1a8d - Revision history

OCA at 15:22, 13 March 2024

OCA — Wed, 13 Mar 2024 15:22:04 GMT

←Older revision		Revision as of 15:22, 13 March 2024
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	<StructureSection load='1a8d' size='340' side='right'caption='[[1a8d]], [[Resolution\|resolution]] 1.57Å' scene=''>		<StructureSection load='1a8d' size='340' side='right'caption='[[1a8d]], [[Resolution\|resolution]] 1.57Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1a8d]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"bacillus_tetani"_flugge_1886 "bacillus~~ tetani~~" flugge 1886~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A8D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1A8D FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1a8d]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Clostridium_tetani Clostridium tetani]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A8D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1A8D FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=AU:GOLD+ION'>AU</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.57Å</td></tr>
-	<tr id='~~activity~~'><td class="sblockLbl"><b>~~Activity~~:</b></td><td class="sblockDat"><~~span class~~='~~plainlinks~~'>~~[https://en.wikipedia.org/wiki/Tentoxilysin Tentoxilysin], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.68 3.4.24.68]~~ </~~span~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AU:GOLD+ION'>AU</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1a8d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1a8d OCA], [https://pdbe.org/1a8d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1a8d RCSB], [https://www.ebi.ac.uk/pdbsum/1a8d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1a8d ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1a8d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1a8d OCA], [https://pdbe.org/1a8d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1a8d RCSB], [https://www.ebi.ac.uk/pdbsum/1a8d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1a8d ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/TETX_CLOTE TETX_CLOTE]] Tetanus toxin acts by inhibiting neurotransmitter release. It binds to peripheral neuronal synapses, is internalized and moves by retrograde transport up the axon into the spinal cord where it can move between postsynaptic and presynaptic neurons. It inhibits neurotransmitter release by acting as a zinc endopeptidase that catalyzes the hydrolysis of the '76-Gln-\|-Phe-77' bond of synaptobrevin-2.	+	[https://www.uniprot.org/uniprot/TETX_CLOTE TETX_CLOTE] Tetanus toxin acts by inhibiting neurotransmitter release. It binds to peripheral neuronal synapses, is internalized and moves by retrograde transport up the axon into the spinal cord where it can move between postsynaptic and presynaptic neurons. It inhibits neurotransmitter release by acting as a zinc endopeptidase that catalyzes the hydrolysis of the '76-Gln-\|-Phe-77' bond of synaptobrevin-2.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 25:		Line 25:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Bacillus~~ tetani ~~flugge 1886~~]]	+	[[Category: Clostridium tetani]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: Tentoxilysin]]~~	+	[[Category: Knapp M]]
-	[[Category: Knapp, M]]	+	[[Category: Rupp B]]
-	[[Category: Rupp, B]]	+
-	~~[[Category: Clostridial]]~~	+
-	~~[[Category: Ganglioside binding region]]~~	+
-	~~[[Category: Neurotoxin~~]]	+

OCA at 09:43, 26 May 2021

OCA — Wed, 26 May 2021 09:43:30 GMT

←Older revision		Revision as of 09:43, 26 May 2021
Line 3:		Line 3:
	<StructureSection load='1a8d' size='340' side='right'caption='[[1a8d]], [[Resolution\|resolution]] 1.57Å' scene=''>		<StructureSection load='1a8d' size='340' side='right'caption='[[1a8d]], [[Resolution\|resolution]] 1.57Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1a8d]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"bacillus_tetani"_flugge_1886 "bacillus tetani" flugge 1886]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A8D OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1A8D FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1a8d]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_tetani"_flugge_1886 "bacillus tetani" flugge 1886]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A8D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1A8D FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AU:GOLD+ION'>AU</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AU:GOLD+ION'>AU</scene></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Tentoxilysin Tentoxilysin], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.68 3.4.24.68] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Tentoxilysin Tentoxilysin], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.68 3.4.24.68] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1a8d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1a8d OCA], [~~http~~://pdbe.org/1a8d PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1a8d RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1a8d PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1a8d ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1a8d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1a8d OCA], [https://pdbe.org/1a8d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1a8d RCSB], [https://www.ebi.ac.uk/pdbsum/1a8d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1a8d ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/TETX_CLOTE TETX_CLOTE]] Tetanus toxin acts by inhibiting neurotransmitter release. It binds to peripheral neuronal synapses, is internalized and moves by retrograde transport up the axon into the spinal cord where it can move between postsynaptic and presynaptic neurons. It inhibits neurotransmitter release by acting as a zinc endopeptidase that catalyzes the hydrolysis of the '76-Gln-\|-Phe-77' bond of synaptobrevin-2.	+	[[https://www.uniprot.org/uniprot/TETX_CLOTE TETX_CLOTE]] Tetanus toxin acts by inhibiting neurotransmitter release. It binds to peripheral neuronal synapses, is internalized and moves by retrograde transport up the axon into the spinal cord where it can move between postsynaptic and presynaptic neurons. It inhibits neurotransmitter release by acting as a zinc endopeptidase that catalyzes the hydrolysis of the '76-Gln-\|-Phe-77' bond of synaptobrevin-2.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 07:21, 21 August 2019

OCA — Wed, 21 Aug 2019 07:21:13 GMT

←Older revision		Revision as of 07:21, 21 August 2019
Line 1:		Line 1:

	==TETANUS TOXIN C FRAGMENT==		==TETANUS TOXIN C FRAGMENT==
-	<StructureSection load='1a8d' size='340' side='right' caption='[[1a8d]], [[Resolution\|resolution]] 1.57Å' scene=''>	+	<StructureSection load='1a8d' size='340' side='right'caption='[[1a8d]], [[Resolution\|resolution]] 1.57Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1a8d]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_tetani"_flugge_1886 "bacillus tetani" flugge 1886]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A8D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1A8D FirstGlance]. <br>		<table><tr><td colspan='2'>[[1a8d]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_tetani"_flugge_1886 "bacillus tetani" flugge 1886]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A8D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1A8D FirstGlance]. <br>
Line 14:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/a8/1a8d_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/a8/1a8d_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 20:		Line 20:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1a8d ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1a8d ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
		+
		+	==See Also==
		+	*[[Tetanus toxin\|Tetanus toxin]]
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Bacillus tetani flugge 1886]]		[[Category: Bacillus tetani flugge 1886]]
		+	[[Category: Large Structures]]
	[[Category: Tentoxilysin]]		[[Category: Tentoxilysin]]
	[[Category: Knapp, M]]		[[Category: Knapp, M]]

OCA at 10:45, 15 November 2017

OCA — Wed, 15 Nov 2017 10:45:46 GMT

←Older revision		Revision as of 10:45, 15 November 2017
Line 1:		Line 1:
		+
	==TETANUS TOXIN C FRAGMENT==		==TETANUS TOXIN C FRAGMENT==
	<StructureSection load='1a8d' size='340' side='right' caption='[[1a8d]], [[Resolution\|resolution]] 1.57Å' scene=''>		<StructureSection load='1a8d' size='340' side='right' caption='[[1a8d]], [[Resolution\|resolution]] 1.57Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AU:GOLD+ION'>AU</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AU:GOLD+ION'>AU</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Tentoxilysin Tentoxilysin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.68 3.4.24.68] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Tentoxilysin Tentoxilysin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.68 3.4.24.68] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1a8d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1a8d OCA], [http://pdbe.org/1a8d PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1a8d RCSB], [http://www.ebi.ac.uk/pdbsum/1a8d PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1a8d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1a8d OCA], [http://pdbe.org/1a8d PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1a8d RCSB], [http://www.ebi.ac.uk/pdbsum/1a8d PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1a8d ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 19:		Line 20:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1a8d ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1a8d ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-
-	==See Also==
-	*[[Tetanus toxin\|Tetanus toxin]]
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 02:42, 9 February 2016

OCA — Tue, 09 Feb 2016 02:42:07 GMT

←Older revision		Revision as of 02:42, 9 February 2016
Line 17:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1a8d ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>

OCA at 16:01, 9 September 2015

OCA — Wed, 09 Sep 2015 16:01:29 GMT

←Older revision		Revision as of 16:01, 9 September 2015
Line 2:		Line 2:
	<StructureSection load='1a8d' size='340' side='right' caption='[[1a8d]], [[Resolution\|resolution]] 1.57Å' scene=''>		<StructureSection load='1a8d' size='340' side='right' caption='[[1a8d]], [[Resolution\|resolution]] 1.57Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1a8d]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Clostridium_tetani Clostridium~~ tetani]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A8D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1A8D FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1a8d]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_tetani"_flugge_1886 "bacillus tetani" flugge 1886]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A8D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1A8D FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AU:GOLD+ION'>AU</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AU:GOLD+ION'>AU</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Tentoxilysin Tentoxilysin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.68 3.4.24.68] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Tentoxilysin Tentoxilysin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.68 3.4.24.68] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1a8d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1a8d OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1a8d RCSB], [http://www.ebi.ac.uk/pdbsum/1a8d PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1a8d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1a8d OCA], [http://pdbe.org/1a8d PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1a8d RCSB], [http://www.ebi.ac.uk/pdbsum/1a8d PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 24:		Line 24:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Clostridium~~ tetani]]	+	[[Category: Bacillus tetani flugge 1886]]
	[[Category: Tentoxilysin]]		[[Category: Tentoxilysin]]
	[[Category: Knapp, M]]		[[Category: Knapp, M]]

OCA at 03:51, 25 December 2014

OCA — Thu, 25 Dec 2014 03:51:23 GMT

←Older revision		Revision as of 03:51, 25 December 2014
Line 7:		Line 7:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1a8d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1a8d OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1a8d RCSB], [http://www.ebi.ac.uk/pdbsum/1a8d PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1a8d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1a8d OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1a8d RCSB], [http://www.ebi.ac.uk/pdbsum/1a8d PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/TETX_CLOTE TETX_CLOTE]] Tetanus toxin acts by inhibiting neurotransmitter release. It binds to peripheral neuronal synapses, is internalized and moves by retrograde transport up the axon into the spinal cord where it can move between postsynaptic and presynaptic neurons. It inhibits neurotransmitter release by acting as a zinc endopeptidase that catalyzes the hydrolysis of the '76-Gln-\|-Phe-77' bond of synaptobrevin-2.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 10:47, 22 December 2014

OCA — Mon, 22 Dec 2014 10:47:50 GMT

←Older revision		Revision as of 10:47, 22 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1a8d]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Clostridium_tetani Clostridium tetani]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A8D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1A8D FirstGlance]. <br>		<table><tr><td colspan='2'>[[1a8d]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Clostridium_tetani Clostridium tetani]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A8D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1A8D FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AU:GOLD+ION'>AU</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AU:GOLD+ION'>AU</scene></td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Tentoxilysin Tentoxilysin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.68 3.4.24.68] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Tentoxilysin Tentoxilysin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.68 3.4.24.68] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1a8d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1a8d OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1a8d RCSB], [http://www.ebi.ac.uk/pdbsum/1a8d PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1a8d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1a8d OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1a8d RCSB], [http://www.ebi.ac.uk/pdbsum/1a8d PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 24:		Line 24:
	[[Category: Clostridium tetani]]		[[Category: Clostridium tetani]]
	[[Category: Tentoxilysin]]		[[Category: Tentoxilysin]]
-	[[Category: Knapp, M.]]	+	[[Category: Knapp, M]]
-	[[Category: Rupp, B.]]	+	[[Category: Rupp, B]]
	[[Category: Clostridial]]		[[Category: Clostridial]]
	[[Category: Ganglioside binding region]]		[[Category: Ganglioside binding region]]
	[[Category: Neurotoxin]]		[[Category: Neurotoxin]]

OCA at 08:35, 23 July 2014

OCA — Wed, 23 Jul 2014 08:35:49 GMT

←Older revision		Revision as of 08:35, 23 July 2014
Line 1:		Line 1:
-	[[~~Image~~:1a8d.~~png\|left~~\|200px]]	+	==TETANUS TOXIN C FRAGMENT==
		+	<StructureSection load='1a8d' size='340' side='right' caption='[[1a8d]], [[Resolution\|resolution]] 1.57Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1a8d]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Clostridium_tetani Clostridium tetani]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A8D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1A8D FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AU:GOLD+ION'>AU</scene><br>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Tentoxilysin Tentoxilysin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.68 3.4.24.68] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1a8d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1a8d OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1a8d RCSB], [http://www.ebi.ac.uk/pdbsum/1a8d PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/a8/1a8d_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>

-	~~{{STRUCTURE_1a8d\| PDB~~=~~1a8d \| SCENE= }}~~	+	==See Also==
-		+	*[[Tetanus toxin\|Tetanus toxin]]
-	~~===TETANUS TOXIN C FRAGMENT~~===	+	__TOC__
-		+	</StructureSection>
-	~~{{ABSTRACT_PUBMED_011880627}}~~	+
-		+
-	~~==About this Structure==~~	+
-	[[~~1a8d~~]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Clostridium_tetani Clostridium tetani]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A8D OCA].	+
-		+
-	~~==Reference==~~	+
-	<~~ref group="xtra">PMID:011880627</ref><ref group="xtra">PMID:011917145</ref><references group="xtra"~~/>	+
	[[Category: Clostridium tetani]]		[[Category: Clostridium tetani]]
	[[Category: Tentoxilysin]]		[[Category: Tentoxilysin]]

OCA: Protected "1a8d" [edit=sysop:move=sysop]

OCA — Sun, 21 Oct 2012 12:17:51 GMT

Protected "1a8d" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:17, 21 October 2012