1alb - Revision history

OCA at 06:31, 7 February 2024

OCA — Wed, 07 Feb 2024 06:31:40 GMT

←Older revision		Revision as of 06:31, 7 February 2024
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	<StructureSection load='1alb' size='340' side='right'caption='[[1alb]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='1alb' size='340' side='right'caption='[[1alb]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1alb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ALB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ALB FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1alb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ALB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ALB FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1alb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1alb OCA], [https://pdbe.org/1alb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1alb RCSB], [https://www.ebi.ac.uk/pdbsum/1alb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1alb ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.5Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1alb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1alb OCA], [https://pdbe.org/1alb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1alb RCSB], [https://www.ebi.ac.uk/pdbsum/1alb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1alb ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/FABP4_MOUSE FABP4_MOUSE]] Lipid transport protein in adipocytes. Binds both long chain fatty acids and retinoic acid. Delivers long-chain fatty acids and retinoic acid to their cognate receptors in the nucleus.<ref>PMID:12077340</ref> <ref>PMID:16574478</ref> <ref>PMID:17516629</ref>	+	[https://www.uniprot.org/uniprot/FABP4_MOUSE FABP4_MOUSE] Lipid transport protein in adipocytes. Binds both long chain fatty acids and retinoic acid. Delivers long-chain fatty acids and retinoic acid to their cognate receptors in the nucleus.<ref>PMID:12077340</ref> <ref>PMID:16574478</ref> <ref>PMID:17516629</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1alb ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1alb ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	Adipocyte lipid-binding protein (ALBP) is the adipocyte member of an intracellular hydrophobic ligand-binding protein family. ALBP is phosphorylated by the insulin receptor kinase upon insulin stimulation. The crystal structure of recombinant murine ALBP has been determined and refined to 2.5 A. The final R factor for the model is 0.18 with good canonical properties. Crystalline ALBP has a conformation which is essentially identical to that of intestinal fatty acid binding protein and myelin P2 protein. Although the crystal structure is of the apo- form, a cavity resembling that in other family members is present. It contains a number of bound and implied unbound water molecules and shows no large obvious portal to the external milieu. The cavity of ALBP, which by homology is the ligand-binding site, is formed by both polar and hydrophobic residues among which is tyrosine 19. Y19 is phosphorylated by the insulin receptor kinase as described in the accompanying paper [Buelt, M. K., Xu, Z., Banaszak, L. J., & Bernlohr, D. A. (1992) Biochemistry (following paper in this issue)]. By comparing ALBP with the earlier structural results on intestinal fatty acid binding protein, it is now possible to delineate conserved amino acids which help form the binding site in this family.
-
-	Crystal structure of recombinant murine adipocyte lipid-binding protein.,Xu Z, Bernlohr DA, Banaszak LJ Biochemistry. 1992 Apr 7;31(13):3484-92. PMID:1554730<ref>PMID:1554730</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 1alb" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Lk3 transgenic mice~~]]	+	[[Category: Mus musculus]]
-	[[Category: Banaszak~~, L J~~]]	+	[[Category: Banaszak LJ]]
-	[[Category: Xu, Z]]	+	[[Category: Xu Z]]
-	~~[[Category: Lipid binding protein]]~~	+
-	~~[[Category: Lipid-binding protein~~]]	+

OCA at 10:26, 14 July 2021

OCA — Wed, 14 Jul 2021 10:26:19 GMT

←Older revision		Revision as of 10:26, 14 July 2021
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	<StructureSection load='1alb' size='340' side='right'caption='[[1alb]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='1alb' size='340' side='right'caption='[[1alb]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1alb]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ALB OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1ALB FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1alb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ALB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ALB FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1alb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1alb OCA], [~~http~~://pdbe.org/1alb PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1alb RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1alb PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1alb ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1alb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1alb OCA], [https://pdbe.org/1alb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1alb RCSB], [https://www.ebi.ac.uk/pdbsum/1alb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1alb ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/FABP4_MOUSE FABP4_MOUSE]] Lipid transport protein in adipocytes. Binds both long chain fatty acids and retinoic acid. Delivers long-chain fatty acids and retinoic acid to their cognate receptors in the nucleus.<ref>PMID:12077340</ref> <ref>PMID:16574478</ref> <ref>PMID:17516629</ref>	+	[[https://www.uniprot.org/uniprot/FABP4_MOUSE FABP4_MOUSE]] Lipid transport protein in adipocytes. Binds both long chain fatty acids and retinoic acid. Delivers long-chain fatty acids and retinoic acid to their cognate receptors in the nucleus.<ref>PMID:12077340</ref> <ref>PMID:16574478</ref> <ref>PMID:17516629</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 06:59, 10 October 2019

OCA — Thu, 10 Oct 2019 06:59:34 GMT

←Older revision		Revision as of 06:59, 10 October 2019
Line 1:		Line 1:

	==CRYSTAL STRUCTURE OF RECOMBINANT MURINE ADIPOCYTE LIPID-BINDING PROTEIN==		==CRYSTAL STRUCTURE OF RECOMBINANT MURINE ADIPOCYTE LIPID-BINDING PROTEIN==
-	<StructureSection load='1alb' size='340' side='right' caption='[[1alb]], [[Resolution\|resolution]] 2.50Å' scene=''>	+	<StructureSection load='1alb' size='340' side='right'caption='[[1alb]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1alb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ALB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ALB FirstGlance]. <br>		<table><tr><td colspan='2'>[[1alb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ALB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ALB FirstGlance]. <br>
Line 12:		Line 12:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/al/1alb_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/al/1alb_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 27:		Line 27:
	</div>		</div>
	<div class="pdbe-citations 1alb" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1alb" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Fatty acid-binding protein 3D structures\|Fatty acid-binding protein 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Lk3 transgenic mice]]		[[Category: Lk3 transgenic mice]]
	[[Category: Banaszak, L J]]		[[Category: Banaszak, L J]]

OCA at 06:22, 29 November 2017

OCA — Wed, 29 Nov 2017 06:22:55 GMT

←Older revision		Revision as of 06:22, 29 November 2017
Line 34:		Line 34:
	[[Category: Banaszak, L J]]		[[Category: Banaszak, L J]]
	[[Category: Xu, Z]]		[[Category: Xu, Z]]
		+	[[Category: Lipid binding protein]]
	[[Category: Lipid-binding protein]]		[[Category: Lipid-binding protein]]

OCA at 10:57, 8 November 2017

OCA — Wed, 08 Nov 2017 10:57:45 GMT

←Older revision		Revision as of 10:57, 8 November 2017
Line 1:		Line 1:
		+
	==CRYSTAL STRUCTURE OF RECOMBINANT MURINE ADIPOCYTE LIPID-BINDING PROTEIN==		==CRYSTAL STRUCTURE OF RECOMBINANT MURINE ADIPOCYTE LIPID-BINDING PROTEIN==
	<StructureSection load='1alb' size='340' side='right' caption='[[1alb]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='1alb' size='340' side='right' caption='[[1alb]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1alb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ALB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ALB FirstGlance]. <br>		<table><tr><td colspan='2'>[[1alb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ALB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ALB FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1alb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1alb OCA], [http://pdbe.org/1alb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1alb RCSB], [http://www.ebi.ac.uk/pdbsum/1alb PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1alb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1alb OCA], [http://pdbe.org/1alb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1alb RCSB], [http://www.ebi.ac.uk/pdbsum/1alb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1alb ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	</div>		</div>
	<div class="pdbe-citations 1alb" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1alb" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Fatty acid-binding protein\|Fatty acid-binding protein]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 20:50, 7 February 2016

OCA — Sun, 07 Feb 2016 20:50:30 GMT

←Older revision		Revision as of 20:50, 7 February 2016
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	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1alb ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 04:52, 10 September 2015

OCA — Thu, 10 Sep 2015 04:52:27 GMT

←Older revision		Revision as of 04:52, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='1alb' size='340' side='right' caption='[[1alb]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='1alb' size='340' side='right' caption='[[1alb]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1alb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Mus_musculus Mus musculus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ALB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ALB FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1alb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ALB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ALB FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1alb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1alb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1alb RCSB], [http://www.ebi.ac.uk/pdbsum/1alb PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1alb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1alb OCA], [http://pdbe.org/1alb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1alb RCSB], [http://www.ebi.ac.uk/pdbsum/1alb PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 25:		Line 25:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1alb" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 32:		Line 33:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Mus musculus~~]]	+	[[Category: Lk3 transgenic mice]]
	[[Category: Banaszak, L J]]		[[Category: Banaszak, L J]]
	[[Category: Xu, Z]]		[[Category: Xu, Z]]
	[[Category: Lipid-binding protein]]		[[Category: Lipid-binding protein]]

OCA at 18:09, 24 December 2014

OCA — Wed, 24 Dec 2014 18:09:54 GMT

←Older revision		Revision as of 18:09, 24 December 2014
Line 5:		Line 5:
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1alb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1alb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1alb RCSB], [http://www.ebi.ac.uk/pdbsum/1alb PDBsum]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1alb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1alb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1alb RCSB], [http://www.ebi.ac.uk/pdbsum/1alb PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/FABP4_MOUSE FABP4_MOUSE]] Lipid transport protein in adipocytes. Binds both long chain fatty acids and retinoic acid. Delivers long-chain fatty acids and retinoic acid to their cognate receptors in the nucleus.<ref>PMID:12077340</ref> <ref>PMID:16574478</ref> <ref>PMID:17516629</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 09:54, 22 December 2014

OCA — Mon, 22 Dec 2014 09:54:07 GMT

←Older revision		Revision as of 09:54, 22 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1alb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ALB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ALB FirstGlance]. <br>		<table><tr><td colspan='2'>[[1alb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ALB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ALB FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1alb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1alb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1alb RCSB], [http://www.ebi.ac.uk/pdbsum/1alb PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1alb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1alb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1alb RCSB], [http://www.ebi.ac.uk/pdbsum/1alb PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 31:		Line 31:
	</StructureSection>		</StructureSection>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
-	[[Category: Banaszak, L J.]]	+	[[Category: Banaszak, L J]]
-	[[Category: Xu, Z.]]	+	[[Category: Xu, Z]]
	[[Category: Lipid-binding protein]]		[[Category: Lipid-binding protein]]

OCA at 08:16, 30 July 2014

OCA — Wed, 30 Jul 2014 08:16:12 GMT

←Older revision		Revision as of 08:16, 30 July 2014
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-	[[~~Image~~:1alb.~~png\|left~~\|200px]]	+	==CRYSTAL STRUCTURE OF RECOMBINANT MURINE ADIPOCYTE LIPID-BINDING PROTEIN==
		+	<StructureSection load='1alb' size='340' side='right' caption='[[1alb]], [[Resolution\|resolution]] 2.50Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1alb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ALB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ALB FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1alb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1alb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1alb RCSB], [http://www.ebi.ac.uk/pdbsum/1alb PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/al/1alb_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Adipocyte lipid-binding protein (ALBP) is the adipocyte member of an intracellular hydrophobic ligand-binding protein family. ALBP is phosphorylated by the insulin receptor kinase upon insulin stimulation. The crystal structure of recombinant murine ALBP has been determined and refined to 2.5 A. The final R factor for the model is 0.18 with good canonical properties. Crystalline ALBP has a conformation which is essentially identical to that of intestinal fatty acid binding protein and myelin P2 protein. Although the crystal structure is of the apo- form, a cavity resembling that in other family members is present. It contains a number of bound and implied unbound water molecules and shows no large obvious portal to the external milieu. The cavity of ALBP, which by homology is the ligand-binding site, is formed by both polar and hydrophobic residues among which is tyrosine 19. Y19 is phosphorylated by the insulin receptor kinase as described in the accompanying paper [Buelt, M. K., Xu, Z., Banaszak, L. J., & Bernlohr, D. A. (1992) Biochemistry (following paper in this issue)]. By comparing ALBP with the earlier structural results on intestinal fatty acid binding protein, it is now possible to delineate conserved amino acids which help form the binding site in this family.

-	~~{{STRUCTURE_1alb\| PDB=1alb \| SCENE= }}~~	+	Crystal structure of recombinant murine adipocyte lipid-binding protein.,Xu Z, Bernlohr DA, Banaszak LJ Biochemistry. 1992 Apr 7;31(13):3484-92. PMID:1554730<ref>PMID:1554730</ref>

-	~~===CRYSTAL STRUCTURE OF RECOMBINANT MURINE ADIPOCYTE LIPID-BINDING PROTEIN===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

-	~~{{ABSTRACT_PUBMED_1554730}}~~	+	==See Also==
-		+	*[[Fatty acid-binding protein\|Fatty acid-binding protein]]
-	==~~About this Structure~~==	+	== References ==
-	[[~~1alb~~]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ALB OCA].	+	<references/>
-		+	__TOC__
-	==~~Reference~~==	+	</StructureSection>
-	<~~ref group="xtra">PMID:001554730<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Banaszak, L J.]]		[[Category: Banaszak, L J.]]
	[[Category: Xu, Z.]]		[[Category: Xu, Z.]]
	[[Category: Lipid-binding protein]]		[[Category: Lipid-binding protein]]