Symplekin - Revision history

Michal Harel at 11:09, 15 November 2020

2020-11-15T11:09:29Z

←Older revision		Revision as of 11:09, 15 November 2020
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	[[3o2s]] – hSMPK N terminal + RNA polymerase II subunit A C terminal phosphatase<br />		[[3o2s]] – hSMPK N terminal + RNA polymerase II subunit A C terminal phosphatase<br />
	[[4h3h]], [[3o2q]], [[4h3k]] – hSMPK N terminal + RNA polymerase II subunit A C terminal phosphatase + phosphorylated peptide<br />		[[4h3h]], [[3o2q]], [[4h3k]] – hSMPK N terminal + RNA polymerase II subunit A C terminal phosphatase + phosphorylated peptide<br />
		+	[[6v4x]] – hSMPK inhistone pre-mRNA 3’-end processing machinery – Cryo EM<br />
	[[3gs3]] – DmSMPK N terminal – ''Drosophila melanogaster'' <br />		[[3gs3]] – DmSMPK N terminal – ''Drosophila melanogaster'' <br />
	[[4imi]], [[4imj]], [[4ygx]], [[6npw]] – DmSMPK + SSU72 + phosphorylated peptide<br />		[[4imi]], [[4imj]], [[4ygx]], [[6npw]] – DmSMPK + SSU72 + phosphorylated peptide<br />

Michal Harel at 08:52, 12 February 2020

2020-02-12T08:52:36Z

←Older revision		Revision as of 08:52, 12 February 2020
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	Updated on {{REVISIONDAY2}}-{{MONTHNAME\|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}		Updated on {{REVISIONDAY2}}-{{MONTHNAME\|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}

-	[[3gs3]] – DmSMPK N terminal – ''Drosophila melanogaster'' <br />
	[[3o2t]], [[3odr]] – hSMPK N terminal – human <br />		[[3o2t]], [[3odr]] – hSMPK N terminal – human <br />
	[[3ods]] – hSMPK N terminal (mutant) <br />		[[3ods]] – hSMPK N terminal (mutant) <br />
	[[3o2s]] – hSMPK N terminal + RNA polymerase II subunit A C terminal phosphatase<br />		[[3o2s]] – hSMPK N terminal + RNA polymerase II subunit A C terminal phosphatase<br />
	[[4h3h]], [[3o2q]], [[4h3k]] – hSMPK N terminal + RNA polymerase II subunit A C terminal phosphatase + phosphorylated peptide<br />		[[4h3h]], [[3o2q]], [[4h3k]] – hSMPK N terminal + RNA polymerase II subunit A C terminal phosphatase + phosphorylated peptide<br />
-	[[4imi]], [[4imj]], [[4ygx]] – DmSMPK ~~N terminal~~ + ~~RNA polymerase II subunit A C terminal phosphatase~~ + phosphorylated peptide<br />	+	[[3gs3]] – DmSMPK N terminal – ''Drosophila melanogaster'' <br />
		+	[[4imi]], [[4imj]], [[4ygx]], [[6npw]] – DmSMPK + SSU72 + phosphorylated peptide<br />

	== References ==		== References ==
	<references/>		<references/>
	[[Category:Topic Page]]		[[Category:Topic Page]]

Michal Harel at 18:39, 6 October 2017

2017-10-06T18:39:06Z

←Older revision		Revision as of 18:39, 6 October 2017
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	== References ==		== References ==
	<references/>		<references/>
		+	[[Category:Topic Page]]

Michal Harel at 08:06, 6 September 2016

2016-09-06T08:06:34Z

←Older revision		Revision as of 08:06, 6 September 2016
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	[[3o2s]] – hSMPK N terminal + RNA polymerase II subunit A C terminal phosphatase<br />		[[3o2s]] – hSMPK N terminal + RNA polymerase II subunit A C terminal phosphatase<br />
	[[4h3h]], [[3o2q]], [[4h3k]] – hSMPK N terminal + RNA polymerase II subunit A C terminal phosphatase + phosphorylated peptide<br />		[[4h3h]], [[3o2q]], [[4h3k]] – hSMPK N terminal + RNA polymerase II subunit A C terminal phosphatase + phosphorylated peptide<br />
-	[[4imi]], [[4imj]] – DmSMPK N terminal + RNA polymerase II subunit A C terminal phosphatase + phosphorylated peptide<br />	+	[[4imi]], [[4imj]], [[4ygx]] – DmSMPK N terminal + RNA polymerase II subunit A C terminal phosphatase + phosphorylated peptide<br />

	== References ==		== References ==
	<references/>		<references/>

Michal Harel at 08:00, 6 September 2016

2016-09-06T08:00:57Z

←Older revision		Revision as of 08:00, 6 September 2016
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	== Relevance ==		== Relevance ==
	Overexpression of SMPK promotes tumorigenicity in the colon<ref>PMID20133805</ref>.		Overexpression of SMPK promotes tumorigenicity in the colon<ref>PMID20133805</ref>.
-	== Structural highlights ==

	</StructureSection>		</StructureSection>

Michal Harel at 08:00, 6 September 2016

2016-09-06T08:00:23Z

←Older revision		Revision as of 08:00, 6 September 2016
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-	<StructureSection load='3o2s' size='340' side='right' caption='Human symplekin N terminal (grey) complex with RNA polymerase II subunit A C terminal ~~phosphatase~~ (green) and phosphate ion (PDB code [[3o2s]])' scene=''>	+	<StructureSection load='3o2s' size='340' side='right' caption='Human symplekin N terminal (grey) complex with RNA polymerase II subunit A phosphatase C terminal (green) and phosphate ion (PDB code [[3o2s]])' scene=''>
	== Function ==		== Function ==
	'''Symplekin''' (SMPK) is a scaffold protein recruiting regulatory factors to the multimolecular complex involved in histone mRNA 3’-end processing. SMPK is involved in pre-mRNA polyadenylation. It enhances the activity of RNA polymerase II subunit A C terminal phosphatase (Ssu72)<ref>PMID:8769423</ref>.		'''Symplekin''' (SMPK) is a scaffold protein recruiting regulatory factors to the multimolecular complex involved in histone mRNA 3’-end processing. SMPK is involved in pre-mRNA polyadenylation. It enhances the activity of RNA polymerase II subunit A C terminal phosphatase (Ssu72)<ref>PMID:8769423</ref>.

Michal Harel at 07:58, 6 September 2016

2016-09-06T07:58:20Z

←Older revision		Revision as of 07:58, 6 September 2016
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	<StructureSection load='3o2s' size='340' side='right' caption='Human symplekin N terminal (grey) complex with RNA polymerase II subunit A C terminal phosphatase (green) and phosphate ion (PDB code [[3o2s]])' scene=''>		<StructureSection load='3o2s' size='340' side='right' caption='Human symplekin N terminal (grey) complex with RNA polymerase II subunit A C terminal phosphatase (green) and phosphate ion (PDB code [[3o2s]])' scene=''>
-	'''Symplekin''' (SMPK) is a scaffold protein recruiting regulatory factors to the multimolecular complex involved in histone mRNA 3’-end processing. SMPK is involved in pre-mRNA polyadenylation. It enhances the activity of RNA polymerase II subunit A C terminal phosphatase (Ssu72).
-
	== Function ==		== Function ==
-		+	'''Symplekin''' (SMPK) is a scaffold protein recruiting regulatory factors to the multimolecular complex involved in histone mRNA 3’-end processing. SMPK is involved in pre-mRNA polyadenylation. It enhances the activity of RNA polymerase II subunit A C terminal phosphatase (Ssu72)<ref>PMID:8769423</ref>.
-	~~== Disease ==~~	+

	== Relevance ==		== Relevance ==
-		+	Overexpression of SMPK promotes tumorigenicity in the colon<ref>PMID20133805</ref>.
	== Structural highlights ==		== Structural highlights ==

Michal Harel at 09:53, 8 July 2015

2015-07-08T09:53:21Z

←Older revision		Revision as of 09:53, 8 July 2015
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-		+	<StructureSection load='3o2s' size='340' side='right' caption='Human symplekin N terminal (grey) complex with RNA polymerase II subunit A C terminal phosphatase (green) and phosphate ion (PDB code [[3o2s]])' scene=''>
-	<StructureSection load='3o2s' size='340' side='right' caption='Human symplekin N terminal complex with RNA polymerase II subunit A C terminal phosphatase (PDB code [[3o2s]])' scene=''>	+
	'''Symplekin''' (SMPK) is a scaffold protein recruiting regulatory factors to the multimolecular complex involved in histone mRNA 3’-end processing. SMPK is involved in pre-mRNA polyadenylation. It enhances the activity of RNA polymerase II subunit A C terminal phosphatase (Ssu72).		'''Symplekin''' (SMPK) is a scaffold protein recruiting regulatory factors to the multimolecular complex involved in histone mRNA 3’-end processing. SMPK is involved in pre-mRNA polyadenylation. It enhances the activity of RNA polymerase II subunit A C terminal phosphatase (Ssu72).

Michal Harel: New page: ''...

2015-07-08T09:51:54Z

New page: <StructureSection load='3o2s' size='340' side='right' caption='Human symplekin N terminal complex with RNA polymerase II subunit A C terminal phosphatase (PDB code 3o2s)' scene=''> ''...

New page

<StructureSection load='3o2s' size='340' side='right' caption='Human symplekin N terminal complex with RNA polymerase II subunit A C terminal phosphatase (PDB code [[3o2s]])' scene=''>
'''Symplekin''' (SMPK) is a scaffold protein recruiting regulatory factors to the multimolecular complex involved in histone mRNA 3’-end processing. SMPK is involved in pre-mRNA polyadenylation. It enhances the activity of RNA polymerase II subunit A C terminal phosphatase (Ssu72).

== Function ==

== Disease ==

== Relevance ==

== Structural highlights ==

</StructureSection>

== 3D Structures of symplekin ==

Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}

[[3gs3]] – DmSMPK N terminal – ''Drosophila melanogaster'' 
[[3o2t]], [[3odr]] – hSMPK N terminal – human 
[[3ods]] – hSMPK N terminal (mutant) 
[[3o2s]] – hSMPK N terminal + RNA polymerase II subunit A C terminal phosphatase 
[[4h3h]], [[3o2q]], [[4h3k]] – hSMPK N terminal + RNA polymerase II subunit A C terminal phosphatase + phosphorylated peptide 
[[4imi]], [[4imj]] – DmSMPK N terminal + RNA polymerase II subunit A C terminal phosphatase + phosphorylated peptide 

== References ==
<references/>