Sandbox elodie weider - Revision history

http://52.214.119.220/wiki/index.php?action=history&feed=atom&title=Sandbox_elodie_weider Sandbox elodie weider - Revision history 2026-04-13T23:51:21Z Revision history for this page on the wiki MediaWiki 1.11.2 http://52.214.119.220/wiki/index.php?title=Sandbox_elodie_weider&diff=1019899&oldid=prev Élodie Weider at 15:37, 20 November 2009 2009-11-20T15:37:27Z

<p></p> <table style="background-color: white; color:black;"> <col class='diff-marker' /> <col class='diff-content' /> <col class='diff-marker' /> <col class='diff-content' /> <tr> <td colspan='2' style="background-color: white; color:black;">←Older revision</td> <td colspan='2' style="background-color: white; color:black;">Revision as of 15:37, 20 November 2009</td> </tr> <tr><td colspan="2" class="diff-lineno">Line 1:</td> <td colspan="2" class="diff-lineno">Line 1:</td></tr> <tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>== '''2g49 : Insulin-Degrading Enzyme''' ==</div></td></tr> <tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"></td></tr> <tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>== Introduction == </div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>== Introduction == </div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> </table>

Élodie Weider http://52.214.119.220/wiki/index.php?title=Sandbox_elodie_weider&diff=1016752&oldid=prev Élodie Weider at 14:13, 13 November 2009 2009-11-13T14:13:15Z

<p></p> <table style="background-color: white; color:black;"> <col class='diff-marker' /> <col class='diff-content' /> <col class='diff-marker' /> <col class='diff-content' /> <tr> <td colspan='2' style="background-color: white; color:black;">←Older revision</td> <td colspan='2' style="background-color: white; color:black;">Revision as of 14:13, 13 November 2009</td> </tr> <tr><td colspan="2" class="diff-lineno">Line 1:</td> <td colspan="2" class="diff-lineno">Line 1:</td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>== Introduction == </div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>== Introduction == </div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>Insulin-Degrading Enzyme is a highly conserved <del style="color: red; font-weight: bold; text-decoration: none;">226 </del>kDa <del style="color: red; font-weight: bold; text-decoration: none;">dimeric </del>zinc metalloprotease. It belongs to the M16A family of metalloproteases within the ME clan. It hydrolyses insulin and several amyloidogenic peptides like amyloid-β (Aβ). </div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>Insulin-Degrading Enzyme is a highly conserved <ins style="color: red; font-weight: bold; text-decoration: none;">2*113 </ins>kDa <ins style="color: red; font-weight: bold; text-decoration: none;">homodimeric </ins>zinc metalloprotease. It belongs to the M16A family of metalloproteases within the ME clan. It hydrolyses insulin and several amyloidogenic peptides like amyloid-β (Aβ). </div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>Aβ is the main component of brain and of the amyloid islets found in Alzheimer’s disease.</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>Aβ is the main component of brain and of the amyloid islets found in Alzheimer’s disease.</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>Insulin is a peptide associated with diabete. The gene encoding IDE is located on human chromosome 10q and is in a region linked to type 2 diabete and Alzheimer’s disease.</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>Insulin is a peptide associated with diabete. The gene encoding IDE is located on human chromosome 10q and is in a region linked to type 2 diabete and Alzheimer’s disease.</div></td></tr> <tr><td colspan="2" class="diff-lineno">Line 14:</td> <td colspan="2" class="diff-lineno">Line 14:</td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>=== Structure general points ===</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>=== Structure general points ===</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>IDE is a <del style="color: red; font-weight: bold; text-decoration: none;">dimeric </del>protein. Each IDE monomer is composed of four 25-27 kDa structurally homologous αβ roll domains:</div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>IDE is a <ins style="color: red; font-weight: bold; text-decoration: none;">homodimeric </ins>protein. Each IDE monomer is composed of four 25-27 kDa structurally homologous αβ roll domains:</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>* <scene name='Sandbox_elodie_weider/Domain_1/2'>domain 1</scene>: residues 43-285</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>* <scene name='Sandbox_elodie_weider/Domain_1/2'>domain 1</scene>: residues 43-285</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>* <scene name='Sandbox_elodie_weider/Domain_2/1'>domain 2</scene>: residues 286-515</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>* <scene name='Sandbox_elodie_weider/Domain_2/1'>domain 2</scene>: residues 286-515</div></td></tr> </table>

Élodie Weider http://52.214.119.220/wiki/index.php?title=Sandbox_elodie_weider&diff=1016663&oldid=prev Élodie Weider at 18:09, 12 November 2009 2009-11-12T18:09:23Z

<p></p> <table style="background-color: white; color:black;"> <col class='diff-marker' /> <col class='diff-content' /> <col class='diff-marker' /> <col class='diff-content' /> <tr> <td colspan='2' style="background-color: white; color:black;">←Older revision</td> <td colspan='2' style="background-color: white; color:black;">Revision as of 18:09, 12 November 2009</td> </tr> <tr><td colspan="2" class="diff-lineno">Line 1:</td> <td colspan="2" class="diff-lineno">Line 1:</td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>== Introduction == </div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>== Introduction == </div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>Insulin-Degrading Enzyme <del style="color: red; font-weight: bold; text-decoration: none;">(IDE or insulinase or insulysin) </del>is a highly conserved <del style="color: red; font-weight: bold; text-decoration: none;">113 </del>kDa zinc metalloprotease. It belongs to the M16A family of metalloproteases within the ME clan. It hydrolyses insulin and several amyloidogenic peptides like amyloid-β (Aβ). </div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>Insulin-Degrading Enzyme is a highly conserved <ins style="color: red; font-weight: bold; text-decoration: none;">226 </ins>kDa <ins style="color: red; font-weight: bold; text-decoration: none;">dimeric </ins>zinc metalloprotease. It belongs to the M16A family of metalloproteases within the ME clan. It hydrolyses insulin and several amyloidogenic peptides like amyloid-β (Aβ). </div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>Aβ is the main component of brain and of the amyloid islets found in Alzheimer’s disease.</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>Aβ is the main component of brain and of the amyloid islets found in Alzheimer’s disease.</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>Insulin is a peptide associated with diabete. The gene encoding IDE is located on human chromosome 10q and is in a region linked to type 2 diabete and Alzheimer’s disease.</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>Insulin is a peptide associated with diabete. The gene encoding IDE is located on human chromosome 10q and is in a region linked to type 2 diabete and Alzheimer’s disease.</div></td></tr> </table>

Élodie Weider http://52.214.119.220/wiki/index.php?title=Sandbox_elodie_weider&diff=1016662&oldid=prev Élodie Weider at 17:55, 12 November 2009 2009-11-12T17:55:23Z

<p></p> <table style="background-color: white; color:black;"> <col class='diff-marker' /> <col class='diff-content' /> <col class='diff-marker' /> <col class='diff-content' /> <tr> <td colspan='2' style="background-color: white; color:black;">←Older revision</td> <td colspan='2' style="background-color: white; color:black;">Revision as of 17:55, 12 November 2009</td> </tr> <tr><td colspan="2" class="diff-lineno">Line 20:</td> <td colspan="2" class="diff-lineno">Line 20:</td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>* <scene name='Sandbox_elodie_weider/Domain_4/1'>domain 4</scene>: residues 769-1,016</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>* <scene name='Sandbox_elodie_weider/Domain_4/1'>domain 4</scene>: residues 769-1,016</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>These domains share less than 25 % sequence similarity, and show similar secondary structures.</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>These domains share less than 25 % sequence similarity, and show similar secondary structures.</div></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>The N-terminal domains 1 and 2 form a αβαβα sandwich (<scene name='Sandbox_elodie_weider/Ide-n/1'>IDE-N</scene>), as do domains 3 and 4 (IDE-C). The size of each IDE-N and IDE-C is about 56 kDa. </div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>The N-terminal domains 1 and 2 form a αβαβα sandwich (<scene name='Sandbox_elodie_weider/Ide-n/1'>IDE-N</scene>), as do domains 3 and 4 (<ins style="color: red; font-weight: bold; text-decoration: none;"><scene name='Sandbox_elodie_weider/Ide-c/1'></ins>IDE-C<ins style="color: red; font-weight: bold; text-decoration: none;"></scene></ins>). The size of each IDE-N and IDE-C is about 56 kDa. </div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>They are joined by a <scene name='Sandbox_elodie_weider/Loop/1'>26-residue loop</scene> (residues 516-541) which interacts with both domains 2 and 3, but not with domains 1 and 4.</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>They are joined by a <scene name='Sandbox_elodie_weider/Loop/1'>26-residue loop</scene> (residues 516-541) which interacts with both domains 2 and 3, but not with domains 1 and 4.</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>There is an extensive interaction between IDE-N and IDE-C domains, that bury a large surface ( 11,200 Ȧ<sup>2</sup>), with good shape complementarity. This interaction between the two domains of IDE is mediated by charge complementarity and Van der Waals interactions.</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>There is an extensive interaction between IDE-N and IDE-C domains, that bury a large surface ( 11,200 Ȧ<sup>2</sup>), with good shape complementarity. This interaction between the two domains of IDE is mediated by charge complementarity and Van der Waals interactions.</div></td></tr> </table>

Élodie Weider http://52.214.119.220/wiki/index.php?title=Sandbox_elodie_weider&diff=1016661&oldid=prev Élodie Weider at 17:52, 12 November 2009 2009-11-12T17:52:45Z

<p></p> <table style="background-color: white; color:black;"> <col class='diff-marker' /> <col class='diff-content' /> <col class='diff-marker' /> <col class='diff-content' /> <tr> <td colspan='2' style="background-color: white; color:black;">←Older revision</td> <td colspan='2' style="background-color: white; color:black;">Revision as of 17:52, 12 November 2009</td> </tr> <tr><td colspan="2" class="diff-lineno">Line 20:</td> <td colspan="2" class="diff-lineno">Line 20:</td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>* <scene name='Sandbox_elodie_weider/Domain_4/1'>domain 4</scene>: residues 769-1,016</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>* <scene name='Sandbox_elodie_weider/Domain_4/1'>domain 4</scene>: residues 769-1,016</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>These domains share less than 25 % sequence similarity, and show similar secondary structures.</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>These domains share less than 25 % sequence similarity, and show similar secondary structures.</div></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>The N-terminal domains 1 and 2 form a αβαβα sandwich (IDE-N), as do domains 3 and 4 (IDE-C). The size of each IDE-N and IDE-C is about 56 kDa. </div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>The N-terminal domains 1 and 2 form a αβαβα sandwich (<ins style="color: red; font-weight: bold; text-decoration: none;"><scene name='Sandbox_elodie_weider/Ide-n/1'></ins>IDE-N<ins style="color: red; font-weight: bold; text-decoration: none;"></scene></ins>), as do domains 3 and 4 (IDE-C). The size of each IDE-N and IDE-C is about 56 kDa. </div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>They are joined by a <scene name='Sandbox_elodie_weider/Loop/1'>26-residue loop</scene> (residues 516-541) which interacts with both domains 2 and 3, but not with domains 1 and 4.</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>They are joined by a <scene name='Sandbox_elodie_weider/Loop/1'>26-residue loop</scene> (residues 516-541) which interacts with both domains 2 and 3, but not with domains 1 and 4.</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>There is an extensive interaction between IDE-N and IDE-C domains, that bury a large surface ( 11,200 Ȧ<sup>2</sup>), with good shape complementarity. This interaction between the two domains of IDE is mediated by charge complementarity and Van der Waals interactions.</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>There is an extensive interaction between IDE-N and IDE-C domains, that bury a large surface ( 11,200 Ȧ<sup>2</sup>), with good shape complementarity. This interaction between the two domains of IDE is mediated by charge complementarity and Van der Waals interactions.</div></td></tr> </table>

Élodie Weider http://52.214.119.220/wiki/index.php?title=Sandbox_elodie_weider&diff=1016660&oldid=prev Élodie Weider at 17:48, 12 November 2009 2009-11-12T17:48:41Z

<p></p> <table style="background-color: white; color:black;"> <col class='diff-marker' /> <col class='diff-content' /> <col class='diff-marker' /> <col class='diff-content' /> <tr> <td colspan='2' style="background-color: white; color:black;">←Older revision</td> <td colspan='2' style="background-color: white; color:black;">Revision as of 17:48, 12 November 2009</td> </tr> <tr><td colspan="2" class="diff-lineno">Line 21:</td> <td colspan="2" class="diff-lineno">Line 21:</td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>These domains share less than 25 % sequence similarity, and show similar secondary structures.</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>These domains share less than 25 % sequence similarity, and show similar secondary structures.</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>The N-terminal domains 1 and 2 form a αβαβα sandwich (IDE-N), as do domains 3 and 4 (IDE-C). The size of each IDE-N and IDE-C is about 56 kDa. </div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>The N-terminal domains 1 and 2 form a αβαβα sandwich (IDE-N), as do domains 3 and 4 (IDE-C). The size of each IDE-N and IDE-C is about 56 kDa. </div></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>They are joined by a 26-residue loop (residues 516-541) which interacts with both domains 2 and 3, but not with domains 1 and 4.</div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>They are joined by a <ins style="color: red; font-weight: bold; text-decoration: none;"><scene name='Sandbox_elodie_weider/Loop/1'></ins>26-residue loop<ins style="color: red; font-weight: bold; text-decoration: none;"></scene> </ins>(residues 516-541) which interacts with both domains 2 and 3, but not with domains 1 and 4.</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>There is an extensive interaction between IDE-N and IDE-C domains, that bury a large surface ( 11,200 Ȧ<sup>2</sup>), with good shape complementarity. This interaction between the two domains of IDE is mediated by charge complementarity and Van der Waals interactions.</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>There is an extensive interaction between IDE-N and IDE-C domains, that bury a large surface ( 11,200 Ȧ<sup>2</sup>), with good shape complementarity. This interaction between the two domains of IDE is mediated by charge complementarity and Van der Waals interactions.</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>IDE-C plays also is also involved in the oligomerization of IDE.</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>IDE-C plays also is also involved in the oligomerization of IDE.</div></td></tr> </table>

Élodie Weider http://52.214.119.220/wiki/index.php?title=Sandbox_elodie_weider&diff=1016658&oldid=prev Élodie Weider at 17:37, 12 November 2009 2009-11-12T17:37:54Z

<p></p> <table style="background-color: white; color:black;"> <col class='diff-marker' /> <col class='diff-content' /> <col class='diff-marker' /> <col class='diff-content' /> <tr> <td colspan='2' style="background-color: white; color:black;">←Older revision</td> <td colspan='2' style="background-color: white; color:black;">Revision as of 17:37, 12 November 2009</td> </tr> <tr><td colspan="2" class="diff-lineno">Line 18:</td> <td colspan="2" class="diff-lineno">Line 18:</td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>* <scene name='Sandbox_elodie_weider/Domain_2/1'>domain 2</scene>: residues 286-515</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>* <scene name='Sandbox_elodie_weider/Domain_2/1'>domain 2</scene>: residues 286-515</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>* <scene name='Sandbox_elodie_weider/Domain_3/1'>domain 3</scene>: residues 542-768</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>* <scene name='Sandbox_elodie_weider/Domain_3/1'>domain 3</scene>: residues 542-768</div></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>* domain 4: residues 769-1,016</div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>* <ins style="color: red; font-weight: bold; text-decoration: none;"><scene name='Sandbox_elodie_weider/Domain_4/1'></ins>domain 4<ins style="color: red; font-weight: bold; text-decoration: none;"></scene></ins>: residues 769-1,016</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>These domains share less than 25 % sequence similarity, and show similar secondary structures.</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>These domains share less than 25 % sequence similarity, and show similar secondary structures.</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>The N-terminal domains 1 and 2 form a αβαβα sandwich (IDE-N), as do domains 3 and 4 (IDE-C). The size of each IDE-N and IDE-C is about 56 kDa. </div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>The N-terminal domains 1 and 2 form a αβαβα sandwich (IDE-N), as do domains 3 and 4 (IDE-C). The size of each IDE-N and IDE-C is about 56 kDa. </div></td></tr> </table>

Élodie Weider http://52.214.119.220/wiki/index.php?title=Sandbox_elodie_weider&diff=1016657&oldid=prev Élodie Weider at 17:35, 12 November 2009 2009-11-12T17:35:37Z

<p></p> <table style="background-color: white; color:black;"> <col class='diff-marker' /> <col class='diff-content' /> <col class='diff-marker' /> <col class='diff-content' /> <tr> <td colspan='2' style="background-color: white; color:black;">←Older revision</td> <td colspan='2' style="background-color: white; color:black;">Revision as of 17:35, 12 November 2009</td> </tr> <tr><td colspan="2" class="diff-lineno">Line 17:</td> <td colspan="2" class="diff-lineno">Line 17:</td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>* <scene name='Sandbox_elodie_weider/Domain_1/2'>domain 1</scene>: residues 43-285</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>* <scene name='Sandbox_elodie_weider/Domain_1/2'>domain 1</scene>: residues 43-285</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>* <scene name='Sandbox_elodie_weider/Domain_2/1'>domain 2</scene>: residues 286-515</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>* <scene name='Sandbox_elodie_weider/Domain_2/1'>domain 2</scene>: residues 286-515</div></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>* domain 3: residues 542-768</div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>* <ins style="color: red; font-weight: bold; text-decoration: none;"><scene name='Sandbox_elodie_weider/Domain_3/1'></ins>domain 3<ins style="color: red; font-weight: bold; text-decoration: none;"></scene></ins>: residues 542-768</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>* domain 4: residues 769-1,016</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>* domain 4: residues 769-1,016</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>These domains share less than 25 % sequence similarity, and show similar secondary structures.</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>These domains share less than 25 % sequence similarity, and show similar secondary structures.</div></td></tr> </table>

Élodie Weider http://52.214.119.220/wiki/index.php?title=Sandbox_elodie_weider&diff=1016656&oldid=prev Élodie Weider at 17:33, 12 November 2009 2009-11-12T17:33:17Z

<p></p> <table style="background-color: white; color:black;"> <col class='diff-marker' /> <col class='diff-content' /> <col class='diff-marker' /> <col class='diff-content' /> <tr> <td colspan='2' style="background-color: white; color:black;">←Older revision</td> <td colspan='2' style="background-color: white; color:black;">Revision as of 17:33, 12 November 2009</td> </tr> <tr><td colspan="2" class="diff-lineno">Line 16:</td> <td colspan="2" class="diff-lineno">Line 16:</td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>IDE is a dimeric protein. Each IDE monomer is composed of four 25-27 kDa structurally homologous αβ roll domains:</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>IDE is a dimeric protein. Each IDE monomer is composed of four 25-27 kDa structurally homologous αβ roll domains:</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>* <scene name='Sandbox_elodie_weider/Domain_1/2'>domain 1</scene>: residues 43-285</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>* <scene name='Sandbox_elodie_weider/Domain_1/2'>domain 1</scene>: residues 43-285</div></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>* domain 2: residues 286-515</div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>* <ins style="color: red; font-weight: bold; text-decoration: none;"><scene name='Sandbox_elodie_weider/Domain_2/1'></ins>domain 2<ins style="color: red; font-weight: bold; text-decoration: none;"></scene></ins>: residues 286-515</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>* domain 3: residues 542-768</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>* domain 3: residues 542-768</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>* domain 4: residues 769-1,016</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>* domain 4: residues 769-1,016</div></td></tr> </table>

Élodie Weider http://52.214.119.220/wiki/index.php?title=Sandbox_elodie_weider&diff=1016655&oldid=prev Élodie Weider at 17:30, 12 November 2009 2009-11-12T17:30:43Z

<p></p> <table style="background-color: white; color:black;"> <col class='diff-marker' /> <col class='diff-content' /> <col class='diff-marker' /> <col class='diff-content' /> <tr> <td colspan='2' style="background-color: white; color:black;">←Older revision</td> <td colspan='2' style="background-color: white; color:black;">Revision as of 17:30, 12 November 2009</td> </tr> <tr><td colspan="2" class="diff-lineno">Line 15:</td> <td colspan="2" class="diff-lineno">Line 15:</td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>IDE is a dimeric protein. Each IDE monomer is composed of four 25-27 kDa structurally homologous αβ roll domains:</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>IDE is a dimeric protein. Each IDE monomer is composed of four 25-27 kDa structurally homologous αβ roll domains:</div></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>* domain 1: residues 43-285</div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>* <ins style="color: red; font-weight: bold; text-decoration: none;"><scene name='Sandbox_elodie_weider/Domain_1/2'></ins>domain 1<ins style="color: red; font-weight: bold; text-decoration: none;"></scene></ins>: residues 43-285</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>* domain 2: residues 286-515</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>* domain 2: residues 286-515</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>* domain 3: residues 542-768</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>* domain 3: residues 542-768</div></td></tr> </table>

Élodie Weider