1a5i - Revision history

OCA at 10:47, 2 August 2023

OCA — Wed, 02 Aug 2023 10:47:29 GMT

←Older revision		Revision as of 10:47, 2 August 2023
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	<StructureSection load='1a5i' size='340' side='right'caption='[[1a5i]], [[Resolution\|resolution]] 2.90Å' scene=''>		<StructureSection load='1a5i' size='340' side='right'caption='[[1a5i]], [[Resolution\|resolution]] 2.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1a5i]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A5I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1A5I FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1a5i]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Desmodus_rotundus Desmodus rotundus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A5I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1A5I FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0GJ:L-ALPHA-GLUTAMYL-N-{(1S)-4-{[AMINO(IMINIO)METHYL]AMINO}-1-[(1S)-2-CHLORO-1-HYDROXYETHYL]BUTYL}GLYCINAMIDE'>0GJ</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.9Å</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/T-plasminogen_activator T-plasminogen activator], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.68 3.4.21.68] </span></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0GJ:L-ALPHA-GLUTAMYL-N-{(1S)-4-{[AMINO(IMINIO)METHYL]AMINO}-1-[(1S)-2-CHLORO-1-HYDROXYETHYL]BUTYL}GLYCINAMIDE'>0GJ</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1a5i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1a5i OCA], [https://pdbe.org/1a5i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1a5i RCSB], [https://www.ebi.ac.uk/pdbsum/1a5i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1a5i ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1a5i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1a5i OCA], [https://pdbe.org/1a5i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1a5i RCSB], [https://www.ebi.ac.uk/pdbsum/1a5i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1a5i ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/URT1_DESRO URT1_DESRO]] Probably essential to support the feeding habits of this exclusively haematophagous animal. Potent thrombolytic agent.	+	[https://www.uniprot.org/uniprot/URT1_DESRO URT1_DESRO] Probably essential to support the feeding habits of this exclusively haematophagous animal. Potent thrombolytic agent.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 36:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Desmodus rotundus]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: T-plasminogen activator]]~~	+	[[Category: Bode W]]
-	[[Category: Bode, W]]	+	[[Category: Renatus M]]
-	[[Category: Renatus, M]]	+	[[Category: Stubbs MT]]
-	[[Category: Stubbs~~, M T]]~~	+
-	~~[[Category: Fibrinolytic enzyme]]~~	+
-	~~[[Category: Hydrolase-hydrolase inhibitor complex]]~~	+
-	~~[[Category: Plasminogen activator]]~~	+
-	~~[[Category: Serine protease~~]]	+

OCA at 10:16, 17 February 2021

OCA — Wed, 17 Feb 2021 10:16:55 GMT

←Older revision		Revision as of 10:16, 17 February 2021
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	<StructureSection load='1a5i' size='340' side='right'caption='[[1a5i]], [[Resolution\|resolution]] 2.90Å' scene=''>		<StructureSection load='1a5i' size='340' side='right'caption='[[1a5i]], [[Resolution\|resolution]] 2.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1a5i]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A5I OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1A5I FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1a5i]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A5I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1A5I FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=0GJ:L-ALPHA-GLUTAMYL-N-{(1S)-4-{[AMINO(IMINIO)METHYL]AMINO}-1-[(1S)-2-CHLORO-1-HYDROXYETHYL]BUTYL}GLYCINAMIDE'>0GJ</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0GJ:L-ALPHA-GLUTAMYL-N-{(1S)-4-{[AMINO(IMINIO)METHYL]AMINO}-1-[(1S)-2-CHLORO-1-HYDROXYETHYL]BUTYL}GLYCINAMIDE'>0GJ</scene></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/T-plasminogen_activator T-plasminogen activator], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.68 3.4.21.68] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/T-plasminogen_activator T-plasminogen activator], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.68 3.4.21.68] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1a5i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1a5i OCA], [~~http~~://pdbe.org/1a5i PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1a5i RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1a5i PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1a5i ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1a5i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1a5i OCA], [https://pdbe.org/1a5i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1a5i RCSB], [https://www.ebi.ac.uk/pdbsum/1a5i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1a5i ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/URT1_DESRO URT1_DESRO]] Probably essential to support the feeding habits of this exclusively haematophagous animal. Potent thrombolytic agent.	+	[[https://www.uniprot.org/uniprot/URT1_DESRO URT1_DESRO]] Probably essential to support the feeding habits of this exclusively haematophagous animal. Potent thrombolytic agent.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 15:11, 10 May 2019

OCA — Fri, 10 May 2019 15:11:44 GMT

←Older revision		Revision as of 15:11, 10 May 2019
Line 1:		Line 1:

	==CATALYTIC DOMAIN OF VAMPIRE BAT (DESMODUS ROTUNDUS) SALIVA PLASMINOGEN ACTIVATOR IN COMPLEX WITH EGR-CMK (GLU-GLY-ARG CHLOROMETHYL KETONE)==		==CATALYTIC DOMAIN OF VAMPIRE BAT (DESMODUS ROTUNDUS) SALIVA PLASMINOGEN ACTIVATOR IN COMPLEX WITH EGR-CMK (GLU-GLY-ARG CHLOROMETHYL KETONE)==
-	<StructureSection load='1a5i' size='340' side='right' caption='[[1a5i]], [[Resolution\|resolution]] 2.90Å' scene=''>	+	<StructureSection load='1a5i' size='340' side='right'caption='[[1a5i]], [[Resolution\|resolution]] 2.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1a5i]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A5I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1A5I FirstGlance]. <br>		<table><tr><td colspan='2'>[[1a5i]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A5I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1A5I FirstGlance]. <br>
Line 14:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/a5/1a5i_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/a5/1a5i_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 36:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: T-plasminogen activator]]		[[Category: T-plasminogen activator]]
	[[Category: Bode, W]]		[[Category: Bode, W]]

OCA at 09:25, 9 August 2017

OCA — Wed, 09 Aug 2017 09:25:47 GMT

←Older revision		Revision as of 09:25, 9 August 2017
Line 1:		Line 1:
		+
	==CATALYTIC DOMAIN OF VAMPIRE BAT (DESMODUS ROTUNDUS) SALIVA PLASMINOGEN ACTIVATOR IN COMPLEX WITH EGR-CMK (GLU-GLY-ARG CHLOROMETHYL KETONE)==		==CATALYTIC DOMAIN OF VAMPIRE BAT (DESMODUS ROTUNDUS) SALIVA PLASMINOGEN ACTIVATOR IN COMPLEX WITH EGR-CMK (GLU-GLY-ARG CHLOROMETHYL KETONE)==
	<StructureSection load='1a5i' size='340' side='right' caption='[[1a5i]], [[Resolution\|resolution]] 2.90Å' scene=''>		<StructureSection load='1a5i' size='340' side='right' caption='[[1a5i]], [[Resolution\|resolution]] 2.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1a5i]] is a 1 chain structure ~~with sequence from [http://en.wikipedia.org/wiki/Desro Desro]~~. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A5I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1A5I FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1a5i]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A5I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1A5I FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=0GJ:L-ALPHA-GLUTAMYL-N-{(1S)-4-{[AMINO(IMINIO)METHYL]AMINO}-1-[(1S)-2-CHLORO-1-HYDROXYETHYL]BUTYL}GLYCINAMIDE'>0GJ</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=0GJ:L-ALPHA-GLUTAMYL-N-{(1S)-4-{[AMINO(IMINIO)METHYL]AMINO}-1-[(1S)-2-CHLORO-1-HYDROXYETHYL]BUTYL}GLYCINAMIDE'>0GJ</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/T-plasminogen_activator T-plasminogen activator], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.68 3.4.21.68] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/T-plasminogen_activator T-plasminogen activator], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.68 3.4.21.68] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1a5i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1a5i OCA], [http://pdbe.org/1a5i PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1a5i RCSB], [http://www.ebi.ac.uk/pdbsum/1a5i PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1a5i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1a5i OCA], [http://pdbe.org/1a5i PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1a5i RCSB], [http://www.ebi.ac.uk/pdbsum/1a5i PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1a5i ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 18:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1a5i ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 35:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Desro]]
	[[Category: T-plasminogen activator]]		[[Category: T-plasminogen activator]]
	[[Category: Bode, W]]		[[Category: Bode, W]]

OCA at 16:06, 9 September 2015

OCA — Wed, 09 Sep 2015 16:06:27 GMT

←Older revision		Revision as of 16:06, 9 September 2015
Line 2:		Line 2:
	<StructureSection load='1a5i' size='340' side='right' caption='[[1a5i]], [[Resolution\|resolution]] 2.90Å' scene=''>		<StructureSection load='1a5i' size='340' side='right' caption='[[1a5i]], [[Resolution\|resolution]] 2.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1a5i]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Desmodus_rotundus Desmodus rotundus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A5I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1A5I FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1a5i]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Desro Desro]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A5I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1A5I FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=0GJ:L-ALPHA-GLUTAMYL-N-{(1S)-4-{[AMINO(IMINIO)METHYL]AMINO}-1-[(1S)-2-CHLORO-1-HYDROXYETHYL]BUTYL}GLYCINAMIDE'>0GJ</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=0GJ:L-ALPHA-GLUTAMYL-N-{(1S)-4-{[AMINO(IMINIO)METHYL]AMINO}-1-[(1S)-2-CHLORO-1-HYDROXYETHYL]BUTYL}GLYCINAMIDE'>0GJ</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/T-plasminogen_activator T-plasminogen activator], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.68 3.4.21.68] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/T-plasminogen_activator T-plasminogen activator], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.68 3.4.21.68] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1a5i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1a5i OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1a5i RCSB], [http://www.ebi.ac.uk/pdbsum/1a5i PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1a5i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1a5i OCA], [http://pdbe.org/1a5i PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1a5i RCSB], [http://www.ebi.ac.uk/pdbsum/1a5i PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 27:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1a5i" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 34:		Line 35:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Desmodus rotundus~~]]	+	[[Category: Desro]]
	[[Category: T-plasminogen activator]]		[[Category: T-plasminogen activator]]
	[[Category: Bode, W]]		[[Category: Bode, W]]

OCA at 19:28, 25 December 2014

OCA — Thu, 25 Dec 2014 19:28:29 GMT

←Older revision		Revision as of 19:28, 25 December 2014
Line 7:		Line 7:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1a5i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1a5i OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1a5i RCSB], [http://www.ebi.ac.uk/pdbsum/1a5i PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1a5i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1a5i OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1a5i RCSB], [http://www.ebi.ac.uk/pdbsum/1a5i PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/URT1_DESRO URT1_DESRO]] Probably essential to support the feeding habits of this exclusively haematophagous animal. Potent thrombolytic agent.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 09:24, 22 December 2014

OCA — Mon, 22 Dec 2014 09:24:37 GMT

←Older revision		Revision as of 09:24, 22 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1a5i]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Desmodus_rotundus Desmodus rotundus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A5I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1A5I FirstGlance]. <br>		<table><tr><td colspan='2'>[[1a5i]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Desmodus_rotundus Desmodus rotundus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A5I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1A5I FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=0GJ:L-ALPHA-GLUTAMYL-N-{(1S)-4-{[AMINO(IMINIO)METHYL]AMINO}-1-[(1S)-2-CHLORO-1-HYDROXYETHYL]BUTYL}GLYCINAMIDE'>0GJ</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=0GJ:L-ALPHA-GLUTAMYL-N-{(1S)-4-{[AMINO(IMINIO)METHYL]AMINO}-1-[(1S)-2-CHLORO-1-HYDROXYETHYL]BUTYL}GLYCINAMIDE'>0GJ</scene></td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/T-plasminogen_activator T-plasminogen activator], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.68 3.4.21.68] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/T-plasminogen_activator T-plasminogen activator], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.68 3.4.21.68] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1a5i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1a5i OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1a5i RCSB], [http://www.ebi.ac.uk/pdbsum/1a5i PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1a5i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1a5i OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1a5i RCSB], [http://www.ebi.ac.uk/pdbsum/1a5i PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 34:		Line 34:
	[[Category: Desmodus rotundus]]		[[Category: Desmodus rotundus]]
	[[Category: T-plasminogen activator]]		[[Category: T-plasminogen activator]]
-	[[Category: Bode, W.]]	+	[[Category: Bode, W]]
-	[[Category: Renatus, M.]]	+	[[Category: Renatus, M]]
-	[[Category: Stubbs, M T.]]	+	[[Category: Stubbs, M T]]
	[[Category: Fibrinolytic enzyme]]		[[Category: Fibrinolytic enzyme]]
	[[Category: Hydrolase-hydrolase inhibitor complex]]		[[Category: Hydrolase-hydrolase inhibitor complex]]
	[[Category: Plasminogen activator]]		[[Category: Plasminogen activator]]
	[[Category: Serine protease]]		[[Category: Serine protease]]

OCA at 08:37, 23 July 2014

OCA — Wed, 23 Jul 2014 08:37:52 GMT

←Older revision		Revision as of 08:37, 23 July 2014
Line 1:		Line 1:
-	[[~~Image~~:1a5i.~~png\|left~~\|200px]]	+	==CATALYTIC DOMAIN OF VAMPIRE BAT (DESMODUS ROTUNDUS) SALIVA PLASMINOGEN ACTIVATOR IN COMPLEX WITH EGR-CMK (GLU-GLY-ARG CHLOROMETHYL KETONE)==
		+	<StructureSection load='1a5i' size='340' side='right' caption='[[1a5i]], [[Resolution\|resolution]] 2.90Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1a5i]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Desmodus_rotundus Desmodus rotundus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A5I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1A5I FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=0GJ:L-ALPHA-GLUTAMYL-N-{(1S)-4-{[AMINO(IMINIO)METHYL]AMINO}-1-[(1S)-2-CHLORO-1-HYDROXYETHYL]BUTYL}GLYCINAMIDE'>0GJ</scene><br>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/T-plasminogen_activator T-plasminogen activator], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.68 3.4.21.68] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1a5i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1a5i OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1a5i RCSB], [http://www.ebi.ac.uk/pdbsum/1a5i PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/a5/1a5i_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The saliva of the blood-eating vampire bat Desmodus rotundus contains plasminogen activators (PAs) that maintain the fluidity of the prey's blood by activating plasminogen and dissolving developing fibrin clots. D. rotundus salivary PAs (DSPAs) are composed of evolutionarily conserved domains reminiscent of human tissue-type PA (tPA), but their catalytic domain lacks a plasmin-sensitive "activation cleavage site". Despite this, all DSPAs are intrinsically active and enormously stimulated in the presence of fibrin. The recombinant catalytic domain of DSPAalpha1 has been crystallized in a covalent complex with Glu-Gly-Arg-chloromethyl ketone and its structure solved at 2.9 A resolution. The structure is similar to that of activated two-chain human tPA. Despite its single-chain status, the activation domain is observed in an enzymatically active conformation, with a functional substrate binding site and active site accommodating the peptidylmethylene inhibitor. The activation pocket, which normally receives the N-terminal Ile16, is occupied by the side chain of Lys156, whose distal ammonium group makes an internal salt bridge with the carboxylate group of Asp194. Lys156 is in a groove shielded from the bulk solvent by the intact "activation loop" (Gln10-Phe21), favoring Lys156-Asp194 salt bridge formation and stabilization of a functional substrate binding site. Together with the characteristic 186 insertion loop, the activation loop could act as a switch, effecting full single-chain enzymatic activity upon binding to fibrin.

-	~~{{STRUCTURE_1a5i\| PDB=1a5i \| SCENE= }}~~	+	Catalytic domain structure of vampire bat plasminogen activator: a molecular paradigm for proteolysis without activation cleavage.,Renatus M, Stubbs MT, Huber R, Bringmann P, Donner P, Schleuning WD, Bode W Biochemistry. 1997 Nov 4;36(44):13483-93. PMID:9354616<ref>PMID:9354616</ref>

-	~~===CATALYTIC DOMAIN OF VAMPIRE BAT (DESMODUS ROTUNDUS) SALIVA PLASMINOGEN ACTIVATOR IN COMPLEX WITH EGR-CMK (GLU-GLY-ARG CHLOROMETHYL KETONE)===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_9354616}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[1a5i]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Desmodus_rotundus Desmodus rotundus]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1A5I OCA].~~	+

	==See Also==		==See Also==
	*[[Plasminogen activator\|Plasminogen activator]]		*[[Plasminogen activator\|Plasminogen activator]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:009354616<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Desmodus rotundus]]		[[Category: Desmodus rotundus]]
	[[Category: T-plasminogen activator]]		[[Category: T-plasminogen activator]]

OCA at 20:32, 20 October 2012

OCA — Sat, 20 Oct 2012 20:32:44 GMT

←Older revision		Revision as of 20:32, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[1a5i]] is a 1 chain structure ~~of [[Plasminogen activator]]~~ with sequence from [http://en.wikipedia.org/wiki/Desmodus_rotundus Desmodus rotundus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A5I OCA].	+	[[1a5i]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Desmodus_rotundus Desmodus rotundus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A5I OCA].

	==See Also==		==See Also==

OCA: Protected "1a5i" [edit=sysop:move=sysop]

OCA — Fri, 27 Jul 2012 10:51:28 GMT

Protected "1a5i" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:51, 27 July 2012