1a4u - Revision history

OCA at 10:46, 2 August 2023

OCA — Wed, 02 Aug 2023 10:46:42 GMT

←Older revision		Revision as of 10:46, 2 August 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1a4u]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Scaptodrosophila_lebanonensis Scaptodrosophila lebanonensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A4U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1A4U FirstGlance]. <br>		<table><tr><td colspan='2'>[[1a4u]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Scaptodrosophila_lebanonensis Scaptodrosophila lebanonensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A4U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1A4U FirstGlance]. <br>
-	</td></tr><tr id='~~activity~~'><td class="sblockLbl"><b>~~Activity~~:</b></td><td class="sblockDat"~~><span class~~=~~'plainlinks'~~>[~~https://en.wikipedia.org/wiki/Alcohol_dehydrogenase Alcohol dehydrogenase~~]~~, with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=~~1.~~1.1.1 1.1.1.1] </span>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.92Å</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1a4u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1a4u OCA], [https://pdbe.org/1a4u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1a4u RCSB], [https://www.ebi.ac.uk/pdbsum/1a4u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1a4u ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1a4u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1a4u OCA], [https://pdbe.org/1a4u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1a4u RCSB], [https://www.ebi.ac.uk/pdbsum/1a4u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1a4u ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/ADH_DROLE ADH_DROLE]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Alcohol dehydrogenase]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Scaptodrosophila lebanonensis]]		[[Category: Scaptodrosophila lebanonensis]]
-	[[Category: Atrian, S]]	+	[[Category: Atrian S]]
-	[[Category: Benach, J]]	+	[[Category: Benach J]]
-	[[Category: Gonzalez-Duarte, R]]	+	[[Category: Gonzalez-Duarte R]]
-	[[Category: Ladenstein, R]]	+	[[Category: Ladenstein R]]
-	~~[[Category: Detoxification]]~~	+
-	~~[[Category: Drosophila lebanonensis]]~~	+
-	~~[[Category: Metabolism]]~~	+
-	~~[[Category: Oxidoreductase]]~~	+
-	~~[[Category: Short-chain dehydrogenases/reductase~~]]	+

OCA at 09:42, 26 May 2021

OCA — Wed, 26 May 2021 09:42:12 GMT

←Older revision		Revision as of 09:42, 26 May 2021
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	<StructureSection load='1a4u' size='340' side='right'caption='[[1a4u]], [[Resolution\|resolution]] 1.92Å' scene=''>		<StructureSection load='1a4u' size='340' side='right'caption='[[1a4u]], [[Resolution\|resolution]] 1.92Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1a4u]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Scaptodrosophila_lebanonensis Scaptodrosophila lebanonensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A4U OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1A4U FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1a4u]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Scaptodrosophila_lebanonensis Scaptodrosophila lebanonensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A4U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1A4U FirstGlance]. <br>
-	</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Alcohol_dehydrogenase Alcohol dehydrogenase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.1 1.1.1.1] </span></td></tr>	+	</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Alcohol_dehydrogenase Alcohol dehydrogenase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.1 1.1.1.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1a4u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1a4u OCA], [~~http~~://pdbe.org/1a4u PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1a4u RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1a4u PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1a4u ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1a4u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1a4u OCA], [https://pdbe.org/1a4u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1a4u RCSB], [https://www.ebi.ac.uk/pdbsum/1a4u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1a4u ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	==See Also==		==See Also==
	*[[Alcohol dehydrogenase 3D structures\|Alcohol dehydrogenase 3D structures]]		*[[Alcohol dehydrogenase 3D structures\|Alcohol dehydrogenase 3D structures]]
-	*[[InhA\|InhA]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 07:48, 21 August 2019

OCA — Wed, 21 Aug 2019 07:48:53 GMT

←Older revision		Revision as of 07:48, 21 August 2019
Line 1:		Line 1:

	==ALCOHOL DEHYDROGENASE FROM DROSOPHILA LEBANONENSIS==		==ALCOHOL DEHYDROGENASE FROM DROSOPHILA LEBANONENSIS==
-	<StructureSection load='1a4u' size='340' side='right' caption='[[1a4u]], [[Resolution\|resolution]] 1.92Å' scene=''>	+	<StructureSection load='1a4u' size='340' side='right'caption='[[1a4u]], [[Resolution\|resolution]] 1.92Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1a4u]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Scaptodrosophila_lebanonensis Scaptodrosophila lebanonensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A4U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1A4U FirstGlance]. <br>		<table><tr><td colspan='2'>[[1a4u]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Scaptodrosophila_lebanonensis Scaptodrosophila lebanonensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A4U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1A4U FirstGlance]. <br>
Line 11:		Line 11:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/a4/1a4u_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/a4/1a4u_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 28:		Line 28:

	==See Also==		==See Also==
		+	*[[Alcohol dehydrogenase 3D structures\|Alcohol dehydrogenase 3D structures]]
	*[[InhA\|InhA]]		*[[InhA\|InhA]]
	== References ==		== References ==
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	</StructureSection>		</StructureSection>
	[[Category: Alcohol dehydrogenase]]		[[Category: Alcohol dehydrogenase]]
		+	[[Category: Large Structures]]
	[[Category: Scaptodrosophila lebanonensis]]		[[Category: Scaptodrosophila lebanonensis]]
	[[Category: Atrian, S]]		[[Category: Atrian, S]]

OCA at 10:47, 15 November 2017

OCA — Wed, 15 Nov 2017 10:47:21 GMT

←Older revision		Revision as of 10:47, 15 November 2017
Line 1:		Line 1:
		+
	==ALCOHOL DEHYDROGENASE FROM DROSOPHILA LEBANONENSIS==		==ALCOHOL DEHYDROGENASE FROM DROSOPHILA LEBANONENSIS==
	<StructureSection load='1a4u' size='340' side='right' caption='[[1a4u]], [[Resolution\|resolution]] 1.92Å' scene=''>		<StructureSection load='1a4u' size='340' side='right' caption='[[1a4u]], [[Resolution\|resolution]] 1.92Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[1a4u]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Scaptodrosophila_lebanonensis Scaptodrosophila lebanonensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A4U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1A4U FirstGlance]. <br>		<table><tr><td colspan='2'>[[1a4u]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Scaptodrosophila_lebanonensis Scaptodrosophila lebanonensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A4U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1A4U FirstGlance]. <br>
	</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Alcohol_dehydrogenase Alcohol dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.1 1.1.1.1] </span></td></tr>		</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Alcohol_dehydrogenase Alcohol dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.1 1.1.1.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1a4u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1a4u OCA], [http://pdbe.org/1a4u PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1a4u RCSB], [http://www.ebi.ac.uk/pdbsum/1a4u PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1a4u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1a4u OCA], [http://pdbe.org/1a4u PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1a4u RCSB], [http://www.ebi.ac.uk/pdbsum/1a4u PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1a4u ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 27:		Line 28:

	==See Also==		==See Also==
-	*[[Alcohol dehydrogenase\|Alcohol dehydrogenase]]
	*[[InhA\|InhA]]		*[[InhA\|InhA]]
	== References ==		== References ==

OCA at 01:54, 9 February 2016

OCA — Tue, 09 Feb 2016 01:54:14 GMT

←Older revision		Revision as of 01:54, 9 February 2016
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	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1a4u ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 16:04, 9 September 2015

OCA — Wed, 09 Sep 2015 16:04:10 GMT

←Older revision		Revision as of 16:04, 9 September 2015
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	<table><tr><td colspan='2'>[[1a4u]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Scaptodrosophila_lebanonensis Scaptodrosophila lebanonensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A4U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1A4U FirstGlance]. <br>		<table><tr><td colspan='2'>[[1a4u]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Scaptodrosophila_lebanonensis Scaptodrosophila lebanonensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A4U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1A4U FirstGlance]. <br>
	</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Alcohol_dehydrogenase Alcohol dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.1 1.1.1.1] </span></td></tr>		</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Alcohol_dehydrogenase Alcohol dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.1 1.1.1.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1a4u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1a4u OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1a4u RCSB], [http://www.ebi.ac.uk/pdbsum/1a4u PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1a4u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1a4u OCA], [http://pdbe.org/1a4u PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1a4u RCSB], [http://www.ebi.ac.uk/pdbsum/1a4u PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 24:		Line 24:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1a4u" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 10:21, 22 December 2014

OCA — Mon, 22 Dec 2014 10:21:42 GMT

←Older revision		Revision as of 10:21, 22 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1a4u]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Scaptodrosophila_lebanonensis Scaptodrosophila lebanonensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A4U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1A4U FirstGlance]. <br>		<table><tr><td colspan='2'>[[1a4u]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Scaptodrosophila_lebanonensis Scaptodrosophila lebanonensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A4U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1A4U FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Alcohol_dehydrogenase Alcohol dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.1 1.1.1.1] </span></td></tr>	+	</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Alcohol_dehydrogenase Alcohol dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.1 1.1.1.1] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1a4u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1a4u OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1a4u RCSB], [http://www.ebi.ac.uk/pdbsum/1a4u PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1a4u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1a4u OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1a4u RCSB], [http://www.ebi.ac.uk/pdbsum/1a4u PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 34:		Line 34:
	[[Category: Alcohol dehydrogenase]]		[[Category: Alcohol dehydrogenase]]
	[[Category: Scaptodrosophila lebanonensis]]		[[Category: Scaptodrosophila lebanonensis]]
-	[[Category: Atrian, S.]]	+	[[Category: Atrian, S]]
-	[[Category: Benach, J.]]	+	[[Category: Benach, J]]
-	[[Category: Gonzalez-Duarte, R.]]	+	[[Category: Gonzalez-Duarte, R]]
-	[[Category: Ladenstein, R~~.]]~~	+	[[Category: Ladenstein, R]]
-	~~[[Category: Alcohol dehydrogenase~~]]	+
	[[Category: Detoxification]]		[[Category: Detoxification]]
	[[Category: Drosophila lebanonensis]]		[[Category: Drosophila lebanonensis]]

OCA at 14:49, 29 September 2014

OCA — Mon, 29 Sep 2014 14:49:13 GMT

←Older revision		Revision as of 14:49, 29 September 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_1a4u~~\| ~~PDB~~=1a4u \| ~~SCENE~~= }}	+	==ALCOHOL DEHYDROGENASE FROM DROSOPHILA LEBANONENSIS==
-	===~~ALCOHOL DEHYDROGENASE FROM DROSOPHILA LEBANONENSIS~~===	+	<StructureSection load='1a4u' size='340' side='right' caption='[[1a4u]], [[Resolution\|resolution]] 1.92Å' scene=''>
-	~~{{ABSTRACT_PUBMED_9735295}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1a4u]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Scaptodrosophila_lebanonensis Scaptodrosophila lebanonensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A4U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1A4U FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Alcohol_dehydrogenase Alcohol dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.1 1.1.1.1] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1a4u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1a4u OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1a4u RCSB], [http://www.ebi.ac.uk/pdbsum/1a4u PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/a4/1a4u_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Drosophila alcohol dehydrogenase (DADH; EC 1.1.1.1) is a NAD(H)-dependent oxidoreductase belonging to the short-chain dehydrogenases/reductases (SDR) family. This homodimeric enzyme catalyzes the dehydrogenation of alcohols to their respective ketones or aldehydes in the fruit-fly Drosophila, both for metabolic assimilation and detoxification purposes. The crystal structure of the apo form of DADH, one of the first biochemically characterized member of the SDR family, was solved at 1.9 A resolution by Patterson methods. The initial model was improved by crystallographic refinement accompanied by electron density averaging, R-factor=20.5%, R-free=23.8%.DADH subunits show an alpha/beta single domain structure with a characteristic NAD(H) binding motif (Rossmann fold). The peptide chain of a subunit is folded into a central eight-stranded beta-sheet flanked on each side by three alpha-helices. The dimers have local 2-fold symmetry. Dimer association is dominated by a four-helix bundle motif as well as two C-terminal loops from each subunit, which represent a unique structural feature in SDR enzymes with known structure. Three structural features are characteristic for the active site architecture. (1) A deep cavity which is covered by a flexible loop (33 residues) and the C-terminal tail (11 residues) from the neighboring subunit. The hydrophobic surface of the cavity is likely to increase the specificity of this enzyme towards secondary aliphatic alcohols. (2) The residues of the catalytic triad (Ser138, Tyr151, Lys155) are known to be involved in enzymatic catalysis in the first line. The Tyr151 OH group is involved in an ionic bond with the Lys155 side-chain. Preliminary electrostatic calculations have provided evidence that the active form of Tyr151 is a tyrosinate ion at physiological pH. (3) Three well-ordered water molecules in hydrogen bond distance to side-chains of the catalytic triad may be significant for the proton release steps in DADH catalysis.A ternary structure-based sequence alignment with ten members of the SDR family with known three-dimensional structure has suggested to define a model consisting of four groups of residues, which relates the observed low degree of sequence identity to quite similar folding patterns and nearly identical distributions of residues involved in catalysis.

-	~~==About this Structure==~~	+	The refined crystal structure of Drosophila lebanonensis alcohol dehydrogenase at 1.9 A resolution.,Benach J, Atrian S, Gonzalez-Duarte R, Ladenstein R J Mol Biol. 1998 Sep 18;282(2):383-99. PMID:9735295<ref>PMID:9735295</ref>
-	~~[[1a4u]] is a 2 chain~~ structure ~~with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Scaptodrosophila_lebanonensis Scaptodrosophila lebanonensis]~~. ~~Full crystallographic information is available from [http~~://~~oca~~.~~weizmann~~.ac.il/~~oca-bin/ocashort?id=1A4U OCA].~~	+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

	==See Also==		==See Also==
	*[[Alcohol dehydrogenase\|Alcohol dehydrogenase]]		*[[Alcohol dehydrogenase\|Alcohol dehydrogenase]]
	*[[InhA\|InhA]]		*[[InhA\|InhA]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:009735295<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Alcohol dehydrogenase]]		[[Category: Alcohol dehydrogenase]]
	[[Category: Scaptodrosophila lebanonensis]]		[[Category: Scaptodrosophila lebanonensis]]

OCA at 10:10, 11 March 2013

OCA — Mon, 11 Mar 2013 10:10:10 GMT

←Older revision		Revision as of 10:10, 11 March 2013
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-	[[Image:1a4u.png\|left\|200px]]
-
	{{STRUCTURE_1a4u\| PDB=1a4u \| SCENE= }}		{{STRUCTURE_1a4u\| PDB=1a4u \| SCENE= }}
-
	===ALCOHOL DEHYDROGENASE FROM DROSOPHILA LEBANONENSIS===		===ALCOHOL DEHYDROGENASE FROM DROSOPHILA LEBANONENSIS===
-
	{{ABSTRACT_PUBMED_9735295}}		{{ABSTRACT_PUBMED_9735295}}

OCA at 12:14, 20 October 2012

OCA — Sat, 20 Oct 2012 12:14:23 GMT

←Older revision		Revision as of 12:14, 20 October 2012
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	==About this Structure==		==About this Structure==
-	[[1a4u]] is a 2 chain structure ~~of [[Alcohol dehydrogenase]]~~ with sequence from [http://en.wikipedia.org/wiki/Scaptodrosophila_lebanonensis Scaptodrosophila lebanonensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A4U OCA].	+	[[1a4u]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Scaptodrosophila_lebanonensis Scaptodrosophila lebanonensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A4U OCA].

	==See Also==		==See Also==