1bku - Revision history

OCA at 15:33, 13 March 2024

OCA — Wed, 13 Mar 2024 15:33:46 GMT

←Older revision		Revision as of 15:33, 13 March 2024
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	==EFFECTS OF GLYCOSYLATION ON THE STRUCTURE AND DYNAMICS OF EEL CALCITONIN, NMR, 10 STRUCTURES==		==EFFECTS OF GLYCOSYLATION ON THE STRUCTURE AND DYNAMICS OF EEL CALCITONIN, NMR, 10 STRUCTURES==
-	<StructureSection load='1bku' size='340' side='right'caption='[[1bku~~]], [[NMR_Ensembles_of_Models \| 10 NMR models~~]]' scene=''>	+	<StructureSection load='1bku' size='340' side='right'caption='[[1bku]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1bku]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Angja Angja~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BKU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1BKU FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1bku]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Anguilla_japonica Anguilla japonica]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BKU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1BKU FirstGlance]. <br>
-	</td></tr><tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1bku FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bku OCA], [https://pdbe.org/1bku PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1bku RCSB], [https://www.ebi.ac.uk/pdbsum/1bku PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1bku ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1bku FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bku OCA], [https://pdbe.org/1bku PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1bku RCSB], [https://www.ebi.ac.uk/pdbsum/1bku PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1bku ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/CALC_ANGJA CALC_ANGJA]] Causes a rapid but short-lived drop in the level of calcium and phosphate in blood by promoting the incorporation of those ions in the bones.	+	[https://www.uniprot.org/uniprot/CALC_ANGJA CALC_ANGJA] Causes a rapid but short-lived drop in the level of calcium and phosphate in blood by promoting the incorporation of those ions in the bones.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 19:		Line 20:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1bku ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1bku ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	The three-dimensional structures of eel calcitonin (CT) and two glycosylated CT derivatives, [Asn(GlcNAc)3]-CT (CT-GlcNAc) and [Asn(Man6-GlcNAc2)3]-CT (CT-M6), in micelles were determined by solution NMR spectroscopy. The topologies of these peptides associated with oriented lipid bilayers were determined with solid-state NMR. All of the peptides were found to have an identical conformation in micelles characterized by an amphipathic alpha-helix consisting of residues Ser5 through Leu19 followed by an unstructured region at the C-terminus. The overall conformation of the peptide moiety was not affected by the glycosylation. Nevertheless, comparison of the relative exchange rates of the Leu12 amide proton might suggest the possibility that fluctuations of the alpha-helix are reduced by glycosylation. The presence of NOEs between the carbohydrate and the peptide moieties of CT-GlcNAc and CT-M6 and the amide proton chemical shift data suggested that the carbohydrate interacted with the peptide, and this might account for the conformational stabilization of the alpha-helix. Both the unmodified CT and the glycosylated CT were found to have orientations with their helix axes parallel to the plane of the lipid bilayers by solid-state NMR spectroscopy.
-
-	Effects of glycosylation on the structure and dynamics of eel calcitonin in micelles and lipid bilayers determined by nuclear magnetic resonance spectroscopy.,Hashimoto Y, Toma K, Nishikido J, Yamamoto K, Haneda K, Inazu T, Valentine KG, Opella SJ Biochemistry. 1999 Jun 29;38(26):8377-84. PMID:10387083<ref>PMID:10387083</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 1bku" style="background-color:#fffaf0;"></div>
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Angja~~]]	+	[[Category: Anguilla japonica]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Haneda, K]]	+	[[Category: Haneda K]]
-	[[Category: Hashimoto, Y]]	+	[[Category: Hashimoto Y]]
-	[[Category: Inazu, T]]	+	[[Category: Inazu T]]
-	[[Category: Nishikido, J]]	+	[[Category: Nishikido J]]
-	[[Category: Opella~~, S J~~]]	+	[[Category: Opella SJ]]
-	[[Category: Toma, K]]	+	[[Category: Toma K]]
-	[[Category: Valentine, K]]	+	[[Category: Valentine K]]
-	[[Category: Yamamoto, K]]	+	[[Category: Yamamoto K]]
-	~~[[Category: Calcium-regulating hormone]]~~	+
-	~~[[Category: Hormone~~]]	+

OCA at 15:08, 2 June 2021

OCA — Wed, 02 Jun 2021 15:08:20 GMT

←Older revision		Revision as of 15:08, 2 June 2021
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	<StructureSection load='1bku' size='340' side='right'caption='[[1bku]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>		<StructureSection load='1bku' size='340' side='right'caption='[[1bku]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1bku]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Angja Angja]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BKU OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1BKU FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1bku]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Angja Angja]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BKU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1BKU FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1bku FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bku OCA], [~~http~~://pdbe.org/1bku PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1bku RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1bku PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1bku ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1bku FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bku OCA], [https://pdbe.org/1bku PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1bku RCSB], [https://www.ebi.ac.uk/pdbsum/1bku PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1bku ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/CALC_ANGJA CALC_ANGJA]] Causes a rapid but short-lived drop in the level of calcium and phosphate in blood by promoting the incorporation of those ions in the bones.	+	[[https://www.uniprot.org/uniprot/CALC_ANGJA CALC_ANGJA]] Causes a rapid but short-lived drop in the level of calcium and phosphate in blood by promoting the incorporation of those ions in the bones.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 16:35, 28 August 2019

OCA — Wed, 28 Aug 2019 16:35:40 GMT

←Older revision		Revision as of 16:35, 28 August 2019
Line 1:		Line 1:

	==EFFECTS OF GLYCOSYLATION ON THE STRUCTURE AND DYNAMICS OF EEL CALCITONIN, NMR, 10 STRUCTURES==		==EFFECTS OF GLYCOSYLATION ON THE STRUCTURE AND DYNAMICS OF EEL CALCITONIN, NMR, 10 STRUCTURES==
-	<StructureSection load='1bku' size='340' side='right' caption='[[1bku]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>	+	<StructureSection load='1bku' size='340' side='right'caption='[[1bku]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1bku]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Angja Angja]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BKU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1BKU FirstGlance]. <br>		<table><tr><td colspan='2'>[[1bku]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Angja Angja]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BKU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1BKU FirstGlance]. <br>
Line 13:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bk/1bku_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bk/1bku_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 33:		Line 33:
	</StructureSection>		</StructureSection>
	[[Category: Angja]]		[[Category: Angja]]
		+	[[Category: Large Structures]]
	[[Category: Haneda, K]]		[[Category: Haneda, K]]
	[[Category: Hashimoto, Y]]		[[Category: Hashimoto, Y]]

OCA at 11:22, 22 November 2017

OCA — Wed, 22 Nov 2017 11:22:05 GMT

←Older revision		Revision as of 11:22, 22 November 2017
Line 1:		Line 1:
		+
	==EFFECTS OF GLYCOSYLATION ON THE STRUCTURE AND DYNAMICS OF EEL CALCITONIN, NMR, 10 STRUCTURES==		==EFFECTS OF GLYCOSYLATION ON THE STRUCTURE AND DYNAMICS OF EEL CALCITONIN, NMR, 10 STRUCTURES==
	<StructureSection load='1bku' size='340' side='right' caption='[[1bku]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>		<StructureSection load='1bku' size='340' side='right' caption='[[1bku]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[1bku]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Angja Angja]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BKU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1BKU FirstGlance]. <br>		<table><tr><td colspan='2'>[[1bku]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Angja Angja]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BKU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1BKU FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1bku FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bku OCA], [http://pdbe.org/1bku PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1bku RCSB], [http://www.ebi.ac.uk/pdbsum/1bku PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1bku FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bku OCA], [http://pdbe.org/1bku PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1bku RCSB], [http://www.ebi.ac.uk/pdbsum/1bku PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1bku ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 06:08, 8 February 2016

OCA — Mon, 08 Feb 2016 06:08:22 GMT

←Older revision		Revision as of 06:08, 8 February 2016
Line 16:		Line 16:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1bku ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 08:38, 10 September 2015

OCA — Thu, 10 Sep 2015 08:38:46 GMT

←Older revision		Revision as of 08:38, 10 September 2015
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	<StructureSection load='1bku' size='340' side='right' caption='[[1bku]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>		<StructureSection load='1bku' size='340' side='right' caption='[[1bku]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1bku]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Anguilla_japonica Anguilla japonica~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BKU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1BKU FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1bku]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Angja Angja]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BKU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1BKU FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1bku FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bku OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1bku RCSB], [http://www.ebi.ac.uk/pdbsum/1bku PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1bku FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bku OCA], [http://pdbe.org/1bku PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1bku RCSB], [http://www.ebi.ac.uk/pdbsum/1bku PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 26:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1bku" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Anguilla japonica~~]]	+	[[Category: Angja]]
	[[Category: Haneda, K]]		[[Category: Haneda, K]]
	[[Category: Hashimoto, Y]]		[[Category: Hashimoto, Y]]

OCA at 21:11, 24 December 2014

OCA — Wed, 24 Dec 2014 21:11:57 GMT

←Older revision		Revision as of 21:11, 24 December 2014
Line 6:		Line 6:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1bku FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bku OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1bku RCSB], [http://www.ebi.ac.uk/pdbsum/1bku PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1bku FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bku OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1bku RCSB], [http://www.ebi.ac.uk/pdbsum/1bku PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/CALC_ANGJA CALC_ANGJA]] Causes a rapid but short-lived drop in the level of calcium and phosphate in blood by promoting the incorporation of those ions in the bones.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 10:55, 22 December 2014

OCA — Mon, 22 Dec 2014 10:55:39 GMT

←Older revision		Revision as of 10:55, 22 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1bku]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Anguilla_japonica Anguilla japonica]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BKU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1BKU FirstGlance]. <br>		<table><tr><td colspan='2'>[[1bku]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Anguilla_japonica Anguilla japonica]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BKU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1BKU FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>	+	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1bku FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bku OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1bku RCSB], [http://www.ebi.ac.uk/pdbsum/1bku PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1bku FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bku OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1bku RCSB], [http://www.ebi.ac.uk/pdbsum/1bku PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 29:		Line 29:
	</StructureSection>		</StructureSection>
	[[Category: Anguilla japonica]]		[[Category: Anguilla japonica]]
-	[[Category: Haneda, K.]]	+	[[Category: Haneda, K]]
-	[[Category: Hashimoto, Y.]]	+	[[Category: Hashimoto, Y]]
-	[[Category: Inazu, T.]]	+	[[Category: Inazu, T]]
-	[[Category: Nishikido, J.]]	+	[[Category: Nishikido, J]]
-	[[Category: Opella, S J.]]	+	[[Category: Opella, S J]]
-	[[Category: Toma, K.]]	+	[[Category: Toma, K]]
-	[[Category: Valentine, K.]]	+	[[Category: Valentine, K]]
-	[[Category: Yamamoto, K.]]	+	[[Category: Yamamoto, K]]
	[[Category: Calcium-regulating hormone]]		[[Category: Calcium-regulating hormone]]
	[[Category: Hormone]]		[[Category: Hormone]]

OCA at 09:49, 13 August 2014

OCA — Wed, 13 Aug 2014 09:49:09 GMT

←Older revision		Revision as of 09:49, 13 August 2014
Line 1:		Line 1:
-	[[~~Image~~:1bku.~~png\|left~~\|200px]]	+	==EFFECTS OF GLYCOSYLATION ON THE STRUCTURE AND DYNAMICS OF EEL CALCITONIN, NMR, 10 STRUCTURES==
		+	<StructureSection load='1bku' size='340' side='right' caption='[[1bku]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1bku]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Anguilla_japonica Anguilla japonica]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BKU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1BKU FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1bku FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bku OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1bku RCSB], [http://www.ebi.ac.uk/pdbsum/1bku PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bk/1bku_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The three-dimensional structures of eel calcitonin (CT) and two glycosylated CT derivatives, [Asn(GlcNAc)3]-CT (CT-GlcNAc) and [Asn(Man6-GlcNAc2)3]-CT (CT-M6), in micelles were determined by solution NMR spectroscopy. The topologies of these peptides associated with oriented lipid bilayers were determined with solid-state NMR. All of the peptides were found to have an identical conformation in micelles characterized by an amphipathic alpha-helix consisting of residues Ser5 through Leu19 followed by an unstructured region at the C-terminus. The overall conformation of the peptide moiety was not affected by the glycosylation. Nevertheless, comparison of the relative exchange rates of the Leu12 amide proton might suggest the possibility that fluctuations of the alpha-helix are reduced by glycosylation. The presence of NOEs between the carbohydrate and the peptide moieties of CT-GlcNAc and CT-M6 and the amide proton chemical shift data suggested that the carbohydrate interacted with the peptide, and this might account for the conformational stabilization of the alpha-helix. Both the unmodified CT and the glycosylated CT were found to have orientations with their helix axes parallel to the plane of the lipid bilayers by solid-state NMR spectroscopy.

-	~~{{STRUCTURE_1bku\| PDB=1bku \| SCENE= }}~~	+	Effects of glycosylation on the structure and dynamics of eel calcitonin in micelles and lipid bilayers determined by nuclear magnetic resonance spectroscopy.,Hashimoto Y, Toma K, Nishikido J, Yamamoto K, Haneda K, Inazu T, Valentine KG, Opella SJ Biochemistry. 1999 Jun 29;38(26):8377-84. PMID:10387083<ref>PMID:10387083</ref>

-	~~===EFFECTS OF GLYCOSYLATION ON THE STRUCTURE AND DYNAMICS OF EEL CALCITONIN~~, ~~NMR, 10 STRUCTURES===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_10387083}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[1bku]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Anguilla_japonica Anguilla japonica]~~. ~~Full experimental information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1BKU OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:010387083<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Anguilla japonica]]		[[Category: Anguilla japonica]]
	[[Category: Haneda, K.]]		[[Category: Haneda, K.]]

OCA: Protected "1bku" [edit=sysop:move=sysop]

OCA — Sun, 21 Oct 2012 20:25:04 GMT

Protected "1bku" [edit=sysop:move=sysop]

←Older revision

Revision as of 20:25, 21 October 2012