User:Hippolyte Personne/Sandbox 1 - Revision history

http://52.214.119.220/wiki/index.php?action=history&feed=atom&title=User%3AHippolyte_Personne%2FSandbox_1 User:Hippolyte Personne/Sandbox 1 - Revision history 2026-04-05T06:09:28Z Revision history for this page on the wiki MediaWiki 1.11.2 http://52.214.119.220/wiki/index.php?title=User:Hippolyte_Personne/Sandbox_1&diff=2715870&oldid=prev Hippolyte Personne at 14:35, 17 February 2017 2017-02-17T14:35:30Z

<p></p> <table style="background-color: white; color:black;"> <col class='diff-marker' /> <col class='diff-content' /> <col class='diff-marker' /> <col class='diff-content' /> <tr> <td colspan='2' style="background-color: white; color:black;">←Older revision</td> <td colspan='2' style="background-color: white; color:black;">Revision as of 14:35, 17 February 2017</td> </tr> <tr><td colspan="2" class="diff-lineno">Line 5:</td> <td colspan="2" class="diff-lineno">Line 5:</td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>== Structure ==</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>== Structure ==</div></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div> </div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;"><ref>https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3356457/</ref></ins></div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>*hKor structure</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>*hKor structure</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> </table>

Hippolyte Personne http://52.214.119.220/wiki/index.php?title=User:Hippolyte_Personne/Sandbox_1&diff=2715869&oldid=prev Hippolyte Personne at 14:33, 17 February 2017 2017-02-17T14:33:23Z

<p></p> <table style="background-color: white; color:black;"> <col class='diff-marker' /> <col class='diff-content' /> <col class='diff-marker' /> <col class='diff-content' /> <tr> <td colspan='2' style="background-color: white; color:black;">←Older revision</td> <td colspan='2' style="background-color: white; color:black;">Revision as of 14:33, 17 February 2017</td> </tr> <tr><td colspan="2" class="diff-lineno">Line 5:</td> <td colspan="2" class="diff-lineno">Line 5:</td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>== Structure ==</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>== Structure ==</div></td></tr> <tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"></td></tr> <tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>*hKor structure</div></td></tr> <tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"></td></tr> <tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>The Kor structure consists on a 7TM bundle of alpha helices and an helix VII, parallel to the membrane. It is crystallized in a parallel-dimer form composed of helices I, II and VIII in contact each others for study. Kor has a disulfide bound between its Cys131 and Cys210. The Thr273 stabilize the inactive structure whereas the NPxxY motif, in the helix VII, composed of Asn326, Pro327, Ile328, Leu239 and Tyr 330 is supposed to be responsible for the molecular switch needed for the activation. Kor’s Arg156 is use to made hydrogen bonds to the helix VI residue.</div></td></tr> <tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"></td></tr> <tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>*hKor-JDTic complex</div></td></tr> <tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"></td></tr> <tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>This crystalar structure forms ionic, polar and hydrophobic interactions with the receptor. This structure allowed numerous rotable bonds, which permit different conformations. It also facilate the ligand passage through the narrow binding pocket entrance. This repose on an interaction of two amino groups linked to Asp138, wich fixe the ligand in a V-shape. The N- and C- termini domain are totally disordered in this structure. This structure is selected thanks to the Glu297 specificty for JDTic and its derivatives.</div></td></tr> <tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"></td></tr> <tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>*hKor-BNI/GNTI complexes</div></td></tr> <tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"></td></tr> <tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>BNI and GNTI are ligands which can forme a salt bridge with Kor’s Glu297 thanks to their amino groups, which give them ans important selectivity for Kor and its morphinan derivatives</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> </table>

Hippolyte Personne http://52.214.119.220/wiki/index.php?title=User:Hippolyte_Personne/Sandbox_1&diff=2715835&oldid=prev Hippolyte Personne at 14:15, 16 February 2017 2017-02-16T14:15:29Z

<p></p> <table style="background-color: white; color:black;"> <col class='diff-marker' /> <col class='diff-content' /> <col class='diff-marker' /> <col class='diff-content' /> <tr> <td colspan='2' style="background-color: white; color:black;">←Older revision</td> <td colspan='2' style="background-color: white; color:black;">Revision as of 14:15, 16 February 2017</td> </tr> <tr><td colspan="2" class="diff-lineno">Line 1:</td> <td colspan="2" class="diff-lineno">Line 1:</td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>==<del style="color: red; font-weight: bold; text-decoration: none;">Your Heading Here (maybe something like 'Structure')</del>== <del style="color: red; font-weight: bold; text-decoration: none;">2</del></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>== <ins style="color: red; font-weight: bold; text-decoration: none;">Kappa Opioid Receptors </ins>== </div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div><StructureSection load='4djh' size='340' side='right' caption='Caption for this structure' scene=''></div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div><StructureSection load='4djh' size='340' side='right' caption='Caption for this structure' scene=''></div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>Kappa opioid receptor (KOR) belongs to the opioid system. This system plays an essential role in addiction. Opioid receptors and endogenous opioid peptides are very widely present in brain structures that control reward phenomena, particularly the mesolimbic system. These opioid receptors and peptides participate selectively in several aspects of the addictive processes induced by opiates, cannabinoids, psychostimulants, alcohol and nicotine.<ref>https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3444724/</ref></div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>Kappa opioid receptor (KOR) belongs to the opioid system. This system plays an essential role in addiction. Opioid receptors and endogenous opioid peptides are very widely present in brain structures that control reward phenomena, particularly the mesolimbic system. These opioid receptors and peptides participate selectively in several aspects of the addictive processes induced by opiates, cannabinoids, psychostimulants, alcohol and nicotine.<ref>https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3444724/</ref></div></td></tr> </table>

Hippolyte Personne http://52.214.119.220/wiki/index.php?title=User:Hippolyte_Personne/Sandbox_1&diff=2715834&oldid=prev Hippolyte Personne at 14:14, 16 February 2017 2017-02-16T14:14:21Z

<p></p> <table style="background-color: white; color:black;"> <col class='diff-marker' /> <col class='diff-content' /> <col class='diff-marker' /> <col class='diff-content' /> <tr> <td colspan='2' style="background-color: white; color:black;">←Older revision</td> <td colspan='2' style="background-color: white; color:black;">Revision as of 14:14, 16 February 2017</td> </tr> <tr><td colspan="2" class="diff-lineno">Line 1:</td> <td colspan="2" class="diff-lineno">Line 1:</td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>==Your Heading Here (maybe something like 'Structure')== 2</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>==Your Heading Here (maybe something like 'Structure')== 2</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div><StructureSection load='4djh' size='340' side='right' caption='Caption for this structure' scene=''></div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div><StructureSection load='4djh' size='340' side='right' caption='Caption for this structure' scene=''></div></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"></td><td colspan="2"> </td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>Kappa opioid receptor (KOR) belongs to the opioid system. This system plays an essential role in addiction. Opioid receptors and endogenous opioid peptides are very widely present in brain structures that control reward phenomena, particularly the mesolimbic system. These opioid receptors and peptides participate selectively in several aspects of the addictive processes induced by opiates, cannabinoids, psychostimulants, alcohol and nicotine.<ref>https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3444724/</ref></div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>Kappa opioid receptor (KOR) belongs to the opioid system. This system plays an essential role in addiction. Opioid receptors and endogenous opioid peptides are very widely present in brain structures that control reward phenomena, particularly the mesolimbic system. These opioid receptors and peptides participate selectively in several aspects of the addictive processes induced by opiates, cannabinoids, psychostimulants, alcohol and nicotine.<ref>https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3444724/</ref></div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>Though they are also found in the spinal cord and the peripheral tissues, those receptors are mainly located in most brain regions.</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>Though they are also found in the spinal cord and the peripheral tissues, those receptors are mainly located in most brain regions.</div></td></tr> </table>

Hippolyte Personne http://52.214.119.220/wiki/index.php?title=User:Hippolyte_Personne/Sandbox_1&diff=2715833&oldid=prev Hippolyte Personne at 14:13, 16 February 2017 2017-02-16T14:13:57Z

<p></p> <table style="background-color: white; color:black;"> <col class='diff-marker' /> <col class='diff-content' /> <col class='diff-marker' /> <col class='diff-content' /> <tr> <td colspan='2' style="background-color: white; color:black;">←Older revision</td> <td colspan='2' style="background-color: white; color:black;">Revision as of 14:13, 16 February 2017</td> </tr> <tr><td colspan="2" class="diff-lineno">Line 1:</td> <td colspan="2" class="diff-lineno">Line 1:</td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>==Your Heading Here (maybe something like 'Structure')== 2</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>==Your Heading Here (maybe something like 'Structure')== 2</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div><StructureSection load='4djh' size='340' side='right' caption='Caption for this structure' scene=''></div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div><StructureSection load='4djh' size='340' side='right' caption='Caption for this structure' scene=''></div></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"></td><td colspan="2"> </td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"></td><td colspan="2"> </td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>Kappa opioid receptor (KOR) belongs to the opioid system. This system plays an essential role in addiction. Opioid receptors and endogenous opioid peptides are very widely present in brain structures that control reward phenomena, particularly the mesolimbic system. These opioid receptors and peptides participate selectively in several aspects of the addictive processes induced by opiates, cannabinoids, psychostimulants, alcohol and nicotine.<ref>https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3444724/</ref></div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>Kappa opioid receptor (KOR) belongs to the opioid system. This system plays an essential role in addiction. Opioid receptors and endogenous opioid peptides are very widely present in brain structures that control reward phenomena, particularly the mesolimbic system. These opioid receptors and peptides participate selectively in several aspects of the addictive processes induced by opiates, cannabinoids, psychostimulants, alcohol and nicotine.<ref>https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3444724/</ref></div></td></tr> <tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>Though they are also found in the spinal cord and the peripheral tissues, those receptors are mainly located in most brain regions.</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>== Structure ==</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>== Structure ==</div></td></tr> </table>

Hippolyte Personne http://52.214.119.220/wiki/index.php?title=User:Hippolyte_Personne/Sandbox_1&diff=2715832&oldid=prev Hippolyte Personne at 13:55, 16 February 2017 2017-02-16T13:55:16Z

<p></p> <table style="background-color: white; color:black;"> <col class='diff-marker' /> <col class='diff-content' /> <col class='diff-marker' /> <col class='diff-content' /> <tr> <td colspan='2' style="background-color: white; color:black;">←Older revision</td> <td colspan='2' style="background-color: white; color:black;">Revision as of 13:55, 16 February 2017</td> </tr> <tr><td colspan="2" class="diff-lineno">Line 9:</td> <td colspan="2" class="diff-lineno">Line 9:</td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>== Function <ref>https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2612708/</ref><ref>https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2641011/</ref> ==</div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>== Function<ref>https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2612708/</ref><ref>https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2641011/</ref> ==</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>The kappa opioid receptor, just as the oher opioid receptors is a powerful analgesic and hence could be used as a pain regulator. Nevertheless, unlike other opioid receptors such as morphin, the clinical use of the KOR is extreamely rare because of the impornt psychological effects triggered by this receptor such as dysphoria, dissociations or drug predispositions :</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>The kappa opioid receptor, just as the oher opioid receptors is a powerful analgesic and hence could be used as a pain regulator. Nevertheless, unlike other opioid receptors such as morphin, the clinical use of the KOR is extreamely rare because of the impornt psychological effects triggered by this receptor such as dysphoria, dissociations or drug predispositions :</div></td></tr> </table>

Hippolyte Personne http://52.214.119.220/wiki/index.php?title=User:Hippolyte_Personne/Sandbox_1&diff=2715831&oldid=prev Hippolyte Personne at 13:47, 16 February 2017 2017-02-16T13:47:07Z

<p></p> <table style="background-color: white; color:black;"> <col class='diff-marker' /> <col class='diff-content' /> <col class='diff-marker' /> <col class='diff-content' /> <tr> <td colspan='2' style="background-color: white; color:black;">←Older revision</td> <td colspan='2' style="background-color: white; color:black;">Revision as of 13:47, 16 February 2017</td> </tr> <tr><td colspan="2" class="diff-lineno">Line 20:</td> <td colspan="2" class="diff-lineno">Line 20:</td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>Therefore the KOR antagonist molecules are now looked for their potenial against all type of addiction.</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>Therefore the KOR antagonist molecules are now looked for their potenial against all type of addiction.</div></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>== Structural highlights ==</div></td><td colspan="2"> </td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.</div></td><td colspan="2"> </td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div></StructureSection></div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div></StructureSection></div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>== References ==</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>== References ==</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div><references/></div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div><references/></div></td></tr> </table>

Hippolyte Personne http://52.214.119.220/wiki/index.php?title=User:Hippolyte_Personne/Sandbox_1&diff=2715830&oldid=prev Hippolyte Personne at 13:45, 16 February 2017 2017-02-16T13:45:18Z

<p></p> <table style="background-color: white; color:black;"> <col class='diff-marker' /> <col class='diff-content' /> <col class='diff-marker' /> <col class='diff-content' /> <tr> <td colspan='2' style="background-color: white; color:black;">←Older revision</td> <td colspan='2' style="background-color: white; color:black;">Revision as of 13:45, 16 February 2017</td> </tr> <tr><td colspan="2" class="diff-lineno">Line 4:</td> <td colspan="2" class="diff-lineno">Line 4:</td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>Kappa opioid receptor (KOR) belongs to the opioid system. This system plays an essential role in addiction. Opioid receptors and endogenous opioid peptides are very widely present in brain structures that control reward phenomena, particularly the mesolimbic system. These opioid receptors and peptides participate selectively in several aspects of the addictive processes induced by opiates, cannabinoids, psychostimulants, alcohol and nicotine.</div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>Kappa opioid receptor (KOR) belongs to the opioid system. This system plays an essential role in addiction. Opioid receptors and endogenous opioid peptides are very widely present in brain structures that control reward phenomena, particularly the mesolimbic system. These opioid receptors and peptides participate selectively in several aspects of the addictive processes induced by opiates, cannabinoids, psychostimulants, alcohol and nicotine.<ins style="color: red; font-weight: bold; text-decoration: none;"><ref>https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3444724/</ref></ins></div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>== Structure ==</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>== Structure ==</div></td></tr> </table>

Hippolyte Personne http://52.214.119.220/wiki/index.php?title=User:Hippolyte_Personne/Sandbox_1&diff=2715827&oldid=prev Hippolyte Personne at 13:39, 16 February 2017 2017-02-16T13:39:48Z

<p></p> <table style="background-color: white; color:black;"> <col class='diff-marker' /> <col class='diff-content' /> <col class='diff-marker' /> <col class='diff-content' /> <tr> <td colspan='2' style="background-color: white; color:black;">←Older revision</td> <td colspan='2' style="background-color: white; color:black;">Revision as of 13:39, 16 February 2017</td> </tr> <tr><td colspan="2" class="diff-lineno">Line 1:</td> <td colspan="2" class="diff-lineno">Line 1:</td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>==Your Heading Here (maybe something like 'Structure')== 2</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>==Your Heading Here (maybe something like 'Structure')== 2</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div><StructureSection load='4djh' size='340' side='right' caption='Caption for this structure' scene=''></div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div><StructureSection load='4djh' size='340' side='right' caption='Caption for this structure' scene=''></div></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div><del style="color: red; font-weight: bold; text-decoration: none;">This is a default text for your page '''Hippolyte Personne/Sandbox 1'''. Click above on '''edit this page''' to modify. Be careful with the &lt; and &gt; signs.</del></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div> </div></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div><del style="color: red; font-weight: bold; text-decoration: none;">You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue.</del></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div> </div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>Kappa opioid receptor (KOR) belongs to the opioid system. This system plays an essential role in addiction. Opioid receptors and endogenous opioid peptides are very widely present in brain structures that control reward phenomena, particularly the mesolimbic system. These opioid receptors and peptides participate selectively in several aspects of the addictive processes induced by opiates, cannabinoids, psychostimulants, alcohol and nicotine.</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>Kappa opioid receptor (KOR) belongs to the opioid system. This system plays an essential role in addiction. Opioid receptors and endogenous opioid peptides are very widely present in brain structures that control reward phenomena, particularly the mesolimbic system. These opioid receptors and peptides participate selectively in several aspects of the addictive processes induced by opiates, cannabinoids, psychostimulants, alcohol and nicotine.</div></td></tr> <tr><td colspan="2" class="diff-lineno">Line 9:</td> <td colspan="2" class="diff-lineno">Line 9:</td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>== Function ==</div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>== Function <ins style="color: red; font-weight: bold; text-decoration: none;"><ref>https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2612708/</ref><ref>https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2641011/</ref> </ins>==</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>The kappa opioid receptor, just as the oher opioid receptors is a powerful analgesic and hence could be used as a pain regulator. Nevertheless, unlike other opioid receptors such as morphin, the clinical use of the KOR is extreamely rare because of the impornt psychological effects triggered by this receptor such as dysphoria, dissociations or drug predispositions :</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>The kappa opioid receptor, just as the oher opioid receptors is a powerful analgesic and hence could be used as a pain regulator. Nevertheless, unlike other opioid receptors such as morphin, the clinical use of the KOR is extreamely rare because of the impornt psychological effects triggered by this receptor such as dysphoria, dissociations or drug predispositions :</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>By using a forced swim stress test, it has been determined that the releasing of endogenous dynorphin opioids (which are KOR agonists) by the organism in a stress situation activates the kinase fonction of the KOR which leads to the phosphoryllation of ERK1/2 MAPK. Hence the activation of their pathways which leads to <del style="color: red; font-weight: bold; text-decoration: none;">he </del>attenuation of stress effects over the organism. </div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>By using a forced swim stress test, it has been determined that the releasing of endogenous dynorphin opioids (which are KOR agonists) by the organism in a stress situation activates the kinase fonction of the KOR which leads to the phosphoryllation of ERK1/2 MAPK. Hence the activation of their pathways which leads to <ins style="color: red; font-weight: bold; text-decoration: none;">the </ins>attenuation of stress effects over the organism. </div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>However, it appears that regular stress situations, so regular ERK1/2 MAPK activation, cause the well known psychological problems which prevent the use of the kappa opioids as pain regulators.</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>However, it appears that regular stress situations, so regular ERK1/2 MAPK activation, cause the well known psychological problems which prevent the use of the kappa opioids as pain regulators.</div></td></tr> </table>

Hippolyte Personne http://52.214.119.220/wiki/index.php?title=User:Hippolyte_Personne/Sandbox_1&diff=2715821&oldid=prev Hippolyte Personne at 13:34, 16 February 2017 2017-02-16T13:34:47Z

<p></p> <table style="background-color: white; color:black;"> <col class='diff-marker' /> <col class='diff-content' /> <col class='diff-marker' /> <col class='diff-content' /> <tr> <td colspan='2' style="background-color: white; color:black;">←Older revision</td> <td colspan='2' style="background-color: white; color:black;">Revision as of 13:34, 16 February 2017</td> </tr> <tr><td colspan="2" class="diff-lineno">Line 1:</td> <td colspan="2" class="diff-lineno">Line 1:</td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>==Your Heading Here (maybe something like 'Structure')== 2</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>==Your Heading Here (maybe something like 'Structure')== 2</div></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div><StructureSection load='<del style="color: red; font-weight: bold; text-decoration: none;">1stp</del>' size='340' side='right' caption='Caption for this structure' scene=''></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><StructureSection load='<ins style="color: red; font-weight: bold; text-decoration: none;">4djh</ins>' size='340' side='right' caption='Caption for this structure' scene=''></div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>This is a default text for your page '''Hippolyte Personne/Sandbox 1'''. Click above on '''edit this page''' to modify. Be careful with the &lt; and &gt; signs.</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>This is a default text for your page '''Hippolyte Personne/Sandbox 1'''. Click above on '''edit this page''' to modify. Be careful with the &lt; and &gt; signs.</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue.</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue.</div></td></tr> <tr><td colspan="2" class="diff-lineno">Line 7:</td> <td colspan="2" class="diff-lineno">Line 7:</td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>== Structure ==</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>== Structure ==</div></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div><del style="color: red; font-weight: bold; text-decoration: none;"><Structure load='4djh' size='350' frame='true' align='right' caption='Insert caption here' scene='Insert optional scene name here' /></del></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div> </div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>== Function ==</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>== Function ==</div></td></tr> <tr><td colspan="2" class="diff-lineno">Line 27:</td> <td colspan="2" class="diff-lineno">Line 27:</td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>== References ==</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>== References ==</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div><references/></div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div><references/></div></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2612708/</div></td><td colspan="2"> </td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"></td><td colspan="2"> </td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2641011/</div></td><td colspan="2"> </td></tr> </table>

Hippolyte Personne