1a9v - Revision history

OCA at 15:22, 13 March 2024

OCA — Wed, 13 Mar 2024 15:22:22 GMT

←Older revision		Revision as of 15:22, 13 March 2024
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	==TERTIARY STRUCTURE OF THE MAJOR HOUSE DUST MITE ALLERGEN DER P 2, NMR, 10 STRUCTURES==		==TERTIARY STRUCTURE OF THE MAJOR HOUSE DUST MITE ALLERGEN DER P 2, NMR, 10 STRUCTURES==
-	<StructureSection load='1a9v' size='340' side='right'caption='[[1a9v~~]], [[NMR_Ensembles_of_Models \| 10 NMR models~~]]' scene=''>	+	<StructureSection load='1a9v' size='340' side='right'caption='[[1a9v]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1a9v]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Derpt Derpt~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A9V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1A9V FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1a9v]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Dermatophagoides_pteronyssinus Dermatophagoides pteronyssinus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A9V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1A9V FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1a9v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1a9v OCA], [https://pdbe.org/1a9v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1a9v RCSB], [https://www.ebi.ac.uk/pdbsum/1a9v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1a9v ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1a9v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1a9v OCA], [https://pdbe.org/1a9v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1a9v RCSB], [https://www.ebi.ac.uk/pdbsum/1a9v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1a9v ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/ALL2_DERPT ALL2_DERPT]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 16:		Line 19:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1a9v ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1a9v ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	Sensitization to indoor allergens, especially those of the house dust mite, is strongly correlated with the development of asthma. We report the tertiary structure of the major house dust mite allergen, Der p 2, determined by NMR methods. The structure of Der p 2 is a beta-barrel and is composed of two three-stranded antiparallel beta-pleated sheets. This arrangement of beta-strands is similar to the immunoglobulin fold with respect to the orientation of the two sheets and the interactions of the strands. However, the three-dimensional structure of Der p 2 aligns equivalently with a number of proteins from different families within the immunoglobulin superfamily. The structural homology with the highest significance score from analysis by DALI is to Der f 2. Although Der p 2 and Der f 2 are 87% identical in amino acid sequence, they align in three dimensions rather poorly (4.85 A RMSD; Z-score, 8.58). This unexpected finding is likely due to the different solution conditions used during structure determination by NMR for both proteins. While the structural comparisons did not elucidate a clear homologue for the function of Der p 2 in mites, we report that Der p 2 is sequentially homologous to esr16. This is a protein from moths that is expressed coincident with molting. Thus, this homology has important ramifications for the study of mite allergy. The structure of Der p 2 provides a useful tool in the design of recombinant immunotherapeutics for the group 2 allergens.
-
-	Tertiary structure of the major house dust mite allergen Der p 2: sequential and structural homologies.,Mueller GA, Benjamin DC, Rule GS Biochemistry. 1998 Sep 15;37(37):12707-14. PMID:9737847<ref>PMID:9737847</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 1a9v" style="background-color:#fffaf0;"></div>
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Derpt~~]]	+	[[Category: Dermatophagoides pteronyssinus]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Benjamin~~, D C~~]]	+	[[Category: Benjamin DC]]
-	[[Category: Mueller~~, G A~~]]	+	[[Category: Mueller GA]]
-	[[Category: Rule~~, G S]]~~	+	[[Category: Rule GS]]
-	~~[[Category: Allergen]]~~	+
-	~~[[Category: Immunoglobulin fold~~]]	+

OCA at 10:21, 16 February 2022

OCA — Wed, 16 Feb 2022 10:21:49 GMT

←Older revision		Revision as of 10:21, 16 February 2022
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	<StructureSection load='1a9v' size='340' side='right'caption='[[1a9v]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>		<StructureSection load='1a9v' size='340' side='right'caption='[[1a9v]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1a9v]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A9V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1A9V FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1a9v]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Derpt Derpt]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A9V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1A9V FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1a9v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1a9v OCA], [https://pdbe.org/1a9v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1a9v RCSB], [https://www.ebi.ac.uk/pdbsum/1a9v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1a9v ProSAT]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1a9v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1a9v OCA], [https://pdbe.org/1a9v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1a9v RCSB], [https://www.ebi.ac.uk/pdbsum/1a9v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1a9v ProSAT]</span></td></tr>
	</table>		</table>
Line 29:		Line 29:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Derpt]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Benjamin, D C]]		[[Category: Benjamin, D C]]

OCA at 10:18, 17 February 2021

OCA — Wed, 17 Feb 2021 10:18:21 GMT

←Older revision		Revision as of 10:18, 17 February 2021
Line 3:		Line 3:
	<StructureSection load='1a9v' size='340' side='right'caption='[[1a9v]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>		<StructureSection load='1a9v' size='340' side='right'caption='[[1a9v]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1a9v]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A9V OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1A9V FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1a9v]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A9V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1A9V FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1a9v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1a9v OCA], [~~http~~://pdbe.org/1a9v PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1a9v RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1a9v PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1a9v ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1a9v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1a9v OCA], [https://pdbe.org/1a9v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1a9v RCSB], [https://www.ebi.ac.uk/pdbsum/1a9v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1a9v ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 14:33, 10 May 2019

OCA — Fri, 10 May 2019 14:33:43 GMT

←Older revision		Revision as of 14:33, 10 May 2019
Line 1:		Line 1:

	==TERTIARY STRUCTURE OF THE MAJOR HOUSE DUST MITE ALLERGEN DER P 2, NMR, 10 STRUCTURES==		==TERTIARY STRUCTURE OF THE MAJOR HOUSE DUST MITE ALLERGEN DER P 2, NMR, 10 STRUCTURES==
-	<StructureSection load='1a9v' size='340' side='right' caption='[[1a9v]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>	+	<StructureSection load='1a9v' size='340' side='right'caption='[[1a9v]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1a9v]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A9V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1A9V FirstGlance]. <br>		<table><tr><td colspan='2'>[[1a9v]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A9V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1A9V FirstGlance]. <br>
Line 10:		Line 10:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/a9/1a9v_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/a9/1a9v_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 29:		Line 29:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Benjamin, D C]]		[[Category: Benjamin, D C]]
	[[Category: Mueller, G A]]		[[Category: Mueller, G A]]

OCA at 09:25, 9 August 2017

OCA — Wed, 09 Aug 2017 09:25:17 GMT

←Older revision		Revision as of 09:25, 9 August 2017
Line 1:		Line 1:
		+
	==TERTIARY STRUCTURE OF THE MAJOR HOUSE DUST MITE ALLERGEN DER P 2, NMR, 10 STRUCTURES==		==TERTIARY STRUCTURE OF THE MAJOR HOUSE DUST MITE ALLERGEN DER P 2, NMR, 10 STRUCTURES==
	<StructureSection load='1a9v' size='340' side='right' caption='[[1a9v]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>		<StructureSection load='1a9v' size='340' side='right' caption='[[1a9v]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1a9v]] is a 1 chain structure ~~with sequence from [http://en.wikipedia.org/wiki/Derpt Derpt]~~. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A9V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1A9V FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1a9v]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A9V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1A9V FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1a9v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1a9v OCA], [http://pdbe.org/1a9v PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1a9v RCSB], [http://www.ebi.ac.uk/pdbsum/1a9v PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1a9v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1a9v OCA], [http://pdbe.org/1a9v PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1a9v RCSB], [http://www.ebi.ac.uk/pdbsum/1a9v PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1a9v ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 13:		Line 14:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1a9v ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 28:		Line 29:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Derpt]]
	[[Category: Benjamin, D C]]		[[Category: Benjamin, D C]]
	[[Category: Mueller, G A]]		[[Category: Mueller, G A]]

OCA at 12:10, 11 September 2015

OCA — Fri, 11 Sep 2015 12:10:59 GMT

←Older revision		Revision as of 12:10, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='1a9v' size='340' side='right' caption='[[1a9v]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>		<StructureSection load='1a9v' size='340' side='right' caption='[[1a9v]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1a9v]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Dermatophagoides_pteronyssinus Dermatophagoides pteronyssinus~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A9V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1A9V FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1a9v]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Derpt Derpt]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A9V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1A9V FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1a9v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1a9v OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1a9v RCSB], [http://www.ebi.ac.uk/pdbsum/1a9v PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1a9v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1a9v OCA], [http://pdbe.org/1a9v PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1a9v RCSB], [http://www.ebi.ac.uk/pdbsum/1a9v PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 23:		Line 23:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1a9v" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Dermatophagoides pteronyssinus~~]]	+	[[Category: Derpt]]
	[[Category: Benjamin, D C]]		[[Category: Benjamin, D C]]
	[[Category: Mueller, G A]]		[[Category: Mueller, G A]]

OCA at 10:53, 22 December 2014

OCA — Mon, 22 Dec 2014 10:53:44 GMT

←Older revision		Revision as of 10:53, 22 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1a9v]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Dermatophagoides_pteronyssinus Dermatophagoides pteronyssinus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A9V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1A9V FirstGlance]. <br>		<table><tr><td colspan='2'>[[1a9v]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Dermatophagoides_pteronyssinus Dermatophagoides pteronyssinus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A9V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1A9V FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1a9v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1a9v OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1a9v RCSB], [http://www.ebi.ac.uk/pdbsum/1a9v PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1a9v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1a9v OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1a9v RCSB], [http://www.ebi.ac.uk/pdbsum/1a9v PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 28:		Line 28:
	</StructureSection>		</StructureSection>
	[[Category: Dermatophagoides pteronyssinus]]		[[Category: Dermatophagoides pteronyssinus]]
-	[[Category: Benjamin, D C.]]	+	[[Category: Benjamin, D C]]
-	[[Category: Mueller, G A.]]	+	[[Category: Mueller, G A]]
-	[[Category: Rule, G S.]]	+	[[Category: Rule, G S]]
	[[Category: Allergen]]		[[Category: Allergen]]
	[[Category: Immunoglobulin fold]]		[[Category: Immunoglobulin fold]]

OCA at 08:37, 23 July 2014

OCA — Wed, 23 Jul 2014 08:37:41 GMT

←Older revision		Revision as of 08:37, 23 July 2014
Line 1:		Line 1:
-	[[~~Image~~:1a9v.~~png\|left~~\|200px]]	+	==TERTIARY STRUCTURE OF THE MAJOR HOUSE DUST MITE ALLERGEN DER P 2, NMR, 10 STRUCTURES==
		+	<StructureSection load='1a9v' size='340' side='right' caption='[[1a9v]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1a9v]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Dermatophagoides_pteronyssinus Dermatophagoides pteronyssinus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A9V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1A9V FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1a9v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1a9v OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1a9v RCSB], [http://www.ebi.ac.uk/pdbsum/1a9v PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/a9/1a9v_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Sensitization to indoor allergens, especially those of the house dust mite, is strongly correlated with the development of asthma. We report the tertiary structure of the major house dust mite allergen, Der p 2, determined by NMR methods. The structure of Der p 2 is a beta-barrel and is composed of two three-stranded antiparallel beta-pleated sheets. This arrangement of beta-strands is similar to the immunoglobulin fold with respect to the orientation of the two sheets and the interactions of the strands. However, the three-dimensional structure of Der p 2 aligns equivalently with a number of proteins from different families within the immunoglobulin superfamily. The structural homology with the highest significance score from analysis by DALI is to Der f 2. Although Der p 2 and Der f 2 are 87% identical in amino acid sequence, they align in three dimensions rather poorly (4.85 A RMSD; Z-score, 8.58). This unexpected finding is likely due to the different solution conditions used during structure determination by NMR for both proteins. While the structural comparisons did not elucidate a clear homologue for the function of Der p 2 in mites, we report that Der p 2 is sequentially homologous to esr16. This is a protein from moths that is expressed coincident with molting. Thus, this homology has important ramifications for the study of mite allergy. The structure of Der p 2 provides a useful tool in the design of recombinant immunotherapeutics for the group 2 allergens.

-	~~{{STRUCTURE_1a9v\| PDB=1a9v \| SCENE= }}~~	+	Tertiary structure of the major house dust mite allergen Der p 2: sequential and structural homologies.,Mueller GA, Benjamin DC, Rule GS Biochemistry. 1998 Sep 15;37(37):12707-14. PMID:9737847<ref>PMID:9737847</ref>

-	~~===TERTIARY STRUCTURE OF THE MAJOR HOUSE DUST MITE ALLERGEN DER P 2~~, ~~NMR, 10 STRUCTURES===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_9737847}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[1a9v]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Dermatophagoides_pteronyssinus Dermatophagoides pteronyssinus]~~. ~~Full experimental information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1A9V OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:009737847<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Dermatophagoides pteronyssinus]]		[[Category: Dermatophagoides pteronyssinus]]
	[[Category: Benjamin, D C.]]		[[Category: Benjamin, D C.]]

OCA: Protected "1a9v" [edit=sysop:move=sysop]

OCA — Sun, 21 Oct 2012 12:23:10 GMT

Protected "1a9v" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:23, 21 October 2012

OCA at 12:23, 21 October 2012

OCA — Sun, 21 Oct 2012 12:23:09 GMT

←Older revision		Revision as of 12:23, 21 October 2012
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-	{{Seed}}
	[[Image:1a9v.png\|left\|200px]]		[[Image:1a9v.png\|left\|200px]]

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	{{STRUCTURE_1a9v\| PDB=1a9v \| SCENE= }}		{{STRUCTURE_1a9v\| PDB=1a9v \| SCENE= }}

	===TERTIARY STRUCTURE OF THE MAJOR HOUSE DUST MITE ALLERGEN DER P 2, NMR, 10 STRUCTURES===		===TERTIARY STRUCTURE OF THE MAJOR HOUSE DUST MITE ALLERGEN DER P 2, NMR, 10 STRUCTURES===

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-	<!--
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	{{ABSTRACT_PUBMED_9737847}}		{{ABSTRACT_PUBMED_9737847}}

	==About this Structure==		==About this Structure==
-	~~1A9V~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Dermatophagoides_pteronyssinus Dermatophagoides pteronyssinus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A9V OCA].	+	[[1a9v]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Dermatophagoides_pteronyssinus Dermatophagoides pteronyssinus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A9V OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~9737847~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:009737847</ref><references group="xtra"/>
	[[Category: Dermatophagoides pteronyssinus]]		[[Category: Dermatophagoides pteronyssinus]]
	[[Category: Benjamin, D C.]]		[[Category: Benjamin, D C.]]
Line 30:		Line 18:
	[[Category: Allergen]]		[[Category: Allergen]]
	[[Category: Immunoglobulin fold]]		[[Category: Immunoglobulin fold]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 21:30:53 2009''