Trypanothione reductase - Revision history

http://52.214.119.220/wiki/index.php?action=history&feed=atom&title=Trypanothione_reductase Trypanothione reductase - Revision history 2026-04-14T13:16:41Z Revision history for this page on the wiki MediaWiki 1.11.2 http://52.214.119.220/wiki/index.php?title=Trypanothione_reductase&diff=4020388&oldid=prev Michal Harel at 08:18, 24 January 2024 2024-01-24T08:18:10Z

<p></p> <table style="background-color: white; color:black;"> <col class='diff-marker' /> <col class='diff-content' /> <col class='diff-marker' /> <col class='diff-content' /> <tr> <td colspan='2' style="background-color: white; color:black;">←Older revision</td> <td colspan='2' style="background-color: white; color:black;">Revision as of 08:18, 24 January 2024</td> </tr> <tr><td colspan="2" class="diff-lineno">Line 28:</td> <td colspan="2" class="diff-lineno">Line 28:</td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>**[[1gxf]] - TcTTR + inhibitor<br /> </div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>**[[1gxf]] - TcTTR + inhibitor<br /> </div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>**[[2wba]], [[2wov]] - TbTTR + NADPH <br /></div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>**[[2wba]], [[2wov]] - TbTTR + NADPH <br /></div></td></tr> <tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>**[[5smj]] - TbTTR + FAD<br /></div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>**[[2wp5]], [[2wp6]], [[2wpc]], [[2wpe]], [[2wpf]], [[4nev]], [[4new]], [[6btl]], [[6bu7]] - TbTTR + inhibitor<br /> </div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>**[[2wp5]], [[2wp6]], [[2wpc]], [[2wpe]], [[2wpf]], [[4nev]], [[4new]], [[6btl]], [[6bu7]] - TbTTR + inhibitor<br /> </div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> <tr><td colspan="2" class="diff-lineno">Line 37:</td> <td colspan="2" class="diff-lineno">Line 38:</td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>**[[6er5]], [[6i7n]], [[6t95]], [[6t98]], [[6t97]] - LiTTR + inhibitor + FAD<br /></div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>**[[6er5]], [[6i7n]], [[6t95]], [[6t98]], [[6t97]] - LiTTR + inhibitor + FAD<br /></div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>**[[2wow]] - TbTTR + NADPH + TPT + inhibitor<BR /></div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>**[[2wow]] - TbTTR + NADPH + TPT + inhibitor<BR /></div></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>**[[<del style="color: red; font-weight: bold; text-decoration: none;">6oex</del>]], [[<del style="color: red; font-weight: bold; text-decoration: none;">6oey</del>]], [[<del style="color: red; font-weight: bold; text-decoration: none;">6oez</del>]], [[6buz]], [[6btl]], [[6rb5]] - TbTTR + inhibitor + FAD<br /></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>**[[<ins style="color: red; font-weight: bold; text-decoration: none;">5s9s</ins>]], [[<ins style="color: red; font-weight: bold; text-decoration: none;">5s9t</ins>]], [[<ins style="color: red; font-weight: bold; text-decoration: none;">5s9u]], [[5s9v]], [[5s9w]], [[5s9x]], [[5s9y]], [[5s9z]], [[5sa0]], [[5sa1]], [[5sa2]], [[5sa3</ins>]], [[6buz]], [[6btl<ins style="color: red; font-weight: bold; text-decoration: none;">]], [[6oex]], [[6oey]], [[6oez</ins>]], [[6rb5<ins style="color: red; font-weight: bold; text-decoration: none;">]], [[7nvp</ins>]] - TbTTR + inhibitor + FAD<br /></div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>**[[1typ]] – CfTTR + NADP + TPT<BR /></div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>**[[1typ]] – CfTTR + NADP + TPT<BR /></div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>}}</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>}}</div></td></tr> </table>

Michal Harel http://52.214.119.220/wiki/index.php?title=Trypanothione_reductase&diff=3332713&oldid=prev Michal Harel at 09:59, 20 December 2020 2020-12-20T09:59:35Z

<p></p> <table style="background-color: white; color:black;"> <col class='diff-marker' /> <col class='diff-content' /> <col class='diff-marker' /> <col class='diff-content' /> <tr> <td colspan='2' style="background-color: white; color:black;">←Older revision</td> <td colspan='2' style="background-color: white; color:black;">Revision as of 09:59, 20 December 2020</td> </tr> <tr><td colspan="2" class="diff-lineno">Line 35:</td> <td colspan="2" class="diff-lineno">Line 35:</td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>**[[2yau]], [[4apn]], [[5ebk]] - LiTTR + NADPH + inhibitor<br /></div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>**[[2yau]], [[4apn]], [[5ebk]] - LiTTR + NADPH + inhibitor<br /></div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>**[[4adw]] - LiTTR + NADPH + TPT<br /></div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>**[[4adw]] - LiTTR + NADPH + TPT<br /></div></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>**[[6er5]], [[6i7n]] - LiTTR + inhibitor + FAD<br /></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>**[[6er5]], [[6i7n<ins style="color: red; font-weight: bold; text-decoration: none;">]], [[6t95]], [[6t98]], [[6t97</ins>]] - LiTTR + inhibitor + FAD<br /></div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>**[[2wow]] - TbTTR + NADPH + TPT + inhibitor<BR /></div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>**[[2wow]] - TbTTR + NADPH + TPT + inhibitor<BR /></div></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>**[[6oex]], [[6oey]], [[6oez]] - TbTTR + inhibitor + FAD<br /></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>**[[6oex]], [[6oey]], [[6oez<ins style="color: red; font-weight: bold; text-decoration: none;">]], [[6buz]], [[6btl]], [[6rb5</ins>]] - TbTTR + inhibitor + FAD<br /></div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>**[[1typ]] – CfTTR + NADP + TPT<BR /></div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>**[[1typ]] – CfTTR + NADP + TPT<BR /></div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>}}</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>}}</div></td></tr> </table>

Michal Harel http://52.214.119.220/wiki/index.php?title=Trypanothione_reductase&diff=3172445&oldid=prev Michal Harel at 07:31, 11 March 2020 2020-03-11T07:31:48Z

<p></p> <table style="background-color: white; color:black;"> <col class='diff-marker' /> <col class='diff-content' /> <col class='diff-marker' /> <col class='diff-content' /> <tr> <td colspan='2' style="background-color: white; color:black;">←Older revision</td> <td colspan='2' style="background-color: white; color:black;">Revision as of 07:31, 11 March 2020</td> </tr> <tr><td colspan="2" class="diff-lineno">Line 35:</td> <td colspan="2" class="diff-lineno">Line 35:</td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>**[[2yau]], [[4apn]], [[5ebk]] - LiTTR + NADPH + inhibitor<br /></div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>**[[2yau]], [[4apn]], [[5ebk]] - LiTTR + NADPH + inhibitor<br /></div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>**[[4adw]] - LiTTR + NADPH + TPT<br /></div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>**[[4adw]] - LiTTR + NADPH + TPT<br /></div></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>**[[2wow]] - TbTTR + NADPH + TPT + inhibitor<BR /> </div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">**[[6er5]], [[6i7n]] - LiTTR + inhibitor + FAD<br /></ins></div></td></tr> <tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>**[[2wow]] - TbTTR + NADPH + TPT + inhibitor<BR <ins style="color: red; font-weight: bold; text-decoration: none;">/></ins></div></td></tr> <tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">**[[6oex]], [[6oey]], [[6oez]] - TbTTR + inhibitor + FAD<br </ins>/></div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>**[[1typ]] – CfTTR + NADP + TPT<BR /></div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>**[[1typ]] – CfTTR + NADP + TPT<BR /></div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>}}</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>}}</div></td></tr> </table>

Michal Harel http://52.214.119.220/wiki/index.php?title=Trypanothione_reductase&diff=3092956&oldid=prev Alexander Berchansky at 13:06, 2 October 2019 2019-10-02T13:06:28Z

<p></p> <table style="background-color: white; color:black;"> <col class='diff-marker' /> <col class='diff-content' /> <col class='diff-marker' /> <col class='diff-content' /> <tr> <td colspan='2' style="background-color: white; color:black;">←Older revision</td> <td colspan='2' style="background-color: white; color:black;">Revision as of 13:06, 2 October 2019</td> </tr> <tr><td colspan="2" class="diff-lineno">Line 7:</td> <td colspan="2" class="diff-lineno">Line 7:</td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>== Structural highlights ==</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>== Structural highlights ==</div></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>The <scene name='48/489332/Cv/<del style="color: red; font-weight: bold; text-decoration: none;">4</del>'>active site of TTR</scene> contains <scene name='48/489332/Cv/<del style="color: red; font-weight: bold; text-decoration: none;">5</del>'>two catalytic cysteine</scene> residues which are part of the electron transfer function of the enzyme and the bound TPT substrate<ref>PMID:23733388</ref>.</div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>The <scene name='48/489332/Cv/<ins style="color: red; font-weight: bold; text-decoration: none;">6</ins>'>active site of TTR</scene> contains <scene name='48/489332/Cv/<ins style="color: red; font-weight: bold; text-decoration: none;">7</ins>'>two catalytic cysteine</scene> residues which are part of the electron transfer function of the enzyme and the bound TPT substrate<ref>PMID:23733388</ref>.</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div></StructureSection></div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div></StructureSection></div></td></tr> </table>

Alexander Berchansky http://52.214.119.220/wiki/index.php?title=Trypanothione_reductase&diff=2952431&oldid=prev Michal Harel at 21:10, 27 September 2018 2018-09-27T21:10:23Z

<p></p> <table style="background-color: white; color:black;"> <col class='diff-marker' /> <col class='diff-content' /> <col class='diff-marker' /> <col class='diff-content' /> <tr> <td colspan='2' style="background-color: white; color:black;">←Older revision</td> <td colspan='2' style="background-color: white; color:black;">Revision as of 21:10, 27 September 2018</td> </tr> <tr><td colspan="2" class="diff-lineno">Line 1:</td> <td colspan="2" class="diff-lineno">Line 1:</td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div><StructureSection load='' size='<del style="color: red; font-weight: bold; text-decoration: none;">450</del>' side='right' caption='Trypanosoma FAD-containing trypanothione reductase dimer complex with trypanothione and NADPH [[4adw]]' scene='48/489332/Cv/1' pspeed='8'></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><StructureSection load='' size='<ins style="color: red; font-weight: bold; text-decoration: none;">350</ins>' side='right' caption='Trypanosoma FAD-containing trypanothione reductase dimer complex with trypanothione and NADPH [[4adw]]' scene='48/489332/Cv/1' pspeed='8'></div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>== Function ==</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>== Function ==</div></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>'''Trypanothione reductase''' (TTR) is a flavoenzyme which catalyzes the reaction converting trypanothione (TPT) and NADP to trypanothione disulfide and NADPH. TTR uses FAD as cofactor. </div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>'''Trypanothione reductase''' (TTR) is a flavoenzyme which catalyzes the reaction converting trypanothione (TPT) and NADP to trypanothione disulfide and NADPH. TTR uses FAD as cofactor<ins style="color: red; font-weight: bold; text-decoration: none;"><ref>PMID:1957352</ref></ins>. </div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>== Relevance ==</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>== Relevance ==</div></td></tr> <tr><td colspan="2" class="diff-lineno">Line 28:</td> <td colspan="2" class="diff-lineno">Line 28:</td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>**[[1gxf]] - TcTTR + inhibitor<br /> </div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>**[[1gxf]] - TcTTR + inhibitor<br /> </div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>**[[2wba]], [[2wov]] - TbTTR + NADPH <br /></div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>**[[2wba]], [[2wov]] - TbTTR + NADPH <br /></div></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>**[[2wp5]], [[2wp6]], [[2wpc]], [[2wpe]], [[2wpf]], [[4nev]], [[4new]] - TbTTR + inhibitor<br /> </div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>**[[2wp5]], [[2wp6]], [[2wpc]], [[2wpe]], [[2wpf]], [[4nev]], [[4new<ins style="color: red; font-weight: bold; text-decoration: none;">]], [[6btl]], [[6bu7</ins>]] - TbTTR + inhibitor<br /> </div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>*Trypanothione reductase ternary complex</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>*Trypanothione reductase ternary complex</div></td></tr> </table>

Michal Harel http://52.214.119.220/wiki/index.php?title=Trypanothione_reductase&diff=2788816&oldid=prev Joel L. Sussman at 04:25, 16 October 2017 2017-10-16T04:25:16Z

<p></p> <table style="background-color: white; color:black;"> <col class='diff-marker' /> <col class='diff-content' /> <col class='diff-marker' /> <col class='diff-content' /> <tr> <td colspan='2' style="background-color: white; color:black;">←Older revision</td> <td colspan='2' style="background-color: white; color:black;">Revision as of 04:25, 16 October 2017</td> </tr> <tr><td colspan="2" class="diff-lineno">Line 1:</td> <td colspan="2" class="diff-lineno">Line 1:</td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div><StructureSection load='<del style="color: red; font-weight: bold; text-decoration: none;">4adw</del>' size='450' side='right' caption='Trypanosoma FAD-containing trypanothione reductase dimer complex with trypanothione and NADPH [[4adw]]' scene='48/489332/Cv/1' pspeed='8'></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><StructureSection load='' size='450' side='right' caption='Trypanosoma FAD-containing trypanothione reductase dimer complex with trypanothione and NADPH [[4adw]]' scene='48/489332/Cv/1' pspeed='8'></div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>== Function ==</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>== Function ==</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>'''Trypanothione reductase''' (TTR) is a flavoenzyme which catalyzes the reaction converting trypanothione (TPT) and NADP to trypanothione disulfide and NADPH. TTR uses FAD as cofactor. </div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>'''Trypanothione reductase''' (TTR) is a flavoenzyme which catalyzes the reaction converting trypanothione (TPT) and NADP to trypanothione disulfide and NADPH. TTR uses FAD as cofactor. </div></td></tr> </table>

Joel L. Sussman http://52.214.119.220/wiki/index.php?title=Trypanothione_reductase&diff=2786082&oldid=prev Michal Harel at 21:51, 11 October 2017 2017-10-11T21:51:43Z

<p></p> <table style="background-color: white; color:black;"> <col class='diff-marker' /> <col class='diff-content' /> <col class='diff-marker' /> <col class='diff-content' /> <tr> <td colspan='2' style="background-color: white; color:black;">←Older revision</td> <td colspan='2' style="background-color: white; color:black;">Revision as of 21:51, 11 October 2017</td> </tr> <tr><td colspan="2" class="diff-lineno">Line 33:</td> <td colspan="2" class="diff-lineno">Line 33:</td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>**[[2w0h]], [[2x50]] - LiTTR + NADPH + metal ion<br /></div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>**[[2w0h]], [[2x50]] - LiTTR + NADPH + metal ion<br /></div></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>**[[2yau]] <del style="color: red; font-weight: bold; text-decoration: none;">- LiTTR + NADPH + inhibitor<br /></del></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>**[[2yau]]<ins style="color: red; font-weight: bold; text-decoration: none;">, </ins>[[<ins style="color: red; font-weight: bold; text-decoration: none;">4apn]], [[5ebk</ins>]] - <ins style="color: red; font-weight: bold; text-decoration: none;">LiTTR </ins>+ NADPH + inhibitor<<ins style="color: red; font-weight: bold; text-decoration: none;">br </ins>/></div></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div><del style="color: red; font-weight: bold; text-decoration: none;">**</del>[[<del style="color: red; font-weight: bold; text-decoration: none;">2wow</del>]] - <del style="color: red; font-weight: bold; text-decoration: none;">TbTTR </del>+ NADPH <del style="color: red; font-weight: bold; text-decoration: none;">+ TPT </del>+ inhibitor<<del style="color: red; font-weight: bold; text-decoration: none;">BR </del>/> </div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div></div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>**[[4adw]] - LiTTR + NADPH + TPT<br /></div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>**[[4adw]] - LiTTR + NADPH + TPT<br /></div></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>**[[<del style="color: red; font-weight: bold; text-decoration: none;">4apn</del>]] - <del style="color: red; font-weight: bold; text-decoration: none;">LiTTR </del>+ NADPH + inhibitor<<del style="color: red; font-weight: bold; text-decoration: none;">br </del>/></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>**[[<ins style="color: red; font-weight: bold; text-decoration: none;">2wow</ins>]] - <ins style="color: red; font-weight: bold; text-decoration: none;">TbTTR </ins>+ NADPH <ins style="color: red; font-weight: bold; text-decoration: none;">+ TPT </ins>+ inhibitor<<ins style="color: red; font-weight: bold; text-decoration: none;">BR </ins>/> </div></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div> </div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div></div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>**[[1typ]] – CfTTR + NADP + TPT<BR /></div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>**[[1typ]] – CfTTR + NADP + TPT<BR /></div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>}}</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>}}</div></td></tr> </table>

Michal Harel http://52.214.119.220/wiki/index.php?title=Trypanothione_reductase&diff=2734896&oldid=prev Alexander Berchansky at 11:03, 4 April 2017 2017-04-04T11:03:08Z

<p></p> <table style="background-color: white; color:black;"> <col class='diff-marker' /> <col class='diff-content' /> <col class='diff-marker' /> <col class='diff-content' /> <tr> <td colspan='2' style="background-color: white; color:black;">←Older revision</td> <td colspan='2' style="background-color: white; color:black;">Revision as of 11:03, 4 April 2017</td> </tr> <tr><td colspan="2" class="diff-lineno">Line 7:</td> <td colspan="2" class="diff-lineno">Line 7:</td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>== Structural highlights ==</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>== Structural highlights ==</div></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>The active site of TTR contains two catalytic cysteine residues which are part of the electron transfer function of the enzyme and the bound TPT substrate<ref>PMID:23733388</ref>.</div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>The <ins style="color: red; font-weight: bold; text-decoration: none;"><scene name='48/489332/Cv/4'></ins>active site of TTR<ins style="color: red; font-weight: bold; text-decoration: none;"></scene> </ins>contains <ins style="color: red; font-weight: bold; text-decoration: none;"><scene name='48/489332/Cv/5'></ins>two catalytic cysteine<ins style="color: red; font-weight: bold; text-decoration: none;"></scene> </ins>residues which are part of the electron transfer function of the enzyme and the bound TPT substrate<ref>PMID:23733388</ref>.</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div></StructureSection></div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div></StructureSection></div></td></tr> </table>

Alexander Berchansky http://52.214.119.220/wiki/index.php?title=Trypanothione_reductase&diff=2734895&oldid=prev Alexander Berchansky at 10:44, 4 April 2017 2017-04-04T10:44:31Z

<p></p> <table style="background-color: white; color:black;"> <col class='diff-marker' /> <col class='diff-content' /> <col class='diff-marker' /> <col class='diff-content' /> <tr> <td colspan='2' style="background-color: white; color:black;">←Older revision</td> <td colspan='2' style="background-color: white; color:black;">Revision as of 10:44, 4 April 2017</td> </tr> <tr><td colspan="2" class="diff-lineno">Line 1:</td> <td colspan="2" class="diff-lineno">Line 1:</td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div><StructureSection load='4adw' size='450' side='right' caption='Trypanosoma FAD-containing trypanothione reductase dimer complex with trypanothione and NADPH [[4adw]]' scene=''></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><StructureSection load='4adw' size='450' side='right' caption='Trypanosoma FAD-containing trypanothione reductase dimer complex with trypanothione and NADPH [[4adw]]' scene='<ins style="color: red; font-weight: bold; text-decoration: none;">48/489332/Cv/1' pspeed='8</ins>'></div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>== Function ==</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>== Function ==</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>'''Trypanothione reductase''' (TTR) is a flavoenzyme which catalyzes the reaction converting trypanothione (TPT) and NADP to trypanothione disulfide and NADPH. TTR uses FAD as cofactor. </div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>'''Trypanothione reductase''' (TTR) is a flavoenzyme which catalyzes the reaction converting trypanothione (TPT) and NADP to trypanothione disulfide and NADPH. TTR uses FAD as cofactor. </div></td></tr> </table>

Alexander Berchansky http://52.214.119.220/wiki/index.php?title=Trypanothione_reductase&diff=2734894&oldid=prev Alexander Berchansky at 10:40, 4 April 2017 2017-04-04T10:40:50Z

<p></p> <table style="background-color: white; color:black;"> <col class='diff-marker' /> <col class='diff-content' /> <col class='diff-marker' /> <col class='diff-content' /> <tr> <td colspan='2' style="background-color: white; color:black;">←Older revision</td> <td colspan='2' style="background-color: white; color:black;">Revision as of 10:40, 4 April 2017</td> </tr> <tr><td colspan="2" class="diff-lineno">Line 1:</td> <td colspan="2" class="diff-lineno">Line 1:</td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div><StructureSection load='4adw' size='<del style="color: red; font-weight: bold; text-decoration: none;">340</del>' side='right' caption='Trypanosoma FAD-containing trypanothione reductase dimer complex with trypanothione and NADPH [[4adw]]' scene=''></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><StructureSection load='4adw' size='<ins style="color: red; font-weight: bold; text-decoration: none;">450</ins>' side='right' caption='Trypanosoma FAD-containing trypanothione reductase dimer complex with trypanothione and NADPH [[4adw]]' scene=''></div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>== Function ==</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>== Function ==</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>'''Trypanothione reductase''' (TTR) is a flavoenzyme which catalyzes the reaction converting trypanothione (TPT) and NADP to trypanothione disulfide and NADPH. TTR uses FAD as cofactor. </div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>'''Trypanothione reductase''' (TTR) is a flavoenzyme which catalyzes the reaction converting trypanothione (TPT) and NADP to trypanothione disulfide and NADPH. TTR uses FAD as cofactor. </div></td></tr> </table>

Alexander Berchansky