http://52.214.119.220/wiki/index.php?action=history&feed=atom&title=Tetherin 2026-04-06T11:12:26Z Revision history for this page on the wiki MediaWiki 1.11.2 http://52.214.119.220/wiki/index.php?title=Tetherin&diff=3320168&oldid=prev 2020-11-23T09:35:05Z

<p></p> <table style="background-color: white; color:black;"> <col class='diff-marker' /> <col class='diff-content' /> <col class='diff-marker' /> <col class='diff-content' /> <tr> <td colspan='2' style="background-color: white; color:black;">←Older revision</td> <td colspan='2' style="background-color: white; color:black;">Revision as of 09:35, 23 November 2020</td> </tr> <tr><td colspan="2" class="diff-lineno">Line 16:</td> <td colspan="2" class="diff-lineno">Line 16:</td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} </div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} </div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>[[2x7a]], [[3nwh]], [[2xg7]], [[3mqb]], [[3mqc]] – <del style="color: red; font-weight: bold; text-decoration: none;">hBST2 </del>ectodomain – human&lt;br /&gt;</div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>[[2x7a]], [[3nwh]], [[2xg7]], [[3mqb]], [[3mqc]] – <ins style="color: red; font-weight: bold; text-decoration: none;">hBST-2 </ins>ectodomain – human&lt;br /&gt;</div></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>[[3mq7]], [[3mq9]]<del style="color: red; font-weight: bold; text-decoration: none;">, </del>[[2lk9]] <del style="color: red; font-weight: bold; text-decoration: none;"> </del>- <del style="color: red; font-weight: bold; text-decoration: none;">hBST2 ectodomain </del>(mutant)&lt;br /&gt;</div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>[[3mq7]], [[3mq9]] <ins style="color: red; font-weight: bold; text-decoration: none;">- hBST-2 ectodomain (mutant)&lt;br /&gt;</ins></div></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>[[3ni0]] - <del style="color: red; font-weight: bold; text-decoration: none;">BST2 </del>ectodomain – mouse&lt;br /&gt;</div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>[[2lk9]] <ins style="color: red; font-weight: bold; text-decoration: none;">– hBST</ins>-<ins style="color: red; font-weight: bold; text-decoration: none;">2 transmembrane </ins>(mutant) <ins style="color: red; font-weight: bold; text-decoration: none;">– NMR&lt;br /&gt;</ins></div></td></tr> <tr><td colspan="2">&nbsp;</td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">[[4p6z]] – hBST-2 in adaptor protein complex&lt;br /&gt;</ins></div></td></tr> <tr><td colspan="2">&nbsp;</td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">[[6cm9]], [[6owt]], [[6cri]], [[6d83]], [[6d84]], [[6dff]] – hBST-2/Nef in adaptor protein complex – Cryo EM</ins>&lt;br /&gt;</div></td></tr> <tr><td colspan="2">&nbsp;</td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>[[3ni0]] - <ins style="color: red; font-weight: bold; text-decoration: none;">BST-2 </ins>ectodomain – mouse&lt;br /&gt;</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> </table>

Michal Harel http://52.214.119.220/wiki/index.php?title=Tetherin&diff=3320167&oldid=prev 2020-11-23T09:21:45Z

<p></p> <table style="background-color: white; color:black;"> <col class='diff-marker' /> <col class='diff-content' /> <col class='diff-marker' /> <col class='diff-content' /> <tr> <td colspan='2' style="background-color: white; color:black;">←Older revision</td> <td colspan='2' style="background-color: white; color:black;">Revision as of 09:21, 23 November 2020</td> </tr> <tr><td colspan="2" class="diff-lineno">Line 3:</td> <td colspan="2" class="diff-lineno">Line 3:</td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>'''Tetherin''' has been shown to prevent the release of HIV-1 virions and may be an effective inhibitor of other enveloped viruses as well such as Lassa and Marburg viruses. Tetherin inhibits the release of virions by binding to viral particles budding from the cell membrane, preventing the release of these infectious particles. </div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>'''Tetherin''' <ins style="color: red; font-weight: bold; text-decoration: none;">or '''bone marrow stromal antigen 2''' (BST-2) </ins>has been shown to prevent the release of HIV-1 virions and may be an effective inhibitor of other enveloped viruses as well such as Lassa and Marburg viruses. Tetherin inhibits the release of virions by binding to viral particles budding from the cell membrane, preventing the release of these infectious particles. </div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>The tetherin protein is always found on the surface of B lymphocytes, dendritic cells, and activated T lymphocytes. In brain, kidney, liver, skeletal muscle, pancreas and heart cells. The tetherin gene can be stimulated to be expressed by the production of alpha Interferon, a cytokine. </div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>The tetherin protein is always found on the surface of B lymphocytes, dendritic cells, and activated T lymphocytes. In brain, kidney, liver, skeletal muscle, pancreas and heart cells. The tetherin gene can be stimulated to be expressed by the production of alpha Interferon, a cytokine. </div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> </table>

Michal Harel http://52.214.119.220/wiki/index.php?title=Tetherin&diff=2753615&oldid=prev 2017-06-19T10:04:31Z

<p></p> <table style="background-color: white; color:black;"> <col class='diff-marker' /> <col class='diff-content' /> <col class='diff-marker' /> <col class='diff-content' /> <tr> <td colspan='2' style="background-color: white; color:black;">←Older revision</td> <td colspan='2' style="background-color: white; color:black;">Revision as of 10:04, 19 June 2017</td> </tr> <tr><td colspan="2" class="diff-lineno">Line 1:</td> <td colspan="2" class="diff-lineno">Line 1:</td></tr> <tr><td colspan="2">&nbsp;</td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>&lt;StructureSection load='2xg7' size='350' side='right' scene='' caption='Glycosylated human tetherin ectodomain dimer [[2xg7]]'&gt;</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>==Tetherin is a membrane-associated protein that may prevent the release of enveloped viruses from their host cells==</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>==Tetherin is a membrane-associated protein that may prevent the release of enveloped viruses from their host cells==</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div><del style="color: red; font-weight: bold; text-decoration: none;">{{STRUCTURE_2xg7| PDB=2xg7 | SIZE=400| SCENE= |right|CAPTION=Glycosylated human tetherin ectodomain dimer [[2xg7]] }}</del></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>&#160;</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>'''Tetherin''' has been shown to prevent the release of HIV-1 virions and may be an effective inhibitor of other enveloped viruses as well such as Lassa and Marburg viruses. Tetherin inhibits the release of virions by binding to viral particles budding from the cell membrane, preventing the release of these infectious particles. </div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>'''Tetherin''' has been shown to prevent the release of HIV-1 virions and may be an effective inhibitor of other enveloped viruses as well such as Lassa and Marburg viruses. Tetherin inhibits the release of virions by binding to viral particles budding from the cell membrane, preventing the release of these infectious particles. </div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>The tetherin protein is always found on the surface of B lymphocytes, dendritic cells, and activated T lymphocytes. In brain, kidney, liver, skeletal muscle, pancreas and heart cells. The tetherin gene can be stimulated to be expressed by the production of alpha Interferon, a cytokine. </div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>The tetherin protein is always found on the surface of B lymphocytes, dendritic cells, and activated T lymphocytes. In brain, kidney, liver, skeletal muscle, pancreas and heart cells. The tetherin gene can be stimulated to be expressed by the production of alpha Interferon, a cytokine. </div></td></tr> <tr><td colspan="2" class="diff-lineno">Line 11:</td> <td colspan="2" class="diff-lineno">Line 12:</td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>*[[Viral Infections]]</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>*[[Viral Infections]]</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>&lt;br /&gt;</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>&lt;br /&gt;</div></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>&#160;</div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">&lt;/StructureSection&gt;</ins></div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>==3D structures of tetherin==</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>==3D structures of tetherin==</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} </div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} </div></td></tr> </table>

Alexander Berchansky http://52.214.119.220/wiki/index.php?title=Tetherin&diff=2668923&oldid=prev 2016-09-08T08:56:17Z

<p></p> <table style="background-color: white; color:black;"> <col class='diff-marker' /> <col class='diff-content' /> <col class='diff-marker' /> <col class='diff-content' /> <tr> <td colspan='2' style="background-color: white; color:black;">←Older revision</td> <td colspan='2' style="background-color: white; color:black;">Revision as of 08:56, 8 September 2016</td> </tr> <tr><td colspan="2" class="diff-lineno">Line 13:</td> <td colspan="2" class="diff-lineno">Line 13:</td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>==3D structures of tetherin==</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>==3D structures of tetherin==</div></td></tr> <tr><td colspan="2">&nbsp;</td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} </div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>[[2x7a]], [[3nwh]], [[2xg7]], [[3mqb]] – hBST2 ectodomain – human&lt;br /&gt;</div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>[[2x7a]], [[3nwh]], [[2xg7]], [[3mqb<ins style="color: red; font-weight: bold; text-decoration: none;">]], [[3mqc</ins>]] – hBST2 ectodomain – human&lt;br /&gt;</div></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>[[3mq7]] - hBST2 ectodomain (mutant)</div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>[[3mq7]]<ins style="color: red; font-weight: bold; text-decoration: none;">, [[3mq9]], [[2lk9]] </ins>- hBST2 ectodomain (mutant)<ins style="color: red; font-weight: bold; text-decoration: none;">&lt;br /&gt;</ins></div></td></tr> <tr><td colspan="2">&nbsp;</td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">[[3ni0]] - BST2 ectodomain – mouse&lt;br /&gt;</ins></div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> </table>

Michal Harel http://52.214.119.220/wiki/index.php?title=Tetherin&diff=2668921&oldid=prev 2016-09-08T08:46:03Z

<p></p> <table style="background-color: white; color:black;"> <col class='diff-marker' /> <col class='diff-content' /> <col class='diff-marker' /> <col class='diff-content' /> <tr> <td colspan='2' style="background-color: white; color:black;">←Older revision</td> <td colspan='2' style="background-color: white; color:black;">Revision as of 08:46, 8 September 2016</td> </tr> <tr><td colspan="2" class="diff-lineno">Line 5:</td> <td colspan="2" class="diff-lineno">Line 5:</td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>The tetherin protein is always found on the surface of B lymphocytes, dendritic cells, and activated T lymphocytes. In brain, kidney, liver, skeletal muscle, pancreas and heart cells. The tetherin gene can be stimulated to be expressed by the production of alpha Interferon, a cytokine. </div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>The tetherin protein is always found on the surface of B lymphocytes, dendritic cells, and activated T lymphocytes. In brain, kidney, liver, skeletal muscle, pancreas and heart cells. The tetherin gene can be stimulated to be expressed by the production of alpha Interferon, a cytokine. </div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>While tetherin may be an effective inhibitor of some viruses, other viruses have been shown to produce viral proteins that downregulate the production and expression of some cellular proteins, including tetherin. Some strains of HIV-1 as well as Ebola viral particles produce viral proteins shown to <del style="color: red; font-weight: bold; text-decoration: none;">downregulation </del>tetherin expression on the surface of the cell membrane. </div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>While tetherin may be an effective inhibitor of some viruses, other viruses have been shown to produce viral proteins that downregulate the production and expression of some cellular proteins, including tetherin. Some strains of HIV-1 as well as Ebola viral particles produce viral proteins shown to <ins style="color: red; font-weight: bold; text-decoration: none;">downregulate </ins>tetherin expression on the surface of the cell membrane. </div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>==Additional Resources==</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>==Additional Resources==</div></td></tr> </table>

Michal Harel http://52.214.119.220/wiki/index.php?title=Tetherin&diff=2668920&oldid=prev 2016-09-08T08:45:26Z

<p></p> <table style="background-color: white; color:black;"> <col class='diff-marker' /> <col class='diff-content' /> <col class='diff-marker' /> <col class='diff-content' /> <tr> <td colspan='2' style="background-color: white; color:black;">←Older revision</td> <td colspan='2' style="background-color: white; color:black;">Revision as of 08:45, 8 September 2016</td> </tr> <tr><td colspan="2" class="diff-lineno">Line 5:</td> <td colspan="2" class="diff-lineno">Line 5:</td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>The tetherin protein is always found on the surface of B lymphocytes, dendritic cells, and activated T lymphocytes. In brain, kidney, liver, skeletal muscle, pancreas and heart cells. The tetherin gene can be stimulated to be expressed by the production of alpha Interferon, a cytokine. </div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>The tetherin protein is always found on the surface of B lymphocytes, dendritic cells, and activated T lymphocytes. In brain, kidney, liver, skeletal muscle, pancreas and heart cells. The tetherin gene can be stimulated to be expressed by the production of alpha Interferon, a cytokine. </div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>While tetherin may be an effective inhibitor of some viruses, other viruses have been shown to produce viral proteins that <del style="color: red; font-weight: bold; text-decoration: none;">downregulates </del>the production and expression of some cellular proteins, including tetherin. Some strains of HIV-1 as well as Ebola viral particles produce viral proteins shown to downregulation tetherin expression on the surface of the cell membrane. </div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>While tetherin may be an effective inhibitor of some viruses, other viruses have been shown to produce viral proteins that <ins style="color: red; font-weight: bold; text-decoration: none;">downregulate </ins>the production and expression of some cellular proteins, including tetherin. Some strains of HIV-1 as well as Ebola viral particles produce viral proteins shown to downregulation tetherin expression on the surface of the cell membrane. </div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>==Additional Resources==</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>==Additional Resources==</div></td></tr> </table>

Michal Harel http://52.214.119.220/wiki/index.php?title=Tetherin&diff=2668919&oldid=prev 2016-09-08T08:44:43Z

<p></p> <table style="background-color: white; color:black;"> <col class='diff-marker' /> <col class='diff-content' /> <col class='diff-marker' /> <col class='diff-content' /> <tr> <td colspan='2' style="background-color: white; color:black;">←Older revision</td> <td colspan='2' style="background-color: white; color:black;">Revision as of 08:44, 8 September 2016</td> </tr> <tr><td colspan="2" class="diff-lineno">Line 3:</td> <td colspan="2" class="diff-lineno">Line 3:</td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>{{STRUCTURE_2xg7| PDB=2xg7 | SIZE=400| SCENE= |right|CAPTION=Glycosylated human tetherin ectodomain dimer [[2xg7]] }}</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>{{STRUCTURE_2xg7| PDB=2xg7 | SIZE=400| SCENE= |right|CAPTION=Glycosylated human tetherin ectodomain dimer [[2xg7]] }}</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>'''Tetherin''' has been shown to prevent the release of HIV-1 virions and may be an effective inhibitor of other enveloped viruses as well such as Lassa and Marburg viruses. Tetherin inhibits the release of virions by binding to viral particles budding from the cell membrane, preventing the release of these infectious particles. </div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>'''Tetherin''' has been shown to prevent the release of HIV-1 virions and may be an effective inhibitor of other enveloped viruses as well such as Lassa and Marburg viruses. Tetherin inhibits the release of virions by binding to viral particles budding from the cell membrane, preventing the release of these infectious particles. </div></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>The tetherin protein is always found on the surface of B lymphocytes, dendritic cells, and activated T lymphocytes. In brain, kidney, liver, skeletal muscle, pancreas and heart cells<del style="color: red; font-weight: bold; text-decoration: none;">, the </del>tetherin gene can be stimulated to be expressed by the production of alpha Interferon, a cytokine. </div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>The tetherin protein is always found on the surface of B lymphocytes, dendritic cells, and activated T lymphocytes. In brain, kidney, liver, skeletal muscle, pancreas and heart cells<ins style="color: red; font-weight: bold; text-decoration: none;">. The </ins>tetherin gene can be stimulated to be expressed by the production of alpha Interferon, a cytokine. </div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>While tetherin may be an effective inhibitor of some viruses, other viruses have been shown to produce viral proteins that downregulates the production and expression of some cellular proteins, including tetherin. Some strains of HIV-1 as well as Ebola viral particles produce viral proteins shown to downregulation tetherin expression on the surface of the cell membrane. </div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>While tetherin may be an effective inhibitor of some viruses, other viruses have been shown to produce viral proteins that downregulates the production and expression of some cellular proteins, including tetherin. Some strains of HIV-1 as well as Ebola viral particles produce viral proteins shown to downregulation tetherin expression on the surface of the cell membrane. </div></td></tr> </table>

Michal Harel http://52.214.119.220/wiki/index.php?title=Tetherin&diff=2668917&oldid=prev 2016-09-08T08:43:22Z

<p></p> <table style="background-color: white; color:black;"> <col class='diff-marker' /> <col class='diff-content' /> <col class='diff-marker' /> <col class='diff-content' /> <tr> <td colspan='2' style="background-color: white; color:black;">←Older revision</td> <td colspan='2' style="background-color: white; color:black;">Revision as of 08:43, 8 September 2016</td> </tr> <tr><td colspan="2" class="diff-lineno">Line 1:</td> <td colspan="2" class="diff-lineno">Line 1:</td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>==Tetherin is a membrane-associated protein that may prevent the release of enveloped viruses from their host cells==</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>==Tetherin is a membrane-associated protein that may prevent the release of enveloped viruses from their host cells==</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>{{STRUCTURE_2xg7| PDB=2xg7 | SIZE=400| SCENE= |right|CAPTION=<del style="color: red; font-weight: bold; text-decoration: none;">Human </del>tetherin ectodomain dimer [[2xg7]] }}</div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>{{STRUCTURE_2xg7| PDB=2xg7 | SIZE=400| SCENE= |right|CAPTION=<ins style="color: red; font-weight: bold; text-decoration: none;">Glycosylated human </ins>tetherin ectodomain dimer [[2xg7]] }}</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>'''Tetherin''' has been shown to prevent the release of HIV-1 virions and may be an effective inhibitor of other enveloped viruses as well such as Lassa and Marburg viruses. Tetherin inhibits the release of virions by binding to viral particles budding from the cell membrane, preventing the release of these infectious particles. </div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>'''Tetherin''' has been shown to prevent the release of HIV-1 virions and may be an effective inhibitor of other enveloped viruses as well such as Lassa and Marburg viruses. Tetherin inhibits the release of virions by binding to viral particles budding from the cell membrane, preventing the release of these infectious particles. </div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>The tetherin protein is always found on the surface of B lymphocytes, dendritic cells, and activated T lymphocytes. In brain, kidney, liver, skeletal muscle, pancreas and heart cells, the tetherin gene can be stimulated to be expressed by the production of alpha Interferon, a cytokine. </div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>The tetherin protein is always found on the surface of B lymphocytes, dendritic cells, and activated T lymphocytes. In brain, kidney, liver, skeletal muscle, pancreas and heart cells, the tetherin gene can be stimulated to be expressed by the production of alpha Interferon, a cytokine. </div></td></tr> </table>

Michal Harel http://52.214.119.220/wiki/index.php?title=Tetherin&diff=1830564&oldid=prev 2013-08-12T12:09:17Z

<p></p> <table style="background-color: white; color:black;"> <col class='diff-marker' /> <col class='diff-content' /> <col class='diff-marker' /> <col class='diff-content' /> <tr> <td colspan='2' style="background-color: white; color:black;">←Older revision</td> <td colspan='2' style="background-color: white; color:black;">Revision as of 12:09, 12 August 2013</td> </tr> <tr><td colspan="2" class="diff-lineno">Line 8:</td> <td colspan="2" class="diff-lineno">Line 8:</td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>==Additional Resources==</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>==Additional Resources==</div></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div><del style="color: red; font-weight: bold; text-decoration: none;">For additional information, see: </del>[[Human Immunodeficiency Virus]] &lt;br /&gt;</div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">*</ins>[[Human Immunodeficiency Virus]] &lt;br /&gt;</div></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div><del style="color: red; font-weight: bold; text-decoration: none;">For additional information, see: </del>[[Viral Infections]]</div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">*</ins>[[Viral Infections]]</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>&lt;br /&gt;</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>&lt;br /&gt;</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> </table>

Michal Harel http://52.214.119.220/wiki/index.php?title=Tetherin&diff=1609363&oldid=prev 2012-11-18T10:15:50Z

<p></p> <table style="background-color: white; color:black;"> <col class='diff-marker' /> <col class='diff-content' /> <col class='diff-marker' /> <col class='diff-content' /> <tr> <td colspan='2' style="background-color: white; color:black;">←Older revision</td> <td colspan='2' style="background-color: white; color:black;">Revision as of 10:15, 18 November 2012</td> </tr> <tr><td colspan="2" class="diff-lineno">Line 1:</td> <td colspan="2" class="diff-lineno">Line 1:</td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>==Tetherin is a membrane-associated protein that may prevent the release of enveloped viruses from their host cells==</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>==Tetherin is a membrane-associated protein that may prevent the release of enveloped viruses from their host cells==</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>{{STRUCTURE_2xg7| PDB=2xg7 | SIZE=400| SCENE= |right|CAPTION=Human <del style="color: red; font-weight: bold; text-decoration: none;">Se-Met </del>tetherin ectodomain <del style="color: red; font-weight: bold; text-decoration: none;">complex with glycerol, chloride and Na+ ions, </del>[[2xg7]] }}</div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>{{STRUCTURE_2xg7| PDB=2xg7 | SIZE=400| SCENE= |right|CAPTION=Human tetherin ectodomain <ins style="color: red; font-weight: bold; text-decoration: none;">dimer </ins>[[2xg7]] }}</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>'''Tetherin''' has been shown to prevent the release of HIV-1 virions and may be an effective inhibitor of other enveloped viruses as well such as Lassa and Marburg viruses. Tetherin inhibits the release of virions by binding to viral particles budding from the cell membrane, preventing the release of these infectious particles. </div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>'''Tetherin''' has been shown to prevent the release of HIV-1 virions and may be an effective inhibitor of other enveloped viruses as well such as Lassa and Marburg viruses. Tetherin inhibits the release of virions by binding to viral particles budding from the cell membrane, preventing the release of these infectious particles. </div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>The tetherin protein is always found on the surface of B lymphocytes, dendritic cells, and activated T lymphocytes. In brain, kidney, liver, skeletal muscle, pancreas and heart cells, the tetherin gene can be stimulated to be expressed by the production of alpha Interferon, a cytokine. </div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>The tetherin protein is always found on the surface of B lymphocytes, dendritic cells, and activated T lymphocytes. In brain, kidney, liver, skeletal muscle, pancreas and heart cells, the tetherin gene can be stimulated to be expressed by the production of alpha Interferon, a cytokine. </div></td></tr> </table>

Michal Harel