1c1l - Revision history

OCA at 05:47, 9 August 2023

OCA — Wed, 09 Aug 2023 05:47:12 GMT

←Older revision		Revision as of 05:47, 9 August 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1c1l]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Conger_myriaster Conger myriaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C1L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1C1L FirstGlance]. <br>		<table><tr><td colspan='2'>[[1c1l]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Conger_myriaster Conger myriaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C1L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1C1L FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=BGC:BETA~~-~~D-GLUCOSE'>BGC</scene>~~, ~~<scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.5Å</td></tr>
-	<tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=PRD_900004:beta-lactose'>PRD_900004</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1c1l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1c1l OCA], [https://pdbe.org/1c1l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1c1l RCSB], [https://www.ebi.ac.uk/pdbsum/1c1l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1c1l ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1c1l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1c1l OCA], [https://pdbe.org/1c1l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1c1l RCSB], [https://www.ebi.ac.uk/pdbsum/1c1l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1c1l ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/LEG1_CONMY LEG1_CONMY]] This protein binds beta-galactoside. Its physiological function is not yet known.	+	[https://www.uniprot.org/uniprot/LEG1_CONMY LEG1_CONMY] This protein binds beta-galactoside. Its physiological function is not yet known.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 35:		Line 35:
	[[Category: Conger myriaster]]		[[Category: Conger myriaster]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Hotta, H]]	+	[[Category: Hotta H]]
-	[[Category: Ishii, C]]	+	[[Category: Ishii C]]
-	[[Category: Kamiya, H]]	+	[[Category: Kamiya H]]
-	[[Category: Matsui, Y]]	+	[[Category: Matsui Y]]
-	[[Category: Mitsuyama, C]]	+	[[Category: Mitsuyama C]]
-	[[Category: Muramoto, K]]	+	[[Category: Muramoto K]]
-	[[Category: Niwa, Y]]	+	[[Category: Niwa Y]]
-	[[Category: Ogawa, T]]	+	[[Category: Ogawa T]]
-	[[Category: Shirai, T]]	+	[[Category: Shirai T]]
-	[[Category: Yamane, T]]	+	[[Category: Yamane T]]
-	~~[[Category: Beta-galactose-binding]]~~	+
-	~~[[Category: Galectin]]~~	+
-	~~[[Category: Lectin]]~~	+
-	~~[[Category: Sugar binding protein~~]]	+

OCA at 09:48, 26 May 2021

OCA — Wed, 26 May 2021 09:48:51 GMT

←Older revision		Revision as of 09:48, 26 May 2021
Line 3:		Line 3:
	<StructureSection load='1c1l' size='340' side='right'caption='[[1c1l]], [[Resolution\|resolution]] 1.50Å' scene=''>		<StructureSection load='1c1l' size='340' side='right'caption='[[1c1l]], [[Resolution\|resolution]] 1.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1c1l]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Conger_myriaster Conger myriaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C1L OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1C1L FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1c1l]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Conger_myriaster Conger myriaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C1L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1C1L FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1c1l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1c1l OCA], [~~http~~://pdbe.org/1c1l PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1c1l RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1c1l PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1c1l ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1c1l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1c1l OCA], [https://pdbe.org/1c1l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1c1l RCSB], [https://www.ebi.ac.uk/pdbsum/1c1l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1c1l ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/LEG1_CONMY LEG1_CONMY]] This protein binds beta-galactoside. Its physiological function is not yet known.	+	[[https://www.uniprot.org/uniprot/LEG1_CONMY LEG1_CONMY]] This protein binds beta-galactoside. Its physiological function is not yet known.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 07:06, 21 August 2019

OCA — Wed, 21 Aug 2019 07:06:15 GMT

←Older revision		Revision as of 07:06, 21 August 2019
Line 1:		Line 1:

	==LACTOSE-LIGANDED CONGERIN I==		==LACTOSE-LIGANDED CONGERIN I==
-	<StructureSection load='1c1l' size='340' side='right' caption='[[1c1l]], [[Resolution\|resolution]] 1.50Å' scene=''>	+	<StructureSection load='1c1l' size='340' side='right'caption='[[1c1l]], [[Resolution\|resolution]] 1.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1c1l]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Conger_myriaster Conger myriaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C1L OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1C1L FirstGlance]. <br>		<table><tr><td colspan='2'>[[1c1l]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Conger_myriaster Conger myriaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C1L OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1C1L FirstGlance]. <br>
Line 14:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c1/1c1l_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c1/1c1l_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 34:		Line 34:
	</StructureSection>		</StructureSection>
	[[Category: Conger myriaster]]		[[Category: Conger myriaster]]
		+	[[Category: Large Structures]]
	[[Category: Hotta, H]]		[[Category: Hotta, H]]
	[[Category: Ishii, C]]		[[Category: Ishii, C]]

OCA at 12:51, 16 November 2017

OCA — Thu, 16 Nov 2017 12:51:54 GMT

←Older revision		Revision as of 12:51, 16 November 2017
Line 6:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1c1l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1c1l OCA], [http://pdbe.org/1c1l PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1c1l RCSB], [http://www.ebi.ac.uk/pdbsum/1c1l PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1c1l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1c1l OCA], [http://pdbe.org/1c1l PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1c1l RCSB], [http://www.ebi.ac.uk/pdbsum/1c1l PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1c1l ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 17:45, 10 May 2016

OCA — Tue, 10 May 2016 17:45:46 GMT

←Older revision		Revision as of 17:45, 10 May 2016
Line 1:		Line 1:
		+
	==LACTOSE-LIGANDED CONGERIN I==		==LACTOSE-LIGANDED CONGERIN I==
	<StructureSection load='1c1l' size='340' side='right' caption='[[1c1l]], [[Resolution\|resolution]] 1.50Å' scene=''>		<StructureSection load='1c1l' size='340' side='right' caption='[[1c1l]], [[Resolution\|resolution]] 1.50Å' scene=''>

OCA at 04:06, 7 February 2016

OCA — Sun, 07 Feb 2016 04:06:12 GMT

←Older revision		Revision as of 04:06, 7 February 2016
Line 17:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1c1l ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 21:38, 9 September 2015

OCA — Wed, 09 Sep 2015 21:38:00 GMT

←Older revision		Revision as of 21:38, 9 September 2015
Line 5:		Line 5:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1c1l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1c1l OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1c1l RCSB], [http://www.ebi.ac.uk/pdbsum/1c1l PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1c1l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1c1l OCA], [http://pdbe.org/1c1l PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1c1l RCSB], [http://www.ebi.ac.uk/pdbsum/1c1l PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 27:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1c1l" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 07:43, 24 December 2014

OCA — Wed, 24 Dec 2014 07:43:09 GMT

←Older revision		Revision as of 07:43, 24 December 2014
Line 7:		Line 7:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1c1l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1c1l OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1c1l RCSB], [http://www.ebi.ac.uk/pdbsum/1c1l PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1c1l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1c1l OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1c1l RCSB], [http://www.ebi.ac.uk/pdbsum/1c1l PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/LEG1_CONMY LEG1_CONMY]] This protein binds beta-galactoside. Its physiological function is not yet known.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 09:32, 22 December 2014

OCA — Mon, 22 Dec 2014 09:32:27 GMT

←Older revision		Revision as of 09:32, 22 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1c1l]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Conger_myriaster Conger myriaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C1L OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1C1L FirstGlance]. <br>		<table><tr><td colspan='2'>[[1c1l]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Conger_myriaster Conger myriaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C1L OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1C1L FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>	+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1c1l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1c1l OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1c1l RCSB], [http://www.ebi.ac.uk/pdbsum/1c1l PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1c1l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1c1l OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1c1l RCSB], [http://www.ebi.ac.uk/pdbsum/1c1l PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 30:		Line 30:
	</StructureSection>		</StructureSection>
	[[Category: Conger myriaster]]		[[Category: Conger myriaster]]
-	[[Category: Hotta, H.]]	+	[[Category: Hotta, H]]
-	[[Category: Ishii, C.]]	+	[[Category: Ishii, C]]
-	[[Category: Kamiya, H.]]	+	[[Category: Kamiya, H]]
-	[[Category: Matsui, Y.]]	+	[[Category: Matsui, Y]]
-	[[Category: Mitsuyama, C.]]	+	[[Category: Mitsuyama, C]]
-	[[Category: Muramoto, K.]]	+	[[Category: Muramoto, K]]
-	[[Category: Niwa, Y.]]	+	[[Category: Niwa, Y]]
-	[[Category: Ogawa, T.]]	+	[[Category: Ogawa, T]]
-	[[Category: Shirai, T.]]	+	[[Category: Shirai, T]]
-	[[Category: Yamane, T.]]	+	[[Category: Yamane, T]]
	[[Category: Beta-galactose-binding]]		[[Category: Beta-galactose-binding]]
	[[Category: Galectin]]		[[Category: Galectin]]
	[[Category: Lectin]]		[[Category: Lectin]]
	[[Category: Sugar binding protein]]		[[Category: Sugar binding protein]]

OCA at 16:57, 20 August 2014

OCA — Wed, 20 Aug 2014 16:57:00 GMT

←Older revision		Revision as of 16:57, 20 August 2014
Line 1:		Line 1:
-	[[~~Image:~~1c1l.~~png~~\|~~left~~\|200px]]	+	==LACTOSE-LIGANDED CONGERIN I==
		+	<StructureSection load='1c1l' size='340' side='right' caption='[[1c1l]], [[Resolution\|resolution]] 1.50Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1c1l]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Conger_myriaster Conger myriaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C1L OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1C1L FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1c1l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1c1l OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1c1l RCSB], [http://www.ebi.ac.uk/pdbsum/1c1l PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c1/1c1l_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	BACKGROUND: Congerin I is a member of the galectin (animal beta-galactoside-binding lectin) family and is found in the skin mucus of conger eel. The galectin family proteins perform a variety of biological activities. Because of its histological localization and activity against marine bacteria and starfish embryos, congerin I is thought to take part in the eels' biological defense system against parasites. RESULTS: The crystal structure of congerin I has been determined in both lactose-liganded and ligand-free forms to 1. 5 A and 1.6 A resolution, respectively. The protein is a homodimer of 15 kDa subunits. Congerin I has a beta-sheet topology that is markedly different from those of known relatives. One of the beta-strands is exchanged between two identical subunits. This strand swap might increase the dimer stability. Of the known galectin complexes, congerin I forms the most extensive interaction with lactose molecules. Most of these interactions are substituted by similar interactions with water molecules, including a pi-electron hydrogen bond, in the ligand-free form. This observation indicates an increased affinity of congerin I for the ligand. CONCLUSIONS: The genes for congerin I and an isoform, congerin II, are known to have evolved under positive selection pressure. The strand swap and the modification in the carbohydrate-binding site might enhance the cross-linking activity, and should be the most apparent consequence of positive selection. The protein has been adapted to functioning in skin mucus that is in direct contact with surrounding environments by an enhancement in cross-linking activity. The structure of congerin I demonstrates the emergence of a new structure class by accelerated evolution under selection pressure.

-	~~{{STRUCTURE_1c1l\| PDB=1c1l \| SCENE= }}~~	+	High-resolution structure of the conger eel galectin, congerin I, in lactose-liganded and ligand-free forms: emergence of a new structure class by accelerated evolution.,Shirai T, Mitsuyama C, Niwa Y, Matsui Y, Hotta H, Yamane T, Kamiya H, Ishii C, Ogawa T, Muramoto K Structure. 1999 Oct 15;7(10):1223-33. PMID:10545323<ref>PMID:10545323</ref>

-	~~===LACTOSE-LIGANDED CONGERIN I===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_10545323}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[1c1l]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Conger_myriaster Conger myriaster]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1C1L OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:010545323<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Conger myriaster]]		[[Category: Conger myriaster]]
	[[Category: Hotta, H.]]		[[Category: Hotta, H.]]