1b0n - Revision history

OCA at 23:18, 27 December 2023

OCA — Wed, 27 Dec 2023 23:18:15 GMT

←Older revision		Revision as of 23:18, 27 December 2023
Line 3:		Line 3:
	<StructureSection load='1b0n' size='340' side='right'caption='[[1b0n]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='1b0n' size='340' side='right'caption='[[1b0n]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1b0n]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"vibrio_subtilis"_ehrenberg_1835 "vibrio~~ subtilis~~" ehrenberg 1835~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B0N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1B0N FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1b0n]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B0N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1B0N FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.9Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>SINR, SINI ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~1423~~ "~~Vibrio subtilis~~" ~~Ehrenberg 1835])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1b0n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1b0n OCA], [https://pdbe.org/1b0n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1b0n RCSB], [https://www.ebi.ac.uk/pdbsum/1b0n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1b0n ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1b0n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1b0n OCA], [https://pdbe.org/1b0n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1b0n RCSB], [https://www.ebi.ac.uk/pdbsum/1b0n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1b0n ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/SINR_BACSU SINR_BACSU]] Negative as well as positive regulator of alternate developmental processes that are induced at the end of vegetative growth in response to nutrient depletion. Binds to the alkaline protease (aprE) gene at two sites. Also acts as a repressor of the key sporulation gene spo0A. Negatively regulates transcription of the eps operon, which is responsible for the biosynthesis of an exopolysaccharide involved in biofilm formation; therefore it could govern the transition between a state in which bacteria swim or swarm and a state in which bacteria assemble into multicellular communities. Acts with Hpr as a corepressor of epr expression. Also negatively regulates transcription of the lutABC operon, which is required for lactate utilization. Repressor activity is regulated by SinI.<ref>PMID:1898931</ref> <ref>PMID:7642487</ref> <ref>PMID:15661000</ref> <ref>PMID:16923912</ref> ~~[[https://www.uniprot.org/uniprot/SINI_BACSU SINI_BACSU]] Acts as an antagonist to SinR. SinI prevents SinR from binding to its target sequence on the gene for AprE.~~	+	[https://www.uniprot.org/uniprot/SINR_BACSU SINR_BACSU] Negative as well as positive regulator of alternate developmental processes that are induced at the end of vegetative growth in response to nutrient depletion. Binds to the alkaline protease (aprE) gene at two sites. Also acts as a repressor of the key sporulation gene spo0A. Negatively regulates transcription of the eps operon, which is responsible for the biosynthesis of an exopolysaccharide involved in biofilm formation; therefore it could govern the transition between a state in which bacteria swim or swarm and a state in which bacteria assemble into multicellular communities. Acts with Hpr as a corepressor of epr expression. Also negatively regulates transcription of the lutABC operon, which is required for lactate utilization. Repressor activity is regulated by SinI.<ref>PMID:1898931</ref> <ref>PMID:7642487</ref> <ref>PMID:15661000</ref> <ref>PMID:16923912</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 33:		Line 33:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Vibrio~~ subtilis ~~ehrenberg 1835~~]]	+	[[Category: Bacillus subtilis]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Brannigan~~, J A~~]]	+	[[Category: Brannigan JA]]
-	[[Category: Lewis~~, R J~~]]	+	[[Category: Lewis RJ]]
-	[[Category: Offen~~, W A~~]]	+	[[Category: Offen WA]]
-	[[Category: Smith, I]]	+	[[Category: Smith I]]
-	[[Category: Wilkinson~~, A J]]~~	+	[[Category: Wilkinson AJ]]
-	~~[[Category: Antagonist]]~~	+
-	~~[[Category: Sporulation]]~~	+
-	~~[[Category: Transcription regulator~~]]	+

OCA at 06:56, 24 February 2021

OCA — Wed, 24 Feb 2021 06:56:02 GMT

←Older revision		Revision as of 06:56, 24 February 2021
Line 3:		Line 3:
	<StructureSection load='1b0n' size='340' side='right'caption='[[1b0n]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='1b0n' size='340' side='right'caption='[[1b0n]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1b0n]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"vibrio_subtilis"_ehrenberg_1835 "vibrio subtilis" ehrenberg 1835]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B0N OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1B0N FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1b0n]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/"vibrio_subtilis"_ehrenberg_1835 "vibrio subtilis" ehrenberg 1835]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B0N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1B0N FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SINR, SINI ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1423 "Vibrio subtilis" Ehrenberg 1835])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SINR, SINI ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1423 "Vibrio subtilis" Ehrenberg 1835])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1b0n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1b0n OCA], [~~http~~://pdbe.org/1b0n PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1b0n RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1b0n PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1b0n ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1b0n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1b0n OCA], [https://pdbe.org/1b0n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1b0n RCSB], [https://www.ebi.ac.uk/pdbsum/1b0n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1b0n ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/SINR_BACSU SINR_BACSU]] Negative as well as positive regulator of alternate developmental processes that are induced at the end of vegetative growth in response to nutrient depletion. Binds to the alkaline protease (aprE) gene at two sites. Also acts as a repressor of the key sporulation gene spo0A. Negatively regulates transcription of the eps operon, which is responsible for the biosynthesis of an exopolysaccharide involved in biofilm formation; therefore it could govern the transition between a state in which bacteria swim or swarm and a state in which bacteria assemble into multicellular communities. Acts with Hpr as a corepressor of epr expression. Also negatively regulates transcription of the lutABC operon, which is required for lactate utilization. Repressor activity is regulated by SinI.<ref>PMID:1898931</ref> <ref>PMID:7642487</ref> <ref>PMID:15661000</ref> <ref>PMID:16923912</ref> [[~~http~~://www.uniprot.org/uniprot/SINI_BACSU SINI_BACSU]] Acts as an antagonist to SinR. SinI prevents SinR from binding to its target sequence on the gene for AprE.	+	[[https://www.uniprot.org/uniprot/SINR_BACSU SINR_BACSU]] Negative as well as positive regulator of alternate developmental processes that are induced at the end of vegetative growth in response to nutrient depletion. Binds to the alkaline protease (aprE) gene at two sites. Also acts as a repressor of the key sporulation gene spo0A. Negatively regulates transcription of the eps operon, which is responsible for the biosynthesis of an exopolysaccharide involved in biofilm formation; therefore it could govern the transition between a state in which bacteria swim or swarm and a state in which bacteria assemble into multicellular communities. Acts with Hpr as a corepressor of epr expression. Also negatively regulates transcription of the lutABC operon, which is required for lactate utilization. Repressor activity is regulated by SinI.<ref>PMID:1898931</ref> <ref>PMID:7642487</ref> <ref>PMID:15661000</ref> <ref>PMID:16923912</ref> [[https://www.uniprot.org/uniprot/SINI_BACSU SINI_BACSU]] Acts as an antagonist to SinR. SinI prevents SinR from binding to its target sequence on the gene for AprE.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 08:43, 21 May 2019

OCA — Tue, 21 May 2019 08:43:12 GMT

←Older revision		Revision as of 08:43, 21 May 2019
Line 1:		Line 1:

	==SINR PROTEIN/SINI PROTEIN COMPLEX==		==SINR PROTEIN/SINI PROTEIN COMPLEX==
-	<StructureSection load='1b0n' size='340' side='right' caption='[[1b0n]], [[Resolution\|resolution]] 1.90Å' scene=''>	+	<StructureSection load='1b0n' size='340' side='right'caption='[[1b0n]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1b0n]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B0N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1B0N FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1b0n]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"vibrio_subtilis"_ehrenberg_1835 "vibrio subtilis" ehrenberg 1835]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B0N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1B0N FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SINR, SINI ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1423 "Vibrio subtilis" Ehrenberg 1835])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1b0n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1b0n OCA], [http://pdbe.org/1b0n PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1b0n RCSB], [http://www.ebi.ac.uk/pdbsum/1b0n PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1b0n ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1b0n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1b0n OCA], [http://pdbe.org/1b0n PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1b0n RCSB], [http://www.ebi.ac.uk/pdbsum/1b0n PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1b0n ProSAT]</span></td></tr>
	</table>		</table>
Line 13:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/b0/1b0n_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/b0/1b0n_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 32:		Line 33:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Vibrio subtilis ehrenberg 1835]]
		+	[[Category: Large Structures]]
	[[Category: Brannigan, J A]]		[[Category: Brannigan, J A]]
	[[Category: Lewis, R J]]		[[Category: Lewis, R J]]

OCA at 06:07, 17 August 2017

OCA — Thu, 17 Aug 2017 06:07:36 GMT

←Older revision		Revision as of 06:07, 17 August 2017
Line 1:		Line 1:
		+
	==SINR PROTEIN/SINI PROTEIN COMPLEX==		==SINR PROTEIN/SINI PROTEIN COMPLEX==
	<StructureSection load='1b0n' size='340' side='right' caption='[[1b0n]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='1b0n' size='340' side='right' caption='[[1b0n]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1b0n]] is a 2 chain structure ~~with sequence from [http://en.wikipedia.org/wiki/"bacillus_globigii"_migula_1900 "bacillus globigii" migula 1900]~~. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B0N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1B0N FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1b0n]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B0N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1B0N FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SINR, SINI ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1423 "Bacillus globigii" Migula 1900])</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1b0n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1b0n OCA], [http://pdbe.org/1b0n PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1b0n RCSB], [http://www.ebi.ac.uk/pdbsum/1b0n PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1b0n ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1b0n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1b0n OCA], [http://pdbe.org/1b0n PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1b0n RCSB], [http://www.ebi.ac.uk/pdbsum/1b0n PDBsum]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1b0n ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 32:		Line 32:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Bacillus globigii migula 1900]]
	[[Category: Brannigan, J A]]		[[Category: Brannigan, J A]]
	[[Category: Lewis, R J]]		[[Category: Lewis, R J]]

OCA at 11:58, 11 September 2015

OCA — Fri, 11 Sep 2015 11:58:31 GMT

←Older revision		Revision as of 11:58, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='1b0n' size='340' side='right' caption='[[1b0n]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='1b0n' size='340' side='right' caption='[[1b0n]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1b0n]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Bacillus_subtilis Bacillus subtilis~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B0N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1B0N FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1b0n]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_globigii"_migula_1900 "bacillus globigii" migula 1900]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B0N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1B0N FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SINR, SINI ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1423 Bacillus ~~subtilis~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SINR, SINI ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1423 "Bacillus globigii" Migula 1900])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1b0n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1b0n OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1b0n RCSB], [http://www.ebi.ac.uk/pdbsum/1b0n PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1b0n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1b0n OCA], [http://pdbe.org/1b0n PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1b0n RCSB], [http://www.ebi.ac.uk/pdbsum/1b0n PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 27:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1b0n" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Bacillus ~~subtilis~~]]	+	[[Category: Bacillus globigii migula 1900]]
	[[Category: Brannigan, J A]]		[[Category: Brannigan, J A]]
	[[Category: Lewis, R J]]		[[Category: Lewis, R J]]

OCA at 16:09, 25 December 2014

OCA — Thu, 25 Dec 2014 16:09:07 GMT

←Older revision		Revision as of 16:09, 25 December 2014
Line 7:		Line 7:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1b0n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1b0n OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1b0n RCSB], [http://www.ebi.ac.uk/pdbsum/1b0n PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1b0n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1b0n OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1b0n RCSB], [http://www.ebi.ac.uk/pdbsum/1b0n PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/SINR_BACSU SINR_BACSU]] Negative as well as positive regulator of alternate developmental processes that are induced at the end of vegetative growth in response to nutrient depletion. Binds to the alkaline protease (aprE) gene at two sites. Also acts as a repressor of the key sporulation gene spo0A. Negatively regulates transcription of the eps operon, which is responsible for the biosynthesis of an exopolysaccharide involved in biofilm formation; therefore it could govern the transition between a state in which bacteria swim or swarm and a state in which bacteria assemble into multicellular communities. Acts with Hpr as a corepressor of epr expression. Also negatively regulates transcription of the lutABC operon, which is required for lactate utilization. Repressor activity is regulated by SinI.<ref>PMID:1898931</ref> <ref>PMID:7642487</ref> <ref>PMID:15661000</ref> <ref>PMID:16923912</ref> [[http://www.uniprot.org/uniprot/SINI_BACSU SINI_BACSU]] Acts as an antagonist to SinR. SinI prevents SinR from binding to its target sequence on the gene for AprE.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 10:39, 22 December 2014

OCA — Mon, 22 Dec 2014 10:39:57 GMT

←Older revision		Revision as of 10:39, 22 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1b0n]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B0N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1B0N FirstGlance]. <br>		<table><tr><td colspan='2'>[[1b0n]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B0N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1B0N FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SINR, SINI ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1423 Bacillus subtilis])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SINR, SINI ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1423 Bacillus subtilis])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1b0n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1b0n OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1b0n RCSB], [http://www.ebi.ac.uk/pdbsum/1b0n PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1b0n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1b0n OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1b0n RCSB], [http://www.ebi.ac.uk/pdbsum/1b0n PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 30:		Line 30:
	</StructureSection>		</StructureSection>
	[[Category: Bacillus subtilis]]		[[Category: Bacillus subtilis]]
-	[[Category: Brannigan, J A.]]	+	[[Category: Brannigan, J A]]
-	[[Category: Lewis, R J.]]	+	[[Category: Lewis, R J]]
-	[[Category: Offen, W A.]]	+	[[Category: Offen, W A]]
-	[[Category: Smith, I.]]	+	[[Category: Smith, I]]
-	[[Category: Wilkinson, A J.]]	+	[[Category: Wilkinson, A J]]
	[[Category: Antagonist]]		[[Category: Antagonist]]
	[[Category: Sporulation]]		[[Category: Sporulation]]
	[[Category: Transcription regulator]]		[[Category: Transcription regulator]]

OCA at 03:14, 7 August 2014

OCA — Thu, 07 Aug 2014 03:14:42 GMT

←Older revision		Revision as of 03:14, 7 August 2014
Line 1:		Line 1:
-	[[~~Image:~~1b0n.~~png~~\|~~left~~\|200px]]	+	==SINR PROTEIN/SINI PROTEIN COMPLEX==
		+	<StructureSection load='1b0n' size='340' side='right' caption='[[1b0n]], [[Resolution\|resolution]] 1.90Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1b0n]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B0N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1B0N FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SINR, SINI ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1423 Bacillus subtilis])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1b0n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1b0n OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1b0n RCSB], [http://www.ebi.ac.uk/pdbsum/1b0n PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/b0/1b0n_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Spore formation is an extreme response of some bacteria to adversity. In Bacillus subtilis the proteins of the sin, sporulation inhibition, region form a component of an elaborate molecular circuitry that regulates the commitment to sporulation. SinR is a tetrameric repressor protein that binds to the promoters of genes essential for entry into sporulation and prevents their transcription. This repression is overcome through the activity of SinI, which disrupts the SinR tetramer through the formation of a SinI-SinR heterodimer. The interactions governing this curious quaternary transition are revealed in the crystal structure of the SinI-SinR complex. The most striking, and unexpected, finding is that the tertiary structure of the DNA-binding domain of SinR is identical with that of the corresponding domains of the repressor proteins, CI and Cro, of bacteriophage 434 that regulate lysis/lysogeny. This structural similarity greatly exceeds that between SinR and any bacterial protein or between the 434 repressor proteins and their homologues in the closely related bacteriophage lambda. The close evolutionary relationship implied by the structures of SinR and the 434 repressors provokes both comparison of their functions and a speculative consideration of the intriguing possibility of an evolutionary link between the two adaptive responses, sporulation and prophage induction.

-	~~{{STRUCTURE_1b0n\| PDB=1b0n \| SCENE= }}~~	+	An evolutionary link between sporulation and prophage induction in the structure of a repressor:anti-repressor complex.,Lewis RJ, Brannigan JA, Offen WA, Smith I, Wilkinson AJ J Mol Biol. 1998 Nov 13;283(5):907-12. PMID:9799632<ref>PMID:9799632</ref>

-	~~===SINR PROTEIN~~/~~SINI PROTEIN COMPLEX===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_9799632}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[1b0n]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Bacillus_subtilis Bacillus subtilis]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1B0N OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:009799632<~~/~~ref~~><~~ref group="xtra">PMID:011742118</ref><references group="xtra"~~/>	+
	[[Category: Bacillus subtilis]]		[[Category: Bacillus subtilis]]
	[[Category: Brannigan, J A.]]		[[Category: Brannigan, J A.]]

OCA: Protected "1b0n" [edit=sysop:move=sysop]

OCA — Sun, 21 Oct 2012 11:50:40 GMT

Protected "1b0n" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:50, 21 October 2012

OCA at 11:50, 21 October 2012

OCA — Sun, 21 Oct 2012 11:50:36 GMT

←Older revision		Revision as of 11:50, 21 October 2012
Line 1:		Line 1:
-	{{Seed}}
	[[Image:1b0n.png\|left\|200px]]		[[Image:1b0n.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1b0n", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1b0n\| PDB=1b0n \| SCENE= }}		{{STRUCTURE_1b0n\| PDB=1b0n \| SCENE= }}

	===SINR PROTEIN/SINI PROTEIN COMPLEX===		===SINR PROTEIN/SINI PROTEIN COMPLEX===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_9799632}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 9799632 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_9799632}}		{{ABSTRACT_PUBMED_9799632}}

	==About this Structure==		==About this Structure==
-	~~1B0N~~ is a 2 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B0N OCA].	+	[[1b0n]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B0N OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~9799632~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:009799632</ref><ref group="xtra">PMID:011742118</ref><references group="xtra"/>
	[[Category: Bacillus subtilis]]		[[Category: Bacillus subtilis]]
	[[Category: Brannigan, J A.]]		[[Category: Brannigan, J A.]]
Line 33:		Line 21:
	[[Category: Sporulation]]		[[Category: Sporulation]]
	[[Category: Transcription regulator]]		[[Category: Transcription regulator]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 21:21:04 2009''