1bj4 - Revision history

OCA at 06:50, 8 February 2023

OCA — Wed, 08 Feb 2023 06:50:44 GMT

←Older revision		Revision as of 06:50, 8 February 2023
Line 3:		Line 3:
	<StructureSection load='1bj4' size='340' side='right'caption='[[1bj4]], [[Resolution\|resolution]] 2.65Å' scene=''>		<StructureSection load='1bj4' size='340' side='right'caption='[[1bj4]], [[Resolution\|resolution]] 2.65Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1bj4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BJ4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1BJ4 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1bj4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BJ4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1BJ4 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Glycine_hydroxymethyltransferase Glycine hydroxymethyltransferase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.2.1 2.1.2.1] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1bj4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bj4 OCA], [https://pdbe.org/1bj4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1bj4 RCSB], [https://www.ebi.ac.uk/pdbsum/1bj4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1bj4 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1bj4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bj4 OCA], [https://pdbe.org/1bj4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1bj4 RCSB], [https://www.ebi.ac.uk/pdbsum/1bj4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1bj4 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/GLYC_HUMAN GLYC_HUMAN]] Interconversion of serine and glycine.	+	[https://www.uniprot.org/uniprot/GLYC_HUMAN GLYC_HUMAN] Interconversion of serine and glycine.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 31:		Line 30:

	==See Also==		==See Also==
-	*[[Serine hydroxymethyltransferase\|Serine hydroxymethyltransferase]]	+	*[[Serine hydroxymethyltransferase 3D structures\|Serine hydroxymethyltransferase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Glycine hydroxymethyltransferase]]~~	+	[[Category: Homo sapiens]]
-	~~[[Category: Human~~]]	+
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Renwick~~, S B~~]]	+	[[Category: Renwick SB]]
-	[[Category: Snell, K]]	+	[[Category: Snell K]]
-	~~[[Category: Metabolic role]]~~	+
-	~~[[Category: Pyridoxal 5'-phosphate]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 15:07, 2 June 2021

OCA — Wed, 02 Jun 2021 15:07:52 GMT

←Older revision		Revision as of 15:07, 2 June 2021
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	<StructureSection load='1bj4' size='340' side='right'caption='[[1bj4]], [[Resolution\|resolution]] 2.65Å' scene=''>		<StructureSection load='1bj4' size='340' side='right'caption='[[1bj4]], [[Resolution\|resolution]] 2.65Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1bj4]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BJ4 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1BJ4 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1bj4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BJ4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1BJ4 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Glycine_hydroxymethyltransferase Glycine hydroxymethyltransferase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.2.1 2.1.2.1] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Glycine_hydroxymethyltransferase Glycine hydroxymethyltransferase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.2.1 2.1.2.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1bj4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bj4 OCA], [~~http~~://pdbe.org/1bj4 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1bj4 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1bj4 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1bj4 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1bj4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bj4 OCA], [https://pdbe.org/1bj4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1bj4 RCSB], [https://www.ebi.ac.uk/pdbsum/1bj4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1bj4 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/GLYC_HUMAN GLYC_HUMAN]] Interconversion of serine and glycine.	+	[[https://www.uniprot.org/uniprot/GLYC_HUMAN GLYC_HUMAN]] Interconversion of serine and glycine.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 16:58, 28 August 2019

OCA — Wed, 28 Aug 2019 16:58:35 GMT

←Older revision		Revision as of 16:58, 28 August 2019
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	==RECOMBINANT SERINE HYDROXYMETHYLTRANSFERASE (HUMAN)==		==RECOMBINANT SERINE HYDROXYMETHYLTRANSFERASE (HUMAN)==
-	<StructureSection load='1bj4' size='340' side='right' caption='[[1bj4]], [[Resolution\|resolution]] 2.65Å' scene=''>	+	<StructureSection load='1bj4' size='340' side='right'caption='[[1bj4]], [[Resolution\|resolution]] 2.65Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1bj4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BJ4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1BJ4 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1bj4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BJ4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1BJ4 FirstGlance]. <br>
Line 14:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bj/1bj4_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bj/1bj4_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 29:		Line 29:
	</div>		</div>
	<div class="pdbe-citations 1bj4" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1bj4" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Serine hydroxymethyltransferase\|Serine hydroxymethyltransferase]]
	== References ==		== References ==
	<references/>		<references/>
Line 35:		Line 38:
	[[Category: Glycine hydroxymethyltransferase]]		[[Category: Glycine hydroxymethyltransferase]]
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Renwick, S B]]		[[Category: Renwick, S B]]
	[[Category: Snell, K]]		[[Category: Snell, K]]

OCA at 11:22, 22 November 2017

OCA — Wed, 22 Nov 2017 11:22:05 GMT

←Older revision		Revision as of 11:22, 22 November 2017
Line 1:		Line 1:
		+
	==RECOMBINANT SERINE HYDROXYMETHYLTRANSFERASE (HUMAN)==		==RECOMBINANT SERINE HYDROXYMETHYLTRANSFERASE (HUMAN)==
	<StructureSection load='1bj4' size='340' side='right' caption='[[1bj4]], [[Resolution\|resolution]] 2.65Å' scene=''>		<StructureSection load='1bj4' size='340' side='right' caption='[[1bj4]], [[Resolution\|resolution]] 2.65Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glycine_hydroxymethyltransferase Glycine hydroxymethyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.2.1 2.1.2.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glycine_hydroxymethyltransferase Glycine hydroxymethyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.2.1 2.1.2.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1bj4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bj4 OCA], [http://pdbe.org/1bj4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1bj4 RCSB], [http://www.ebi.ac.uk/pdbsum/1bj4 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1bj4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bj4 OCA], [http://pdbe.org/1bj4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1bj4 RCSB], [http://www.ebi.ac.uk/pdbsum/1bj4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1bj4 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 28:		Line 29:
	</div>		</div>
	<div class="pdbe-citations 1bj4" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1bj4" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Serine hydroxymethyltransferase\|Serine hydroxymethyltransferase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 12:21, 8 February 2016

OCA — Mon, 08 Feb 2016 12:21:31 GMT

←Older revision		Revision as of 12:21, 8 February 2016
Line 17:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1bj4 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 11:31, 10 September 2015

OCA — Thu, 10 Sep 2015 11:31:24 GMT

←Older revision		Revision as of 11:31, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='1bj4' size='340' side='right' caption='[[1bj4]], [[Resolution\|resolution]] 2.65Å' scene=''>		<StructureSection load='1bj4' size='340' side='right' caption='[[1bj4]], [[Resolution\|resolution]] 2.65Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1bj4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BJ4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1BJ4 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1bj4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BJ4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1BJ4 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glycine_hydroxymethyltransferase Glycine hydroxymethyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.2.1 2.1.2.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glycine_hydroxymethyltransferase Glycine hydroxymethyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.2.1 2.1.2.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1bj4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bj4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1bj4 RCSB], [http://www.ebi.ac.uk/pdbsum/1bj4 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1bj4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bj4 OCA], [http://pdbe.org/1bj4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1bj4 RCSB], [http://www.ebi.ac.uk/pdbsum/1bj4 PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 27:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1bj4" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 35:		Line 36:
	</StructureSection>		</StructureSection>
	[[Category: Glycine hydroxymethyltransferase]]		[[Category: Glycine hydroxymethyltransferase]]
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Renwick, S B]]		[[Category: Renwick, S B]]
	[[Category: Snell, K]]		[[Category: Snell, K]]

OCA at 23:16, 24 December 2014

OCA — Wed, 24 Dec 2014 23:16:58 GMT

←Older revision		Revision as of 23:16, 24 December 2014
Line 7:		Line 7:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1bj4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bj4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1bj4 RCSB], [http://www.ebi.ac.uk/pdbsum/1bj4 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1bj4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bj4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1bj4 RCSB], [http://www.ebi.ac.uk/pdbsum/1bj4 PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/GLYC_HUMAN GLYC_HUMAN]] Interconversion of serine and glycine.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 10:26, 22 December 2014

OCA — Mon, 22 Dec 2014 10:26:34 GMT

←Older revision		Revision as of 10:26, 22 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1bj4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BJ4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1BJ4 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1bj4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BJ4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1BJ4 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glycine_hydroxymethyltransferase Glycine hydroxymethyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.2.1 2.1.2.1] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glycine_hydroxymethyltransferase Glycine hydroxymethyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.2.1 2.1.2.1] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1bj4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bj4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1bj4 RCSB], [http://www.ebi.ac.uk/pdbsum/1bj4 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1bj4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bj4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1bj4 RCSB], [http://www.ebi.ac.uk/pdbsum/1bj4 PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 34:		Line 34:
	[[Category: Glycine hydroxymethyltransferase]]		[[Category: Glycine hydroxymethyltransferase]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Renwick, S B.]]	+	[[Category: Renwick, S B]]
-	[[Category: Snell, K.]]	+	[[Category: Snell, K]]
	[[Category: Metabolic role]]		[[Category: Metabolic role]]
	[[Category: Pyridoxal 5'-phosphate]]		[[Category: Pyridoxal 5'-phosphate]]
	[[Category: Transferase]]		[[Category: Transferase]]

OCA at 09:49, 13 August 2014

OCA — Wed, 13 Aug 2014 09:49:13 GMT

←Older revision		Revision as of 09:49, 13 August 2014
Line 1:		Line 1:
-	[[~~Image~~:1bj4.~~png\|left~~\|200px]]	+	==RECOMBINANT SERINE HYDROXYMETHYLTRANSFERASE (HUMAN)==
		+	<StructureSection load='1bj4' size='340' side='right' caption='[[1bj4]], [[Resolution\|resolution]] 2.65Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1bj4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BJ4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1BJ4 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene><br>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glycine_hydroxymethyltransferase Glycine hydroxymethyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.2.1 2.1.2.1] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1bj4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bj4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1bj4 RCSB], [http://www.ebi.ac.uk/pdbsum/1bj4 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bj/1bj4_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	BACKGROUND: Serine hydroxymethyltransferase (SHMT) is a ubiquitous enzyme found in all prokaryotes and eukaryotes. As an enzyme of the thymidylate synthase metabolic cycle, SHMT catalyses the retro-aldol cleavage of serine to glycine, with the resulting hydroxymethyl group being transferred to tetrahydrofolate to form 5, 10-methylene-tetrahydrofolate. The latter is the major source of one-carbon units in metabolism. Elevated SHMT activity has been shown to be coupled to the increased demand for DNA synthesis in rapidly proliferating cells, particularly tumour cells. Consequently, the central role of SHMT in nucleotide biosynthesis makes it an attractive target for cancer chemotherapy. RESULTS: We have solved the crystal structure of human cytosolic SHMT by multiple isomorphous replacement to 2.65 A resolution. The monomer has a fold typical for alpha class pyridoxal 5'-phosphate (PLP) dependent enzymes. The tetramer association is best described as a 'dimer of dimers' where residues from both subunits of one 'tight' dimer contribute to the active site. CONCLUSIONS: The crystal structure shows the evolutionary relationship between SHMT and other alpha class PLP-dependent enzymes, as the fold is highly conserved. Many of the results of site-directed mutagenesis studies can easily be rationalised or re-interpreted in light of the structure presented here. For example, His 151 is not the catalytic base, contrary to the findings of others. A mechanism for the cleavage of serine to glycine and formaldehyde is proposed.

-	~~{{STRUCTURE_1bj4\| PDB=1bj4 \| SCENE= }}~~	+	The crystal structure of human cytosolic serine hydroxymethyltransferase: a target for cancer chemotherapy.,Renwick SB, Snell K, Baumann U Structure. 1998 Sep 15;6(9):1105-16. PMID:9753690<ref>PMID:9753690</ref>

-	~~===RECOMBINANT SERINE HYDROXYMETHYLTRANSFERASE (HUMAN)===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

-	~~{{ABSTRACT_PUBMED_9753690}}~~	+	==See Also==
-		+	*[[Serine hydroxymethyltransferase\|Serine hydroxymethyltransferase]]
-	==~~About this Structure~~==	+	== References ==
-	[[~~1bj4~~]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BJ4 OCA].	+	<references/>
-		+	__TOC__
-	==~~Reference~~==	+	</StructureSection>
-	<~~ref group="xtra">PMID:009753690<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Glycine hydroxymethyltransferase]]		[[Category: Glycine hydroxymethyltransferase]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]

OCA: Protected "1bj4" [edit=sysop:move=sysop]

OCA — Sun, 21 Oct 2012 20:55:46 GMT

Protected "1bj4" [edit=sysop:move=sysop]

←Older revision

Revision as of 20:55, 21 October 2012