1byy - Revision history

OCA at 23:22, 27 December 2023

OCA — Wed, 27 Dec 2023 23:22:45 GMT

←Older revision		Revision as of 23:22, 27 December 2023
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	==SODIUM CHANNEL IIA INACTIVATION GATE==		==SODIUM CHANNEL IIA INACTIVATION GATE==
-	<StructureSection load='1byy' size='340' side='right'caption='[[1byy~~]], [[NMR_Ensembles_of_Models \| 10 NMR models~~]]' scene=''>	+	<StructureSection load='1byy' size='340' side='right'caption='[[1byy]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1byy]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Buffalo_rat Buffalo rat~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BYY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1BYY FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1byy]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BYY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1BYY FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1byy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1byy OCA], [https://pdbe.org/1byy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1byy RCSB], [https://www.ebi.ac.uk/pdbsum/1byy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1byy ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1byy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1byy OCA], [https://pdbe.org/1byy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1byy RCSB], [https://www.ebi.ac.uk/pdbsum/1byy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1byy ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/SCN2A_RAT SCN2A_RAT]] Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.	+	[https://www.uniprot.org/uniprot/SCN2A_RAT SCN2A_RAT] Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 34:		Line 35:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Buffalo rat]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Baker, C]]	+	[[Category: Rattus norvegicus]]
-	[[Category: Boeckman~~, F A~~]]	+	[[Category: Baker C]]
-	[[Category: Catterall~~, W A~~]]	+	[[Category: Boeckman FA]]
-	[[Category: Klevit~~, R E~~]]	+	[[Category: Catterall WA]]
-	[[Category: Rohl~~, C A~~]]	+	[[Category: Klevit RE]]
-	[[Category: Scheuer, T]]	+	[[Category: Rohl CA]]
-	~~[[Category: Membrane protein]]~~	+	[[Category: Scheuer T]]
-	~~[[Category: Sodium channel~~]]	+

OCA at 10:42, 19 May 2021

OCA — Wed, 19 May 2021 10:42:06 GMT

←Older revision		Revision as of 10:42, 19 May 2021
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	<StructureSection load='1byy' size='340' side='right'caption='[[1byy]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>		<StructureSection load='1byy' size='340' side='right'caption='[[1byy]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1byy]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BYY OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1BYY FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1byy]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BYY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1BYY FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1byy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1byy OCA], [~~http~~://pdbe.org/1byy PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1byy RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1byy PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1byy ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1byy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1byy OCA], [https://pdbe.org/1byy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1byy RCSB], [https://www.ebi.ac.uk/pdbsum/1byy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1byy ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/SCN2A_RAT SCN2A_RAT]] Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.	+	[[https://www.uniprot.org/uniprot/SCN2A_RAT SCN2A_RAT]] Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 29:		Line 29:

	==See Also==		==See Also==
-	*[[Ion channels\|Ion channels]]	+	*[[Ion channels 3D structures\|Ion channels 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 17:52, 14 August 2019

OCA — Wed, 14 Aug 2019 17:52:54 GMT

←Older revision		Revision as of 17:52, 14 August 2019
Line 1:		Line 1:

	==SODIUM CHANNEL IIA INACTIVATION GATE==		==SODIUM CHANNEL IIA INACTIVATION GATE==
-	<StructureSection load='1byy' size='340' side='right' caption='[[1byy]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>	+	<StructureSection load='1byy' size='340' side='right'caption='[[1byy]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1byy]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BYY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1BYY FirstGlance]. <br>		<table><tr><td colspan='2'>[[1byy]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BYY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1BYY FirstGlance]. <br>
Line 12:		Line 12:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/by/1byy_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/by/1byy_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 27:		Line 27:
	</div>		</div>
	<div class="pdbe-citations 1byy" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1byy" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Ion channels\|Ion channels]]
	== References ==		== References ==
	<references/>		<references/>
Line 32:		Line 35:
	</StructureSection>		</StructureSection>
	[[Category: Buffalo rat]]		[[Category: Buffalo rat]]
		+	[[Category: Large Structures]]
	[[Category: Baker, C]]		[[Category: Baker, C]]
	[[Category: Boeckman, F A]]		[[Category: Boeckman, F A]]

OCA at 10:52, 8 November 2017

OCA — Wed, 08 Nov 2017 10:52:28 GMT

←Older revision		Revision as of 10:52, 8 November 2017
Line 1:		Line 1:
		+
	==SODIUM CHANNEL IIA INACTIVATION GATE==		==SODIUM CHANNEL IIA INACTIVATION GATE==
	<StructureSection load='1byy' size='340' side='right' caption='[[1byy]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>		<StructureSection load='1byy' size='340' side='right' caption='[[1byy]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1byy]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BYY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1BYY FirstGlance]. <br>		<table><tr><td colspan='2'>[[1byy]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BYY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1BYY FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1byy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1byy OCA], [http://pdbe.org/1byy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1byy RCSB], [http://www.ebi.ac.uk/pdbsum/1byy PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1byy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1byy OCA], [http://pdbe.org/1byy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1byy RCSB], [http://www.ebi.ac.uk/pdbsum/1byy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1byy ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 26:		Line 27:
	</div>		</div>
	<div class="pdbe-citations 1byy" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1byy" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Ion channels\|Ion channels]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 04:32, 7 February 2016

OCA — Sun, 07 Feb 2016 04:32:43 GMT

←Older revision		Revision as of 04:32, 7 February 2016
Line 15:		Line 15:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1byy ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 21:52, 9 September 2015

OCA — Wed, 09 Sep 2015 21:52:50 GMT

←Older revision		Revision as of 21:52, 9 September 2015
Line 2:		Line 2:
	<StructureSection load='1byy' size='340' side='right' caption='[[1byy]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>		<StructureSection load='1byy' size='340' side='right' caption='[[1byy]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1byy]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Rattus_norvegicus Rattus norvegicus~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BYY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1BYY FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1byy]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BYY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1BYY FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1byy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1byy OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1byy RCSB], [http://www.ebi.ac.uk/pdbsum/1byy PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1byy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1byy OCA], [http://pdbe.org/1byy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1byy RCSB], [http://www.ebi.ac.uk/pdbsum/1byy PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 25:		Line 25:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1byy" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 32:		Line 33:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Rattus norvegicus~~]]	+	[[Category: Buffalo rat]]
	[[Category: Baker, C]]		[[Category: Baker, C]]
	[[Category: Boeckman, F A]]		[[Category: Boeckman, F A]]

OCA at 07:53, 24 December 2014

OCA — Wed, 24 Dec 2014 07:53:02 GMT

←Older revision		Revision as of 07:53, 24 December 2014
Line 5:		Line 5:
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1byy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1byy OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1byy RCSB], [http://www.ebi.ac.uk/pdbsum/1byy PDBsum]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1byy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1byy OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1byy RCSB], [http://www.ebi.ac.uk/pdbsum/1byy PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/SCN2A_RAT SCN2A_RAT]] Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 09:47, 22 December 2014

OCA — Mon, 22 Dec 2014 09:47:42 GMT

←Older revision		Revision as of 09:47, 22 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1byy]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BYY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1BYY FirstGlance]. <br>		<table><tr><td colspan='2'>[[1byy]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BYY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1BYY FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1byy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1byy OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1byy RCSB], [http://www.ebi.ac.uk/pdbsum/1byy PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1byy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1byy OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1byy RCSB], [http://www.ebi.ac.uk/pdbsum/1byy PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 31:		Line 31:
	</StructureSection>		</StructureSection>
	[[Category: Rattus norvegicus]]		[[Category: Rattus norvegicus]]
-	[[Category: Baker, C.]]	+	[[Category: Baker, C]]
-	[[Category: Boeckman, F A.]]	+	[[Category: Boeckman, F A]]
-	[[Category: Catterall, W A.]]	+	[[Category: Catterall, W A]]
-	[[Category: Klevit, R E.]]	+	[[Category: Klevit, R E]]
-	[[Category: Rohl, C A.]]	+	[[Category: Rohl, C A]]
-	[[Category: Scheuer, T.]]	+	[[Category: Scheuer, T]]
	[[Category: Membrane protein]]		[[Category: Membrane protein]]
	[[Category: Sodium channel]]		[[Category: Sodium channel]]

OCA at 09:44, 13 August 2014

OCA — Wed, 13 Aug 2014 09:44:02 GMT

←Older revision		Revision as of 09:44, 13 August 2014
Line 1:		Line 1:
-	[[~~Image~~:1byy.~~png\|left~~\|200px]]	+	==SODIUM CHANNEL IIA INACTIVATION GATE==
		+	<StructureSection load='1byy' size='340' side='right' caption='[[1byy]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1byy]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BYY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1BYY FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1byy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1byy OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1byy RCSB], [http://www.ebi.ac.uk/pdbsum/1byy PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/by/1byy_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The sodium channel initiates action potentials by opening in response to membrane depolarization. Fast channel inactivation, which is required for proper physiological function, is mediated by a cytoplasmic loop proposed to occlude the ion pore via a hinged lid mechanism with the triad IFM serving as a hydrophobic "latch". The NMR solution structure of the isolated inactivation gate reveals a stably folded core comprised of an alpha-helix capped by an N-terminal turn, supporting a model in which the tightly folded core containing the latch motif pivots on a more flexible hinge region to occlude the pore during inactivation. The structure, in combination with substituted cysteine mutagenesis experiments, indicates that the IFM triad and adjacent Thr are essential components of the latch and suggests differing roles for the residues of the IFMT motif in fast inactivation.

-	~~{{STRUCTURE_1byy\| PDB=1byy \| SCENE= }}~~	+	Solution structure of the sodium channel inactivation gate.,Rohl CA, Boeckman FA, Baker C, Scheuer T, Catterall WA, Klevit RE Biochemistry. 1999 Jan 19;38(3):855-61. PMID:9893979<ref>PMID:9893979</ref>

-	~~===SODIUM CHANNEL IIA INACTIVATION GATE===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_9893979}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[1byy]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Rattus_norvegicus Rattus norvegicus]~~. ~~Full experimental information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1BYY OCA].~~	+

	==See Also==		==See Also==
	*[[Ion channels\|Ion channels]]		*[[Ion channels\|Ion channels]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:009893979<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Rattus norvegicus]]		[[Category: Rattus norvegicus]]
	[[Category: Baker, C.]]		[[Category: Baker, C.]]

OCA at 05:35, 20 October 2012

OCA — Sat, 20 Oct 2012 05:35:32 GMT

←Older revision		Revision as of 05:35, 20 October 2012
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	==About this Structure==		==About this Structure==
-	[[1byy]] is a 1 chain structure ~~of [[Ion channels]]~~ with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BYY OCA].	+	[[1byy]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BYY OCA].

	==See Also==		==See Also==