User:Jessica Bun/Sandbox1 - Revision history

Jessica Bun at 19:39, 17 April 2015

2015-04-17T19:39:05Z

←Older revision		Revision as of 19:39, 17 April 2015
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	A large hydrophobic core has conserved residues <scene name='69/698113/Conserved_core_residues/3'>Cysteine-155, Arginine-164, Glutamine-160, and Alanine-195</scene>.		A large hydrophobic core has conserved residues <scene name='69/698113/Conserved_core_residues/3'>Cysteine-155, Arginine-164, Glutamine-160, and Alanine-195</scene>.

-	[[Image:~~Core_Web_Logo~~.PNG \|~~600 × 155 px~~\|thumb\|left\|Four strictly conserved residues of five known functional MgtC orthologs of the soluble C-terminal domain.]]	+	[[Image:Final_Final_Core_Logo.PNG \|625× 116px\|thumb\|left\|Four strictly conserved residues of five known functional MgtC orthologs of the soluble C-terminal domain.]]

	The opposite side of the protein has a small cluster of conserved residues <scene name='69/698113/Conserved_surface_residues/1'>Tyrosine-149, Glutamine-208, and Tryptophan-225</scene>.		The opposite side of the protein has a small cluster of conserved residues <scene name='69/698113/Conserved_surface_residues/1'>Tyrosine-149, Glutamine-208, and Tryptophan-225</scene>.

-	[[Image:~~Surface_Web_Logo~~.PNG \|~~419 × 150 px~~\|thumb\|left\|Four strictly conserved residues of five known functional MgtC orthologs of the soluble C-terminal domain.]]	+	[[Image:Final_Surface_Web_Logo.PNG \|625× 121px\|thumb\|left\|Four strictly conserved residues of five known functional MgtC orthologs of the soluble C-terminal domain.]]

Jessica Bun at 22:15, 10 April 2015

2015-04-10T22:15:03Z

←Older revision		Revision as of 22:15, 10 April 2015
Line 10:		Line 10:

	A large hydrophobic core has conserved residues <scene name='69/698113/Conserved_core_residues/3'>Cysteine-155, Arginine-164, Glutamine-160, and Alanine-195</scene>.		A large hydrophobic core has conserved residues <scene name='69/698113/Conserved_core_residues/3'>Cysteine-155, Arginine-164, Glutamine-160, and Alanine-195</scene>.
		+
		+	[[Image:Core_Web_Logo.PNG \|600 × 155 px\|thumb\|left\|Four strictly conserved residues of five known functional MgtC orthologs of the soluble C-terminal domain.]]

	The opposite side of the protein has a small cluster of conserved residues <scene name='69/698113/Conserved_surface_residues/1'>Tyrosine-149, Glutamine-208, and Tryptophan-225</scene>.		The opposite side of the protein has a small cluster of conserved residues <scene name='69/698113/Conserved_surface_residues/1'>Tyrosine-149, Glutamine-208, and Tryptophan-225</scene>.
		+
		+	[[Image:Surface_Web_Logo.PNG \|419 × 150 px\|thumb\|left\|Four strictly conserved residues of five known functional MgtC orthologs of the soluble C-terminal domain.]]

Jessica Bun at 15:51, 9 April 2015

2015-04-09T15:51:43Z

←Older revision		Revision as of 15:51, 9 April 2015
Line 10:		Line 10:

	A large hydrophobic core has conserved residues <scene name='69/698113/Conserved_core_residues/3'>Cysteine-155, Arginine-164, Glutamine-160, and Alanine-195</scene>.		A large hydrophobic core has conserved residues <scene name='69/698113/Conserved_core_residues/3'>Cysteine-155, Arginine-164, Glutamine-160, and Alanine-195</scene>.
		+
		+	The opposite side of the protein has a small cluster of conserved residues <scene name='69/698113/Conserved_surface_residues/1'>Tyrosine-149, Glutamine-208, and Tryptophan-225</scene>.
		+

	[[Image:Entire_Web_Logo.PNG \|617 × 125 px\|thumb\|left\|Seven strictly conserved residues of five known functional MgtC orthologs of the soluble C-terminal domain.]]		[[Image:Entire_Web_Logo.PNG \|617 × 125 px\|thumb\|left\|Seven strictly conserved residues of five known functional MgtC orthologs of the soluble C-terminal domain.]]

Jessica Bun at 15:21, 9 April 2015

2015-04-09T15:21:50Z

←Older revision		Revision as of 15:21, 9 April 2015
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	== Function ==		== Function ==

-	~~The current biochemical function~~ is ~~unknown~~, ~~but it~~ has ~~been proposed~~ to ~~play~~ a ~~role in magnesium uptake~~.	+	This domain of MgtC, in contrast, is highly variable in comparison to several orthologues, as presented by Yang et al. However, through a sequence alignment of five known functional MgtC orthologues from pathogens that survive inside macrophages (''M. tuberculosis, B. melitensis, B. cenocepacia, Y. pestis,'' and ''S. Typhimurium''), seven strictly conserved residues were found to be scattered along the whole sequence of the relatively hydrophilic and soluble C-terminal domain.
		+
		+	A large hydrophobic core has conserved residues <scene name='69/698113/Conserved_core_residues/3'>Cysteine-155, Arginine-164, Glutamine-160, and Alanine-195</scene>.
		+
		+	[[Image:Entire_Web_Logo.PNG \|617 × 125 px\|thumb\|left\|Seven strictly conserved residues of five known functional MgtC orthologs of the soluble C-terminal domain.]]
		+
		+	In the
		+	Additionally, there is a crystal structure available for this domain. When comparing the crystal structure of the C-terminal domain to other protein structures, there are striking similarities between this domain and a class of proteins known as ACT domains.
		+
		+
		+

	===Mechanism===		===Mechanism===

Jessica Bun at 16:31, 8 April 2015

2015-04-08T16:31:17Z

←Older revision		Revision as of 16:31, 8 April 2015
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	==MgtC: A Virulence Factor From ''Mycobacterium tuberculosis''==		==MgtC: A Virulence Factor From ''Mycobacterium tuberculosis''==
-	<StructureSection load='2lqj' size='350' side='right' caption='MgtC Protein' scene=''>	+	<StructureSection load='2lqj' size='350' side='right' caption='MgtC Protein' scene='69/698113/Rainbow-colored_spectrum/1'>TextToBeDisplayed'>
	The MgtC protein is a membrane-bound protein that has been found to be a critical virulence factor for intramacrophage growth.		The MgtC protein is a membrane-bound protein that has been found to be a critical virulence factor for intramacrophage growth.

Jessica Bun at 00:04, 23 March 2015

2015-03-23T00:04:04Z

←Older revision		Revision as of 00:04, 23 March 2015
Line 16:		Line 16:
	[[Image:2lqj_colorful.png \|100 px\|left\|thumb\|Simple Structure]]		[[Image:2lqj_colorful.png \|100 px\|left\|thumb\|Simple Structure]]

-	~~This is~~ a ~~sample scene created with SAT to~~ <scene name="/12/~~3456/Sample~~/1">~~color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation~~</scene> of the protein~~. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes~~.	+	Among the family of MgtC proteins, there are very few residues that are conserved, especially among a highly variable C-terminal. Three conserved residues exist on the <scene name='69/698113/Conserved_surface/1'>surface</scene> of the protein.

	</StructureSection>		</StructureSection>
	== References ==		== References ==
	<references/>		<references/>

Jessica Bun at 23:48, 22 March 2015

2015-03-22T23:48:29Z

←Older revision		Revision as of 23:48, 22 March 2015
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	==MgtC: A Virulence Factor From ''Mycobacterium tuberculosis''==		==MgtC: A Virulence Factor From ''Mycobacterium tuberculosis''==
	<StructureSection load='2lqj' size='350' side='right' caption='MgtC Protein' scene=''>		<StructureSection load='2lqj' size='350' side='right' caption='MgtC Protein' scene=''>
-	~~This~~ is a ~~default text~~ for ~~your page '''Jessica Bun/Sandbox1'''. Click above on '''edit this page''' to modify. Be careful with the < and > signs~~.	+	The MgtC protein is a membrane-bound protein that has been found to be a critical virulence factor for intramacrophage growth.
		+
	You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue.		You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue.

	== Function ==		== Function ==

-	~~===Mechanism===~~	+	The current biochemical function is unknown, but it has been proposed to play a role in magnesium uptake.

-	== ~~Disease~~ ==	+	===Mechanism===

-	== Relevance ==

	== Structural highlights ==		== Structural highlights ==

Jessica Bun at 23:34, 22 March 2015

2015-03-22T23:34:28Z

←Older revision		Revision as of 23:34, 22 March 2015
Line 1:		Line 1:
-	==MgtC: A Virulence Factor From Mycobacterium tuberculosis==	+	==MgtC: A Virulence Factor From ''Mycobacterium tuberculosis''==
-	<StructureSection load='2lqj' size='350' side='right' caption='~~Caption for this structure~~' scene=''>	+	<StructureSection load='2lqj' size='350' side='right' caption='MgtC Protein' scene=''>
	This is a default text for your page '''Jessica Bun/Sandbox1'''. Click above on '''edit this page''' to modify. Be careful with the < and > signs.		This is a default text for your page '''Jessica Bun/Sandbox1'''. Click above on '''edit this page''' to modify. Be careful with the < and > signs.
	You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue.		You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue.

	== Function ==		== Function ==
		+
		+	===Mechanism===

	== Disease ==		== Disease ==
Line 12:		Line 14:
	== Structural highlights ==		== Structural highlights ==

-	[[Image:2lqj_colorful.png \|100 px\|left\|thumb\|~~Figure Legend~~]]	+	[[Image:2lqj_colorful.png \|100 px\|left\|thumb\|Simple Structure]]

	This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.		This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.

Jessica Bun at 21:53, 22 March 2015

2015-03-22T21:53:30Z

←Older revision		Revision as of 21:53, 22 March 2015
Line 1:		Line 1:
-	==~~Your Heading Here (maybe something like 'Structure')~~==	+	==MgtC: A Virulence Factor From Mycobacterium tuberculosis==
-	<StructureSection load='~~1stp~~' size='~~340~~' side='right' caption='Caption for this structure' scene=''>	+	<StructureSection load='2lqj' size='350' side='right' caption='Caption for this structure' scene=''>
	This is a default text for your page '''Jessica Bun/Sandbox1'''. Click above on '''edit this page''' to modify. Be careful with the < and > signs.		This is a default text for your page '''Jessica Bun/Sandbox1'''. Click above on '''edit this page''' to modify. Be careful with the < and > signs.
	You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue.		You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue.

Jessica Bun: New page: ==Your Heading Here (maybe something like 'Structure')== This is a default text for you...

2015-03-22T21:13:14Z

New page: ==Your Heading Here (maybe something like 'Structure')== <StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''> This is a default text for you...

New page

==Your Heading Here (maybe something like 'Structure')==
<StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''>
This is a default text for your page '''Jessica Bun/Sandbox1'''. Click above on '''edit this page''' to modify. Be careful with the < and > signs.
You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue.

== Function ==

== Disease ==

== Relevance ==

== Structural highlights ==

[[Image:2lqj_colorful.png |100 px|left|thumb|Figure Legend]]

This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.

</StructureSection>
== References ==
<references/>