User:Snehalatha Kaliappan/Histamine - Revision history

http://52.214.119.220/wiki/index.php?action=history&feed=atom&title=User%3ASnehalatha_Kaliappan%2FHistamine User:Snehalatha Kaliappan/Histamine - Revision history 2026-04-13T23:16:42Z Revision history for this page on the wiki MediaWiki 1.11.2 http://52.214.119.220/wiki/index.php?title=User:Snehalatha_Kaliappan/Histamine&diff=3603190&oldid=prev Snehalatha Kaliappan at 08:20, 11 August 2022 2022-08-11T08:20:19Z

<p></p> <table style="background-color: white; color:black;"> <col class='diff-marker' /> <col class='diff-content' /> <col class='diff-marker' /> <col class='diff-content' /> <tr> <td colspan='2' style="background-color: white; color:black;">←Older revision</td> <td colspan='2' style="background-color: white; color:black;">Revision as of 08:20, 11 August 2022</td> </tr> <tr><td colspan="2" class="diff-lineno">Line 4:</td> <td colspan="2" class="diff-lineno">Line 4:</td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>'''Histamine''' is an organic compound containing nitrogen atoms found in some of the human body cells. It is part of the immune system that causes the allergy related symptoms such as itching, sneezing and cold like symptoms. It also acts like a neurotransmitter in brain, spinal cord and uterus. It also regulates physiological functions in gut.</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>'''Histamine''' is an organic compound containing nitrogen atoms found in some of the human body cells. It is part of the immune system that causes the allergy related symptoms such as itching, sneezing and cold like symptoms. It also acts like a neurotransmitter in brain, spinal cord and uterus. It also regulates physiological functions in gut.</div></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>The imidazole ring of the histamine can have two <scene name='91/918504/Histamimium-tautomers/1'>tautomeric</scene> forms depending on which of the two nitrogens' is protonated. The nitrogen farther away from the side chain is the 'tele' nitrogen and is denoted by a lowercase tau sign and the nitrogen closer to the side chain is the 'pros' nitrogen and is denoted by the pi sign.The nitrogen on aminoethyl side chain is denoted by alpha. The tele tautomer, Nτ-H-histamine, is preferred in solution as compared to the pros tautomer, Nπ-H-histamine. Histamine has two basic nitrogen atoms. The alpha nitrogen and the pi nitrogen. Under physiological conditions the alpha nitrogen will be protonated. The pKa of the conjugated acid of alpha protonated histamine is 9.4 and pKa of Pi protonated histamine is 5.8.</div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>The imidazole ring of the histamine can have two <scene name='91/918504/Histamimium-tautomers/1'>tautomeric</scene> forms depending on which of the two nitrogens' is protonated. </div></td></tr> <tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">The nitrogens in the histamine are <scene name='91/918504/Label-nitrogens-new/1'>labeled</scene> as follows:</ins></div></td></tr> <tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>The nitrogen farther away from the side chain is the 'tele' nitrogen and is denoted by a lowercase tau sign and the nitrogen closer to the side chain is the 'pros' nitrogen and is denoted by the pi sign.The nitrogen on aminoethyl side chain is denoted by alpha. </div></td></tr> <tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>The tele tautomer, Nτ-H-histamine, is preferred in solution as compared to the pros tautomer, Nπ-H-histamine. Histamine has two basic nitrogen atoms. The alpha nitrogen and the pi nitrogen. Under physiological conditions the alpha nitrogen will be protonated. The pKa of the conjugated acid of alpha protonated histamine is 9.4 and pKa of Pi protonated histamine is 5.8.</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>== References ==</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>== References ==</div></td></tr> </table>

Snehalatha Kaliappan http://52.214.119.220/wiki/index.php?title=User:Snehalatha_Kaliappan/Histamine&diff=3600264&oldid=prev Snehalatha Kaliappan at 10:20, 5 August 2022 2022-08-05T10:20:31Z

<p></p> <table style="background-color: white; color:black;"> <col class='diff-marker' /> <col class='diff-content' /> <col class='diff-marker' /> <col class='diff-content' /> <tr> <td colspan='2' style="background-color: white; color:black;">←Older revision</td> <td colspan='2' style="background-color: white; color:black;">Revision as of 10:20, 5 August 2022</td> </tr> <tr><td colspan="2" class="diff-lineno">Line 4:</td> <td colspan="2" class="diff-lineno">Line 4:</td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>'''Histamine''' is an organic compound containing nitrogen atoms found in some of the human body cells. It is part of the immune system that causes the allergy related symptoms such as itching, sneezing and cold like symptoms. It also acts like a neurotransmitter in brain, spinal cord and uterus. It also regulates physiological functions in gut.</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>'''Histamine''' is an organic compound containing nitrogen atoms found in some of the human body cells. It is part of the immune system that causes the allergy related symptoms such as itching, sneezing and cold like symptoms. It also acts like a neurotransmitter in brain, spinal cord and uterus. It also regulates physiological functions in gut.</div></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>The <scene name='91/918504/<del style="color: red; font-weight: bold; text-decoration: none;">Histidine</del>-<del style="color: red; font-weight: bold; text-decoration: none;">n-label</del>/1'><del style="color: red; font-weight: bold; text-decoration: none;">imidazole</del></scene> <del style="color: red; font-weight: bold; text-decoration: none;">ring of the histamine can have two tautomeric </del>forms depending on which of the two nitrogens' is protonated. The nitrogen farther away from the side chain is the 'tele' nitrogen and is denoted by a lowercase tau sign and the nitrogen closer to the side chain is the 'pros' nitrogen and is denoted by the pi sign.The nitrogen on aminoethyl side chain is denoted by alpha. The tele tautomer, Nτ-H-histamine, is preferred in solution as compared to the pros tautomer, Nπ-H-histamine. Histamine has two basic nitrogen atoms. The alpha nitrogen and the pi nitrogen. Under physiological conditions the alpha nitrogen will be protonated. The pKa of the conjugated acid of alpha protonated histamine is 9.4 and pKa of Pi protonated histamine is 5.8.</div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>The <ins style="color: red; font-weight: bold; text-decoration: none;">imidazole ring of the histamine can have two </ins><scene name='91/918504/<ins style="color: red; font-weight: bold; text-decoration: none;">Histamimium</ins>-<ins style="color: red; font-weight: bold; text-decoration: none;">tautomers</ins>/1'><ins style="color: red; font-weight: bold; text-decoration: none;">tautomeric</ins></scene> forms depending on which of the two nitrogens' is protonated. The nitrogen farther away from the side chain is the 'tele' nitrogen and is denoted by a lowercase tau sign and the nitrogen closer to the side chain is the 'pros' nitrogen and is denoted by the pi sign.The nitrogen on aminoethyl side chain is denoted by alpha. The tele tautomer, Nτ-H-histamine, is preferred in solution as compared to the pros tautomer, Nπ-H-histamine. Histamine has two basic nitrogen atoms. The alpha nitrogen and the pi nitrogen. Under physiological conditions the alpha nitrogen will be protonated. The pKa of the conjugated acid of alpha protonated histamine is 9.4 and pKa of Pi protonated histamine is 5.8.</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>== References ==</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>== References ==</div></td></tr> </table>

Snehalatha Kaliappan http://52.214.119.220/wiki/index.php?title=User:Snehalatha_Kaliappan/Histamine&diff=3600261&oldid=prev Snehalatha Kaliappan at 07:06, 5 August 2022 2022-08-05T07:06:05Z

<p></p> <table style="background-color: white; color:black;"> <col class='diff-marker' /> <col class='diff-content' /> <col class='diff-marker' /> <col class='diff-content' /> <tr> <td colspan='2' style="background-color: white; color:black;">←Older revision</td> <td colspan='2' style="background-color: white; color:black;">Revision as of 07:06, 5 August 2022</td> </tr> <tr><td colspan="2" class="diff-lineno">Line 1:</td> <td colspan="2" class="diff-lineno">Line 1:</td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>==Structure of Histamine==</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>==Structure of Histamine==</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div><Structure load='<del style="color: red; font-weight: bold; text-decoration: none;">Histamine</del>.PNGJ' size='250' frame='true' align='right' caption='Histamine' <del style="color: red; font-weight: bold; text-decoration: none;">scene='Insert optional scene name here' </del>/></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><Structure load='<ins style="color: red; font-weight: bold; text-decoration: none;">Histaminium</ins>.PNGJ' size='250' frame='true' align='right' caption='<ins style="color: red; font-weight: bold; text-decoration: none;">N-alpha Protonated </ins>Histamine' <ins style="color: red; font-weight: bold; text-decoration: none;"> </ins>/></div></td></tr> <tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div> </div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>'''Histamine''' is an organic compound containing nitrogen atoms found in some of the human body cells. It is part of the immune system that causes the allergy related symptoms such as itching, sneezing and cold like symptoms. It also acts like a neurotransmitter in brain, spinal cord and uterus. It also regulates physiological functions in gut.</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>'''Histamine''' is an organic compound containing nitrogen atoms found in some of the human body cells. It is part of the immune system that causes the allergy related symptoms such as itching, sneezing and cold like symptoms. It also acts like a neurotransmitter in brain, spinal cord and uterus. It also regulates physiological functions in gut.</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>The <scene name='91/918504/Histidine-n-label/1'>imidazole</scene> ring of the histamine can have two tautomeric forms depending on which of the two nitrogens' is protonated. The nitrogen farther away from the side chain is the 'tele' nitrogen and is denoted by a lowercase tau sign and the nitrogen closer to the side chain is the 'pros' nitrogen and is denoted by the pi sign.The nitrogen on aminoethyl side chain is denoted by alpha. The tele tautomer, Nτ-H-histamine, is preferred in solution as compared to the pros tautomer, Nπ-H-histamine. Histamine has two basic nitrogen atoms. The alpha nitrogen and the pi nitrogen. Under physiological conditions the alpha nitrogen will be protonated. The pKa of the conjugated acid of alpha protonated histamine is 9.4 and pKa of Pi protonated histamine is 5.8.</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>The <scene name='91/918504/Histidine-n-label/1'>imidazole</scene> ring of the histamine can have two tautomeric forms depending on which of the two nitrogens' is protonated. The nitrogen farther away from the side chain is the 'tele' nitrogen and is denoted by a lowercase tau sign and the nitrogen closer to the side chain is the 'pros' nitrogen and is denoted by the pi sign.The nitrogen on aminoethyl side chain is denoted by alpha. The tele tautomer, Nτ-H-histamine, is preferred in solution as compared to the pros tautomer, Nπ-H-histamine. Histamine has two basic nitrogen atoms. The alpha nitrogen and the pi nitrogen. Under physiological conditions the alpha nitrogen will be protonated. The pKa of the conjugated acid of alpha protonated histamine is 9.4 and pKa of Pi protonated histamine is 5.8.</div></td></tr> </table>

Snehalatha Kaliappan http://52.214.119.220/wiki/index.php?title=User:Snehalatha_Kaliappan/Histamine&diff=3600222&oldid=prev Snehalatha Kaliappan at 11:18, 4 August 2022 2022-08-04T11:18:54Z

<p></p> <table style="background-color: white; color:black;"> <col class='diff-marker' /> <col class='diff-content' /> <col class='diff-marker' /> <col class='diff-content' /> <tr> <td colspan='2' style="background-color: white; color:black;">←Older revision</td> <td colspan='2' style="background-color: white; color:black;">Revision as of 11:18, 4 August 2022</td> </tr> <tr><td colspan="2" class="diff-lineno">Line 3:</td> <td colspan="2" class="diff-lineno">Line 3:</td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div><Structure load='Histamine.PNGJ' size='250' frame='true' align='right' caption='Histamine' scene='Insert optional scene name here' /></div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div><Structure load='Histamine.PNGJ' size='250' frame='true' align='right' caption='Histamine' scene='Insert optional scene name here' /></div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>'''Histamine''' is an organic compound containing nitrogen atoms found in some of the human body cells. It is part of the immune system that causes the allergy related symptoms such as itching, sneezing and cold like symptoms. It also acts like a neurotransmitter in brain, spinal cord and uterus. It also regulates physiological functions in gut.</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>'''Histamine''' is an organic compound containing nitrogen atoms found in some of the human body cells. It is part of the immune system that causes the allergy related symptoms such as itching, sneezing and cold like symptoms. It also acts like a neurotransmitter in brain, spinal cord and uterus. It also regulates physiological functions in gut.</div></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>The <scene name='91/918504/Histidine-n-label/1'>imidazole</scene> ring of the histamine can have two tautomeric forms depending on which of the two nitrogens' is protonated. The nitrogen farther away from the side chain is the 'tele' nitrogen and is denoted by a lowercase tau sign and the nitrogen closer to the side chain is the 'pros' nitrogen and is denoted by the pi sign.The nitrogen on aminoethyl side chain is denoted by alpha. The tele tautomer, Nτ-H-histamine, is preferred in solution as compared to the pros tautomer, Nπ-H-histamine. </div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>The <scene name='91/918504/Histidine-n-label/1'>imidazole</scene> ring of the histamine can have two tautomeric forms depending on which of the two nitrogens' is protonated. The nitrogen farther away from the side chain is the 'tele' nitrogen and is denoted by a lowercase tau sign and the nitrogen closer to the side chain is the 'pros' nitrogen and is denoted by the pi sign.The nitrogen on aminoethyl side chain is denoted by alpha. The tele tautomer, Nτ-H-histamine, is preferred in solution as compared to the pros tautomer, Nπ-H-histamine<ins style="color: red; font-weight: bold; text-decoration: none;">. Histamine has two basic nitrogen atoms. The alpha nitrogen and the pi nitrogen. Under physiological conditions the alpha nitrogen will be protonated. The pKa of the conjugated acid of alpha protonated histamine is 9.4 and pKa of Pi protonated histamine is 5.8</ins>.</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>== References ==</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>== References ==</div></td></tr> </table>

Snehalatha Kaliappan http://52.214.119.220/wiki/index.php?title=User:Snehalatha_Kaliappan/Histamine&diff=3600221&oldid=prev Snehalatha Kaliappan at 11:03, 4 August 2022 2022-08-04T11:03:44Z

<p></p> <table style="background-color: white; color:black;"> <col class='diff-marker' /> <col class='diff-content' /> <col class='diff-marker' /> <col class='diff-content' /> <tr> <td colspan='2' style="background-color: white; color:black;">←Older revision</td> <td colspan='2' style="background-color: white; color:black;">Revision as of 11:03, 4 August 2022</td> </tr> <tr><td colspan="2" class="diff-lineno">Line 3:</td> <td colspan="2" class="diff-lineno">Line 3:</td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div><Structure load='Histamine.PNGJ' size='250' frame='true' align='right' caption='Histamine' scene='Insert optional scene name here' /></div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div><Structure load='Histamine.PNGJ' size='250' frame='true' align='right' caption='Histamine' scene='Insert optional scene name here' /></div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>'''Histamine''' is an organic compound containing nitrogen atoms found in some of the human body cells. It is part of the immune system that causes the allergy related symptoms such as itching, sneezing and cold like symptoms. It also acts like a neurotransmitter in brain, spinal cord and uterus. It also regulates physiological functions in gut.</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>'''Histamine''' is an organic compound containing nitrogen atoms found in some of the human body cells. It is part of the immune system that causes the allergy related symptoms such as itching, sneezing and cold like symptoms. It also acts like a neurotransmitter in brain, spinal cord and uterus. It also regulates physiological functions in gut.</div></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>The <scene name='91/918504/Histidine-n-label/1'>imidazole</scene> ring of the histamine can have two tautomeric forms depending on which of the two nitrogens' is protonated. The nitrogen farther away from the side chain is the 'tele' nitrogen and is denoted by a lowercase tau sign and the nitrogen closer to the side chain is the 'pros' nitrogen and is denoted by the pi sign. The tele tautomer, Nτ-H-histamine, is preferred in solution as compared to the pros tautomer, Nπ-H-histamine. </div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>The <scene name='91/918504/Histidine-n-label/1'>imidazole</scene> ring of the histamine can have two tautomeric forms depending on which of the two nitrogens' is protonated. The nitrogen farther away from the side chain is the 'tele' nitrogen and is denoted by a lowercase tau sign and the nitrogen closer to the side chain is the 'pros' nitrogen and is denoted by the pi sign<ins style="color: red; font-weight: bold; text-decoration: none;">.The nitrogen on aminoethyl side chain is denoted by alpha</ins>. The tele tautomer, Nτ-H-histamine, is preferred in solution as compared to the pros tautomer, Nπ-H-histamine. </div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>== References ==</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>== References ==</div></td></tr> </table>

Snehalatha Kaliappan http://52.214.119.220/wiki/index.php?title=User:Snehalatha_Kaliappan/Histamine&diff=3600211&oldid=prev Snehalatha Kaliappan at 09:47, 4 August 2022 2022-08-04T09:47:40Z

<p></p> <table style="background-color: white; color:black;"> <col class='diff-marker' /> <col class='diff-content' /> <col class='diff-marker' /> <col class='diff-content' /> <tr> <td colspan='2' style="background-color: white; color:black;">←Older revision</td> <td colspan='2' style="background-color: white; color:black;">Revision as of 09:47, 4 August 2022</td> </tr> <tr><td colspan="2" class="diff-lineno">Line 3:</td> <td colspan="2" class="diff-lineno">Line 3:</td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div><Structure load='Histamine.PNGJ' size='250' frame='true' align='right' caption='Histamine' scene='Insert optional scene name here' /></div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div><Structure load='Histamine.PNGJ' size='250' frame='true' align='right' caption='Histamine' scene='Insert optional scene name here' /></div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>'''Histamine''' is an organic compound containing nitrogen atoms found in some of the human body cells. It is part of the immune system that causes the allergy related symptoms such as itching, sneezing and cold like symptoms. It also acts like a neurotransmitter in brain, spinal cord and uterus. It also regulates physiological functions in gut.</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>'''Histamine''' is an organic compound containing nitrogen atoms found in some of the human body cells. It is part of the immune system that causes the allergy related symptoms such as itching, sneezing and cold like symptoms. It also acts like a neurotransmitter in brain, spinal cord and uterus. It also regulates physiological functions in gut.</div></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>The imidazole ring of the histamine can have two tautomeric forms depending on which of the two nitrogens' is protonated. The nitrogen farther away from the side chain is the 'tele' nitrogen and is denoted by a lowercase tau sign and the nitrogen closer to the side chain is the 'pros' nitrogen and is denoted by the pi sign. The tele tautomer, Nτ-H-histamine, is preferred in solution as compared to the pros tautomer, Nπ-H-histamine. </div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>The <ins style="color: red; font-weight: bold; text-decoration: none;"><scene name='91/918504/Histidine-n-label/1'></ins>imidazole<ins style="color: red; font-weight: bold; text-decoration: none;"></scene> </ins>ring of the histamine can have two tautomeric forms depending on which of the two nitrogens' is protonated. The nitrogen farther away from the side chain is the 'tele' nitrogen and is denoted by a lowercase tau sign and the nitrogen closer to the side chain is the 'pros' nitrogen and is denoted by the pi sign. The tele tautomer, Nτ-H-histamine, is preferred in solution as compared to the pros tautomer, Nπ-H-histamine. </div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>== References ==</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>== References ==</div></td></tr> </table>

Snehalatha Kaliappan http://52.214.119.220/wiki/index.php?title=User:Snehalatha_Kaliappan/Histamine&diff=3600198&oldid=prev Snehalatha Kaliappan at 06:01, 4 August 2022 2022-08-04T06:01:26Z

<p></p> <table style="background-color: white; color:black;"> <col class='diff-marker' /> <col class='diff-content' /> <col class='diff-marker' /> <col class='diff-content' /> <tr> <td colspan='2' style="background-color: white; color:black;">←Older revision</td> <td colspan='2' style="background-color: white; color:black;">Revision as of 06:01, 4 August 2022</td> </tr> <tr><td colspan="2" class="diff-lineno">Line 19:</td> <td colspan="2" class="diff-lineno">Line 19:</td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div><Structure load='3rze' size='350' frame='true' align='right' caption='H1 Receptor with Doxepin' scene='Insert optional scene name here' /></div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div><Structure load='3rze' size='350' frame='true' align='right' caption='H1 Receptor with Doxepin' scene='Insert optional scene name here' /></div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>Histamine receptors belong to class A of the GPCR superfamily(G protein‐coupled receptors) contain a bundle of seven antiparallel transmembrane helices. Histamine binds to these receptors as primary endogenous ligand<del style="color: red; font-weight: bold; text-decoration: none;">. There are 4 known histamine receptors, H1, H2, H3 and H4. H1 receptor is expressed in It is expressed in smooth muscles, on vascular endothelial cells, in the heart, and in the central nervous system.The H1 receptor is linked to an intracellular G-protein (Gq) that activates phospholipase C and the inositol triphosphate (IP3) signalling pathway. Antihistamines, which act on this receptor, are used as anti-allergy drugs</del>.The crystal structure of the histamine H 1 receptor was obtained in 2011 and is still the only <del style="color: red; font-weight: bold; text-decoration: none;">structureof histaminergic </del>receptor deposited in the Protein Data Bank( PDB ID: 3RZE). It shows the crystal structure of the H1 receptor complex with doxepin, a first-generation H1 receptor antagonist.Doxepin sits deep in the ligand-binding pocket and directly interacts with <scene name='91/918504/Hydrophobic_pocket/1'>Trp 428</scene>, a highly conserved key residue in G-protein-coupled-receptor activation.This well-conserved pocket with mostly hydrophobic nature contributes to the low selectivity of the first-generation compounds. The pocket is associated with an anion-binding region occupied by a phosphate ion. Docking of various second-generation H(1)R antagonists reveals that the unique carboxyl group present in this class of compounds <scene name='91/918504/Hydrophobic_pocket_2/2'>interacts</scene> with Lys 191 and/or Lys 179, both of which form part of the anion-binding region. </div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>Histamine receptors belong to class A of the GPCR superfamily(G protein‐coupled receptors) contain a bundle of seven antiparallel transmembrane helices. Histamine binds to these receptors as primary endogenous ligand. The crystal structure of the histamine H 1 receptor was obtained in 2011 and is still the only <ins style="color: red; font-weight: bold; text-decoration: none;">structure of histamine </ins>receptor deposited in the Protein Data Bank( PDB ID: 3RZE). It shows the crystal structure of the H1 receptor complex with doxepin, a first-generation H1 receptor antagonist. Doxepin sits deep in the <ins style="color: red; font-weight: bold; text-decoration: none;"><scene name='91/918504/Ligand_contacts/1'></ins>ligand-binding pocket<ins style="color: red; font-weight: bold; text-decoration: none;"></scene> </ins>and directly interacts with <scene name='91/918504/Hydrophobic_pocket/1'>Trp 428</scene>, a highly conserved key residue in G-protein-coupled-receptor activation.This well-conserved pocket with mostly hydrophobic nature contributes to the low selectivity of the first-generation compounds. The pocket is associated with an anion-binding region occupied by a phosphate ion. Docking of various second-generation H(1)R antagonists reveals that the unique carboxyl group present in this class of compounds <scene name='91/918504/Hydrophobic_pocket_2/2'>interacts</scene> with Lys 191 and/or Lys 179, both of which form part of the anion-binding region. </div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> </table>

Snehalatha Kaliappan http://52.214.119.220/wiki/index.php?title=User:Snehalatha_Kaliappan/Histamine&diff=3600177&oldid=prev Snehalatha Kaliappan at 09:14, 3 August 2022 2022-08-03T09:14:22Z

<p></p> <table style="background-color: white; color:black;"> <col class='diff-marker' /> <col class='diff-content' /> <col class='diff-marker' /> <col class='diff-content' /> <tr> <td colspan='2' style="background-color: white; color:black;">←Older revision</td> <td colspan='2' style="background-color: white; color:black;">Revision as of 09:14, 3 August 2022</td> </tr> <tr><td colspan="2" class="diff-lineno">Line 19:</td> <td colspan="2" class="diff-lineno">Line 19:</td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div><Structure load='3rze' size='350' frame='true' align='right' caption='H1 Receptor with Doxepin' scene='Insert optional scene name here' /></div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div><Structure load='3rze' size='350' frame='true' align='right' caption='H1 Receptor with Doxepin' scene='Insert optional scene name here' /></div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>Histamine receptors belong to class A of the GPCR superfamily(G protein‐coupled receptors) contain a bundle of seven antiparallel transmembrane helices. Histamine binds to these receptors as primary endogenous ligand. There are 4 known histamine receptors, H1, H2, H3 and H4. H1 receptor is expressed in It is expressed in smooth muscles, on vascular endothelial cells, in the heart, and in the central nervous system.The H1 receptor is linked to an intracellular G-protein (Gq) that activates phospholipase C and the inositol triphosphate (IP3) signalling pathway. Antihistamines, which act on this receptor, are used as anti-allergy drugs.The crystal structure of the histamine H 1 receptor was obtained in 2011 and is still the only structureof histaminergic receptor deposited in the Protein Data Bank( PDB ID: 3RZE). It shows the crystal structure of the H1 receptor complex with doxepin, a first-generation H1 receptor antagonist.Doxepin sits deep in the ligand-binding pocket and directly interacts with <scene name='91/918504/Hydrophobic_pocket/1'>Trp 428</scene>, a highly conserved key residue in G-protein-coupled-receptor activation.This well-conserved pocket with mostly hydrophobic nature contributes to the low selectivity of the first-generation compounds. The pocket is associated with an anion-binding region occupied by a phosphate ion. Docking of various second-generation H(1)R antagonists reveals that the unique carboxyl group present in this class of compounds interacts with Lys 191<del style="color: red; font-weight: bold; text-decoration: none;">(5.39) </del>and/or Lys 179<del style="color: red; font-weight: bold; text-decoration: none;">(ECL2)</del>, both of which form part of the anion-binding region<del style="color: red; font-weight: bold; text-decoration: none;">. This region is not conserved in other aminergic receptors, demonstrating how minor differences in receptors lead to pronounced selectivity differences with small molecules</del>.</div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>Histamine receptors belong to class A of the GPCR superfamily(G protein‐coupled receptors) contain a bundle of seven antiparallel transmembrane helices. Histamine binds to these receptors as primary endogenous ligand. There are 4 known histamine receptors, H1, H2, H3 and H4. H1 receptor is expressed in It is expressed in smooth muscles, on vascular endothelial cells, in the heart, and in the central nervous system.The H1 receptor is linked to an intracellular G-protein (Gq) that activates phospholipase C and the inositol triphosphate (IP3) signalling pathway. Antihistamines, which act on this receptor, are used as anti-allergy drugs.The crystal structure of the histamine H 1 receptor was obtained in 2011 and is still the only structureof histaminergic receptor deposited in the Protein Data Bank( PDB ID: 3RZE). It shows the crystal structure of the H1 receptor complex with doxepin, a first-generation H1 receptor antagonist.Doxepin sits deep in the ligand-binding pocket and directly interacts with <scene name='91/918504/Hydrophobic_pocket/1'>Trp 428</scene>, a highly conserved key residue in G-protein-coupled-receptor activation.This well-conserved pocket with mostly hydrophobic nature contributes to the low selectivity of the first-generation compounds. The pocket is associated with an anion-binding region occupied by a phosphate ion. Docking of various second-generation H(1)R antagonists reveals that the unique carboxyl group present in this class of compounds <ins style="color: red; font-weight: bold; text-decoration: none;"><scene name='91/918504/Hydrophobic_pocket_2/2'></ins>interacts<ins style="color: red; font-weight: bold; text-decoration: none;"></scene> </ins>with Lys 191 and/or Lys 179, both of which form part of the anion-binding region. </div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> </table>

Snehalatha Kaliappan http://52.214.119.220/wiki/index.php?title=User:Snehalatha_Kaliappan/Histamine&diff=3600176&oldid=prev Snehalatha Kaliappan at 08:24, 3 August 2022 2022-08-03T08:24:51Z

<p></p> <table style="background-color: white; color:black;"> <col class='diff-marker' /> <col class='diff-content' /> <col class='diff-marker' /> <col class='diff-content' /> <tr> <td colspan='2' style="background-color: white; color:black;">←Older revision</td> <td colspan='2' style="background-color: white; color:black;">Revision as of 08:24, 3 August 2022</td> </tr> <tr><td colspan="2" class="diff-lineno">Line 19:</td> <td colspan="2" class="diff-lineno">Line 19:</td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div><Structure load='3rze' size='350' frame='true' align='right' caption='H1 Receptor with Doxepin' scene='Insert optional scene name here' /></div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div><Structure load='3rze' size='350' frame='true' align='right' caption='H1 Receptor with Doxepin' scene='Insert optional scene name here' /></div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>Histamine receptors belong to class A of the GPCR superfamily(G protein‐coupled receptors) contain a bundle of seven antiparallel transmembrane helices. Histamine binds to these receptors as primary endogenous ligand. There are 4 known histamine receptors, H1, H2, H3 and H4. H1 receptor is expressed in It is expressed in smooth muscles, on vascular endothelial cells, in the heart, and in the central nervous system.The H1 receptor is linked to an intracellular G-protein (Gq) that activates phospholipase C and the inositol triphosphate (IP3) signalling pathway. Antihistamines, which act on this receptor, are used as anti-allergy drugs.The crystal structure of the histamine H 1 receptor was obtained in 2011 and is still the only structureof histaminergic receptor deposited in the Protein Data Bank( PDB ID: 3RZE). It shows the crystal structure of the H1 receptor complex with doxepin, a first-generation H1 receptor antagonist.Doxepin sits deep in the ligand-binding pocket and directly interacts with Trp 428, a highly conserved key residue in G-protein-coupled-receptor activation.This well-conserved pocket with mostly hydrophobic nature contributes to the low selectivity of the first-generation compounds. The pocket is associated with an anion-binding region occupied by a phosphate ion. Docking of various second-generation H(1)R antagonists reveals that the unique carboxyl group present in this class of compounds interacts with Lys 191(5.39) and/or Lys 179(ECL2), both of which form part of the anion-binding region. This region is not conserved in other aminergic receptors, demonstrating how minor differences in receptors lead to pronounced selectivity differences with small molecules.</div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>Histamine receptors belong to class A of the GPCR superfamily(G protein‐coupled receptors) contain a bundle of seven antiparallel transmembrane helices. Histamine binds to these receptors as primary endogenous ligand. There are 4 known histamine receptors, H1, H2, H3 and H4. H1 receptor is expressed in It is expressed in smooth muscles, on vascular endothelial cells, in the heart, and in the central nervous system.The H1 receptor is linked to an intracellular G-protein (Gq) that activates phospholipase C and the inositol triphosphate (IP3) signalling pathway. Antihistamines, which act on this receptor, are used as anti-allergy drugs.The crystal structure of the histamine H 1 receptor was obtained in 2011 and is still the only structureof histaminergic receptor deposited in the Protein Data Bank( PDB ID: 3RZE). It shows the crystal structure of the H1 receptor complex with doxepin, a first-generation H1 receptor antagonist.Doxepin sits deep in the ligand-binding pocket and directly interacts with <ins style="color: red; font-weight: bold; text-decoration: none;"><scene name='91/918504/Hydrophobic_pocket/1'></ins>Trp 428<ins style="color: red; font-weight: bold; text-decoration: none;"></scene></ins>, a highly conserved key residue in G-protein-coupled-receptor activation.This well-conserved pocket with mostly hydrophobic nature contributes to the low selectivity of the first-generation compounds. The pocket is associated with an anion-binding region occupied by a phosphate ion. Docking of various second-generation H(1)R antagonists reveals that the unique carboxyl group present in this class of compounds interacts with Lys 191(5.39) and/or Lys 179(ECL2), both of which form part of the anion-binding region. This region is not conserved in other aminergic receptors, demonstrating how minor differences in receptors lead to pronounced selectivity differences with small molecules.</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> </table>

Snehalatha Kaliappan http://52.214.119.220/wiki/index.php?title=User:Snehalatha_Kaliappan/Histamine&diff=3600171&oldid=prev Snehalatha Kaliappan at 07:25, 3 August 2022 2022-08-03T07:25:48Z

<p></p> <table style="background-color: white; color:black;"> <col class='diff-marker' /> <col class='diff-content' /> <col class='diff-marker' /> <col class='diff-content' /> <tr> <td colspan='2' style="background-color: white; color:black;">←Older revision</td> <td colspan='2' style="background-color: white; color:black;">Revision as of 07:25, 3 August 2022</td> </tr> <tr><td colspan="2" class="diff-lineno">Line 17:</td> <td colspan="2" class="diff-lineno">Line 17:</td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>==Histamine H1 Receptor==</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>==Histamine H1 Receptor==</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div><Structure load='<del style="color: red; font-weight: bold; text-decoration: none;">Insert PDB code or filename here</del>' size='350' frame='true' align='right' caption='<del style="color: red; font-weight: bold; text-decoration: none;">Insert caption here</del>' scene='Insert optional scene name here' /></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><Structure load='<ins style="color: red; font-weight: bold; text-decoration: none;">3rze</ins>' size='350' frame='true' align='right' caption='<ins style="color: red; font-weight: bold; text-decoration: none;">H1 Receptor with Doxepin</ins>' scene='Insert optional scene name here' /></div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>Histamine receptors belong to class A of the GPCR superfamily(G protein‐coupled receptors) contain a bundle of seven antiparallel transmembrane helices. Histamine binds to these receptors as primary endogenous ligand. There are 4 known histamine receptors, H1, H2, H3 and H4. H1 receptor is expressed in It is expressed in smooth muscles, on vascular endothelial cells, in the heart, and in the central nervous system.The H1 receptor is linked to an intracellular G-protein (Gq) that activates phospholipase C and the inositol triphosphate (IP3) signalling pathway. Antihistamines, which act on this receptor, are used as anti-allergy drugs.The crystal structure of the histamine H 1 receptor was obtained in 2011 and is still the only structureof histaminergic receptor deposited in the Protein Data Bank( PDB ID: 3RZE). It shows the crystal structure of the H1 receptor complex with doxepin, a first-generation H1 receptor antagonist.Doxepin sits deep in the ligand-binding pocket and directly interacts with Trp 428, a highly conserved key residue in G-protein-coupled-receptor activation.This well-conserved pocket with mostly hydrophobic nature contributes to the low selectivity of the first-generation compounds. The pocket is associated with an anion-binding region occupied by a phosphate ion. Docking of various second-generation H(1)R antagonists reveals that the unique carboxyl group present in this class of compounds interacts with Lys 191(5.39) and/or Lys 179(ECL2), both of which form part of the anion-binding region. This region is not conserved in other aminergic receptors, demonstrating how minor differences in receptors lead to pronounced selectivity differences with small molecules.</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>Histamine receptors belong to class A of the GPCR superfamily(G protein‐coupled receptors) contain a bundle of seven antiparallel transmembrane helices. Histamine binds to these receptors as primary endogenous ligand. There are 4 known histamine receptors, H1, H2, H3 and H4. H1 receptor is expressed in It is expressed in smooth muscles, on vascular endothelial cells, in the heart, and in the central nervous system.The H1 receptor is linked to an intracellular G-protein (Gq) that activates phospholipase C and the inositol triphosphate (IP3) signalling pathway. Antihistamines, which act on this receptor, are used as anti-allergy drugs.The crystal structure of the histamine H 1 receptor was obtained in 2011 and is still the only structureof histaminergic receptor deposited in the Protein Data Bank( PDB ID: 3RZE). It shows the crystal structure of the H1 receptor complex with doxepin, a first-generation H1 receptor antagonist.Doxepin sits deep in the ligand-binding pocket and directly interacts with Trp 428, a highly conserved key residue in G-protein-coupled-receptor activation.This well-conserved pocket with mostly hydrophobic nature contributes to the low selectivity of the first-generation compounds. The pocket is associated with an anion-binding region occupied by a phosphate ion. Docking of various second-generation H(1)R antagonists reveals that the unique carboxyl group present in this class of compounds interacts with Lys 191(5.39) and/or Lys 179(ECL2), both of which form part of the anion-binding region. This region is not conserved in other aminergic receptors, demonstrating how minor differences in receptors lead to pronounced selectivity differences with small molecules.</div></td></tr> </table>

Snehalatha Kaliappan