1a3f - Revision history

OCA at 10:45, 2 August 2023

OCA — Wed, 02 Aug 2023 10:45:29 GMT

←Older revision		Revision as of 10:45, 2 August 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1a3f]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Naja_naja Naja naja]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A3F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1A3F FirstGlance]. <br>		<table><tr><td colspan='2'>[[1a3f]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Naja_naja Naja naja]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A3F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1A3F FirstGlance]. <br>
-	</td></tr><tr id='~~activity~~'><td class="sblockLbl"><b>~~Activity~~:</b></td><td class="sblockDat"~~><span class~~=~~'plainlinks'~~>[~~https://en.wikipedia.org/wiki/Phospholipase_A(~~2~~) Phospholipase A(2)], with EC number [https://www~~.~~brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.4 3.1.1.4] </span>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.65Å</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1a3f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1a3f OCA], [https://pdbe.org/1a3f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1a3f RCSB], [https://www.ebi.ac.uk/pdbsum/1a3f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1a3f ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1a3f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1a3f OCA], [https://pdbe.org/1a3f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1a3f RCSB], [https://www.ebi.ac.uk/pdbsum/1a3f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1a3f ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/PA2A2_NAJNA PA2A2_NAJNA]] PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.	+	[https://www.uniprot.org/uniprot/PA2A2_NAJNA PA2A2_NAJNA] PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 37:		Line 37:
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Naja naja]]		[[Category: Naja naja]]
-	[[Category: Chee, R]]	+	[[Category: Chee R]]
-	[[Category: Dennis~~, E A~~]]	+	[[Category: Dennis EA]]
-	[[Category: Nguyen, D]]	+	[[Category: Nguyen D]]
-	[[Category: Segelke~~, B W~~]]	+	[[Category: Segelke BW]]
-	[[Category: Xuong~~, H N]]~~	+	[[Category: Xuong HN]]
-	~~[[Category: Activator site]]~~	+
-	~~[[Category: Calcium binding]]~~	+
-	~~[[Category: Carboxylic ester hydrolase]]~~	+
-	~~[[Category: Phospholipase]]~~	+
-	~~[[Category: Trimer~~]]	+

OCA at 09:41, 26 May 2021

OCA — Wed, 26 May 2021 09:41:49 GMT

←Older revision		Revision as of 09:41, 26 May 2021
Line 3:		Line 3:
	<StructureSection load='1a3f' size='340' side='right'caption='[[1a3f]], [[Resolution\|resolution]] 2.65Å' scene=''>		<StructureSection load='1a3f' size='340' side='right'caption='[[1a3f]], [[Resolution\|resolution]] 2.65Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1a3f]] is a 3 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Naja_naja Naja naja]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A3F OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1A3F FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1a3f]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Naja_naja Naja naja]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A3F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1A3F FirstGlance]. <br>
-	</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Phospholipase_A(2) Phospholipase A(2)], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.4 3.1.1.4] </span></td></tr>	+	</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Phospholipase_A(2) Phospholipase A(2)], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.4 3.1.1.4] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1a3f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1a3f OCA], [~~http~~://pdbe.org/1a3f PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1a3f RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1a3f PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1a3f ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1a3f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1a3f OCA], [https://pdbe.org/1a3f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1a3f RCSB], [https://www.ebi.ac.uk/pdbsum/1a3f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1a3f ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/PA2A2_NAJNA PA2A2_NAJNA]] PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.	+	[[https://www.uniprot.org/uniprot/PA2A2_NAJNA PA2A2_NAJNA]] PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 30:		Line 30:

	==See Also==		==See Also==
-	*[[Phospholipase A2\|Phospholipase A2]]	+	*[[Phospholipase A2 3D structures\|Phospholipase A2 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 07:14, 21 August 2019

OCA — Wed, 21 Aug 2019 07:14:05 GMT

←Older revision		Revision as of 07:14, 21 August 2019
Line 1:		Line 1:

	==PHOSPHOLIPASE A2 (PLA2) FROM NAJA NAJA VENOM==		==PHOSPHOLIPASE A2 (PLA2) FROM NAJA NAJA VENOM==
-	<StructureSection load='1a3f' size='340' side='right' caption='[[1a3f]], [[Resolution\|resolution]] 2.65Å' scene=''>	+	<StructureSection load='1a3f' size='340' side='right'caption='[[1a3f]], [[Resolution\|resolution]] 2.65Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1a3f]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Naja_naja Naja naja]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A3F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1A3F FirstGlance]. <br>		<table><tr><td colspan='2'>[[1a3f]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Naja_naja Naja naja]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A3F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1A3F FirstGlance]. <br>
Line 13:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/a3/1a3f_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/a3/1a3f_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 28:		Line 28:
	</div>		</div>
	<div class="pdbe-citations 1a3f" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1a3f" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Phospholipase A2\|Phospholipase A2]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Naja naja]]		[[Category: Naja naja]]
	[[Category: Chee, R]]		[[Category: Chee, R]]

OCA at 10:42, 15 November 2017

OCA — Wed, 15 Nov 2017 10:42:00 GMT

←Older revision		Revision as of 10:42, 15 November 2017
Line 1:		Line 1:
		+
	==PHOSPHOLIPASE A2 (PLA2) FROM NAJA NAJA VENOM==		==PHOSPHOLIPASE A2 (PLA2) FROM NAJA NAJA VENOM==
	<StructureSection load='1a3f' size='340' side='right' caption='[[1a3f]], [[Resolution\|resolution]] 2.65Å' scene=''>		<StructureSection load='1a3f' size='340' side='right' caption='[[1a3f]], [[Resolution\|resolution]] 2.65Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1a3f]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Indian_cobra Indian cobra~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A3F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1A3F FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1a3f]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Naja_naja Naja naja]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A3F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1A3F FirstGlance]. <br>
	</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phospholipase_A(2) Phospholipase A(2)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.4 3.1.1.4] </span></td></tr>		</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phospholipase_A(2) Phospholipase A(2)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.4 3.1.1.4] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1a3f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1a3f OCA], [http://pdbe.org/1a3f PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1a3f RCSB], [http://www.ebi.ac.uk/pdbsum/1a3f PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1a3f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1a3f OCA], [http://pdbe.org/1a3f PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1a3f RCSB], [http://www.ebi.ac.uk/pdbsum/1a3f PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1a3f ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 27:		Line 28:
	</div>		</div>
	<div class="pdbe-citations 1a3f" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1a3f" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Phospholipase A2\|Phospholipase A2]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Indian cobra~~]]	+	[[Category: Naja naja]]
	[[Category: Chee, R]]		[[Category: Chee, R]]
	[[Category: Dennis, E A]]		[[Category: Dennis, E A]]

OCA at 03:59, 8 February 2016

OCA — Mon, 08 Feb 2016 03:59:37 GMT

←Older revision		Revision as of 03:59, 8 February 2016
Line 16:		Line 16:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1a3f ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 15:54, 9 September 2015

OCA — Wed, 09 Sep 2015 15:54:53 GMT

←Older revision		Revision as of 15:54, 9 September 2015
Line 2:		Line 2:
	<StructureSection load='1a3f' size='340' side='right' caption='[[1a3f]], [[Resolution\|resolution]] 2.65Å' scene=''>		<StructureSection load='1a3f' size='340' side='right' caption='[[1a3f]], [[Resolution\|resolution]] 2.65Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1a3f]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Naja_naja Naja naja~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A3F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1A3F FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1a3f]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Indian_cobra Indian cobra]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A3F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1A3F FirstGlance]. <br>
	</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phospholipase_A(2) Phospholipase A(2)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.4 3.1.1.4] </span></td></tr>		</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phospholipase_A(2) Phospholipase A(2)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.4 3.1.1.4] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1a3f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1a3f OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1a3f RCSB], [http://www.ebi.ac.uk/pdbsum/1a3f PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1a3f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1a3f OCA], [http://pdbe.org/1a3f PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1a3f RCSB], [http://www.ebi.ac.uk/pdbsum/1a3f PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[http://www.uniprot.org/uniprot/~~PA2_NAJNA PA2_NAJNA~~]] PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.	+	[[http://www.uniprot.org/uniprot/PA2A2_NAJNA PA2A2_NAJNA]] PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 26:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1a3f" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 33:		Line 34:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Naja naja~~]]	+	[[Category: Indian cobra]]
	[[Category: Chee, R]]		[[Category: Chee, R]]
	[[Category: Dennis, E A]]		[[Category: Dennis, E A]]

OCA at 20:26, 24 December 2014

OCA — Wed, 24 Dec 2014 20:26:50 GMT

←Older revision		Revision as of 20:26, 24 December 2014
Line 6:		Line 6:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1a3f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1a3f OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1a3f RCSB], [http://www.ebi.ac.uk/pdbsum/1a3f PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1a3f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1a3f OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1a3f RCSB], [http://www.ebi.ac.uk/pdbsum/1a3f PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/PA2_NAJNA PA2_NAJNA]] PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 09:43, 22 December 2014

OCA — Mon, 22 Dec 2014 09:43:55 GMT

←Older revision		Revision as of 09:43, 22 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1a3f]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Naja_naja Naja naja]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A3F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1A3F FirstGlance]. <br>		<table><tr><td colspan='2'>[[1a3f]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Naja_naja Naja naja]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A3F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1A3F FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phospholipase_A(2) Phospholipase A(2)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.4 3.1.1.4] </span></td></tr>	+	</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phospholipase_A(2) Phospholipase A(2)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.4 3.1.1.4] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1a3f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1a3f OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1a3f RCSB], [http://www.ebi.ac.uk/pdbsum/1a3f PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1a3f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1a3f OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1a3f RCSB], [http://www.ebi.ac.uk/pdbsum/1a3f PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 32:		Line 32:
	</StructureSection>		</StructureSection>
	[[Category: Naja naja]]		[[Category: Naja naja]]
-	[[Category: Chee, R.]]	+	[[Category: Chee, R]]
-	[[Category: Dennis, E A.]]	+	[[Category: Dennis, E A]]
-	[[Category: Nguyen, D.]]	+	[[Category: Nguyen, D]]
-	[[Category: Segelke, B W.]]	+	[[Category: Segelke, B W]]
-	[[Category: Xuong, H N.]]	+	[[Category: Xuong, H N]]
	[[Category: Activator site]]		[[Category: Activator site]]
	[[Category: Calcium binding]]		[[Category: Calcium binding]]

OCA at 08:32, 23 July 2014

OCA — Wed, 23 Jul 2014 08:32:37 GMT

←Older revision		Revision as of 08:32, 23 July 2014
Line 1:		Line 1:
-	[[~~Image~~:1a3f.~~png\|left~~\|200px]]	+	==PHOSPHOLIPASE A2 (PLA2) FROM NAJA NAJA VENOM==
		+	<StructureSection load='1a3f' size='340' side='right' caption='[[1a3f]], [[Resolution\|resolution]] 2.65Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1a3f]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Naja_naja Naja naja]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A3F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1A3F FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phospholipase_A(2) Phospholipase A(2)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.4 3.1.1.4] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1a3f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1a3f OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1a3f RCSB], [http://www.ebi.ac.uk/pdbsum/1a3f PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/a3/1a3f_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Three crystal forms of Naja naja naja phospholipase A2 were discovered through random crystallization screening, including two heretofore uncharacterized forms. The crystallization conditions for both of these novel crystal forms are Ca(2+)-free whereas previously reported conditions include Ca2+. One of the new crystal forms has a cubic lattice in the space group P2(1)3 (a = b = c = 69.24 A), the other has an orthorhombic lattice in the space group P2(1)2(1)2(1) (a = 67.22 A, b = 73.48 A, c = 87.52 A) and a previously characterized crystal belong to the tetragonal space group P4(3)2(1)2 (a = b = 88.6 A, c = 107.4 A). The structure from the cubic crystal form has been determined to 1.8 A and refined to an R-factor of 17% while the structure from the orthorhombic form has been determined to 2.65 A and has been refined to an R-factor of 21%. The determination of the cubic structure extends the resolution to which structures of this molecule have been determined from 2.3 A to 1.8 A. The two newly determined structures, in combination with the previously determined structure, generate an informative structural ensemble from which structural changes due to Ca2+, which is required for catalysis, and the effect of crystal contacts on side-chain conformations and oligomeric association can be inferred. Both of the newly determined structures reveal a trimeric oligomer as observed in the tetragonal structure; this appears to be a unique feature of the Naja naja naja enzyme.

-	~~{{STRUCTURE_1a3f\| PDB=1a3f \| SCENE= }}~~	+	Structures of two novel crystal forms of Naja naja naja phospholipase A2 lacking Ca2+ reveal trimeric packing.,Segelke BW, Nguyen D, Chee R, Xuong NH, Dennis EA J Mol Biol. 1998 May 29;279(1):223-32. PMID:9636712<ref>PMID:9636712</ref>

-	~~===PHOSPHOLIPASE A2 (PLA2) FROM NAJA NAJA VENOM===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_9636712}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[1a3f]] is~~ a ~~3 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Naja_naja Naja naja]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1A3F OCA].~~	+

	==See Also==		==See Also==
	*[[Phospholipase A2\|Phospholipase A2]]		*[[Phospholipase A2\|Phospholipase A2]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:009636712<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Naja naja]]		[[Category: Naja naja]]
	[[Category: Chee, R.]]		[[Category: Chee, R.]]

OCA at 08:50, 20 October 2012

OCA — Sat, 20 Oct 2012 08:50:09 GMT

←Older revision		Revision as of 08:50, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[1a3f]] is a 3 chain structure ~~of [[Phospholipase A2]]~~ with sequence from [http://en.wikipedia.org/wiki/Naja_naja Naja naja]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A3F OCA].	+	[[1a3f]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Naja_naja Naja naja]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A3F OCA].

	==See Also==		==See Also==