1b9a - Revision history

OCA at 05:38, 9 August 2023

OCA — Wed, 09 Aug 2023 05:38:20 GMT

←Older revision		Revision as of 05:38, 9 August 2023
Line 3:		Line 3:
	<StructureSection load='1b9a' size='340' side='right'caption='[[1b9a]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='1b9a' size='340' side='right'caption='[[1b9a]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1b9a]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Cypca Cypca~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B9A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1B9A FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1b9a]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Cyprinus_carpio Cyprinus carpio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B9A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1B9A FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1b9a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1b9a OCA], [https://pdbe.org/1b9a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1b9a RCSB], [https://www.ebi.ac.uk/pdbsum/1b9a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1b9a ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1b9a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1b9a OCA], [https://pdbe.org/1b9a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1b9a RCSB], [https://www.ebi.ac.uk/pdbsum/1b9a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1b9a ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/PRVB_CYPCA PRVB_CYPCA]] In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions.	+	[https://www.uniprot.org/uniprot/PRVB_CYPCA PRVB_CYPCA] In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 35:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Cypca~~]]	+	[[Category: Cyprinus carpio]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Berry~~, M B~~]]	+	[[Category: Berry MB]]
-	[[Category: Cates~~, M S~~]]	+	[[Category: Cates MS]]
-	[[Category: Ho~~, E L~~]]	+	[[Category: Ho EL]]
-	[[Category: Li, Q]]	+	[[Category: Li Q]]
-	[[Category: Phillips~~, G N~~]]	+	[[Category: Phillips Jr GN]]
-	[[Category: Potter~~, J D]]~~	+	[[Category: Potter JD]]
-	~~[[Category: Calcium binding protein]]~~	+
-	~~[[Category: Calcium-binding]]~~	+
-	~~[[Category: Ef-hand protein]]~~	+
-	~~[[Category: Parvalbumin~~]]	+

OCA at 10:39, 19 May 2021

OCA — Wed, 19 May 2021 10:39:51 GMT

←Older revision		Revision as of 10:39, 19 May 2021
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	<StructureSection load='1b9a' size='340' side='right'caption='[[1b9a]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='1b9a' size='340' side='right'caption='[[1b9a]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1b9a]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Cypca Cypca]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B9A OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1B9A FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1b9a]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Cypca Cypca]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B9A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1B9A FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1b9a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1b9a OCA], [~~http~~://pdbe.org/1b9a PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1b9a RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1b9a PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1b9a ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1b9a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1b9a OCA], [https://pdbe.org/1b9a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1b9a RCSB], [https://www.ebi.ac.uk/pdbsum/1b9a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1b9a ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/PRVB_CYPCA PRVB_CYPCA]] In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions.	+	[[https://www.uniprot.org/uniprot/PRVB_CYPCA PRVB_CYPCA]] In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 17:55, 14 August 2019

OCA — Wed, 14 Aug 2019 17:55:40 GMT

←Older revision		Revision as of 17:55, 14 August 2019
Line 1:		Line 1:

	==PARVALBUMIN (MUTATION;D51A, F102W)==		==PARVALBUMIN (MUTATION;D51A, F102W)==
-	<StructureSection load='1b9a' size='340' side='right' caption='[[1b9a]], [[Resolution\|resolution]] 2.00Å' scene=''>	+	<StructureSection load='1b9a' size='340' side='right'caption='[[1b9a]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1b9a]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Cypca Cypca]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B9A OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1B9A FirstGlance]. <br>		<table><tr><td colspan='2'>[[1b9a]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Cypca Cypca]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B9A OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1B9A FirstGlance]. <br>
Line 13:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/b9/1b9a_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/b9/1b9a_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 28:		Line 28:
	</div>		</div>
	<div class="pdbe-citations 1b9a" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1b9a" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Parvalbumin\|Parvalbumin]]
	== References ==		== References ==
	<references/>		<references/>
Line 33:		Line 36:
	</StructureSection>		</StructureSection>
	[[Category: Cypca]]		[[Category: Cypca]]
		+	[[Category: Large Structures]]
	[[Category: Berry, M B]]		[[Category: Berry, M B]]
	[[Category: Cates, M S]]		[[Category: Cates, M S]]

OCA at 10:54, 8 November 2017

OCA — Wed, 08 Nov 2017 10:54:57 GMT

←Older revision		Revision as of 10:54, 8 November 2017
Line 1:		Line 1:
		+
	==PARVALBUMIN (MUTATION;D51A, F102W)==		==PARVALBUMIN (MUTATION;D51A, F102W)==
	<StructureSection load='1b9a' size='340' side='right' caption='[[1b9a]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='1b9a' size='340' side='right' caption='[[1b9a]], [[Resolution\|resolution]] 2.00Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[1b9a]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Cypca Cypca]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B9A OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1B9A FirstGlance]. <br>		<table><tr><td colspan='2'>[[1b9a]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Cypca Cypca]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B9A OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1B9A FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1b9a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1b9a OCA], [http://pdbe.org/1b9a PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1b9a RCSB], [http://www.ebi.ac.uk/pdbsum/1b9a PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1b9a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1b9a OCA], [http://pdbe.org/1b9a PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1b9a RCSB], [http://www.ebi.ac.uk/pdbsum/1b9a PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1b9a ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 27:		Line 28:
	</div>		</div>
	<div class="pdbe-citations 1b9a" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1b9a" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Parvalbumin\|Parvalbumin]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 16:45, 7 February 2016

OCA — Sun, 07 Feb 2016 16:45:30 GMT

←Older revision		Revision as of 16:45, 7 February 2016
Line 16:		Line 16:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1b9a ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 03:21, 10 September 2015

OCA — Thu, 10 Sep 2015 03:21:45 GMT

←Older revision		Revision as of 03:21, 10 September 2015
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	<StructureSection load='1b9a' size='340' side='right' caption='[[1b9a]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='1b9a' size='340' side='right' caption='[[1b9a]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1b9a]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Cyprinus_carpio Cyprinus carpio~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B9A OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1B9A FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1b9a]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Cypca Cypca]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B9A OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1B9A FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1b9a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1b9a OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1b9a RCSB], [http://www.ebi.ac.uk/pdbsum/1b9a PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1b9a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1b9a OCA], [http://pdbe.org/1b9a PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1b9a RCSB], [http://www.ebi.ac.uk/pdbsum/1b9a PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 26:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1b9a" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 33:		Line 34:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Cyprinus carpio~~]]	+	[[Category: Cypca]]
	[[Category: Berry, M B]]		[[Category: Berry, M B]]
	[[Category: Cates, M S]]		[[Category: Cates, M S]]

OCA at 16:47, 24 December 2014

OCA — Wed, 24 Dec 2014 16:47:54 GMT

←Older revision		Revision as of 16:47, 24 December 2014
Line 6:		Line 6:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1b9a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1b9a OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1b9a RCSB], [http://www.ebi.ac.uk/pdbsum/1b9a PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1b9a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1b9a OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1b9a RCSB], [http://www.ebi.ac.uk/pdbsum/1b9a PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/PRVB_CYPCA PRVB_CYPCA]] In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 11:42, 22 December 2014

OCA — Mon, 22 Dec 2014 11:42:20 GMT

←Older revision		Revision as of 11:42, 22 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1b9a]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Cyprinus_carpio Cyprinus carpio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B9A OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1B9A FirstGlance]. <br>		<table><tr><td colspan='2'>[[1b9a]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Cyprinus_carpio Cyprinus carpio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B9A OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1B9A FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1b9a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1b9a OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1b9a RCSB], [http://www.ebi.ac.uk/pdbsum/1b9a PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1b9a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1b9a OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1b9a RCSB], [http://www.ebi.ac.uk/pdbsum/1b9a PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 32:		Line 32:
	</StructureSection>		</StructureSection>
	[[Category: Cyprinus carpio]]		[[Category: Cyprinus carpio]]
-	[[Category: Berry, M B.]]	+	[[Category: Berry, M B]]
-	[[Category: Cates, M S.]]	+	[[Category: Cates, M S]]
-	[[Category: Ho, E L.]]	+	[[Category: Ho, E L]]
-	[[Category: Li, Q.]]	+	[[Category: Li, Q]]
-	[[Category: Phillips, G N.]]	+	[[Category: Phillips, G N]]
-	[[Category: Potter, J D.]]	+	[[Category: Potter, J D]]
	[[Category: Calcium binding protein]]		[[Category: Calcium binding protein]]
	[[Category: Calcium-binding]]		[[Category: Calcium-binding]]
	[[Category: Ef-hand protein]]		[[Category: Ef-hand protein]]
	[[Category: Parvalbumin]]		[[Category: Parvalbumin]]

OCA at 03:22, 7 August 2014

OCA — Thu, 07 Aug 2014 03:22:25 GMT

←Older revision		Revision as of 03:22, 7 August 2014
Line 1:		Line 1:
-	[[~~Image~~:1b9a.~~png\|left~~\|200px]]	+	==PARVALBUMIN (MUTATION;D51A, F102W)==
		+	<StructureSection load='1b9a' size='340' side='right' caption='[[1b9a]], [[Resolution\|resolution]] 2.00Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1b9a]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Cyprinus_carpio Cyprinus carpio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B9A OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1B9A FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene><br>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1b9a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1b9a OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1b9a RCSB], [http://www.ebi.ac.uk/pdbsum/1b9a PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/b9/1b9a_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	BACKGROUND: The EF-hand family is a large set of Ca(2+)-binding proteins that contain characteristic helix-loop-helix binding motifs that are highly conserved in sequence. Members of this family include parvalbumin and many prominent regulatory proteins such as calmodulin and troponin C. EF-hand proteins are involved in a variety of physiological processes including cell-cycle regulation, second messenger production, muscle contraction, microtubule organization and vision. RESULTS: We have determined the structures of parvalbumin mutants designed to explore the role of the last coordinating residue of the Ca(2+)-binding loop. An E101D substitution has been made in the parvalbumin EF site. The substitution decreases the Ca(2+)-binding affinity 100-fold and increases the Mg(2+)-binding affinity 10-fold. Both the Ca(2+)- and Mg(2+)-bound structures have been determined, and a structural basis has been proposed for the metal-ion-binding properties. CONCLUSIONS: The E101D mutation does not affect the Mg(2+) coordination geometry of the binding loop, but it does pull the F helix 1.1 A towards the loop. The E101D-Ca(2+) structure reveals that this mutant cannot obtain the sevenfold coordination preferred by Ca(2+), presumably because of strain limits imposed by tertiary structure. Analysis of these results relative to previously reported structural information supports a model wherein the characteristics of the last coordinating residue and the plasticity of the Ca(2+)-binding loop delimit the allowable geometries for the coordinating sphere.

-	~~{{STRUCTURE_1b9a\| PDB=1b9a \| SCENE= }}~~	+	Metal-ion affinity and specificity in EF-hand proteins: coordination geometry and domain plasticity in parvalbumin.,Cates MS, Berry MB, Ho EL, Li Q, Potter JD, Phillips GN Jr Structure. 1999 Oct 15;7(10):1269-78. PMID:10545326<ref>PMID:10545326</ref>

-	~~===PARVALBUMIN (MUTATION~~;~~D51A~~, ~~F102W)===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_10545326}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[1b9a]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Cyprinus_carpio Cyprinus carpio]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1B9A OCA].~~	+

	==See Also==		==See Also==
	*[[Parvalbumin\|Parvalbumin]]		*[[Parvalbumin\|Parvalbumin]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:010545326<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Cyprinus carpio]]		[[Category: Cyprinus carpio]]
	[[Category: Berry, M B.]]		[[Category: Berry, M B.]]

OCA at 07:16, 20 October 2012

OCA — Sat, 20 Oct 2012 07:16:19 GMT

←Older revision		Revision as of 07:16, 20 October 2012
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	==About this Structure==		==About this Structure==
-	[[1b9a]] is a 1 chain structure ~~of [[Parvalbumin]]~~ with sequence from [http://en.wikipedia.org/wiki/Cyprinus_carpio Cyprinus carpio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B9A OCA].	+	[[1b9a]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Cyprinus_carpio Cyprinus carpio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B9A OCA].

	==See Also==		==See Also==