg2' size='340' side='right' caption='Kinesin Protein' scene=''>
-	Kinesin is an ATP-dependent motor protein responsible for the transportation of cargo. It is a heterotetramer composed of light and heavy ~~chain~~.	+	Kinesin is an ATP-dependent motor protein responsible for the transportation of cargo. It is a heterotetramer composed of light and heavy chains.

	== '''Function''' ==		== '''Function''' ==

Student at 19:00, 28 April 2021

2021-04-28T19:00:48Z

←Older revision		Revision as of 19:00, 28 April 2021
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	*Charcot Marie Tooth (CMT): Charcot Marie Tooth is one of many diseases that affect the peripheral nervous system. Individuals may suffer physical disabilities due to weakness in transmission of signals firing from the central nervous system		*Charcot Marie Tooth (CMT): Charcot Marie Tooth is one of many diseases that affect the peripheral nervous system. Individuals may suffer physical disabilities due to weakness in transmission of signals firing from the central nervous system

-	== '''Relevance''' ==

	== '''Structural highlights''' ==		== '''Structural highlights''' ==

Student at 19:00, 28 April 2021

2021-04-28T19:00:30Z

←Older revision		Revision as of 19:00, 28 April 2021
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	== '''Function''' ==		== '''Function''' ==
-	* Moving cargo usually from the center of the cell to the ~~periphery~~ <br/>	+	* Moving cargo usually from the center of the cell to the margins <br/>
	* Involved in cell replication and axonal signaling		* Involved in cell replication and axonal signaling

Student at 18:50, 28 April 2021

2021-04-28T18:50:48Z

←Older revision		Revision as of 18:50, 28 April 2021
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	==Kinesin Motor Domain==		==Kinesin Motor Domain==
	<StructureSection load='1bg2' size='340' side='right' caption='Kinesin Protein' scene=''>		<StructureSection load='1bg2' size='340' side='right' caption='Kinesin Protein' scene=''>
-	~~This~~ is ~~a default text~~ for ~~your page. Click above on '''edit this page''' to modify. Be careful with~~ the ~~< and > signs~~.	+	Kinesin is an ATP-dependent motor protein responsible for the transportation of cargo. It is a heterotetramer composed of light and heavy chain.
-	~~You may include any references to papers as in: the use~~ of ~~JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:8606779</ref> to the rescue~~.	+

	== '''Function''' ==		== '''Function''' ==

Student at 18:44, 28 April 2021

2021-04-28T18:44:20Z

←Older revision		Revision as of 18:44, 28 April 2021
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	== '''Function''' ==		== '''Function''' ==
-	* Moving cargo usually from the center of the cell to the periphery.<br/>	+	* Moving cargo usually from the center of the cell to the periphery <br/>
-	* Involved in cell replication.	+	* Involved in cell replication and axonal signaling

	== '''Disease''' ==		== '''Disease''' ==
-	*Charcot Marie Tooth (CMT)	+	*Charcot Marie Tooth (CMT): Charcot Marie Tooth is one of many diseases that affect the peripheral nervous system. Individuals may suffer physical disabilities due to weakness in transmission of signals firing from the central nervous system

	== '''Relevance''' ==		== '''Relevance''' ==
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	== '''Structural highlights''' ==		== '''Structural highlights''' ==

-	;Scene #1: Kinesin structure is composed of eight anti-parallel B sheets ~~surrounded by~~ three alpha helices on ~~either side~~ <scene name='75/752263/Alpha_beta_sheets/5'> Alpha-beta structure </scene>	+	;Scene #1: Kinesin structure is composed of eight anti-parallel Beta sheets and three alpha helices on opposite sides <scene name='75/752263/Alpha_beta_sheets/5'> Alpha-beta structure </scene>

	;Scene #2: This is the ATP binding site. Upon the binding of phosphate to ADP, ATP is formed giving Kinesin the energy needed to move the cargo one step a head to its destination <scene name='75/752263/Atp_binding_site/5'> ATP-binding site </scene>		;Scene #2: This is the ATP binding site. Upon the binding of phosphate to ADP, ATP is formed giving Kinesin the energy needed to move the cargo one step a head to its destination <scene name='75/752263/Atp_binding_site/5'> ATP-binding site </scene>
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	;Scene #3: This is the Microtubule-binding site, where Kinesin binds to microtubules for stability <scene name='75/752263/Mt-binding_site/1'> MT-binding site </scene>		;Scene #3: This is the Microtubule-binding site, where Kinesin binds to microtubules for stability <scene name='75/752263/Mt-binding_site/1'> MT-binding site </scene>

-	;Scene #4: ~~Charcot Marie Tooth is one of many diseases that affect~~ the ~~peripheral nervous system~~. ~~Individuals may suffer physical disabilities due to weakness~~ in ~~transmission~~ of ~~signals firing from the central nervous system~~ <scene name='75/752263/Cmt/1'> CMT </scene>	+	;Scene #4: some patients with CMT show mutation in the p-loop. A missense mutation results in a leucine in place of glutamine affecting signal transmission <scene name='75/752263/Cmt/1'> CMT </scene>

	This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.		This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.

Student at 23:54, 27 April 2021

2021-04-27T23:54:54Z

←Older revision		Revision as of 23:54, 27 April 2021
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	;Scene #3: This is the Microtubule-binding site, where Kinesin binds to microtubules for stability <scene name='75/752263/Mt-binding_site/1'> MT-binding site </scene>		;Scene #3: This is the Microtubule-binding site, where Kinesin binds to microtubules for stability <scene name='75/752263/Mt-binding_site/1'> MT-binding site </scene>

-	;Scene #4: Charcot Marie Tooth is	+	;Scene #4: Charcot Marie Tooth is one of many diseases that affect the peripheral nervous system. Individuals may suffer physical disabilities due to weakness in transmission of signals firing from the central nervous system <scene name='75/752263/Cmt/1'> CMT </scene>

	This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.		This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.

Student at 23:31, 27 April 2021

2021-04-27T23:31:58Z

←Older revision		Revision as of 23:31, 27 April 2021
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	== '''Structural highlights''' ==		== '''Structural highlights''' ==

-	Scene #1: Kinesin structure is composed of eight anti-parallel B sheets surrounded by three alpha helices on either side <scene name='75/752263/Alpha_beta_sheets/5'> Alpha-beta structure </scene>	+	;Scene #1: Kinesin structure is composed of eight anti-parallel B sheets surrounded by three alpha helices on either side <scene name='75/752263/Alpha_beta_sheets/5'> Alpha-beta structure </scene>

-	Scene #2: This is the ATP binding site. Upon the binding of phosphate to ADP, ATP is formed giving Kinesin the energy needed to move the cargo one step a head to its destination <scene name='75/752263/Atp_binding_site/5'> ATP-binding site </scene>	+	;Scene #2: This is the ATP binding site. Upon the binding of phosphate to ADP, ATP is formed giving Kinesin the energy needed to move the cargo one step a head to its destination <scene name='75/752263/Atp_binding_site/5'> ATP-binding site </scene>

-	Scene #3: This is the Microtubule-binding site, where Kinesin binds to microtubules for stability <scene name='75/752263/Mt-binding_site/1'> MT-binding site </scene>	+	;Scene #3: This is the Microtubule-binding site, where Kinesin binds to microtubules for stability <scene name='75/752263/Mt-binding_site/1'> MT-binding site </scene>

-	Scene #4:	+	;Scene #4: Charcot Marie Tooth is

	This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.		This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.

Student at 23:28, 27 April 2021

2021-04-27T23:28:24Z

←Older revision		Revision as of 23:28, 27 April 2021
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	== '''Disease''' ==		== '''Disease''' ==
	*Charcot Marie Tooth (CMT)		*Charcot Marie Tooth (CMT)
-	*

	== '''Relevance''' ==		== '''Relevance''' ==
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	Scene #2: This is the ATP binding site. Upon the binding of phosphate to ADP, ATP is formed giving Kinesin the energy needed to move the cargo one step a head to its destination <scene name='75/752263/Atp_binding_site/5'> ATP-binding site </scene>		Scene #2: This is the ATP binding site. Upon the binding of phosphate to ADP, ATP is formed giving Kinesin the energy needed to move the cargo one step a head to its destination <scene name='75/752263/Atp_binding_site/5'> ATP-binding site </scene>

-	Scene #3:	+	Scene #3: This is the Microtubule-binding site, where Kinesin binds to microtubules for stability <scene name='75/752263/Mt-binding_site/1'> MT-binding site </scene>

	Scene #4:		Scene #4:

Student at 23:15, 27 April 2021

2021-04-27T23:15:15Z

←Older revision		Revision as of 23:15, 27 April 2021
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	== '''Structural highlights''' ==		== '''Structural highlights''' ==

-	Kinesin structure is composed of eight anti-parallel B sheets surrounded by three alpha helices on either side <scene name='75/752263/Alpha_beta_sheets/5'>~~alpha~~-beta ~~struchture~~</scene>	+	Scene #1: Kinesin structure is composed of eight anti-parallel B sheets surrounded by three alpha helices on either side <scene name='75/752263/Alpha_beta_sheets/5'> Alpha-beta structure </scene>
		+
		+	Scene #2: This is the ATP binding site. Upon the binding of phosphate to ADP, ATP is formed giving Kinesin the energy needed to move the cargo one step a head to its destination <scene name='75/752263/Atp_binding_site/5'> ATP-binding site </scene>
		+
		+	Scene #3:
		+
		+	Scene #4:

	This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.		This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.