Vitamin D receptor - Revision history

Alexander Berchansky at 13:10, 22 January 2024

2024-01-22T13:10:35Z

←Older revision		Revision as of 13:10, 22 January 2024
Line 3:		Line 3:
	'''Vitamin D receptor''' (<scene name='56/562378/Vit_d_receptor_3m7r/3'>VDR</scene>; also called calcitriol receptor) is a transcription factor. Upon binding to vitamin D, VDR forms a heterodimer with [[retinoid X receptor]] and binds to hormone response receptors on DNA causing gene expression. The <scene name='56/562378/Vit_d_receptor_ligand/1'>vitamin D hormone</scene> (in green) binds to receptors in its target cells, controlling the synthesis of many different proteins involved in calcium transport and utilization. <scene name='51/517370/Cv/2'>Vitamin D hormone binding site</scene>. <scene name='51/517370/Cv/3'>Vitamin D hormone is located in deep pocket</scene>. VDR contains two domains: a <scene name='56/562378/Lbd/1'>ligand binding domain (LBD)</scene> (see [[Nuclear receptors]]). that binds to the hormone (grey) and <scene name='56/562378/Dbd/2'>DNA-binding domain (DBD)</scene> that binds to DNA. (Green and blue are two same VDR structures). It pairs up with a similar protein, 9-cis retinoic acid receptor (RXR), and together they bind to the DNA, activating synthesis in some cases and repressing it in others<ref>PMID:11425573</ref>.		'''Vitamin D receptor''' (<scene name='56/562378/Vit_d_receptor_3m7r/3'>VDR</scene>; also called calcitriol receptor) is a transcription factor. Upon binding to vitamin D, VDR forms a heterodimer with [[retinoid X receptor]] and binds to hormone response receptors on DNA causing gene expression. The <scene name='56/562378/Vit_d_receptor_ligand/1'>vitamin D hormone</scene> (in green) binds to receptors in its target cells, controlling the synthesis of many different proteins involved in calcium transport and utilization. <scene name='51/517370/Cv/2'>Vitamin D hormone binding site</scene>. <scene name='51/517370/Cv/3'>Vitamin D hormone is located in deep pocket</scene>. VDR contains two domains: a <scene name='56/562378/Lbd/1'>ligand binding domain (LBD)</scene> (see [[Nuclear receptors]]). that binds to the hormone (grey) and <scene name='56/562378/Dbd/2'>DNA-binding domain (DBD)</scene> that binds to DNA. (Green and blue are two same VDR structures). It pairs up with a similar protein, 9-cis retinoic acid receptor (RXR), and together they bind to the DNA, activating synthesis in some cases and repressing it in others<ref>PMID:11425573</ref>.

-	See also [[Secosteroids]] ~~and~~ [[Intracellular receptors]]	+	See also [[Secosteroids]], [[Intracellular receptors]], and [[Calcipotriol]].

	<!--		<!--

Alexander Berchansky at 13:08, 22 January 2024

2024-01-22T13:08:02Z

←Older revision		Revision as of 13:08, 22 January 2024
Line 1:		Line 1:
	<StructureSection load='1db1' size='350' side='right' caption='Structure of human vitamin D receptor ligand-binding domain complex with vitamin D (PDB entry [[1db1]])' scene=''>		<StructureSection load='1db1' size='350' side='right' caption='Structure of human vitamin D receptor ligand-binding domain complex with vitamin D (PDB entry [[1db1]])' scene=''>
	== Introduction ==		== Introduction ==
-	'''Vitamin D receptor''' (<scene name='56/562378/Vit_d_receptor_3m7r/3'>VDR</scene>; also called calcitriol receptor) is a transcription factor. Upon binding to vitamin D, VDR forms a heterodimer with r[[~~etinoid~~ X receptor]] and binds to hormone response receptors on DNA causing gene expression. The <scene name='56/562378/Vit_d_receptor_ligand/1'>vitamin D hormone</scene> (in green) binds to receptors in its target cells, controlling the synthesis of many different proteins involved in calcium transport and utilization. <scene name='51/517370/Cv/2'>Vitamin D hormone binding site</scene>. <scene name='51/517370/Cv/3'>Vitamin D hormone is located in deep pocket</scene>. VDR contains two domains: a <scene name='56/562378/Lbd/1'>ligand binding domain (LBD)</scene> (see [[Nuclear receptors]]). that binds to the hormone (grey) and <scene name='56/562378/Dbd/2'>DNA-binding domain (DBD)</scene> that binds to DNA. (Green and blue are two same VDR structures). It pairs up with a similar protein, 9-cis retinoic acid receptor (RXR), and together they bind to the DNA, activating synthesis in some cases and repressing it in others<ref>PMID:11425573</ref>.	+	'''Vitamin D receptor''' (<scene name='56/562378/Vit_d_receptor_3m7r/3'>VDR</scene>; also called calcitriol receptor) is a transcription factor. Upon binding to vitamin D, VDR forms a heterodimer with [[retinoid X receptor]] and binds to hormone response receptors on DNA causing gene expression. The <scene name='56/562378/Vit_d_receptor_ligand/1'>vitamin D hormone</scene> (in green) binds to receptors in its target cells, controlling the synthesis of many different proteins involved in calcium transport and utilization. <scene name='51/517370/Cv/2'>Vitamin D hormone binding site</scene>. <scene name='51/517370/Cv/3'>Vitamin D hormone is located in deep pocket</scene>. VDR contains two domains: a <scene name='56/562378/Lbd/1'>ligand binding domain (LBD)</scene> (see [[Nuclear receptors]]). that binds to the hormone (grey) and <scene name='56/562378/Dbd/2'>DNA-binding domain (DBD)</scene> that binds to DNA. (Green and blue are two same VDR structures). It pairs up with a similar protein, 9-cis retinoic acid receptor (RXR), and together they bind to the DNA, activating synthesis in some cases and repressing it in others<ref>PMID:11425573</ref>.

	See also [[Secosteroids]] and [[Intracellular receptors]]		See also [[Secosteroids]] and [[Intracellular receptors]]

Alexander Berchansky at 13:07, 22 January 2024

2024-01-22T13:07:03Z

←Older revision		Revision as of 13:07, 22 January 2024
Line 1:		Line 1:
	<StructureSection load='1db1' size='350' side='right' caption='Structure of human vitamin D receptor ligand-binding domain complex with vitamin D (PDB entry [[1db1]])' scene=''>		<StructureSection load='1db1' size='350' side='right' caption='Structure of human vitamin D receptor ligand-binding domain complex with vitamin D (PDB entry [[1db1]])' scene=''>
	== Introduction ==		== Introduction ==
-	'''Vitamin D receptor''' (<scene name='56/562378/Vit_d_receptor_3m7r/3'>VDR</scene>; also called calcitriol receptor) is a transcription factor. Upon binding to vitamin D, VDR forms a heterodimer with ~~retinoid-~~X receptor and binds to hormone response receptors on DNA causing gene expression. The <scene name='56/562378/Vit_d_receptor_ligand/1'>vitamin D hormone</scene> (in green) binds to receptors in its target cells, controlling the synthesis of many different proteins involved in calcium transport and utilization. <scene name='51/517370/Cv/2'>Vitamin D hormone binding site</scene>. <scene name='51/517370/Cv/3'>Vitamin D hormone is located in deep pocket</scene>. VDR contains two domains: a <scene name='56/562378/Lbd/1'>ligand binding domain (LBD)</scene> (see [[Nuclear receptors]]). that binds to the hormone (grey) and <scene name='56/562378/Dbd/2'>DNA-binding domain (DBD)</scene> that binds to DNA. (Green and blue are two same VDR structures). It pairs up with a similar protein, 9-cis retinoic acid receptor (RXR), and together they bind to the DNA, activating synthesis in some cases and repressing it in others<ref>PMID:11425573</ref>.	+	'''Vitamin D receptor''' (<scene name='56/562378/Vit_d_receptor_3m7r/3'>VDR</scene>; also called calcitriol receptor) is a transcription factor. Upon binding to vitamin D, VDR forms a heterodimer with r[[etinoid X receptor]] and binds to hormone response receptors on DNA causing gene expression. The <scene name='56/562378/Vit_d_receptor_ligand/1'>vitamin D hormone</scene> (in green) binds to receptors in its target cells, controlling the synthesis of many different proteins involved in calcium transport and utilization. <scene name='51/517370/Cv/2'>Vitamin D hormone binding site</scene>. <scene name='51/517370/Cv/3'>Vitamin D hormone is located in deep pocket</scene>. VDR contains two domains: a <scene name='56/562378/Lbd/1'>ligand binding domain (LBD)</scene> (see [[Nuclear receptors]]). that binds to the hormone (grey) and <scene name='56/562378/Dbd/2'>DNA-binding domain (DBD)</scene> that binds to DNA. (Green and blue are two same VDR structures). It pairs up with a similar protein, 9-cis retinoic acid receptor (RXR), and together they bind to the DNA, activating synthesis in some cases and repressing it in others<ref>PMID:11425573</ref>.

	See also [[Secosteroids]] and [[Intracellular receptors]]		See also [[Secosteroids]] and [[Intracellular receptors]]

Michal Harel at 09:37, 12 January 2023

2023-01-12T09:37:08Z

←Older revision		Revision as of 09:37, 12 January 2023
Line 3:		Line 3:
	'''Vitamin D receptor''' (<scene name='56/562378/Vit_d_receptor_3m7r/3'>VDR</scene>; also called calcitriol receptor) is a transcription factor. Upon binding to vitamin D, VDR forms a heterodimer with retinoid-X receptor and binds to hormone response receptors on DNA causing gene expression. The <scene name='56/562378/Vit_d_receptor_ligand/1'>vitamin D hormone</scene> (in green) binds to receptors in its target cells, controlling the synthesis of many different proteins involved in calcium transport and utilization. <scene name='51/517370/Cv/2'>Vitamin D hormone binding site</scene>. <scene name='51/517370/Cv/3'>Vitamin D hormone is located in deep pocket</scene>. VDR contains two domains: a <scene name='56/562378/Lbd/1'>ligand binding domain (LBD)</scene> (see [[Nuclear receptors]]). that binds to the hormone (grey) and <scene name='56/562378/Dbd/2'>DNA-binding domain (DBD)</scene> that binds to DNA. (Green and blue are two same VDR structures). It pairs up with a similar protein, 9-cis retinoic acid receptor (RXR), and together they bind to the DNA, activating synthesis in some cases and repressing it in others<ref>PMID:11425573</ref>.		'''Vitamin D receptor''' (<scene name='56/562378/Vit_d_receptor_3m7r/3'>VDR</scene>; also called calcitriol receptor) is a transcription factor. Upon binding to vitamin D, VDR forms a heterodimer with retinoid-X receptor and binds to hormone response receptors on DNA causing gene expression. The <scene name='56/562378/Vit_d_receptor_ligand/1'>vitamin D hormone</scene> (in green) binds to receptors in its target cells, controlling the synthesis of many different proteins involved in calcium transport and utilization. <scene name='51/517370/Cv/2'>Vitamin D hormone binding site</scene>. <scene name='51/517370/Cv/3'>Vitamin D hormone is located in deep pocket</scene>. VDR contains two domains: a <scene name='56/562378/Lbd/1'>ligand binding domain (LBD)</scene> (see [[Nuclear receptors]]). that binds to the hormone (grey) and <scene name='56/562378/Dbd/2'>DNA-binding domain (DBD)</scene> that binds to DNA. (Green and blue are two same VDR structures). It pairs up with a similar protein, 9-cis retinoic acid receptor (RXR), and together they bind to the DNA, activating synthesis in some cases and repressing it in others<ref>PMID:11425573</ref>.

-	See also [[Secosteroids]].	+	See also [[Secosteroids]] and [[Intracellular receptors]]

	<!--		<!--

Michal Harel at 09:42, 24 January 2022

2022-01-24T09:42:30Z

←Older revision		Revision as of 09:42, 24 January 2022
Line 2:		Line 2:
	== Introduction ==		== Introduction ==
	'''Vitamin D receptor''' (<scene name='56/562378/Vit_d_receptor_3m7r/3'>VDR</scene>; also called calcitriol receptor) is a transcription factor. Upon binding to vitamin D, VDR forms a heterodimer with retinoid-X receptor and binds to hormone response receptors on DNA causing gene expression. The <scene name='56/562378/Vit_d_receptor_ligand/1'>vitamin D hormone</scene> (in green) binds to receptors in its target cells, controlling the synthesis of many different proteins involved in calcium transport and utilization. <scene name='51/517370/Cv/2'>Vitamin D hormone binding site</scene>. <scene name='51/517370/Cv/3'>Vitamin D hormone is located in deep pocket</scene>. VDR contains two domains: a <scene name='56/562378/Lbd/1'>ligand binding domain (LBD)</scene> (see [[Nuclear receptors]]). that binds to the hormone (grey) and <scene name='56/562378/Dbd/2'>DNA-binding domain (DBD)</scene> that binds to DNA. (Green and blue are two same VDR structures). It pairs up with a similar protein, 9-cis retinoic acid receptor (RXR), and together they bind to the DNA, activating synthesis in some cases and repressing it in others<ref>PMID:11425573</ref>.		'''Vitamin D receptor''' (<scene name='56/562378/Vit_d_receptor_3m7r/3'>VDR</scene>; also called calcitriol receptor) is a transcription factor. Upon binding to vitamin D, VDR forms a heterodimer with retinoid-X receptor and binds to hormone response receptors on DNA causing gene expression. The <scene name='56/562378/Vit_d_receptor_ligand/1'>vitamin D hormone</scene> (in green) binds to receptors in its target cells, controlling the synthesis of many different proteins involved in calcium transport and utilization. <scene name='51/517370/Cv/2'>Vitamin D hormone binding site</scene>. <scene name='51/517370/Cv/3'>Vitamin D hormone is located in deep pocket</scene>. VDR contains two domains: a <scene name='56/562378/Lbd/1'>ligand binding domain (LBD)</scene> (see [[Nuclear receptors]]). that binds to the hormone (grey) and <scene name='56/562378/Dbd/2'>DNA-binding domain (DBD)</scene> that binds to DNA. (Green and blue are two same VDR structures). It pairs up with a similar protein, 9-cis retinoic acid receptor (RXR), and together they bind to the DNA, activating synthesis in some cases and repressing it in others<ref>PMID:11425573</ref>.
		+
		+	See also [[Secosteroids]].

	<!--		<!--

Alexander Berchansky at 11:19, 15 November 2021

2021-11-15T11:19:37Z

←Older revision		Revision as of 11:19, 15 November 2021
Line 1:		Line 1:
	<StructureSection load='1db1' size='350' side='right' caption='Structure of human vitamin D receptor ligand-binding domain complex with vitamin D (PDB entry [[1db1]])' scene=''>		<StructureSection load='1db1' size='350' side='right' caption='Structure of human vitamin D receptor ligand-binding domain complex with vitamin D (PDB entry [[1db1]])' scene=''>
	== Introduction ==		== Introduction ==
-	'''Vitamin D receptor''' (<scene name='56/562378/Vit_d_receptor_3m7r/3'>VDR</scene>) is a transcription factor. Upon binding to vitamin D, VDR forms a heterodimer with retinoid-X receptor and binds to hormone response receptors on DNA causing gene expression. The <scene name='56/562378/Vit_d_receptor_ligand/1'>vitamin D hormone</scene> (in green) binds to receptors in its target cells, controlling the synthesis of many different proteins involved in calcium transport and utilization. <scene name='51/517370/Cv/2'>Vitamin D hormone binding site</scene>. <scene name='51/517370/Cv/3'>Vitamin D hormone is located in deep pocket</scene>. VDR contains two domains: a <scene name='56/562378/Lbd/1'>ligand binding domain (LBD)</scene> (see [[Nuclear receptors]]). that binds to the hormone (grey) and <scene name='56/562378/Dbd/2'>DNA-binding domain (DBD)</scene> that binds to DNA. (Green and blue are two same VDR structures). It pairs up with a similar protein, 9-cis retinoic acid receptor (RXR), and together they bind to the DNA, activating synthesis in some cases and repressing it in others<ref>PMID:11425573</ref>.	+	'''Vitamin D receptor''' (<scene name='56/562378/Vit_d_receptor_3m7r/3'>VDR</scene>; also called calcitriol receptor) is a transcription factor. Upon binding to vitamin D, VDR forms a heterodimer with retinoid-X receptor and binds to hormone response receptors on DNA causing gene expression. The <scene name='56/562378/Vit_d_receptor_ligand/1'>vitamin D hormone</scene> (in green) binds to receptors in its target cells, controlling the synthesis of many different proteins involved in calcium transport and utilization. <scene name='51/517370/Cv/2'>Vitamin D hormone binding site</scene>. <scene name='51/517370/Cv/3'>Vitamin D hormone is located in deep pocket</scene>. VDR contains two domains: a <scene name='56/562378/Lbd/1'>ligand binding domain (LBD)</scene> (see [[Nuclear receptors]]). that binds to the hormone (grey) and <scene name='56/562378/Dbd/2'>DNA-binding domain (DBD)</scene> that binds to DNA. (Green and blue are two same VDR structures). It pairs up with a similar protein, 9-cis retinoic acid receptor (RXR), and together they bind to the DNA, activating synthesis in some cases and repressing it in others<ref>PMID:11425573</ref>.

	<!--		<!--

Alexander Berchansky at 16:46, 25 January 2021

2021-01-25T16:46:20Z

←Older revision		Revision as of 16:46, 25 January 2021
Line 1:		Line 1:
	<StructureSection load='1db1' size='350' side='right' caption='Structure of human vitamin D receptor ligand-binding domain complex with vitamin D (PDB entry [[1db1]])' scene=''>		<StructureSection load='1db1' size='350' side='right' caption='Structure of human vitamin D receptor ligand-binding domain complex with vitamin D (PDB entry [[1db1]])' scene=''>
	== Introduction ==		== Introduction ==
-	'''Vitamin D receptor''' (<scene name='56/562378/Vit_d_receptor_3m7r/3'>VDR</scene>) is a transcription factor. Upon binding to vitamin D, VDR forms a heterodimer with retinoid-X receptor and binds to hormone response receptors on DNA causing gene expression. The <scene name='56/562378/Vit_d_receptor_ligand/1'>vitamin D hormone</scene> (in green) binds to receptors in its target cells, controlling the synthesis of many different proteins involved in calcium transport and utilization. <scene name='51/517370/Cv/2'>Vitamin D hormone binding site</scene>. <scene name='51/517370/Cv/3'>Vitamin D hormone is located in deep pocket</scene>. VDR contains two domains: a <scene name='56/562378/Lbd/1'>ligand binding domain (LBD)</scene> (see [[Nuclear ~~receptor~~]]). that binds to the hormone (grey) and <scene name='56/562378/Dbd/2'>DNA-binding domain (DBD)</scene> that binds to DNA. (Green and blue are two same VDR structures). It pairs up with a similar protein, 9-cis retinoic acid receptor (RXR), and together they bind to the DNA, activating synthesis in some cases and repressing it in others<ref>PMID:11425573</ref>.	+	'''Vitamin D receptor''' (<scene name='56/562378/Vit_d_receptor_3m7r/3'>VDR</scene>) is a transcription factor. Upon binding to vitamin D, VDR forms a heterodimer with retinoid-X receptor and binds to hormone response receptors on DNA causing gene expression. The <scene name='56/562378/Vit_d_receptor_ligand/1'>vitamin D hormone</scene> (in green) binds to receptors in its target cells, controlling the synthesis of many different proteins involved in calcium transport and utilization. <scene name='51/517370/Cv/2'>Vitamin D hormone binding site</scene>. <scene name='51/517370/Cv/3'>Vitamin D hormone is located in deep pocket</scene>. VDR contains two domains: a <scene name='56/562378/Lbd/1'>ligand binding domain (LBD)</scene> (see [[Nuclear receptors]]). that binds to the hormone (grey) and <scene name='56/562378/Dbd/2'>DNA-binding domain (DBD)</scene> that binds to DNA. (Green and blue are two same VDR structures). It pairs up with a similar protein, 9-cis retinoic acid receptor (RXR), and together they bind to the DNA, activating synthesis in some cases and repressing it in others<ref>PMID:11425573</ref>.

	<!--		<!--

Michal Harel at 09:59, 27 March 2020

2020-03-27T09:59:33Z

←Older revision		Revision as of 09:59, 27 March 2020
Line 35:		Line 35:
	</StructureSection>		</StructureSection>

-	==3D structures of vitamin D receptor==
-
-	Updated on {{REVISIONDAY2}}-{{MONTHNAME\|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
-	{{#tree:id=OrganizedByTopic\|openlevels=0\|
-
-	*Vitamin D receptor ligand-binding domain residues 116-423
-
-	**[[3m7r]] - hVDR LBD (mutant) – human<br />
-	**[[1db1]] – hVDR LBD + vitamin D <br />
-	**[[3ogt]], [[2ham]], [[2har]], [[2has]], [[2hb7]], [[2hb8]], [[3p8x]], [[3az1]], [[3az2]], [[3az3]], [[3tkc]], [[1s0z]], [[1s19]], [[3a78]], [[4g2i]] - hVDR LBD + vitamin D analog<br />
-	**[[3auq]], [[3aur]], [[3kpz]], [[3x36]], [[3x31]], [[4ynk]], [[3a2i]], [[3a2j]], [[3b0t]], [[3ax8]], [[3vhw]] - hVDR LBD (mutant) + vitamin D analog<br />
-	**[[3a3z]], [[3a40]] - hVDR LBD + agonist<br />
-	**[[1ie8]], [[1ie9]], [[3cs4]], [[3cs6]], [[1txi]] – hVDR LBD + superagonist <br />
-	**[[3w5q]], [[3w5r]], [[3w5t]] - hVDR LBD + lithocholic acid derivative <br />
-	**[[5gt4]] - hVDR LBD + secocholesta derivative <br />
-	**[[5v39]] - hVDR LBD + VDRM <br />
-	**[[5xuq]], [[5ysy]], [[5yt2]] - hVDR LBD + antagonist <br />
-
-	*Vitamin D receptor LBD binary complex with peptide
-
-	**[[1rjk]], [[1rk3]], [[1rkg]], [[1rkh]], [[2o4j]], [[2o4r]] – rVDR LBD (mutant) + peroxisome proliferator-activated receptor peptide – rat<br />
-	**[[2zfx]], [[3a2h]], [[2zxm]], [[2zxn]] - rVDR LBD + coactivator peptide DRIP<br />
-	**[[3aun]], [[2zmh]], [[2zmi]], [[2zmj]], [[3afr]], [[3vjs]], [[3vjt]], [[5zwe]], [[5zwf]], [[5zwh]] - rVDR LBD (mutant) + coactivator peptide DRIP<br />
-	**[[5gic]], [[5gid]], [[5gie]] - rVDR LBD + steroid receptor coactivator 1 peptide <br />
-	**[[5h1e]] - rVDR LBD + NCOA-2 peptide <br />
-	**[[2hbh]], [[2hcd]] - zVDR LBD + steroid receptor coactivator 1 peptide – zebrafish<br />
-	**[[5nky]], [[5nma]], [[5nmb]], [[5ow9]], [[5owd]] - zVDR LBD + NCOA-1 peptide derivative<br />
-	**[[4ruj]], [[4rup]] - zVDR LBD (mutant) + NCOA-1 peptide <br />
-	**[[5lga]] - zVDR LBD + NCOA-2 peptide <br />
-	**[[4roj]] - zVDR LBD (mutant) + NCOA-2 peptide <br />
-
-	*Vitamin D receptor LBD ternary complex with peptide
-
-	**[[2zl9]], [[2zla]], [[2zlc]] - rVDR LBD + coactivator peptide DRIP + vitamin D analog<br />
-	**[[3vrt]], [[3vru]], [[3vrv]], [[3vrw]] - rVDR LBD (mutant) + coactivator peptide DRIP + vitamin D analog<br />
-	**[[5zwi]] - rVDR LBD + coactivator peptide DRIP + ligand<br />
-	**[[3w0g]], [[3w0h]], [[3w0i]], [[3w0j]] - rVDR LBD + mediator of RNA polymerase II peptide + nonsecosteroidal ligand<br />
-	**[[3w5p]] - rVDR LBD + mediator of RNA polymerase II peptide + lithocholic acid derivative<br />
-	**[[6k5o]] - rVDR LBD (mutant) + mediator of RNA polymerase II peptide + lithocholic acid derivative<br />
-	**[[6jez]] - rVDR LBD + mediator of RNA polymerase II peptide + fluorescence probe<br />
-	**[[3wt5]], [[3wt6]], [[3wt7]], [[3wtq]], [[5b41]], [[5b5b]], [[5xzf]], [[5xzh]] - rVDR LBD + mediator of RNA polymerase II peptide + vitamin D analog<br />
-	**[[5awj]], [[5awk]] - rVDR LBD + mediator of RNA polymerase II peptide + agonist<br />
-	**[[5xpl]], [[5xpm]], [[5xpn]], [[5xpo]], [[5xpp]] - rVDR LBD + NCOA-2 peptide + vitamin D analog<br />
-	**[[2hc4]], [[5e7v]], [[6f0b]] - zVDR LBD + steroid receptor coactivator 1 peptide + vitamin D derivative<br />
-	**[[6fo7]], [[6fo8]], [[6fo9]], [[6fod]] - zVDR LBD + NCOA-1 peptide + agonist<br />
-	**[[5ow7]] - zVDR LBD + NCOA-1 peptide + vitamin D analog<br />
-
-	*Vitamin D receptor DNA-binding domain 16-125
-
-	**[[1kb2]] – hVDR DBD + osteopontin response element DNA<br />
-	**[[1kb4]] – hVDR DBD + DR3 response element DNA<br />
-	**[[1ynw]] – hVDR DBD (mutant) + DR3 response element DNA<br />
-	**[[1kb6]] – hVDR DBD + osteocalcin response element DNA<br />
-	}}
	==References==		==References==
	<references />		<references />
	[[Category:Topic Page]]		[[Category:Topic Page]]

Michal Harel at 09:58, 27 March 2020

2020-03-27T09:58:20Z

←Older revision		Revision as of 09:58, 27 March 2020
Line 31:		Line 31:
	==About this Structure==		==About this Structure==
	[[1db1]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DB1 OCA]. On right hand side is Structure of human vitamin D receptor ligand-binding domain complex with vitamin D (PDB entry [[1db1]]).		[[1db1]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DB1 OCA]. On right hand side is Structure of human vitamin D receptor ligand-binding domain complex with vitamin D (PDB entry [[1db1]]).
		+	==3D structures of vitamin D receptor==
		+	[[Vitamin D receptor 3D structures]]
	</StructureSection>		</StructureSection>

Line 38:		Line 40:
	{{#tree:id=OrganizedByTopic\|openlevels=0\|		{{#tree:id=OrganizedByTopic\|openlevels=0\|

-	*Vitamin D receptor ligand-binding domain	+	*Vitamin D receptor ligand-binding domain residues 116-423

	**[[3m7r]] - hVDR LBD (mutant) – human<br />		**[[3m7r]] - hVDR LBD (mutant) – human<br />
Line 71:		Line 73:
	**[[3w0g]], [[3w0h]], [[3w0i]], [[3w0j]] - rVDR LBD + mediator of RNA polymerase II peptide + nonsecosteroidal ligand<br />		**[[3w0g]], [[3w0h]], [[3w0i]], [[3w0j]] - rVDR LBD + mediator of RNA polymerase II peptide + nonsecosteroidal ligand<br />
	**[[3w5p]] - rVDR LBD + mediator of RNA polymerase II peptide + lithocholic acid derivative<br />		**[[3w5p]] - rVDR LBD + mediator of RNA polymerase II peptide + lithocholic acid derivative<br />
		+	**[[6k5o]] - rVDR LBD (mutant) + mediator of RNA polymerase II peptide + lithocholic acid derivative<br />
		+	**[[6jez]] - rVDR LBD + mediator of RNA polymerase II peptide + fluorescence probe<br />
	**[[3wt5]], [[3wt6]], [[3wt7]], [[3wtq]], [[5b41]], [[5b5b]], [[5xzf]], [[5xzh]] - rVDR LBD + mediator of RNA polymerase II peptide + vitamin D analog<br />		**[[3wt5]], [[3wt6]], [[3wt7]], [[3wtq]], [[5b41]], [[5b5b]], [[5xzf]], [[5xzh]] - rVDR LBD + mediator of RNA polymerase II peptide + vitamin D analog<br />
	**[[5awj]], [[5awk]] - rVDR LBD + mediator of RNA polymerase II peptide + agonist<br />		**[[5awj]], [[5awk]] - rVDR LBD + mediator of RNA polymerase II peptide + agonist<br />
Line 78:		Line 82:
	**[[5ow7]] - zVDR LBD + NCOA-1 peptide + vitamin D analog<br />		**[[5ow7]] - zVDR LBD + NCOA-1 peptide + vitamin D analog<br />

-	*Vitamin D receptor DNA-binding domain	+	*Vitamin D receptor DNA-binding domain 16-125

	**[[1kb2]] – hVDR DBD + osteopontin response element DNA<br />		**[[1kb2]] – hVDR DBD + osteopontin response element DNA<br />

Michal Harel at 11:12, 23 January 2019

2019-01-23T11:12:25Z

←Older revision		Revision as of 11:12, 23 January 2019
Line 1:		Line 1:
	<StructureSection load='1db1' size='350' side='right' caption='Structure of human vitamin D receptor ligand-binding domain complex with vitamin D (PDB entry [[1db1]])' scene=''>		<StructureSection load='1db1' size='350' side='right' caption='Structure of human vitamin D receptor ligand-binding domain complex with vitamin D (PDB entry [[1db1]])' scene=''>
	== Introduction ==		== Introduction ==
-	'''Vitamin D receptor''' (<scene name='56/562378/Vit_d_receptor_3m7r/3'>VDR</scene>) is a transcription factor. Upon binding to vitamin D, VDR forms a heterodimer with retinoid-X receptor and binds to hormone response receptors on DNA causing gene expression. The <scene name='56/562378/Vit_d_receptor_ligand/1'>vitamin D hormone</scene> (in green) binds to receptors in its target cells, controlling the synthesis of many different proteins involved in calcium transport and utilization. <scene name='51/517370/Cv/2'>Vitamin D hormone binding site</scene>. <scene name='51/517370/Cv/3'>Vitamin D hormone is located in deep pocket</scene>. VDR contains two domains: a <scene name='56/562378/Lbd/1'>ligand binding domain (LBD)</scene> that binds to the hormone (grey) and <scene name='56/562378/Dbd/2'>DNA-binding domain (DBD)</scene> that binds to DNA. (Green and blue are two same VDR structures). It pairs up with a similar protein, 9-cis retinoic acid receptor (RXR), and together they bind to the DNA, activating synthesis in some cases and repressing it in others<ref>PMID:11425573</ref>.	+	'''Vitamin D receptor''' (<scene name='56/562378/Vit_d_receptor_3m7r/3'>VDR</scene>) is a transcription factor. Upon binding to vitamin D, VDR forms a heterodimer with retinoid-X receptor and binds to hormone response receptors on DNA causing gene expression. The <scene name='56/562378/Vit_d_receptor_ligand/1'>vitamin D hormone</scene> (in green) binds to receptors in its target cells, controlling the synthesis of many different proteins involved in calcium transport and utilization. <scene name='51/517370/Cv/2'>Vitamin D hormone binding site</scene>. <scene name='51/517370/Cv/3'>Vitamin D hormone is located in deep pocket</scene>. VDR contains two domains: a <scene name='56/562378/Lbd/1'>ligand binding domain (LBD)</scene> (see [[Nuclear receptor]]). that binds to the hormone (grey) and <scene name='56/562378/Dbd/2'>DNA-binding domain (DBD)</scene> that binds to DNA. (Green and blue are two same VDR structures). It pairs up with a similar protein, 9-cis retinoic acid receptor (RXR), and together they bind to the DNA, activating synthesis in some cases and repressing it in others<ref>PMID:11425573</ref>.

	<!--		<!--

-	===Crystal Structure of the nuclear receptor for ~~Vitamnin~~ D complexed to Vitamin D===	+	===Crystal Structure of the nuclear receptor for Vitamin D complexed to Vitamin D===

	{{ABSTRACT_PUBMED_10678179}}		{{ABSTRACT_PUBMED_10678179}}