Synapsin - Revision history

Alexander Berchansky at 12:56, 30 April 2020

2020-04-30T12:56:28Z

←Older revision		Revision as of 12:56, 30 April 2020
Line 8:		Line 8:
	== Structural highlights ==		== Structural highlights ==

-	The 3D structure of the rat synapsin 1 complex with ATP shows the catalytically essential multifunctional loop surrounding the <scene name='84/843883/Cv/4'>~~ATP which makes both~~ hydrogen bonds and Van-der Waals contacts</scene> with the protein<ref>PMID:14688264</ref>. Water molecules are shown as red spheres.	+	The 3D structure of the rat synapsin 1 complex with ATP shows the catalytically essential multifunctional loop surrounding the ATP which makes both <scene name='84/843883/Cv/4'>hydrogen bonds</scene> and <scene name='84/843883/Cv/5'>Van-der Waals contacts</scene> with the protein<ref>PMID:14688264</ref>. Water molecules are shown as red spheres.

	</StructureSection>		</StructureSection>

Alexander Berchansky at 12:51, 30 April 2020

2020-04-30T12:51:27Z

←Older revision		Revision as of 12:51, 30 April 2020
Line 8:		Line 8:
	== Structural highlights ==		== Structural highlights ==

-	The 3D structure of the rat synapsin 1 complex with ATP shows the catalytically essential multifunctional loop surrounding the ATP which makes both hydrogen bonds and Van-der Waals contacts with the protein<ref>PMID:14688264</ref>.	+	The 3D structure of the rat synapsin 1 complex with ATP shows the catalytically essential multifunctional loop surrounding the <scene name='84/843883/Cv/4'>ATP which makes both hydrogen bonds and Van-der Waals contacts</scene> with the protein<ref>PMID:14688264</ref>. Water molecules are shown as red spheres.

	</StructureSection>		</StructureSection>

Alexander Berchansky at 12:22, 30 April 2020

2020-04-30T12:22:17Z

←Older revision		Revision as of 12:22, 30 April 2020
Line 1:		Line 1:
-	<StructureSection load='1px2' size='~~340~~' side='right' caption='Rat synapsin 1 complex with ATP ~~anc~~ Ca++ ion (green) (PDB code [[1px2]])' scene=''>	+	<StructureSection load='1px2' size='400' side='right' caption='Rat synapsin 1 complex with ATP and Ca++ ion (green) (PDB code [[1px2]])' scene='84/843883/Cv/1'>

Michal Harel at 09:41, 29 April 2020

2020-04-29T09:41:45Z

←Older revision		Revision as of 09:41, 29 April 2020
Line 1:		Line 1:
-
	<StructureSection load='1px2' size='340' side='right' caption='Rat synapsin 1 complex with ATP anc Ca++ ion (green) (PDB code [[1px2]])' scene=''>		<StructureSection load='1px2' size='340' side='right' caption='Rat synapsin 1 complex with ATP anc Ca++ ion (green) (PDB code [[1px2]])' scene=''>

Line 22:		Line 21:
	**[[1auv]] - bSYN1A C-terminal 110-421 - bovine<br />		**[[1auv]] - bSYN1A C-terminal 110-421 - bovine<br />
	**[[1aux]] - bSYN1A C-terminal + ATPgS<br />		**[[1aux]] - bSYN1A C-terminal + ATPgS<br />
-	**[[1pk8]], [[1px2]] - rSYN1 ~~C-terminal~~ + ATP - rat<br />	+	**[[1pk8]], [[1px2]] - rSYN1 + ATP - rat<br />

	*Synapsin 2		*Synapsin 2

Michal Harel: New page: == Function == '''Synapsins''' (SYN) ...

2020-04-29T09:38:20Z

New page: <StructureSection load='1px2' size='340' side='right' caption='Rat synapsin 1 complex with ATP anc Ca++ ion (green) (PDB code 1px2)' scene=''> == Function == '''Synapsins''' (SYN) ...

New page

<StructureSection load='1px2' size='340' side='right' caption='Rat synapsin 1 complex with ATP anc Ca++ ion (green) (PDB code [[1px2]])' scene=''>

== Function ==

'''Synapsins''' (SYN) are neuronal phosphoproteins which modulate neurotransmitter release at the pre-synaptic terminal by reversibly tethering synaptic vescicles to the actin cytoskeleton<ref>PMID:20438797</ref>.

== Structural highlights ==

The 3D structure of the rat synapsin 1 complex with ATP shows the catalytically essential multifunctional loop surrounding the ATP which makes both hydrogen bonds and Van-der Waals contacts with the protein<ref>PMID:14688264</ref>.

</StructureSection>

==3D structures of synapsin==

Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
{{#tree:id=OrganizedByTopic|openlevels=0|

*Synapsin 1

**[[1auv]] - bSYN1A C-terminal 110-421 - bovine 
**[[1aux]] - bSYN1A C-terminal + ATPgS 
**[[1pk8]], [[1px2]] - rSYN1 C-terminal + ATP - rat 

*Synapsin 2

**[[1i7n]] - rSYN2 C-terminal 
**[[1i7l]] - rSYN2 C-terminal + ATP 

*Synapsin 3

**[[2p0a]] - hSYN3 actin-binding+synaptic vescicle binding domains 76-417 + AMPPNP - human 
}}
== References ==
<references/>

[[Category:Topic Page]]