1bl1 - Revision history

OCA at 11:37, 22 November 2023

OCA — Wed, 22 Nov 2023 11:37:10 GMT

←Older revision		Revision as of 11:37, 22 November 2023
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	==PTH RECEPTOR N-TERMINUS FRAGMENT, NMR, 1 STRUCTURE==		==PTH RECEPTOR N-TERMINUS FRAGMENT, NMR, 1 STRUCTURE==
-	<StructureSection load='1bl1' size='340' side='right'caption='[[1bl1~~]], [[NMR_Ensembles_of_Models \| 1 NMR models~~]]' scene=''>	+	<StructureSection load='1bl1' size='340' side='right'caption='[[1bl1]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1bl1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BL1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1BL1 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1bl1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BL1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1BL1 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1bl1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bl1 OCA], [https://pdbe.org/1bl1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1bl1 RCSB], [https://www.ebi.ac.uk/pdbsum/1bl1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1bl1 ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1bl1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bl1 OCA], [https://pdbe.org/1bl1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1bl1 RCSB], [https://www.ebi.ac.uk/pdbsum/1bl1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1bl1 ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[https://www.uniprot.org/uniprot/PTH1R_HUMAN PTH1R_HUMAN]] Blomstrand lethal chondrodysplasia;Dental ankylosis;Eiken syndrome;Metaphyseal chondrodysplasia, Jansen type;Enchondromatosis. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease may be caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.	+	[https://www.uniprot.org/uniprot/PTH1R_HUMAN PTH1R_HUMAN] Blomstrand lethal chondrodysplasia;Dental ankylosis;Eiken syndrome;Metaphyseal chondrodysplasia, Jansen type;Enchondromatosis. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease may be caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/PTH1R_HUMAN PTH1R_HUMAN]] This is a receptor for parathyroid hormone and for parathyroid hormone-related peptide. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system.<ref>PMID:18611381</ref> <ref>PMID:20172855</ref>	+	[https://www.uniprot.org/uniprot/PTH1R_HUMAN PTH1R_HUMAN] This is a receptor for parathyroid hormone and for parathyroid hormone-related peptide. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system.<ref>PMID:18611381</ref> <ref>PMID:20172855</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 23:		Line 24:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Bisello, A]]	+	[[Category: Bisello A]]
-	[[Category: Chorev, M]]	+	[[Category: Chorev M]]
-	[[Category: Mierke~~, D F~~]]	+	[[Category: Mierke DF]]
-	[[Category: Pellegrini, M]]	+	[[Category: Pellegrini M]]
-	[[Category: Rosenblatt, M]]	+	[[Category: Rosenblatt M]]
-	~~[[Category: Calciotropic hormone]]~~	+
-	~~[[Category: Hormone receptor]]~~	+
-	~~[[Category: Micelle structure]]~~	+
-	~~[[Category: Nmr structure]]~~	+
-	~~[[Category: Parathyroid hormone~~]]	+

OCA at 10:28, 16 February 2022

OCA — Wed, 16 Feb 2022 10:28:27 GMT

←Older revision		Revision as of 10:28, 16 February 2022
Line 3:		Line 3:
	<StructureSection load='1bl1' size='340' side='right'caption='[[1bl1]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>		<StructureSection load='1bl1' size='340' side='right'caption='[[1bl1]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1bl1]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BL1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1BL1 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1bl1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BL1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1BL1 FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1bl1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bl1 OCA], [https://pdbe.org/1bl1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1bl1 RCSB], [https://www.ebi.ac.uk/pdbsum/1bl1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1bl1 ProSAT]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1bl1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bl1 OCA], [https://pdbe.org/1bl1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1bl1 RCSB], [https://www.ebi.ac.uk/pdbsum/1bl1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1bl1 ProSAT]</span></td></tr>
	</table>		</table>
Line 23:		Line 23:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Bisello, A]]		[[Category: Bisello, A]]

OCA at 07:00, 24 February 2021

OCA — Wed, 24 Feb 2021 07:00:25 GMT

←Older revision		Revision as of 07:00, 24 February 2021
Line 3:		Line 3:
	<StructureSection load='1bl1' size='340' side='right'caption='[[1bl1]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>		<StructureSection load='1bl1' size='340' side='right'caption='[[1bl1]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1bl1]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BL1 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1BL1 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1bl1]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BL1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1BL1 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1bl1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bl1 OCA], [~~http~~://pdbe.org/1bl1 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1bl1 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1bl1 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1bl1 ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1bl1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bl1 OCA], [https://pdbe.org/1bl1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1bl1 RCSB], [https://www.ebi.ac.uk/pdbsum/1bl1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1bl1 ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[~~http~~://www.uniprot.org/uniprot/PTH1R_HUMAN PTH1R_HUMAN]] Blomstrand lethal chondrodysplasia;Dental ankylosis;Eiken syndrome;Metaphyseal chondrodysplasia, Jansen type;Enchondromatosis. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease may be caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.	+	[[https://www.uniprot.org/uniprot/PTH1R_HUMAN PTH1R_HUMAN]] Blomstrand lethal chondrodysplasia;Dental ankylosis;Eiken syndrome;Metaphyseal chondrodysplasia, Jansen type;Enchondromatosis. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease may be caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/PTH1R_HUMAN PTH1R_HUMAN]] This is a receptor for parathyroid hormone and for parathyroid hormone-related peptide. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system.<ref>PMID:18611381</ref> <ref>PMID:20172855</ref>	+	[[https://www.uniprot.org/uniprot/PTH1R_HUMAN PTH1R_HUMAN]] This is a receptor for parathyroid hormone and for parathyroid hormone-related peptide. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system.<ref>PMID:18611381</ref> <ref>PMID:20172855</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 08:32, 21 May 2019

OCA — Tue, 21 May 2019 08:32:04 GMT

←Older revision		Revision as of 08:32, 21 May 2019
Line 1:		Line 1:

	==PTH RECEPTOR N-TERMINUS FRAGMENT, NMR, 1 STRUCTURE==		==PTH RECEPTOR N-TERMINUS FRAGMENT, NMR, 1 STRUCTURE==
-	<StructureSection load='1bl1' size='340' side='right' caption='[[1bl1]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>	+	<StructureSection load='1bl1' size='340' side='right'caption='[[1bl1]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1bl1]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BL1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1BL1 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1bl1]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BL1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1BL1 FirstGlance]. <br>
Line 23:		Line 23:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Bisello, A]]		[[Category: Bisello, A]]
	[[Category: Chorev, M]]		[[Category: Chorev, M]]

OCA at 06:00, 17 August 2017

OCA — Thu, 17 Aug 2017 06:00:32 GMT

←Older revision		Revision as of 06:00, 17 August 2017
Line 1:		Line 1:
		+
	==PTH RECEPTOR N-TERMINUS FRAGMENT, NMR, 1 STRUCTURE==		==PTH RECEPTOR N-TERMINUS FRAGMENT, NMR, 1 STRUCTURE==
	<StructureSection load='1bl1' size='340' side='right' caption='[[1bl1]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>		<StructureSection load='1bl1' size='340' side='right' caption='[[1bl1]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1bl1]] is a 1 chain structure ~~with sequence from [http://en.wikipedia.org/wiki/Human Human]~~. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BL1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1BL1 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1bl1]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BL1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1BL1 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1bl1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bl1 OCA], [http://pdbe.org/1bl1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1bl1 RCSB], [http://www.ebi.ac.uk/pdbsum/1bl1 PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1bl1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bl1 OCA], [http://pdbe.org/1bl1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1bl1 RCSB], [http://www.ebi.ac.uk/pdbsum/1bl1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1bl1 ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 22:		Line 23:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Human]]
	[[Category: Bisello, A]]		[[Category: Bisello, A]]
	[[Category: Chorev, M]]		[[Category: Chorev, M]]

OCA at 02:57, 11 September 2015

OCA — Fri, 11 Sep 2015 02:57:43 GMT

←Older revision		Revision as of 02:57, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='1bl1' size='340' side='right' caption='[[1bl1]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>		<StructureSection load='1bl1' size='340' side='right' caption='[[1bl1]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1bl1]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BL1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1BL1 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1bl1]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BL1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1BL1 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1bl1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bl1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1bl1 RCSB], [http://www.ebi.ac.uk/pdbsum/1bl1 PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1bl1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bl1 OCA], [http://pdbe.org/1bl1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1bl1 RCSB], [http://www.ebi.ac.uk/pdbsum/1bl1 PDBsum]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[http://www.uniprot.org/uniprot/~~PTHR1_HUMAN PTHR1_HUMAN~~]] ~~Chondrodysplasia,~~ Blomstrand ~~type~~;Dental ankylosis;Eiken syndrome;Metaphyseal chondrodysplasia, Jansen type;Enchondromatosis. The disease is caused by mutations affecting the gene represented in this entry.~~<ref>PMID:7701349</ref> <ref>PMID:8703170</ref> <ref>PMID:9178745</ref> <ref>PMID:10487664</ref> <ref>PMID:15240651</ref>~~ The disease is caused by mutations affecting the gene represented in this entry.~~<ref>PMID:9745456</ref>~~ The disease may be caused by mutations affecting the gene represented in this entry.~~<ref>PMID:11850620</ref> <ref>PMID:15523647</ref>~~ The disease is caused by mutations affecting the gene represented in this entry.~~<ref>PMID:15525660</ref>~~ The disease is caused by mutations affecting the gene represented in this entry.	+	[[http://www.uniprot.org/uniprot/PTH1R_HUMAN PTH1R_HUMAN]] Blomstrand lethal chondrodysplasia;Dental ankylosis;Eiken syndrome;Metaphyseal chondrodysplasia, Jansen type;Enchondromatosis. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease may be caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.
	== Function ==		== Function ==
-	[[http://www.uniprot.org/uniprot/~~PTHR1_HUMAN PTHR1_HUMAN~~]] This is a receptor for parathyroid hormone and for parathyroid hormone-related peptide. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system.<ref>PMID:18611381</ref> <ref>PMID:20172855</ref>	+	[[http://www.uniprot.org/uniprot/PTH1R_HUMAN PTH1R_HUMAN]] This is a receptor for parathyroid hormone and for parathyroid hormone-related peptide. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system.<ref>PMID:18611381</ref> <ref>PMID:20172855</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 17:		Line 17:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1bl1" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Bisello, A]]		[[Category: Bisello, A]]
	[[Category: Chorev, M]]		[[Category: Chorev, M]]

OCA at 10:27, 22 December 2014

OCA — Mon, 22 Dec 2014 10:27:32 GMT

←Older revision		Revision as of 10:27, 22 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1bl1]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BL1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1BL1 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1bl1]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BL1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1BL1 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1bl1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bl1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1bl1 RCSB], [http://www.ebi.ac.uk/pdbsum/1bl1 PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1bl1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bl1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1bl1 RCSB], [http://www.ebi.ac.uk/pdbsum/1bl1 PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Disease ==		== Disease ==
	[[http://www.uniprot.org/uniprot/PTHR1_HUMAN PTHR1_HUMAN]] Chondrodysplasia, Blomstrand type;Dental ankylosis;Eiken syndrome;Metaphyseal chondrodysplasia, Jansen type;Enchondromatosis. The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:7701349</ref> <ref>PMID:8703170</ref> <ref>PMID:9178745</ref> <ref>PMID:10487664</ref> <ref>PMID:15240651</ref> The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:9745456</ref> The disease may be caused by mutations affecting the gene represented in this entry.<ref>PMID:11850620</ref> <ref>PMID:15523647</ref> The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:15525660</ref> The disease is caused by mutations affecting the gene represented in this entry.		[[http://www.uniprot.org/uniprot/PTHR1_HUMAN PTHR1_HUMAN]] Chondrodysplasia, Blomstrand type;Dental ankylosis;Eiken syndrome;Metaphyseal chondrodysplasia, Jansen type;Enchondromatosis. The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:7701349</ref> <ref>PMID:8703170</ref> <ref>PMID:9178745</ref> <ref>PMID:10487664</ref> <ref>PMID:15240651</ref> The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:9745456</ref> The disease may be caused by mutations affecting the gene represented in this entry.<ref>PMID:11850620</ref> <ref>PMID:15523647</ref> The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:15525660</ref> The disease is caused by mutations affecting the gene represented in this entry.
Line 22:		Line 22:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Bisello, A.]]	+	[[Category: Bisello, A]]
-	[[Category: Chorev, M.]]	+	[[Category: Chorev, M]]
-	[[Category: Mierke, D F.]]	+	[[Category: Mierke, D F]]
-	[[Category: Pellegrini, M.]]	+	[[Category: Pellegrini, M]]
-	[[Category: Rosenblatt, M.]]	+	[[Category: Rosenblatt, M]]
	[[Category: Calciotropic hormone]]		[[Category: Calciotropic hormone]]
	[[Category: Hormone receptor]]		[[Category: Hormone receptor]]

OCA at 09:33, 13 August 2014

OCA — Wed, 13 Aug 2014 09:33:22 GMT

←Older revision		Revision as of 09:33, 13 August 2014
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-	[[~~Image~~:1bl1.~~png\|left\|200px~~]]	+	==PTH RECEPTOR N-TERMINUS FRAGMENT, NMR, 1 STRUCTURE==
		+	<StructureSection load='1bl1' size='340' side='right' caption='[[1bl1]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1bl1]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BL1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1BL1 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1bl1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bl1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1bl1 RCSB], [http://www.ebi.ac.uk/pdbsum/1bl1 PDBsum]</span></td></tr>
		+	<table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/PTHR1_HUMAN PTHR1_HUMAN]] Chondrodysplasia, Blomstrand type;Dental ankylosis;Eiken syndrome;Metaphyseal chondrodysplasia, Jansen type;Enchondromatosis. The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:7701349</ref> <ref>PMID:8703170</ref> <ref>PMID:9178745</ref> <ref>PMID:10487664</ref> <ref>PMID:15240651</ref> The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:9745456</ref> The disease may be caused by mutations affecting the gene represented in this entry.<ref>PMID:11850620</ref> <ref>PMID:15523647</ref> The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:15525660</ref> The disease is caused by mutations affecting the gene represented in this entry.
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/PTHR1_HUMAN PTHR1_HUMAN]] This is a receptor for parathyroid hormone and for parathyroid hormone-related peptide. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system.<ref>PMID:18611381</ref> <ref>PMID:20172855</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	A 31 amino acid fragment of the extracellular N-terminus of the human G-protein coupled receptor for parathyroid hormone (PTH1R) has been structurally characterized by NMR and molecular dynamics simulations. The fragment PTH1R[168-198] includes residues 173-189, shown by photoaffinity cross-linking to be a contact domain with position 13 of parathyroid hormone (PTH). The structure of PTH1R[168-198], determined in a micellar solution of dodecylphosphocholine to mimic the membrane environment, consists of three alpha-helices, separated by a well-defined turn and a flexible region. The topological orientation of PTH1R[168-198] was determined from nitroxide-radical induced relaxation of NMR signals utilizing 5- and 16-doxylstearic acid. The C-terminal helix (residues 190-196), consisting of seven amino acids of the first transmembrane domain, is very hydrophobic and embedded in the lipid core. This helix is preceded by a well-defined turn, forming an approximate 90 degrees bend, placing the other helices (residues 169-176 and 180-189), both of which are amphipathic, on the surface of the micelle. In this orientation, many hydrophilic residues of the receptor, including Glu177, Arg179, Arg181, Glu182, Asp185, and Arg186, are projecting toward the solvent available to form complementary Coulombic interactions with the polar residues of the principal binding domain of the ligand (e.g., Arg25, Lys26, Lys27, Asp30, and His32). Given that the binding domain of PTH adopts an amphipathic alpha-helix which lies on the membrane, we visualize ligand binding as a two stage process involving a nonspecific hydrophobic interaction of amphipathic helices with the membrane, followed by two-dimensional diffusion leading to highly specific, ligand-receptor interaction.

-	~~{{STRUCTURE_1bl1\| PDB=1bl1 \| SCENE= }}~~	+	Binding domain of human parathyroid hormone receptor: from conformation to function.,Pellegrini M, Bisello A, Rosenblatt M, Chorev M, Mierke DF Biochemistry. 1998 Sep 15;37(37):12737-43. PMID:9737850<ref>PMID:9737850</ref>

-	~~===PTH RECEPTOR N-TERMINUS FRAGMENT~~, ~~NMR, 1 STRUCTURE===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_9737850}}~~	+	== References ==
-		+	<references/>
-	==~~About this Structure~~==	+	__TOC__
-	~~[[1bl1]] is a 1 chain structure with sequence from [http:~~//~~en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BL1 OCA].~~	+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Bisello, A.]]		[[Category: Bisello, A.]]

OCA: Protected "1bl1" [edit=sysop:move=sysop]

OCA — Sun, 21 Oct 2012 19:56:54 GMT

Protected "1bl1" [edit=sysop:move=sysop]

←Older revision

Revision as of 19:56, 21 October 2012

OCA at 19:56, 21 October 2012

OCA — Sun, 21 Oct 2012 19:56:51 GMT

←Older revision		Revision as of 19:56, 21 October 2012
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-	{{Seed}}
	[[Image:1bl1.png\|left\|200px]]		[[Image:1bl1.png\|left\|200px]]

-	<!--
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	{{STRUCTURE_1bl1\| PDB=1bl1 \| SCENE= }}		{{STRUCTURE_1bl1\| PDB=1bl1 \| SCENE= }}

	===PTH RECEPTOR N-TERMINUS FRAGMENT, NMR, 1 STRUCTURE===		===PTH RECEPTOR N-TERMINUS FRAGMENT, NMR, 1 STRUCTURE===

-
-	<!--
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	{{ABSTRACT_PUBMED_9737850}}		{{ABSTRACT_PUBMED_9737850}}

	==About this Structure==		==About this Structure==
-	~~1BL1 is a~~ [[~~Single protein~~]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BL1 OCA].	+	[[1bl1]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BL1 OCA].
-		+
-	~~==Reference==~~	+
-	Binding domain of human parathyroid hormone receptor: from conformation to function., Pellegrini M, Bisello A, Rosenblatt M, Chorev M, Mierke DF, Biochemistry. 1998 Sep 15;37(37):12737-43. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9737850 9737850]	+
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Single protein]]
	[[Category: Bisello, A.]]		[[Category: Bisello, A.]]
	[[Category: Chorev, M.]]		[[Category: Chorev, M.]]
Line 36:		Line 20:
	[[Category: Nmr structure]]		[[Category: Nmr structure]]
	[[Category: Parathyroid hormone]]		[[Category: Parathyroid hormone]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 19:19:45 2008''