1bgk - Revision history

OCA at 11:36, 22 November 2023

OCA — Wed, 22 Nov 2023 11:36:41 GMT

←Older revision		Revision as of 11:36, 22 November 2023
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	==SEA ANEMONE TOXIN (BGK) WITH HIGH AFFINITY FOR VOLTAGE DEPENDENT POTASSIUM CHANNEL, NMR, 15 STRUCTURES==		==SEA ANEMONE TOXIN (BGK) WITH HIGH AFFINITY FOR VOLTAGE DEPENDENT POTASSIUM CHANNEL, NMR, 15 STRUCTURES==
-	<StructureSection load='1bgk' size='340' side='right'caption='[[1bgk~~]], [[NMR_Ensembles_of_Models \| 15 NMR models~~]]' scene=''>	+	<StructureSection load='1bgk' size='340' side='right'caption='[[1bgk]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1bgk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Actinia_granulifera Actinia granulifera~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BGK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1BGK FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1bgk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bunodosoma_granuliferum Bunodosoma granuliferum]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BGK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1BGK FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1bgk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bgk OCA], [https://pdbe.org/1bgk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1bgk RCSB], [https://www.ebi.ac.uk/pdbsum/1bgk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1bgk ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1bgk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bgk OCA], [https://pdbe.org/1bgk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1bgk RCSB], [https://www.ebi.ac.uk/pdbsum/1bgk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1bgk ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/~~TXT1B_BUNGR TXT1B_BUNGR]~~] Inhibits voltage-dependent potassium channels (Kv1/~~KCNA~~).	+	[https://www.uniprot.org/uniprot/K1B_BUNGR K1B_BUNGR] Inhibits voltage-dependent potassium channels of the Kv1 family (Kv1.1/KCNA1 (Kd=6 nM), Kv1.2/KCNA2 (Kd=15 nM), Kv1.3/KCNA3 (Kd=10-39 nM), Kv1.6/KCNA6, and KCa3.1/KCNN4 (Kd=172 nM)).<ref>PMID:10419508</ref> <ref>PMID:10585444</ref> <ref>PMID:11707459</ref> <ref>PMID:8098956</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 24:		Line 25:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Actinia granulifera~~]]	+	[[Category: Bunodosoma granuliferum]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Cotton, J]]	+	[[Category: Cotton J]]
-	[[Category: Dauplais, M]]	+	[[Category: Dauplais M]]
-	[[Category: Gilquin, B]]	+	[[Category: Gilquin B]]
-	[[Category: Harvey, A]]	+	[[Category: Harvey A]]
-	[[Category: Jamin, N]]	+	[[Category: Jamin N]]
-	[[Category: Lecoq, A]]	+	[[Category: Lecoq A]]
-	[[Category: Menez, A]]	+	[[Category: Menez A]]
-	[[Category: Roumestand, C]]	+	[[Category: Roumestand C]]
-	[[Category: Song, J]]	+	[[Category: Song J]]
-	[[Category: Vita, C]]	+	[[Category: Vita C]]
-	~~[[Category: Neurotoxin]]~~	+
-	~~[[Category: Potassium channel inhibitor~~]]	+

OCA at 10:27, 16 February 2022

OCA — Wed, 16 Feb 2022 10:27:55 GMT

←Older revision		Revision as of 10:27, 16 February 2022
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	<StructureSection load='1bgk' size='340' side='right'caption='[[1bgk]], [[NMR_Ensembles_of_Models \| 15 NMR models]]' scene=''>		<StructureSection load='1bgk' size='340' side='right'caption='[[1bgk]], [[NMR_Ensembles_of_Models \| 15 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1bgk]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BGK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1BGK FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1bgk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Actinia_granulifera Actinia granulifera]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BGK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1BGK FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1bgk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bgk OCA], [https://pdbe.org/1bgk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1bgk RCSB], [https://www.ebi.ac.uk/pdbsum/1bgk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1bgk ProSAT]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1bgk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bgk OCA], [https://pdbe.org/1bgk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1bgk RCSB], [https://www.ebi.ac.uk/pdbsum/1bgk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1bgk ProSAT]</span></td></tr>
	</table>		</table>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Actinia granulifera]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Cotton, J]]		[[Category: Cotton, J]]

OCA at 06:59, 24 February 2021

OCA — Wed, 24 Feb 2021 06:59:22 GMT

←Older revision		Revision as of 06:59, 24 February 2021
Line 3:		Line 3:
	<StructureSection load='1bgk' size='340' side='right'caption='[[1bgk]], [[NMR_Ensembles_of_Models \| 15 NMR models]]' scene=''>		<StructureSection load='1bgk' size='340' side='right'caption='[[1bgk]], [[NMR_Ensembles_of_Models \| 15 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1bgk]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BGK OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1BGK FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1bgk]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BGK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1BGK FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1bgk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bgk OCA], [~~http~~://pdbe.org/1bgk PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1bgk RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1bgk PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1bgk ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1bgk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bgk OCA], [https://pdbe.org/1bgk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1bgk RCSB], [https://www.ebi.ac.uk/pdbsum/1bgk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1bgk ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/TXT1B_BUNGR TXT1B_BUNGR]] Inhibits voltage-dependent potassium channels (Kv1/KCNA).	+	[[https://www.uniprot.org/uniprot/TXT1B_BUNGR TXT1B_BUNGR]] Inhibits voltage-dependent potassium channels (Kv1/KCNA).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 19:		Line 19:

	==See Also==		==See Also==
-	*[[Potassium channel toxin\|Potassium channel toxin]]	+	*[[Potassium channel toxin 3D structures\|Potassium channel toxin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 08:50, 21 May 2019

OCA — Tue, 21 May 2019 08:50:30 GMT

←Older revision		Revision as of 08:50, 21 May 2019
Line 1:		Line 1:

	==SEA ANEMONE TOXIN (BGK) WITH HIGH AFFINITY FOR VOLTAGE DEPENDENT POTASSIUM CHANNEL, NMR, 15 STRUCTURES==		==SEA ANEMONE TOXIN (BGK) WITH HIGH AFFINITY FOR VOLTAGE DEPENDENT POTASSIUM CHANNEL, NMR, 15 STRUCTURES==
-	<StructureSection load='1bgk' size='340' side='right' caption='[[1bgk]], [[NMR_Ensembles_of_Models \| 15 NMR models]]' scene=''>	+	<StructureSection load='1bgk' size='340' side='right'caption='[[1bgk]], [[NMR_Ensembles_of_Models \| 15 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1bgk]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BGK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1BGK FirstGlance]. <br>		<table><tr><td colspan='2'>[[1bgk]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BGK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1BGK FirstGlance]. <br>
Line 24:		Line 24:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Cotton, J]]		[[Category: Cotton, J]]
	[[Category: Dauplais, M]]		[[Category: Dauplais, M]]

OCA at 06:12, 17 August 2017

OCA — Thu, 17 Aug 2017 06:12:47 GMT

←Older revision		Revision as of 06:12, 17 August 2017
Line 1:		Line 1:
		+
	==SEA ANEMONE TOXIN (BGK) WITH HIGH AFFINITY FOR VOLTAGE DEPENDENT POTASSIUM CHANNEL, NMR, 15 STRUCTURES==		==SEA ANEMONE TOXIN (BGK) WITH HIGH AFFINITY FOR VOLTAGE DEPENDENT POTASSIUM CHANNEL, NMR, 15 STRUCTURES==
	<StructureSection load='1bgk' size='340' side='right' caption='[[1bgk]], [[NMR_Ensembles_of_Models \| 15 NMR models]]' scene=''>		<StructureSection load='1bgk' size='340' side='right' caption='[[1bgk]], [[NMR_Ensembles_of_Models \| 15 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1bgk]] is a 1 chain structure ~~with sequence from [http://en.wikipedia.org/wiki/Actinia_granulifera Actinia granulifera]~~. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BGK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1BGK FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1bgk]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BGK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1BGK FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1bgk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bgk OCA], [http://pdbe.org/1bgk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1bgk RCSB], [http://www.ebi.ac.uk/pdbsum/1bgk PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1bgk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bgk OCA], [http://pdbe.org/1bgk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1bgk RCSB], [http://www.ebi.ac.uk/pdbsum/1bgk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1bgk ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Actinia granulifera]]
	[[Category: Cotton, J]]		[[Category: Cotton, J]]
	[[Category: Dauplais, M]]		[[Category: Dauplais, M]]

OCA at 20:46, 9 September 2015

OCA — Wed, 09 Sep 2015 20:46:25 GMT

←Older revision		Revision as of 20:46, 9 September 2015
Line 2:		Line 2:
	<StructureSection load='1bgk' size='340' side='right' caption='[[1bgk]], [[NMR_Ensembles_of_Models \| 15 NMR models]]' scene=''>		<StructureSection load='1bgk' size='340' side='right' caption='[[1bgk]], [[NMR_Ensembles_of_Models \| 15 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1bgk]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Bunodosoma_granuliferum Bunodosoma granuliferum~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BGK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1BGK FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1bgk]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Actinia_granulifera Actinia granulifera]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BGK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1BGK FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1bgk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bgk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1bgk RCSB], [http://www.ebi.ac.uk/pdbsum/1bgk PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1bgk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bgk OCA], [http://pdbe.org/1bgk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1bgk RCSB], [http://www.ebi.ac.uk/pdbsum/1bgk PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[http://www.uniprot.org/uniprot/~~TXBGK_BUNGR TXBGK_BUNGR~~]] Inhibits voltage-dependent potassium channels (Kv1/KCNA).	+	[[http://www.uniprot.org/uniprot/TXT1B_BUNGR TXT1B_BUNGR]] Inhibits voltage-dependent potassium channels (Kv1/KCNA).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 15:		Line 15:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1bgk" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 22:		Line 23:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Bunodosoma granuliferum~~]]	+	[[Category: Actinia granulifera]]
	[[Category: Cotton, J]]		[[Category: Cotton, J]]
	[[Category: Dauplais, M]]		[[Category: Dauplais, M]]

OCA at 07:04, 24 December 2014

OCA — Wed, 24 Dec 2014 07:04:15 GMT

←Older revision		Revision as of 07:04, 24 December 2014
Line 5:		Line 5:
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1bgk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bgk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1bgk RCSB], [http://www.ebi.ac.uk/pdbsum/1bgk PDBsum]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1bgk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bgk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1bgk RCSB], [http://www.ebi.ac.uk/pdbsum/1bgk PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/TXBGK_BUNGR TXBGK_BUNGR]] Inhibits voltage-dependent potassium channels (Kv1/KCNA).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 14:08, 17 December 2014

OCA — Wed, 17 Dec 2014 14:08:36 GMT

←Older revision		Revision as of 14:08, 17 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_1bgk\| PDB=1bgk \| SCENE= }}~~	+	==SEA ANEMONE TOXIN (BGK) WITH HIGH AFFINITY FOR VOLTAGE DEPENDENT POTASSIUM CHANNEL, NMR, 15 STRUCTURES==
-	===SEA ANEMONE TOXIN (BGK) WITH HIGH AFFINITY FOR VOLTAGE DEPENDENT POTASSIUM CHANNEL, NMR, 15 STRUCTURES===	+	<StructureSection load='1bgk' size='340' side='right' caption='[[1bgk]], [[NMR_Ensembles_of_Models \| 15 NMR models]]' scene=''>
-	~~{{ABSTRACT_PUBMED_9020148}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1bgk]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bunodosoma_granuliferum Bunodosoma granuliferum]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BGK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1BGK FirstGlance]. <br>
		+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1bgk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bgk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1bgk RCSB], [http://www.ebi.ac.uk/pdbsum/1bgk PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	BgK is a K+ channel-blocking toxin from the sea anemone Bunodosoma granulifera. It is a 37-residue protein that adopts a novel fold, as determined by NMR and modeling. An alanine-scanning-based analysis revealed the functional importance of five residues, which include a critical lysine and an aromatic residue separated by 6.6 +/- 1.0 A. The same diad is found in the three known homologous toxins from sea anemones. More strikingly, a similar functional diad is present in all K+ channel-blocking toxins from scorpions, although these toxins adopt a distinct scaffold. Moreover, the functional diads of potassium channel-blocking toxins from sea anemone and scorpions superimpose in the three-dimensional structures. Therefore, toxins that have unrelated structures but similar functions possess conserved key functional residues, organized in an identical topology, suggesting a convergent functional evolution for these small proteins.

-	~~==About this Structure==~~	+	On the convergent evolution of animal toxins. Conservation of a diad of functional residues in potassium channel-blocking toxins with unrelated structures.,Dauplais M, Lecoq A, Song J, Cotton J, Jamin N, Gilquin B, Roumestand C, Vita C, de Medeiros CL, Rowan EG, Harvey AL, Menez A J Biol Chem. 1997 Feb 14;272(7):4302-9. PMID:9020148<ref>PMID:9020148</ref>
-	~~[[1bgk]] is~~ a ~~1 chain structure~~ with ~~sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Bunodosoma_granuliferum Bunodosoma granuliferum]~~. ~~Full experimental information is available from [http~~://~~oca~~.~~weizmann~~.ac.il/~~oca-bin/ocashort?id=1BGK OCA].~~	+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

	==See Also==		==See Also==
	*[[Potassium channel toxin\|Potassium channel toxin]]		*[[Potassium channel toxin\|Potassium channel toxin]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:009020148<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Bunodosoma granuliferum]]		[[Category: Bunodosoma granuliferum]]
-	[[Category: Cotton, J.]]	+	[[Category: Cotton, J]]
-	[[Category: Dauplais, M.]]	+	[[Category: Dauplais, M]]
-	[[Category: Gilquin, B.]]	+	[[Category: Gilquin, B]]
-	[[Category: Harvey, A.]]	+	[[Category: Harvey, A]]
-	[[Category: Jamin, N.]]	+	[[Category: Jamin, N]]
-	[[Category: Lecoq, A.]]	+	[[Category: Lecoq, A]]
-	[[Category: Menez, A.]]	+	[[Category: Menez, A]]
-	[[Category: Roumestand, C.]]	+	[[Category: Roumestand, C]]
-	[[Category: Song, J.]]	+	[[Category: Song, J]]
-	[[Category: Vita, C.]]	+	[[Category: Vita, C]]
	[[Category: Neurotoxin]]		[[Category: Neurotoxin]]
	[[Category: Potassium channel inhibitor]]		[[Category: Potassium channel inhibitor]]

OCA at 09:16, 11 March 2013

OCA — Mon, 11 Mar 2013 09:16:46 GMT

←Older revision		Revision as of 09:16, 11 March 2013
Line 1:		Line 1:
-	[[Image:1bgk.png\|left\|200px]]
-
	{{STRUCTURE_1bgk\| PDB=1bgk \| SCENE= }}		{{STRUCTURE_1bgk\| PDB=1bgk \| SCENE= }}
-
	===SEA ANEMONE TOXIN (BGK) WITH HIGH AFFINITY FOR VOLTAGE DEPENDENT POTASSIUM CHANNEL, NMR, 15 STRUCTURES===		===SEA ANEMONE TOXIN (BGK) WITH HIGH AFFINITY FOR VOLTAGE DEPENDENT POTASSIUM CHANNEL, NMR, 15 STRUCTURES===
-
	{{ABSTRACT_PUBMED_9020148}}		{{ABSTRACT_PUBMED_9020148}}

	==About this Structure==		==About this Structure==
	[[1bgk]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bunodosoma_granuliferum Bunodosoma granuliferum]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BGK OCA].		[[1bgk]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bunodosoma_granuliferum Bunodosoma granuliferum]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BGK OCA].
		+
		+	==See Also==
		+	*[[Potassium channel toxin\|Potassium channel toxin]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:009020148~~</ref><ref group="xtra">PMID:011742118~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:009020148</ref><references group="xtra"/>
	[[Category: Bunodosoma granuliferum]]		[[Category: Bunodosoma granuliferum]]
	[[Category: Cotton, J.]]		[[Category: Cotton, J.]]

OCA: Protected "1bgk" [edit=sysop:move=sysop]

OCA — Tue, 14 Aug 2012 15:19:12 GMT

Protected "1bgk" [edit=sysop:move=sysop]

←Older revision

Revision as of 15:19, 14 August 2012