Syntenin - Revision history

Alexander Berchansky at 14:41, 5 July 2022

2022-07-05T14:41:33Z

←Older revision		Revision as of 14:41, 5 July 2022
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	== Structural highlights ==		== Structural highlights ==

-	The 3D structure of the complex of SYNT PDZ1 and PDZ2 domains with a syndecan peptide shows the <scene name='91/916387/Cv/2'>simultaneous binding to the two domains</scene><ref>PMID:16533050</ref>. The peptide forms a β strand which runs antiparallel to the PDZ β strand. <scene name='91/916387/Cv/3'>Syntenin/Syndecan peptide inreactions</scene>.	+	The 3D structure of the complex of SYNT PDZ1 and PDZ2 domains with a syndecan peptide shows the <scene name='91/916387/Cv/2'>simultaneous binding to the two domains</scene><ref>PMID:16533050</ref>. The peptide forms a β strand which runs antiparallel to the PDZ β strand. <scene name='91/916387/Cv/4'>Syntenin/Syndecan peptide inreactions</scene>. Water molecules are shown as red spheres.

	==Syntenin 3D structures==		==Syntenin 3D structures==

Alexander Berchansky at 13:18, 5 July 2022

2022-07-05T13:18:48Z

←Older revision		Revision as of 13:18, 5 July 2022
Line 11:		Line 11:
	== Structural highlights ==		== Structural highlights ==

-	The 3D structure of the complex of SYNT PDZ1 and PDZ2 domains with a syndecan peptide shows the <scene name='91/916387/Cv/2'>simultaneous binding to the two domains</scene><ref>PMID:16533050</ref>. The peptide forms a β strand which runs antiparallel to the PDZ β strand.	+	The 3D structure of the complex of SYNT PDZ1 and PDZ2 domains with a syndecan peptide shows the <scene name='91/916387/Cv/2'>simultaneous binding to the two domains</scene><ref>PMID:16533050</ref>. The peptide forms a β strand which runs antiparallel to the PDZ β strand. <scene name='91/916387/Cv/3'>Syntenin/Syndecan peptide inreactions</scene>.

	==Syntenin 3D structures==		==Syntenin 3D structures==

Alexander Berchansky at 13:10, 5 July 2022

2022-07-05T13:10:55Z

←Older revision		Revision as of 13:10, 5 July 2022
Line 11:		Line 11:
	== Structural highlights ==		== Structural highlights ==

-	The 3D structure of the complex of SYNT PDZ1 and PDZ2 domains with a syndecan peptide shows the simultaneous binding to the two domains<ref>PMID:16533050</ref>. The peptide forms a β strand which runs antiparallel to the PDZ β strand.	+	The 3D structure of the complex of SYNT PDZ1 and PDZ2 domains with a syndecan peptide shows the <scene name='91/916387/Cv/2'>simultaneous binding to the two domains</scene><ref>PMID:16533050</ref>. The peptide forms a β strand which runs antiparallel to the PDZ β strand.

	==Syntenin 3D structures==		==Syntenin 3D structures==

Alexander Berchansky at 11:37, 5 July 2022

2022-07-05T11:37:36Z

←Older revision		Revision as of 11:37, 5 July 2022
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-	<StructureSection load='1ybo' size='340' side='right' caption='Human syntenin PDZ1+PDZ2 domains (~~grey~~ and green) complex with syndecan-4 peptide (pink and yellow) (PDB id [[1ybo]]) ' scene=''>	+	<StructureSection load='1ybo' size='340' side='right' caption='Human syntenin PDZ1+PDZ2 domains (deep sky blue and green) complex with syndecan-4 peptide (pink and yellow) (PDB id [[1ybo]]) ' scene='91/916387/Cv/1'>

	== Function ==		== Function ==

Michal Harel at 10:35, 29 June 2022

2022-06-29T10:35:07Z

←Older revision		Revision as of 10:35, 29 June 2022
Line 14:		Line 14:

	==Syntenin 3D structures==		==Syntenin 3D structures==
		+
	[[3D structures of syntenin]]		[[3D structures of syntenin]]

Michal Harel at 10:31, 29 June 2022

2022-06-29T10:31:38Z

←Older revision		Revision as of 10:31, 29 June 2022
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-
	<StructureSection load='1ybo' size='340' side='right' caption='Human syntenin PDZ1+PDZ2 domains (grey and green) complex with syndecan-4 peptide (pink and yellow) (PDB id [[1ybo]]) ' scene=''>		<StructureSection load='1ybo' size='340' side='right' caption='Human syntenin PDZ1+PDZ2 domains (grey and green) complex with syndecan-4 peptide (pink and yellow) (PDB id [[1ybo]]) ' scene=''>
-	This is a default text for your page '''Syntenin'''. Click above on '''edit this page''' to modify. Be careful with the < and > signs.
-	You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue.

	== Function ==		== Function ==

-	~~== Disease ==~~	+	'''Syntenin''' (SYNT) is a small intracellular adaptor which together with syndecan has a role in the biogenesis of secreted vesicles or exosomes<ref>PMID:26032692</ref>

	== Relevance ==		== Relevance ==
		+
		+	Exosomes secreted by cancer cells contribute to tumor progression and metastasis and analyzing their content can help in early detection of cancer as well as of other diseases. SYNT is over-expressed in breast and gastric cancer

	== Structural highlights ==		== Structural highlights ==

-	~~This is~~ a ~~sample scene created with SAT~~ to <~~scene name="/12/3456/Sample/1"~~>~~color~~</~~scene~~> ~~by Group, and another~~ to ~~make <scene name="/12/3456/Sample/2">a transparent representation</scene> of~~ the ~~protein~~. ~~You can make your own scenes on SAT starting from scratch or loading and editing one~~ of ~~these sample scenes.~~	+	The 3D structure of the complex of SYNT PDZ1 and PDZ2 domains with a syndecan peptide shows the simultaneous binding to the two domains<ref>PMID:16533050</ref>. The peptide forms a β strand which runs antiparallel to the PDZ β strand.
		+
		+	==Syntenin 3D structures==
		+	[[3D structures of syntenin]]

	</StructureSection>		</StructureSection>

Michal Harel: New page:
2022-06-29T09:39:06Z

New page: <StructureSection load='1ybo' size='340' side='right' caption='Human syntenin PDZ1+PDZ2 domains (grey and green) complex with syndecan-4 peptide (pink and yellow) (PDB id 1ybo) ' scen...

New page

<StructureSection load='1ybo' size='340' side='right' caption='Human syntenin PDZ1+PDZ2 domains (grey and green) complex with syndecan-4 peptide (pink and yellow) (PDB id [[1ybo]]) ' scene=''>
This is a default text for your page '''Syntenin'''. Click above on '''edit this page''' to modify. Be careful with the < and > signs.
You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue.

== Function ==

== Disease ==

== Relevance ==

== Structural highlights ==

This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.

</StructureSection>
== References ==
<references/>

[[Category:Topic Page]]