177d - Revision history

OCA at 11:31, 22 November 2023

OCA — Wed, 22 Nov 2023 11:31:47 GMT

←Older revision		Revision as of 11:31, 22 November 2023
Line 1:		Line 1:

	==SOLUTION STRUCTURE AND HYDRATION PATTERNS OF A PYRIMIDINE(DOT)PURINE(DOT)PYRIMIDINE DNA TRIPLEX CONTAINING A NOVEL T(DOT)CG TRIPLE==		==SOLUTION STRUCTURE AND HYDRATION PATTERNS OF A PYRIMIDINE(DOT)PURINE(DOT)PYRIMIDINE DNA TRIPLEX CONTAINING A NOVEL T(DOT)CG TRIPLE==
-	<StructureSection load='177d' size='340' side='right'caption='[[177d~~]], [[NMR_Ensembles_of_Models \| 6 NMR models~~]]' scene=''>	+	<StructureSection load='177d' size='340' side='right'caption='[[177d]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[177d]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=177D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=177D FirstGlance]. <br>		<table><tr><td colspan='2'>[[177d]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=177D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=177D FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=177d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=177d OCA], [https://pdbe.org/177d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=177d RCSB], [https://www.ebi.ac.uk/pdbsum/177d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=177d ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=177d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=177d OCA], [https://pdbe.org/177d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=177d RCSB], [https://www.ebi.ac.uk/pdbsum/177d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=177d ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 20:		Line 21:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Patel~~, D J~~]]	+	[[Category: Patel DJ]]
-	[[Category: Radhakrishnan, I]]	+	[[Category: Radhakrishnan I]]
-	~~[[Category: Dna]]~~	+
-	~~[[Category: Triplex~~]]	+

OCA at 10:14, 17 February 2021

OCA — Wed, 17 Feb 2021 10:14:24 GMT

←Older revision		Revision as of 10:14, 17 February 2021
Line 3:		Line 3:
	<StructureSection load='177d' size='340' side='right'caption='[[177d]], [[NMR_Ensembles_of_Models \| 6 NMR models]]' scene=''>		<StructureSection load='177d' size='340' side='right'caption='[[177d]], [[NMR_Ensembles_of_Models \| 6 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[177d]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=177D OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=177D FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[177d]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=177D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=177D FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=177d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=177d OCA], [~~http~~://pdbe.org/177d PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=177d RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/177d PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=177d ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=177d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=177d OCA], [https://pdbe.org/177d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=177d RCSB], [https://www.ebi.ac.uk/pdbsum/177d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=177d ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 14:06, 10 May 2019

OCA — Fri, 10 May 2019 14:06:23 GMT

←Older revision		Revision as of 14:06, 10 May 2019
Line 1:		Line 1:

	==SOLUTION STRUCTURE AND HYDRATION PATTERNS OF A PYRIMIDINE(DOT)PURINE(DOT)PYRIMIDINE DNA TRIPLEX CONTAINING A NOVEL T(DOT)CG TRIPLE==		==SOLUTION STRUCTURE AND HYDRATION PATTERNS OF A PYRIMIDINE(DOT)PURINE(DOT)PYRIMIDINE DNA TRIPLEX CONTAINING A NOVEL T(DOT)CG TRIPLE==
-	<StructureSection load='177d' size='340' side='right' caption='[[177d]], [[NMR_Ensembles_of_Models \| 6 NMR models]]' scene=''>	+	<StructureSection load='177d' size='340' side='right'caption='[[177d]], [[NMR_Ensembles_of_Models \| 6 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[177d]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=177D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=177D FirstGlance]. <br>		<table><tr><td colspan='2'>[[177d]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=177D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=177D FirstGlance]. <br>
Line 19:		Line 19:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Patel, D J]]		[[Category: Patel, D J]]
	[[Category: Radhakrishnan, I]]		[[Category: Radhakrishnan, I]]
	[[Category: Dna]]		[[Category: Dna]]
	[[Category: Triplex]]		[[Category: Triplex]]

OCA at 09:14, 9 August 2017

OCA — Wed, 09 Aug 2017 09:14:50 GMT

←Older revision		Revision as of 09:14, 9 August 2017
Line 1:		Line 1:
		+
	==SOLUTION STRUCTURE AND HYDRATION PATTERNS OF A PYRIMIDINE(DOT)PURINE(DOT)PYRIMIDINE DNA TRIPLEX CONTAINING A NOVEL T(DOT)CG TRIPLE==		==SOLUTION STRUCTURE AND HYDRATION PATTERNS OF A PYRIMIDINE(DOT)PURINE(DOT)PYRIMIDINE DNA TRIPLEX CONTAINING A NOVEL T(DOT)CG TRIPLE==
	<StructureSection load='177d' size='340' side='right' caption='[[177d]], [[NMR_Ensembles_of_Models \| 6 NMR models]]' scene=''>		<StructureSection load='177d' size='340' side='right' caption='[[177d]], [[NMR_Ensembles_of_Models \| 6 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[177d]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=177D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=177D FirstGlance]. <br>		<table><tr><td colspan='2'>[[177d]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=177D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=177D FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=177d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=177d OCA], [http://pdbe.org/177d PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=177d RCSB], [http://www.ebi.ac.uk/pdbsum/177d PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=177d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=177d OCA], [http://pdbe.org/177d PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=177d RCSB], [http://www.ebi.ac.uk/pdbsum/177d PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=177d ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 15:48, 9 September 2015

OCA — Wed, 09 Sep 2015 15:48:52 GMT

←Older revision		Revision as of 15:48, 9 September 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[177d]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=177D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=177D FirstGlance]. <br>		<table><tr><td colspan='2'>[[177d]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=177D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=177D FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=177d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=177d OCA], [http://www.rcsb.org/pdb/explore.do?structureId=177d RCSB], [http://www.ebi.ac.uk/pdbsum/177d PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=177d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=177d OCA], [http://pdbe.org/177d PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=177d RCSB], [http://www.ebi.ac.uk/pdbsum/177d PDBsum]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 13:		Line 13:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 177d" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 09:37, 22 December 2014

OCA — Mon, 22 Dec 2014 09:37:08 GMT

←Older revision		Revision as of 09:37, 22 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[177d]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=177D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=177D FirstGlance]. <br>		<table><tr><td colspan='2'>[[177d]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=177D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=177D FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=177d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=177d OCA], [http://www.rcsb.org/pdb/explore.do?structureId=177d RCSB], [http://www.ebi.ac.uk/pdbsum/177d PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=177d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=177d OCA], [http://www.rcsb.org/pdb/explore.do?structureId=177d RCSB], [http://www.ebi.ac.uk/pdbsum/177d PDBsum]</span></td></tr>
-	<table>	+	</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 17:		Line 17:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Patel, D J.]]	+	[[Category: Patel, D J]]
-	[[Category: Radhakrishnan, I.]]	+	[[Category: Radhakrishnan, I]]
	[[Category: Dna]]		[[Category: Dna]]
	[[Category: Triplex]]		[[Category: Triplex]]

OCA at 05:37, 8 June 2014

OCA — Sun, 08 Jun 2014 05:37:35 GMT

←Older revision		Revision as of 05:37, 8 June 2014
Line 1:		Line 1:
-	[[~~Image~~:177d.~~png\|left\|200px~~]]	+	==SOLUTION STRUCTURE AND HYDRATION PATTERNS OF A PYRIMIDINE(DOT)PURINE(DOT)PYRIMIDINE DNA TRIPLEX CONTAINING A NOVEL T(DOT)CG TRIPLE==
		+	<StructureSection load='177d' size='340' side='right' caption='[[177d]], [[NMR_Ensembles_of_Models \| 6 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[177d]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=177D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=177D FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=177d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=177d OCA], [http://www.rcsb.org/pdb/explore.do?structureId=177d RCSB], [http://www.ebi.ac.uk/pdbsum/177d PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The solution structure of a pyrimidine.purine.pyrimidine DNA triplex containing a novel T.CG base-triple has been determined via two and three-dimensional NMR spectroscopy and restrained molecular dynamics simulations incorporating explicit solvent and counter-ions. The T.CG triple, which expands the triplex code, is stabilized by a single hydrogen bond between the O-2 atom of thymine and the free amino proton of cytosine in the Watson-Crick C.G base-pair. This hydrogen bonding alignment produces large variations in helical twist at the dinucleotide steps involving the thymine residue. Localized structural perturbations in the purine-rich strand of the molecule are observed around the cytosine residue in the T.CG triple. Globally, the triplex resembles the solution structure of a previously solved pyrimidine.purine.pyrimidine DNA triplex containing an unusual G.TA triple. Also conserved are the sites and patterns of hydration in the two triplexes.

-	~~{{STRUCTURE_177d\| PDB=177d \| SCENE= }}~~	+	Solution structure and hydration patterns of a pyrimidine.purine.pyrimidine DNA triplex containing a novel T.CG base-triple.,Radhakrishnan I, Patel DJ J Mol Biol. 1994 Aug 26;241(4):600-19. PMID:8057381<ref>PMID:8057381</ref>

-	~~===SOLUTION STRUCTURE AND HYDRATION PATTERNS OF A PYRIMIDINE(DOT)PURINE(DOT)PYRIMIDINE DNA TRIPLEX CONTAINING A NOVEL T(DOT)CG TRIPLE===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_8057381}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[177d]] is~~ a ~~1 chain structure~~. ~~Full experimental information is available from [http://oca~~.~~weizmann~~.~~ac.il~~/~~oca-bin/ocashort?id=177D OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:008057381<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Patel, D J.]]		[[Category: Patel, D J.]]
	[[Category: Radhakrishnan, I.]]		[[Category: Radhakrishnan, I.]]
	[[Category: Dna]]		[[Category: Dna]]
	[[Category: Triplex]]		[[Category: Triplex]]

OCA: Protected "177d" [edit=sysop:move=sysop]

OCA — Tue, 14 Aug 2012 17:28:54 GMT

Protected "177d" [edit=sysop:move=sysop]

←Older revision

Revision as of 17:28, 14 August 2012

OCA at 17:28, 14 August 2012

OCA — Tue, 14 Aug 2012 17:28:52 GMT

←Older revision		Revision as of 17:28, 14 August 2012
Line 1:		Line 1:
-	{{Seed}}
	[[Image:177d.png\|left\|200px]]		[[Image:177d.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_177d", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_177d\| PDB=177d \| SCENE= }}		{{STRUCTURE_177d\| PDB=177d \| SCENE= }}

	===SOLUTION STRUCTURE AND HYDRATION PATTERNS OF A PYRIMIDINE(DOT)PURINE(DOT)PYRIMIDINE DNA TRIPLEX CONTAINING A NOVEL T(DOT)CG TRIPLE===		===SOLUTION STRUCTURE AND HYDRATION PATTERNS OF A PYRIMIDINE(DOT)PURINE(DOT)PYRIMIDINE DNA TRIPLEX CONTAINING A NOVEL T(DOT)CG TRIPLE===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_8057381}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 8057381 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_8057381}}		{{ABSTRACT_PUBMED_8057381}}

	==About this Structure==		==About this Structure==
-	Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=177D OCA].	+	[[177d]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=177D OCA].

	==Reference==		==Reference==
-	~~Solution structure and hydration patterns of a pyrimidine.purine.pyrimidine DNA triplex containing a novel T.CG base-triple., Radhakrishnan I, Patel DJ, J Mol Biol. 1994 Aug 26;241(4):600-19.~~ PMID:~~[http://www.ncbi.nlm.nih.gov~~/~~pubmed~~/~~8057381 8057381]~~	+	<ref group="xtra">PMID:008057381</ref><references group="xtra"/>
	[[Category: Patel, D J.]]		[[Category: Patel, D J.]]
	[[Category: Radhakrishnan, I.]]		[[Category: Radhakrishnan, I.]]
	[[Category: Dna]]		[[Category: Dna]]
-	[[Category: Nmr]]
	[[Category: Triplex]]		[[Category: Triplex]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 15:36:32 2008''

OCA at 12:36, 30 June 2008

OCA — Mon, 30 Jun 2008 12:36:36 GMT

←Older revision		Revision as of 12:36, 30 June 2008
Line 1:		Line 1:
-	[[Image:177d.~~jpg~~\|left\|200px]]	+	{{Seed}}
		+	[[Image:177d.png\|left\|200px]]

	<!--		<!--
Line 9:		Line 10:
	{{STRUCTURE_177d\| PDB=177d \| SCENE= }}		{{STRUCTURE_177d\| PDB=177d \| SCENE= }}

-	~~'''~~SOLUTION STRUCTURE AND HYDRATION PATTERNS OF A PYRIMIDINE(DOT)PURINE(DOT)PYRIMIDINE DNA TRIPLEX CONTAINING A NOVEL T(DOT)CG TRIPLE~~'''~~	+	===SOLUTION STRUCTURE AND HYDRATION PATTERNS OF A PYRIMIDINE(DOT)PURINE(DOT)PYRIMIDINE DNA TRIPLEX CONTAINING A NOVEL T(DOT)CG TRIPLE===


-	~~==Overview==~~	+	<!--
-	~~The solution structure of a pyrimidine.purine.pyrimidine DNA triplex containing a novel T.CG base~~-~~triple has been determined via two and three~~-~~dimensional NMR spectroscopy and restrained molecular dynamics simulations incorporating explicit solvent and counter-ions.~~ The ~~T.CG triple~~, ~~which expands the triplex code~~, ~~is stabilized by a single hydrogen bond between~~ the ~~O-2 atom of thymine and~~ the ~~free amino proton of cytosine in the Watson-Crick C.G base-pair. This hydrogen bonding alignment produces large variations in helical twist~~ at ~~the dinucleotide steps involving the thymine residue. Localized structural perturbations in the purine-rich strand of the molecule are observed around the cytosine residue in the T~~.~~CG triple~~. ~~Globally~~, the triplex resembles the solution structure of a previously solved pyrimidine.purine.pyrimidine DNA triplex containing an unusual G.TA triple. Also conserved are the sites and patterns of hydration in the two triplexes.	+	The line below this paragraph, {{ABSTRACT_PUBMED_8057381}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 8057381 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_8057381}}

	==About this Structure==		==About this Structure==
-	Full ~~crystallographic~~ information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=177D OCA].	+	Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=177D OCA].

	==Reference==		==Reference==
Line 25:		Line 29:
	[[Category: Nmr]]		[[Category: Nmr]]
	[[Category: Triplex]]		[[Category: Triplex]]
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Fri May 2 09~~:33:23 2008''	+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 15:36:32 2008''