1as3 - Revision history

OCA at 10:55, 2 August 2023

OCA — Wed, 02 Aug 2023 10:55:35 GMT

←Older revision		Revision as of 10:55, 2 August 2023
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	<StructureSection load='1as3' size='340' side='right'caption='[[1as3]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='1as3' size='340' side='right'caption='[[1as3]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1as3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Buffalo_rat Buffalo rat~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AS3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1AS3 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1as3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AS3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1AS3 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.4Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1as3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1as3 OCA], [https://pdbe.org/1as3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1as3 RCSB], [https://www.ebi.ac.uk/pdbsum/1as3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1as3 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1as3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1as3 OCA], [https://pdbe.org/1as3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1as3 RCSB], [https://www.ebi.ac.uk/pdbsum/1as3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1as3 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/GNAI1_RAT GNAI1_RAT]] Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. The inactive GDP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division.<ref>PMID:16870394</ref>	+	[https://www.uniprot.org/uniprot/GNAI1_RAT GNAI1_RAT] Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. The inactive GDP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division.<ref>PMID:16870394</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Buffalo rat]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Coleman, D E~~]]	+	[[Category: Rattus norvegicus]]
-	[[Category: ~~Gilman, A G~~]]	+	[[Category: Coleman DE]]
-	[[Category: ~~Raw, A S~~]]	+	[[Category: Gilman AG]]
-	[[Category: ~~Sprang, S R~~]]	+	[[Category: Raw AS]]
-	[[Category: ~~Gtpase]]~~	+	[[Category: Sprang SR]]
-	~~[[Category: Signal transduction~~]]	+

OCA at 10:26, 14 July 2021

OCA — Wed, 14 Jul 2021 10:26:55 GMT

←Older revision		Revision as of 10:26, 14 July 2021
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	<StructureSection load='1as3' size='340' side='right'caption='[[1as3]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='1as3' size='340' side='right'caption='[[1as3]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1as3]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AS3 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1AS3 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1as3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AS3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1AS3 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1as3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1as3 OCA], [~~http~~://pdbe.org/1as3 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1as3 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1as3 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1as3 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1as3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1as3 OCA], [https://pdbe.org/1as3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1as3 RCSB], [https://www.ebi.ac.uk/pdbsum/1as3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1as3 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/GNAI1_RAT GNAI1_RAT]] Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. The inactive GDP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division.<ref>PMID:16870394</ref>	+	[[https://www.uniprot.org/uniprot/GNAI1_RAT GNAI1_RAT]] Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. The inactive GDP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division.<ref>PMID:16870394</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 06:41, 10 October 2019

OCA — Thu, 10 Oct 2019 06:41:40 GMT

←Older revision		Revision as of 06:41, 10 October 2019
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	==GDP BOUND G42V GIA1==		==GDP BOUND G42V GIA1==
-	<StructureSection load='1as3' size='340' side='right' caption='[[1as3]], [[Resolution\|resolution]] 2.40Å' scene=''>	+	<StructureSection load='1as3' size='340' side='right'caption='[[1as3]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1as3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AS3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1AS3 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1as3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AS3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1AS3 FirstGlance]. <br>
Line 33:		Line 33:
	</StructureSection>		</StructureSection>
	[[Category: Buffalo rat]]		[[Category: Buffalo rat]]
		+	[[Category: Large Structures]]
	[[Category: Coleman, D E]]		[[Category: Coleman, D E]]
	[[Category: Gilman, A G]]		[[Category: Gilman, A G]]

OCA at 06:18, 3 January 2018

OCA — Wed, 03 Jan 2018 06:18:24 GMT

←Older revision		Revision as of 06:18, 3 January 2018
Line 1:		Line 1:
		+
	==GDP BOUND G42V GIA1==		==GDP BOUND G42V GIA1==
	<StructureSection load='1as3' size='340' side='right' caption='[[1as3]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='1as3' size='340' side='right' caption='[[1as3]], [[Resolution\|resolution]] 2.40Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[1as3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AS3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1AS3 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1as3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AS3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1AS3 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1as3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1as3 OCA], [http://pdbe.org/1as3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1as3 RCSB], [http://www.ebi.ac.uk/pdbsum/1as3 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1as3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1as3 OCA], [http://pdbe.org/1as3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1as3 RCSB], [http://www.ebi.ac.uk/pdbsum/1as3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1as3 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 12:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/as/1as3_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/as/1as3_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1as3 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 27:		Line 28:
	</div>		</div>
	<div class="pdbe-citations 1as3" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1as3" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Guanine nucleotide-binding protein\|Guanine nucleotide-binding protein]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 14:20, 11 September 2015

OCA — Fri, 11 Sep 2015 14:20:26 GMT

←Older revision		Revision as of 14:20, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='1as3' size='340' side='right' caption='[[1as3]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='1as3' size='340' side='right' caption='[[1as3]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1as3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Rattus_norvegicus Rattus norvegicus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AS3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1AS3 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1as3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AS3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1AS3 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1as3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1as3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1as3 RCSB], [http://www.ebi.ac.uk/pdbsum/1as3 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1as3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1as3 OCA], [http://pdbe.org/1as3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1as3 RCSB], [http://www.ebi.ac.uk/pdbsum/1as3 PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 26:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1as3" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 33:		Line 34:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Rattus norvegicus~~]]	+	[[Category: Buffalo rat]]
	[[Category: Coleman, D E]]		[[Category: Coleman, D E]]
	[[Category: Gilman, A G]]		[[Category: Gilman, A G]]

OCA at 17:37, 25 December 2014

OCA — Thu, 25 Dec 2014 17:37:51 GMT

←Older revision		Revision as of 17:37, 25 December 2014
Line 6:		Line 6:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1as3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1as3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1as3 RCSB], [http://www.ebi.ac.uk/pdbsum/1as3 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1as3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1as3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1as3 RCSB], [http://www.ebi.ac.uk/pdbsum/1as3 PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/GNAI1_RAT GNAI1_RAT]] Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. The inactive GDP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division.<ref>PMID:16870394</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 09:36, 22 December 2014

OCA — Mon, 22 Dec 2014 09:36:11 GMT

←Older revision		Revision as of 09:36, 22 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1as3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AS3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1AS3 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1as3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AS3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1AS3 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1as3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1as3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1as3 RCSB], [http://www.ebi.ac.uk/pdbsum/1as3 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1as3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1as3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1as3 RCSB], [http://www.ebi.ac.uk/pdbsum/1as3 PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 32:		Line 32:
	</StructureSection>		</StructureSection>
	[[Category: Rattus norvegicus]]		[[Category: Rattus norvegicus]]
-	[[Category: Coleman, D E.]]	+	[[Category: Coleman, D E]]
-	[[Category: Gilman, A G.]]	+	[[Category: Gilman, A G]]
-	[[Category: Raw, A S.]]	+	[[Category: Raw, A S]]
-	[[Category: Sprang, S R.]]	+	[[Category: Sprang, S R]]
	[[Category: Gtpase]]		[[Category: Gtpase]]
	[[Category: Signal transduction]]		[[Category: Signal transduction]]

OCA at 08:08, 30 July 2014

OCA — Wed, 30 Jul 2014 08:08:10 GMT

←Older revision		Revision as of 08:08, 30 July 2014
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-	[[~~Image~~:1as3.~~png\|left~~\|200px]]	+	==GDP BOUND G42V GIA1==
		+	<StructureSection load='1as3' size='340' side='right' caption='[[1as3]], [[Resolution\|resolution]] 2.40Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1as3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AS3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1AS3 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1as3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1as3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1as3 RCSB], [http://www.ebi.ac.uk/pdbsum/1as3 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/as/1as3_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The Gly42 --> Val mutant of Gialpha1 was characterized structurally and biochemically to elucidate two important features of Gialpha1-catalyzed GTP hydrolysis. The crystal structure of the GTPgammaS-bound G42VGialpha1 protein demonstrates that the steric bulk of Val42 pushes the Gln204 residue into a catalytically incompetent conformation, providing a rationale for the diminished GTPase activity of this mutant. The same phenomenon may also account for the diminished GTPase activity of the homologous transforming Gly42 --> Val mutation in p21(ras). Similarly, the steric bulk of the unique Ser42 residue in Gzalpha may account for the comparatively slower rate of GTP hydrolysis by this Galpha subunit. The G42VGialpha1 subunit was also characterized structurally in its GDP.Pi- and GDP-bound states, providing a unique opportunity to view three "snapshots" of GTP hydrolysis. Hydrolysis of GTP to a transient GDP.Pi-bound intermediate is associated with substantial conformational changes in the switch II segment of the protein. Eventual release of Pi results in further removal of switch I from the active site and a highly mobile switch II segment. Despite their disparate biochemical properties, the structural similarity of G42VGialpha1 to the G203AGialpha1 mutant in the GDP.Pi-bound form suggests that both mutations stabilize a conformation of the GDP. Pi-bound protein that occurs only transiently in the wild-type protein. The structures of the GDP-bound forms of the wild-type and mutant proteins are similar.

-	~~{{STRUCTURE_1as3\| PDB=1as3 \| SCENE= }}~~	+	Structural and biochemical characterization of the GTPgammaS-, GDP.Pi-, and GDP-bound forms of a GTPase-deficient Gly42 --> Val mutant of Gialpha1.,Raw AS, Coleman DE, Gilman AG, Sprang SR Biochemistry. 1997 Dec 16;36(50):15660-9. PMID:9398294<ref>PMID:9398294</ref>

-	~~===GDP BOUND G42V GIA1===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

-	~~{{ABSTRACT_PUBMED_9398294}}~~	+	==See Also==
-		+	*[[Guanine nucleotide-binding protein\|Guanine nucleotide-binding protein]]
-	==~~About this Structure~~==	+	== References ==
-	[[~~1as3~~]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AS3 OCA].	+	<references/>
-		+	__TOC__
-	==~~Reference~~==	+	</StructureSection>
-	<~~ref group="xtra">PMID:009398294<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Rattus norvegicus]]		[[Category: Rattus norvegicus]]
	[[Category: Coleman, D E.]]		[[Category: Coleman, D E.]]

OCA: Protected "1as3" [edit=sysop:move=sysop]

OCA — Sun, 21 Oct 2012 11:45:36 GMT

Protected "1as3" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:45, 21 October 2012

OCA at 11:45, 21 October 2012

OCA — Sun, 21 Oct 2012 11:45:32 GMT

←Older revision		Revision as of 11:45, 21 October 2012
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-	{{Seed}}
	[[Image:1as3.png\|left\|200px]]		[[Image:1as3.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1as3", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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	{{STRUCTURE_1as3\| PDB=1as3 \| SCENE= }}		{{STRUCTURE_1as3\| PDB=1as3 \| SCENE= }}

	===GDP BOUND G42V GIA1===		===GDP BOUND G42V GIA1===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_9398294}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 9398294 is the PubMed ID number.
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	{{ABSTRACT_PUBMED_9398294}}		{{ABSTRACT_PUBMED_9398294}}

	==About this Structure==		==About this Structure==
-	~~1AS3~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AS3 OCA].	+	[[1as3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AS3 OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~9398294~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:009398294</ref><references group="xtra"/>
	[[Category: Rattus norvegicus]]		[[Category: Rattus norvegicus]]
	[[Category: Coleman, D E.]]		[[Category: Coleman, D E.]]
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	[[Category: Gtpase]]		[[Category: Gtpase]]
	[[Category: Signal transduction]]		[[Category: Signal transduction]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 00:25:32 2009''