1at4 - Revision history

OCA at 01:17, 28 December 2023

OCA — Thu, 28 Dec 2023 01:17:38 GMT

←Older revision		Revision as of 01:17, 28 December 2023
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	==INTRAMOLECULAR DNA TRIPLEX CONTAINING A NON-NUCLEOTIDE LINKER (GAGAGA-X-TCTCCT-X-CTCTCT), NMR, 7 STRUCTURES==		==INTRAMOLECULAR DNA TRIPLEX CONTAINING A NON-NUCLEOTIDE LINKER (GAGAGA-X-TCTCCT-X-CTCTCT), NMR, 7 STRUCTURES==
-	<StructureSection load='1at4' size='340' side='right'caption='[[1at4~~]], [[NMR_Ensembles_of_Models \| 7 NMR models~~]]' scene=''>	+	<StructureSection load='1at4' size='340' side='right'caption='[[1at4]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1at4]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AT4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1AT4 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1at4]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AT4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1AT4 FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style~~=~~'overflow: auto; max-height: 3em;'>[[1ao9\|1ao9]]</div~~></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1at4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1at4 OCA], [https://pdbe.org/1at4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1at4 RCSB], [https://www.ebi.ac.uk/pdbsum/1at4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1at4 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1at4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1at4 OCA], [https://pdbe.org/1at4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1at4 RCSB], [https://www.ebi.ac.uk/pdbsum/1at4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1at4 ProSAT]</span></td></tr>
	</table>		</table>
Line 21:		Line 21:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Bartley~~, J P]]~~	+	[[Category: Bartley JP]]
-	~~[[Category: Deoxyribonucleic acid]]~~	+
-	~~[[Category: Dna]]~~	+
-	~~[[Category: Intramolecular triplex~~]]	+

OCA at 06:54, 24 February 2021

OCA — Wed, 24 Feb 2021 06:54:25 GMT

←Older revision		Revision as of 06:54, 24 February 2021
Line 3:		Line 3:
	<StructureSection load='1at4' size='340' side='right'caption='[[1at4]], [[NMR_Ensembles_of_Models \| 7 NMR models]]' scene=''>		<StructureSection load='1at4' size='340' side='right'caption='[[1at4]], [[NMR_Ensembles_of_Models \| 7 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1at4]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AT4 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1AT4 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1at4]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AT4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1AT4 FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ao9\|1ao9]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1ao9\|1ao9]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1at4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1at4 OCA], [~~http~~://pdbe.org/1at4 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1at4 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1at4 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1at4 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1at4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1at4 OCA], [https://pdbe.org/1at4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1at4 RCSB], [https://www.ebi.ac.uk/pdbsum/1at4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1at4 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 08:49, 21 May 2019

OCA — Tue, 21 May 2019 08:49:05 GMT

←Older revision		Revision as of 08:49, 21 May 2019
Line 1:		Line 1:

	==INTRAMOLECULAR DNA TRIPLEX CONTAINING A NON-NUCLEOTIDE LINKER (GAGAGA-X-TCTCCT-X-CTCTCT), NMR, 7 STRUCTURES==		==INTRAMOLECULAR DNA TRIPLEX CONTAINING A NON-NUCLEOTIDE LINKER (GAGAGA-X-TCTCCT-X-CTCTCT), NMR, 7 STRUCTURES==
-	<StructureSection load='1at4' size='340' side='right' caption='[[1at4]], [[NMR_Ensembles_of_Models \| 7 NMR models]]' scene=''>	+	<StructureSection load='1at4' size='340' side='right'caption='[[1at4]], [[NMR_Ensembles_of_Models \| 7 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1at4]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AT4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1AT4 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1at4]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AT4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1AT4 FirstGlance]. <br>
Line 20:		Line 20:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Bartley, J P]]		[[Category: Bartley, J P]]
	[[Category: Deoxyribonucleic acid]]		[[Category: Deoxyribonucleic acid]]
	[[Category: Dna]]		[[Category: Dna]]
	[[Category: Intramolecular triplex]]		[[Category: Intramolecular triplex]]

OCA at 06:11, 17 August 2017

OCA — Thu, 17 Aug 2017 06:11:26 GMT

←Older revision		Revision as of 06:11, 17 August 2017
Line 1:		Line 1:
		+
	==INTRAMOLECULAR DNA TRIPLEX CONTAINING A NON-NUCLEOTIDE LINKER (GAGAGA-X-TCTCCT-X-CTCTCT), NMR, 7 STRUCTURES==		==INTRAMOLECULAR DNA TRIPLEX CONTAINING A NON-NUCLEOTIDE LINKER (GAGAGA-X-TCTCCT-X-CTCTCT), NMR, 7 STRUCTURES==
	<StructureSection load='1at4' size='340' side='right' caption='[[1at4]], [[NMR_Ensembles_of_Models \| 7 NMR models]]' scene=''>		<StructureSection load='1at4' size='340' side='right' caption='[[1at4]], [[NMR_Ensembles_of_Models \| 7 NMR models]]' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[1at4]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AT4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1AT4 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1at4]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AT4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1AT4 FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ao9\|1ao9]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ao9\|1ao9]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1at4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1at4 OCA], [http://pdbe.org/1at4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1at4 RCSB], [http://www.ebi.ac.uk/pdbsum/1at4 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1at4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1at4 OCA], [http://pdbe.org/1at4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1at4 RCSB], [http://www.ebi.ac.uk/pdbsum/1at4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1at4 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 23:18, 10 September 2015

OCA — Thu, 10 Sep 2015 23:18:06 GMT

←Older revision		Revision as of 23:18, 10 September 2015
Line 4:		Line 4:
	<table><tr><td colspan='2'>[[1at4]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AT4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1AT4 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1at4]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AT4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1AT4 FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ao9\|1ao9]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ao9\|1ao9]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1at4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1at4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1at4 RCSB], [http://www.ebi.ac.uk/pdbsum/1at4 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1at4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1at4 OCA], [http://pdbe.org/1at4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1at4 RCSB], [http://www.ebi.ac.uk/pdbsum/1at4 PDBsum]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 14:		Line 14:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1at4" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 06:06, 22 December 2014

OCA — Mon, 22 Dec 2014 06:06:23 GMT

←Older revision		Revision as of 06:06, 22 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1at4]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AT4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1AT4 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1at4]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AT4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1AT4 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ao9\|1ao9]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ao9\|1ao9]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1at4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1at4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1at4 RCSB], [http://www.ebi.ac.uk/pdbsum/1at4 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1at4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1at4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1at4 RCSB], [http://www.ebi.ac.uk/pdbsum/1at4 PDBsum]</span></td></tr>
-	<table>	+	</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 18:		Line 18:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Bartley, J P.]]	+	[[Category: Bartley, J P]]
	[[Category: Deoxyribonucleic acid]]		[[Category: Deoxyribonucleic acid]]
	[[Category: Dna]]		[[Category: Dna]]
	[[Category: Intramolecular triplex]]		[[Category: Intramolecular triplex]]

OCA at 05:46, 8 June 2014

OCA — Sun, 08 Jun 2014 05:46:28 GMT

←Older revision		Revision as of 05:46, 8 June 2014
Line 1:		Line 1:
-	[[~~Image:~~1at4.~~png~~\|~~left~~\|~~200px~~]]	+	==INTRAMOLECULAR DNA TRIPLEX CONTAINING A NON-NUCLEOTIDE LINKER (GAGAGA-X-TCTCCT-X-CTCTCT), NMR, 7 STRUCTURES==
		+	<StructureSection load='1at4' size='340' side='right' caption='[[1at4]], [[NMR_Ensembles_of_Models \| 7 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1at4]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AT4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1AT4 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ao9\|1ao9]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1at4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1at4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1at4 RCSB], [http://www.ebi.ac.uk/pdbsum/1at4 PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The solution properties of the parallel intramolecular DNA triplex d(GAGAGA-oct-TCTCTC-oct-CTCTCT) (oct = -O-(CH2)8-O-PO2-O-(CH2)8-O-PO2-) and the duplex d(GAGAGA-oct-TCTCTC) have been examined by UV melting and high-resolution nuclear magnetic resonance spectroscopy (NMR). All nucleotides were primarily in the S conformation (i.e. near C2'-endo) in both the duplex and the triplex. However, the sugars of the Hoogsteen pyrimidine strand had a lower fraction of the S state than the Watson-Crick strands. Glycosidic torsion angles derived from nuclear Overhauser effect (NOE) build-up curves were found in the range -103 degrees to -133 degrees, with a clear alternation in magnitude along the GAGAGA strand in the triplex, whereas the glycosidic torsion angles were more similar in the duplex. Internucleotide NOEs were also consistent with an overall B-like geometry, rather than the A family. However, particularly in the Hoogsteen strand, some sequential NOE intensities were intermediate between those of the B and A forms. Distance and torsion constraints derived from NMR experiments were used to generate structures and were refined by restrained molecular dynamics. Extensive chemical shift differences between residues in the triplex and duplex were found for the purine strand, and there were remarkable differences in the pattern of shift differences for the A and G residues that correlated with differences in glycosidic torsion angles. Although there are differences in structure between the free duplex and that in the triplex, they are in important respects similar, indicating that only small conformational adjustments are needed to make parallel triple helices.

-	~~{{STRUCTURE_1at4\| PDB=1at4 \| SCENE= }}~~	+	Solution conformation of an intramolecular DNA triplex containing a nonnucleotide linker: comparison with the DNA duplex.,Bartley JP, Brown T, Lane AN Biochemistry. 1997 Nov 25;36(47):14502-11. PMID:9398169<ref>PMID:9398169</ref>

-	~~===INTRAMOLECULAR DNA TRIPLEX CONTAINING A NON-NUCLEOTIDE LINKER (GAGAGA-X-TCTCCT-X-CTCTCT)~~, ~~NMR, 7 STRUCTURES===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_9398169}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[1at4]] is~~ a ~~1 chain structure~~. ~~Full experimental information is available from [http://oca~~.~~weizmann~~.~~ac.il~~/~~oca-bin/ocashort?id=1AT4 OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:009398169<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Bartley, J P.]]		[[Category: Bartley, J P.]]
	[[Category: Deoxyribonucleic acid]]		[[Category: Deoxyribonucleic acid]]
	[[Category: Dna]]		[[Category: Dna]]
	[[Category: Intramolecular triplex]]		[[Category: Intramolecular triplex]]

OCA: Protected "1at4" [edit=sysop:move=sysop]

OCA — Tue, 14 Aug 2012 17:51:32 GMT

Protected "1at4" [edit=sysop:move=sysop]

←Older revision

Revision as of 17:51, 14 August 2012

OCA at 17:51, 14 August 2012

OCA — Tue, 14 Aug 2012 17:51:30 GMT

←Older revision		Revision as of 17:51, 14 August 2012
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-	{{Seed}}
	[[Image:1at4.png\|left\|200px]]		[[Image:1at4.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1at4", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1at4\| PDB=1at4 \| SCENE= }}		{{STRUCTURE_1at4\| PDB=1at4 \| SCENE= }}

	===INTRAMOLECULAR DNA TRIPLEX CONTAINING A NON-NUCLEOTIDE LINKER (GAGAGA-X-TCTCCT-X-CTCTCT), NMR, 7 STRUCTURES===		===INTRAMOLECULAR DNA TRIPLEX CONTAINING A NON-NUCLEOTIDE LINKER (GAGAGA-X-TCTCCT-X-CTCTCT), NMR, 7 STRUCTURES===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_9398169}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 9398169 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_9398169}}		{{ABSTRACT_PUBMED_9398169}}

	==About this Structure==		==About this Structure==
-	Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AT4 OCA].	+	[[1at4]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AT4 OCA].

	==Reference==		==Reference==
-	~~Solution conformation of an intramolecular DNA triplex containing a nonnucleotide linker: comparison with the DNA duplex., Bartley JP, Brown T, Lane AN, Biochemistry. 1997 Nov 25;36(47):14502-11.~~ PMID:~~[http://www.ncbi.nlm.nih.gov~~/~~pubmed~~/~~9398169 9398169]~~	+	<ref group="xtra">PMID:009398169</ref><references group="xtra"/>
	[[Category: Bartley, J P.]]		[[Category: Bartley, J P.]]
	[[Category: Deoxyribonucleic acid]]		[[Category: Deoxyribonucleic acid]]
	[[Category: Dna]]		[[Category: Dna]]
	[[Category: Intramolecular triplex]]		[[Category: Intramolecular triplex]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 17:32:52 2008''

OCA at 14:32, 30 June 2008

OCA — Mon, 30 Jun 2008 14:32:55 GMT

←Older revision		Revision as of 14:32, 30 June 2008
Line 1:		Line 1:
-	[[Image:1at4.~~gif~~\|left\|200px]]	+	{{Seed}}
		+	[[Image:1at4.png\|left\|200px]]

	<!--		<!--
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	{{STRUCTURE_1at4\| PDB=1at4 \| SCENE= }}		{{STRUCTURE_1at4\| PDB=1at4 \| SCENE= }}

-	~~'''~~INTRAMOLECULAR DNA TRIPLEX CONTAINING A NON-NUCLEOTIDE LINKER (GAGAGA-X-TCTCCT-X-CTCTCT), NMR, 7 STRUCTURES~~'''~~	+	===INTRAMOLECULAR DNA TRIPLEX CONTAINING A NON-NUCLEOTIDE LINKER (GAGAGA-X-TCTCCT-X-CTCTCT), NMR, 7 STRUCTURES===


-	~~==Overview==~~	+	<!--
-	The ~~solution properties of~~ the ~~parallel intramolecular DNA triplex d(GAGAGA-oct-TCTCTC-oct-CTCTCT) (oct = -O-(CH2)8-O-PO2-O-(CH2)8-O-PO2-) and~~ the ~~duplex d~~(~~GAGAGA-oct-TCTCTC) have been examined by UV melting and high-resolution nuclear magnetic resonance spectroscopy (NMR)~~. ~~All nucleotides were primarily in the S conformation (i~~.~~e. near C2'-endo~~) ~~in both the duplex and the triplex. However~~, the ~~sugars of the Hoogsteen pyrimidine strand had a lower fraction of the S state than the Watson-Crick strands~~. ~~Glycosidic torsion angles derived from nuclear Overhauser effect (NOE) build~~-~~up curves were found in the range~~ -103 degrees to -133 degrees, with a clear alternation in magnitude along the GAGAGA strand in the triplex, whereas the glycosidic torsion angles were more similar in the duplex. Internucleotide NOEs were also consistent with an overall B-like geometry, rather than the A family. However, particularly in the Hoogsteen strand, some sequential NOE intensities were intermediate between those of the B and A forms. Distance and torsion constraints derived from NMR experiments were used to generate structures and were refined by restrained molecular dynamics. Extensive chemical shift differences between residues in the triplex and duplex were found for the purine strand, and there were remarkable differences in the pattern of shift differences for the A and G residues that correlated with differences in glycosidic torsion angles. Although there are differences in structure between the free duplex and that in the triplex, they are in important respects similar, indicating that only small conformational adjustments are needed to make parallel triple helices.	+	The line below this paragraph, {{ABSTRACT_PUBMED_9398169}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 9398169 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_9398169}}

	==About this Structure==		==About this Structure==
-	Full ~~crystallographic~~ information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AT4 OCA].	+	Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AT4 OCA].

	==Reference==		==Reference==
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	[[Category: Dna]]		[[Category: Dna]]
	[[Category: Intramolecular triplex]]		[[Category: Intramolecular triplex]]
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Fri May 2 10~~:39:54 2008''	+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 17:32:52 2008''