1bww - Revision history

OCA at 05:44, 9 August 2023

OCA — Wed, 09 Aug 2023 05:44:35 GMT

←Older revision		Revision as of 05:44, 9 August 2023
Line 3:		Line 3:
	<StructureSection load='1bww' size='340' side='right'caption='[[1bww]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='1bww' size='340' side='right'caption='[[1bww]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1bww]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BWW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1BWW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1bww]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BWW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1BWW FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1bww FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bww OCA], [https://pdbe.org/1bww PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1bww RCSB], [https://www.ebi.ac.uk/pdbsum/1bww PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1bww ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.7Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1bww FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bww OCA], [https://pdbe.org/1bww PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1bww RCSB], [https://www.ebi.ac.uk/pdbsum/1bww PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1bww ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/KVD33_HUMAN KVD33_HUMAN] V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).<ref>PMID:17576170</ref> <ref>PMID:20176268</ref> <ref>PMID:22158414</ref> <ref>PMID:24600447</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 29:		Line 32:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Dauter, Z]]	+	[[Category: Dauter Z]]
-	[[Category: Fritz~~, H J~~]]	+	[[Category: Fritz HJ]]
-	[[Category: Pohl, E]]	+	[[Category: Pohl E]]
-	[[Category: Schmidt, A]]	+	[[Category: Schmidt A]]
-	[[Category: Schneider~~, T R~~]]	+	[[Category: Schneider TR]]
-	[[Category: Sheldrick~~, G M~~]]	+	[[Category: Sheldrick GM]]
-	[[Category: Uson, I]]	+	[[Category: Uson I]]
-	~~[[Category: Bence-jones protein]]~~	+
-	~~[[Category: Immune system]]~~	+
-	~~[[Category: Reiv]]~~	+
-	~~[[Category: Stabilized immunoglobulin fragment~~]]	+

OCA at 10:30, 14 July 2021

OCA — Wed, 14 Jul 2021 10:30:51 GMT

←Older revision		Revision as of 10:30, 14 July 2021
Line 3:		Line 3:
	<StructureSection load='1bww' size='340' side='right'caption='[[1bww]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='1bww' size='340' side='right'caption='[[1bww]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1bww]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BWW OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1BWW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1bww]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BWW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1BWW FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1bww FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bww OCA], [~~http~~://pdbe.org/1bww PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1bww RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1bww PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1bww ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1bww FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bww OCA], [https://pdbe.org/1bww PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1bww RCSB], [https://www.ebi.ac.uk/pdbsum/1bww PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1bww ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 07:10, 10 October 2019

OCA — Thu, 10 Oct 2019 07:10:34 GMT

←Older revision		Revision as of 07:10, 10 October 2019
Line 1:		Line 1:

	==BENCE-JONES IMMUNOGLOBULIN REI VARIABLE PORTION, T39K MUTANT==		==BENCE-JONES IMMUNOGLOBULIN REI VARIABLE PORTION, T39K MUTANT==
-	<StructureSection load='1bww' size='340' side='right' caption='[[1bww]], [[Resolution\|resolution]] 1.70Å' scene=''>	+	<StructureSection load='1bww' size='340' side='right'caption='[[1bww]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1bww]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BWW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1BWW FirstGlance]. <br>		<table><tr><td colspan='2'>[[1bww]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BWW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1BWW FirstGlance]. <br>
Line 10:		Line 10:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bw/1bww_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bw/1bww_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 30:		Line 30:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Dauter, Z]]		[[Category: Dauter, Z]]
	[[Category: Fritz, H J]]		[[Category: Fritz, H J]]

OCA at 08:07, 29 November 2017

OCA — Wed, 29 Nov 2017 08:07:16 GMT

←Older revision		Revision as of 08:07, 29 November 2017
Line 1:		Line 1:
		+
	==BENCE-JONES IMMUNOGLOBULIN REI VARIABLE PORTION, T39K MUTANT==		==BENCE-JONES IMMUNOGLOBULIN REI VARIABLE PORTION, T39K MUTANT==
	<StructureSection load='1bww' size='340' side='right' caption='[[1bww]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='1bww' size='340' side='right' caption='[[1bww]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1bww]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BWW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1BWW FirstGlance]. <br>		<table><tr><td colspan='2'>[[1bww]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BWW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1BWW FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1bww FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bww OCA], [http://pdbe.org/1bww PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1bww RCSB], [http://www.ebi.ac.uk/pdbsum/1bww PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1bww FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bww OCA], [http://pdbe.org/1bww PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1bww RCSB], [http://www.ebi.ac.uk/pdbsum/1bww PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1bww ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 01:47, 10 February 2016

OCA — Wed, 10 Feb 2016 01:47:08 GMT

←Older revision		Revision as of 01:47, 10 February 2016
Line 13:		Line 13:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1bww ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 04:09, 11 September 2015

OCA — Fri, 11 Sep 2015 04:09:34 GMT

←Older revision		Revision as of 04:09, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='1bww' size='340' side='right' caption='[[1bww]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='1bww' size='340' side='right' caption='[[1bww]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1bww]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BWW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1BWW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1bww]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BWW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1BWW FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1bww FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bww OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1bww RCSB], [http://www.ebi.ac.uk/pdbsum/1bww PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1bww FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bww OCA], [http://pdbe.org/1bww PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1bww RCSB], [http://www.ebi.ac.uk/pdbsum/1bww PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 23:		Line 23:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1bww" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Dauter, Z]]		[[Category: Dauter, Z]]
	[[Category: Fritz, H J]]		[[Category: Fritz, H J]]

OCA at 11:53, 22 December 2014

OCA — Mon, 22 Dec 2014 11:53:46 GMT

←Older revision		Revision as of 11:53, 22 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1bww]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BWW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1BWW FirstGlance]. <br>		<table><tr><td colspan='2'>[[1bww]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BWW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1BWW FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1bww FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bww OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1bww RCSB], [http://www.ebi.ac.uk/pdbsum/1bww PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1bww FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bww OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1bww RCSB], [http://www.ebi.ac.uk/pdbsum/1bww PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 28:		Line 28:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Dauter, Z.]]	+	[[Category: Dauter, Z]]
-	[[Category: Fritz, H J.]]	+	[[Category: Fritz, H J]]
-	[[Category: Pohl, E.]]	+	[[Category: Pohl, E]]
-	[[Category: Schmidt, A.]]	+	[[Category: Schmidt, A]]
-	[[Category: Schneider, T R.]]	+	[[Category: Schneider, T R]]
-	[[Category: Sheldrick, G M.]]	+	[[Category: Sheldrick, G M]]
-	[[Category: Uson, I.]]	+	[[Category: Uson, I]]
	[[Category: Bence-jones protein]]		[[Category: Bence-jones protein]]
	[[Category: Immune system]]		[[Category: Immune system]]
	[[Category: Reiv]]		[[Category: Reiv]]
	[[Category: Stabilized immunoglobulin fragment]]		[[Category: Stabilized immunoglobulin fragment]]

OCA at 09:37, 13 August 2014

OCA — Wed, 13 Aug 2014 09:37:41 GMT

←Older revision		Revision as of 09:37, 13 August 2014
Line 1:		Line 1:
-	[[~~Image~~:1bww.~~png\|left~~\|200px]]	+	==BENCE-JONES IMMUNOGLOBULIN REI VARIABLE PORTION, T39K MUTANT==
		+	<StructureSection load='1bww' size='340' side='right' caption='[[1bww]], [[Resolution\|resolution]] 1.70Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1bww]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BWW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1BWW FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1bww FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bww OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1bww RCSB], [http://www.ebi.ac.uk/pdbsum/1bww PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bw/1bww_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The X-ray structure of the T39K mutant of the variable domain of a human immunoglobulin kappa light chain has been determined at room temperature to 1.7 A resolution with a conventional R factor of 0. 182. T39K crystallizes in the triclinic space group P1 [a = 35.4 (1), b = 40.1 (1), c = 43.1 (1) A, alpha = 66.9 (1), beta = 85.4 (1), gamma = 73.8 (1) degrees ]. The unit-cell contains two monomers, related by a non-crystallographic twofold axis. The use of a novel type of local non-crystallographic symmetry restraints on related isotropic displacement parameters and 1-4 distances as incorporated in the refinement program SHELXL improves the model and quality of the maps, but local differences between both monomers in areas subject to different packing contacts can still be observed. 12 overall anisotropic scaling parameters were refined. These may have compensated for the difficulties in accurately scaling single rotation axis image plate data from a triclinic crystal, because of the scarcity of common equivalent reflections. The final model has been used to perform a number of tests on anisotropic scaling, non-crystallographic symmetry, anisotropic refinement, determination of standard uncertainties and bulk solvent correction. It is remarkable that removal of the NCS restraints from the final model caused Rfree to increase. These tests clarify the strategies for optimum use of SHELXL for refinement at medium as opposed to atomic resolution.

-	~~{{STRUCTURE_1bww\| PDB=1bww \| SCENE= }}~~	+	1.7 A structure of the stabilized REIv mutant T39K. Application of local NCS restraints.,Uson I, Pohl E, Schneider TR, Dauter Z, Schmidt A, Fritz HJ, Sheldrick GM Acta Crystallogr D Biol Crystallogr. 1999 Jun;55(Pt 6):1158-67. PMID:10329778<ref>PMID:10329778</ref>

-	~~===BENCE-JONES IMMUNOGLOBULIN REI VARIABLE PORTION~~, ~~T39K MUTANT===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_10329778}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[1bww]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1BWW OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:010329778<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Dauter, Z.]]		[[Category: Dauter, Z.]]

OCA: Protected "1bww" [edit=sysop:move=sysop]

OCA — Sun, 21 Oct 2012 20:34:00 GMT

Protected "1bww" [edit=sysop:move=sysop]

←Older revision

Revision as of 20:34, 21 October 2012

OCA at 20:33, 21 October 2012

OCA — Sun, 21 Oct 2012 20:33:58 GMT

←Older revision		Revision as of 20:33, 21 October 2012
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	[[Image:1bww.png\|left\|200px]]		[[Image:1bww.png\|left\|200px]]

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	{{STRUCTURE_1bww\| PDB=1bww \| SCENE= }}		{{STRUCTURE_1bww\| PDB=1bww \| SCENE= }}

	===BENCE-JONES IMMUNOGLOBULIN REI VARIABLE PORTION, T39K MUTANT===		===BENCE-JONES IMMUNOGLOBULIN REI VARIABLE PORTION, T39K MUTANT===

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	{{ABSTRACT_PUBMED_10329778}}		{{ABSTRACT_PUBMED_10329778}}

	==About this Structure==		==About this Structure==
-	~~1BWW~~ is a 2 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BWW OCA].	+	[[1bww]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BWW OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~10329778~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:010329778</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Dauter, Z.]]		[[Category: Dauter, Z.]]
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	[[Category: Uson, I.]]		[[Category: Uson, I.]]
	[[Category: Bence-jones protein]]		[[Category: Bence-jones protein]]
		+	[[Category: Immune system]]
	[[Category: Reiv]]		[[Category: Reiv]]
	[[Category: Stabilized immunoglobulin fragment]]		[[Category: Stabilized immunoglobulin fragment]]
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-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 14:25:57 2009''