1c1p - Revision history

OCA at 23:23, 27 December 2023

OCA — Wed, 27 Dec 2023 23:23:05 GMT

←Older revision		Revision as of 23:23, 27 December 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1c1p]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C1P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1C1P FirstGlance]. <br>		<table><tr><td colspan='2'>[[1c1p]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C1P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1C1P FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BAI:(5-AMIDINO-2-BENZIMIDAZOLYL)(2-BENZIMIDAZOLYL)METHANE'>BAI</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.37Å</td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1c2d\|1c2d]], [[1c2f\|1c2f]], [[1c2g\|1c2g]], [[1c2h\|1c2h]], [[1c2i\|1c2i]], [[1c2l\|1c2l]], [[1c2m\|1c2m]], [[1c1n\|1c1n]], [[1c1o\|1c1o]], [[1c2e\|1c2e]], [[1c1q\|1c1q]], [[1c1r\|1c1r]], [[1c1s\|1c1s]], [[1c1t\|1c1t]], [[1c1u\|1c1u]], [[1c1v\|1c1v]], [[1c1w\|1c1w]], [[1c2j\|1c2j]]</div></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BAI:(5-AMIDINO-2-BENZIMIDAZOLYL)(2-BENZIMIDAZOLYL)METHANE'>BAI</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Trypsin Trypsin], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.4 3.4.21.4] </span></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1c1p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1c1p OCA], [https://pdbe.org/1c1p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1c1p RCSB], [https://www.ebi.ac.uk/pdbsum/1c1p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1c1p ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1c1p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1c1p OCA], [https://pdbe.org/1c1p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1c1p RCSB], [https://www.ebi.ac.uk/pdbsum/1c1p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1c1p ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/TRY1_BOVIN TRY1_BOVIN]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	[[Category: Bos taurus]]		[[Category: Bos taurus]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: Trypsin]]~~	+	[[Category: Katz BA]]
-	[[Category: Katz~~, B A~~]]	+	[[Category: Luong C]]
-	[[Category: Luong, C]]	+
-	~~[[Category: Hydrolase-hydrolase inhibitor complex]]~~	+
-	~~[[Category: Ph dependence]]~~	+
-	~~[[Category: Serine protease serine protease/inhibitor~~]]	+

OCA at 15:13, 3 March 2021

OCA — Wed, 03 Mar 2021 15:13:18 GMT

←Older revision		Revision as of 15:13, 3 March 2021
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	<StructureSection load='1c1p' size='340' side='right'caption='[[1c1p]], [[Resolution\|resolution]] 1.37Å' scene=''>		<StructureSection load='1c1p' size='340' side='right'caption='[[1c1p]], [[Resolution\|resolution]] 1.37Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1c1p]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C1P OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1C1P FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1c1p]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C1P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1C1P FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BAI:(5-AMIDINO-2-BENZIMIDAZOLYL)(2-BENZIMIDAZOLYL)METHANE'>BAI</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BAI:(5-AMIDINO-2-BENZIMIDAZOLYL)(2-BENZIMIDAZOLYL)METHANE'>BAI</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1c2d\|1c2d]], [[1c2f\|1c2f]], [[1c2g\|1c2g]], [[1c2h\|1c2h]], [[1c2i\|1c2i]], [[1c2l\|1c2l]], [[1c2m\|1c2m]], [[1c1n\|1c1n]], [[1c1o\|1c1o]], [[1c2e\|1c2e]], [[1c1q\|1c1q]], [[1c1r\|1c1r]], [[1c1s\|1c1s]], [[1c1t\|1c1t]], [[1c1u\|1c1u]], [[1c1v\|1c1v]], [[1c1w\|1c1w]], [[1c2j\|1c2j]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1c2d\|1c2d]], [[1c2f\|1c2f]], [[1c2g\|1c2g]], [[1c2h\|1c2h]], [[1c2i\|1c2i]], [[1c2l\|1c2l]], [[1c2m\|1c2m]], [[1c1n\|1c1n]], [[1c1o\|1c1o]], [[1c2e\|1c2e]], [[1c1q\|1c1q]], [[1c1r\|1c1r]], [[1c1s\|1c1s]], [[1c1t\|1c1t]], [[1c1u\|1c1u]], [[1c1v\|1c1v]], [[1c1w\|1c1w]], [[1c2j\|1c2j]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Trypsin Trypsin], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.4 3.4.21.4] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Trypsin Trypsin], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.4 3.4.21.4] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1c1p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1c1p OCA], [~~http~~://pdbe.org/1c1p PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1c1p RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1c1p PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1c1p ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1c1p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1c1p OCA], [https://pdbe.org/1c1p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1c1p RCSB], [https://www.ebi.ac.uk/pdbsum/1c1p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1c1p ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 30:		Line 30:

	==See Also==		==See Also==
-	*[[Trypsin\|Trypsin]]	+	*[[Trypsin 3D structures\|Trypsin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 07:22, 29 May 2019

OCA — Wed, 29 May 2019 07:22:29 GMT

←Older revision		Revision as of 07:22, 29 May 2019
Line 1:		Line 1:

	==RECRUITING ZINC TO MEDIATE POTENT, SPECIFIC INHIBITION OF SERINE PROTEASES==		==RECRUITING ZINC TO MEDIATE POTENT, SPECIFIC INHIBITION OF SERINE PROTEASES==
-	<StructureSection load='1c1p' size='340' side='right' caption='[[1c1p]], [[Resolution\|resolution]] 1.37Å' scene=''>	+	<StructureSection load='1c1p' size='340' side='right'caption='[[1c1p]], [[Resolution\|resolution]] 1.37Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1c1p]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C1P OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1C1P FirstGlance]. <br>		<table><tr><td colspan='2'>[[1c1p]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C1P OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1C1P FirstGlance]. <br>
Line 13:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c1/1c1p_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c1/1c1p_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 36:		Line 36:
	</StructureSection>		</StructureSection>
	[[Category: Bos taurus]]		[[Category: Bos taurus]]
		+	[[Category: Large Structures]]
	[[Category: Trypsin]]		[[Category: Trypsin]]
	[[Category: Katz, B A]]		[[Category: Katz, B A]]

OCA at 11:09, 24 August 2017

OCA — Thu, 24 Aug 2017 11:09:00 GMT

←Older revision		Revision as of 11:09, 24 August 2017
Line 1:		Line 1:
		+
	==RECRUITING ZINC TO MEDIATE POTENT, SPECIFIC INHIBITION OF SERINE PROTEASES==		==RECRUITING ZINC TO MEDIATE POTENT, SPECIFIC INHIBITION OF SERINE PROTEASES==
	<StructureSection load='1c1p' size='340' side='right' caption='[[1c1p]], [[Resolution\|resolution]] 1.37Å' scene=''>		<StructureSection load='1c1p' size='340' side='right' caption='[[1c1p]], [[Resolution\|resolution]] 1.37Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1c2d\|1c2d]], [[1c2f\|1c2f]], [[1c2g\|1c2g]], [[1c2h\|1c2h]], [[1c2i\|1c2i]], [[1c2l\|1c2l]], [[1c2m\|1c2m]], [[1c1n\|1c1n]], [[1c1o\|1c1o]], [[1c2e\|1c2e]], [[1c1q\|1c1q]], [[1c1r\|1c1r]], [[1c1s\|1c1s]], [[1c1t\|1c1t]], [[1c1u\|1c1u]], [[1c1v\|1c1v]], [[1c1w\|1c1w]], [[1c2j\|1c2j]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1c2d\|1c2d]], [[1c2f\|1c2f]], [[1c2g\|1c2g]], [[1c2h\|1c2h]], [[1c2i\|1c2i]], [[1c2l\|1c2l]], [[1c2m\|1c2m]], [[1c1n\|1c1n]], [[1c1o\|1c1o]], [[1c2e\|1c2e]], [[1c1q\|1c1q]], [[1c1r\|1c1r]], [[1c1s\|1c1s]], [[1c1t\|1c1t]], [[1c1u\|1c1u]], [[1c1v\|1c1v]], [[1c1w\|1c1w]], [[1c2j\|1c2j]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Trypsin Trypsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.4 3.4.21.4] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Trypsin Trypsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.4 3.4.21.4] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1c1p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1c1p OCA], [http://pdbe.org/1c1p PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1c1p RCSB], [http://www.ebi.ac.uk/pdbsum/1c1p PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1c1p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1c1p OCA], [http://pdbe.org/1c1p PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1c1p RCSB], [http://www.ebi.ac.uk/pdbsum/1c1p PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1c1p ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 16:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1c1p ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 07:53, 11 September 2015

OCA — Fri, 11 Sep 2015 07:53:29 GMT

←Older revision		Revision as of 07:53, 11 September 2015
Line 6:		Line 6:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1c2d\|1c2d]], [[1c2f\|1c2f]], [[1c2g\|1c2g]], [[1c2h\|1c2h]], [[1c2i\|1c2i]], [[1c2l\|1c2l]], [[1c2m\|1c2m]], [[1c1n\|1c1n]], [[1c1o\|1c1o]], [[1c2e\|1c2e]], [[1c1q\|1c1q]], [[1c1r\|1c1r]], [[1c1s\|1c1s]], [[1c1t\|1c1t]], [[1c1u\|1c1u]], [[1c1v\|1c1v]], [[1c1w\|1c1w]], [[1c2j\|1c2j]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1c2d\|1c2d]], [[1c2f\|1c2f]], [[1c2g\|1c2g]], [[1c2h\|1c2h]], [[1c2i\|1c2i]], [[1c2l\|1c2l]], [[1c2m\|1c2m]], [[1c1n\|1c1n]], [[1c1o\|1c1o]], [[1c2e\|1c2e]], [[1c1q\|1c1q]], [[1c1r\|1c1r]], [[1c1s\|1c1s]], [[1c1t\|1c1t]], [[1c1u\|1c1u]], [[1c1v\|1c1v]], [[1c1w\|1c1w]], [[1c2j\|1c2j]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Trypsin Trypsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.4 3.4.21.4] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Trypsin Trypsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.4 3.4.21.4] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1c1p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1c1p OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1c1p RCSB], [http://www.ebi.ac.uk/pdbsum/1c1p PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1c1p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1c1p OCA], [http://pdbe.org/1c1p PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1c1p RCSB], [http://www.ebi.ac.uk/pdbsum/1c1p PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 26:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1c1p" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 09:02, 22 December 2014

OCA — Mon, 22 Dec 2014 09:02:37 GMT

←Older revision		Revision as of 09:02, 22 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1c1p]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C1P OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1C1P FirstGlance]. <br>		<table><tr><td colspan='2'>[[1c1p]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C1P OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1C1P FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BAI:(5-AMIDINO-2-BENZIMIDAZOLYL)(2-BENZIMIDAZOLYL)METHANE'>BAI</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BAI:(5-AMIDINO-2-BENZIMIDAZOLYL)(2-BENZIMIDAZOLYL)METHANE'>BAI</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1c2d\|1c2d]], [[1c2f\|1c2f]], [[1c2g\|1c2g]], [[1c2h\|1c2h]], [[1c2i\|1c2i]], [[1c2l\|1c2l]], [[1c2m\|1c2m]], [[1c1n\|1c1n]], [[1c1o\|1c1o]], [[1c2e\|1c2e]], [[1c1q\|1c1q]], [[1c1r\|1c1r]], [[1c1s\|1c1s]], [[1c1t\|1c1t]], [[1c1u\|1c1u]], [[1c1v\|1c1v]], [[1c1w\|1c1w]], [[1c2j\|1c2j]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1c2d\|1c2d]], [[1c2f\|1c2f]], [[1c2g\|1c2g]], [[1c2h\|1c2h]], [[1c2i\|1c2i]], [[1c2l\|1c2l]], [[1c2m\|1c2m]], [[1c1n\|1c1n]], [[1c1o\|1c1o]], [[1c2e\|1c2e]], [[1c1q\|1c1q]], [[1c1r\|1c1r]], [[1c1s\|1c1s]], [[1c1t\|1c1t]], [[1c1u\|1c1u]], [[1c1v\|1c1v]], [[1c1w\|1c1w]], [[1c2j\|1c2j]]</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Trypsin Trypsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.4 3.4.21.4] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Trypsin Trypsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.4 3.4.21.4] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1c1p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1c1p OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1c1p RCSB], [http://www.ebi.ac.uk/pdbsum/1c1p PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1c1p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1c1p OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1c1p RCSB], [http://www.ebi.ac.uk/pdbsum/1c1p PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 35:		Line 35:
	[[Category: Bos taurus]]		[[Category: Bos taurus]]
	[[Category: Trypsin]]		[[Category: Trypsin]]
-	[[Category: Katz, B A.]]	+	[[Category: Katz, B A]]
-	[[Category: Luong, C.]]	+	[[Category: Luong, C]]
	[[Category: Hydrolase-hydrolase inhibitor complex]]		[[Category: Hydrolase-hydrolase inhibitor complex]]
	[[Category: Ph dependence]]		[[Category: Ph dependence]]
	[[Category: Serine protease serine protease/inhibitor]]		[[Category: Serine protease serine protease/inhibitor]]

OCA at 16:58, 20 August 2014

OCA — Wed, 20 Aug 2014 16:58:05 GMT

←Older revision		Revision as of 16:58, 20 August 2014
Line 1:		Line 1:
-	[[~~Image:~~1c1p.~~png~~\|~~left~~\|200px]]	+	==RECRUITING ZINC TO MEDIATE POTENT, SPECIFIC INHIBITION OF SERINE PROTEASES==
		+	<StructureSection load='1c1p' size='340' side='right' caption='[[1c1p]], [[Resolution\|resolution]] 1.37Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1c1p]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C1P OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1C1P FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BAI:(5-AMIDINO-2-BENZIMIDAZOLYL)(2-BENZIMIDAZOLYL)METHANE'>BAI</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1c2d\|1c2d]], [[1c2f\|1c2f]], [[1c2g\|1c2g]], [[1c2h\|1c2h]], [[1c2i\|1c2i]], [[1c2l\|1c2l]], [[1c2m\|1c2m]], [[1c1n\|1c1n]], [[1c1o\|1c1o]], [[1c2e\|1c2e]], [[1c1q\|1c1q]], [[1c1r\|1c1r]], [[1c1s\|1c1s]], [[1c1t\|1c1t]], [[1c1u\|1c1u]], [[1c1v\|1c1v]], [[1c1w\|1c1w]], [[1c2j\|1c2j]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Trypsin Trypsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.4 3.4.21.4] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1c1p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1c1p OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1c1p RCSB], [http://www.ebi.ac.uk/pdbsum/1c1p PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c1/1c1p_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Many serine proteases are targets for therapeutic intervention because they often play key roles in disease. Small molecule inhibitors of serine proteases with high affinity are especially interesting as they could be used as scaffolds from which to develop drugs selective for protease targets. One such inhibitor is bis(5-amidino-2-benzimidazolyl)methane (BABIM), standing out as the best inhibitor of trypsin (by a factor of over 100) in a series of over 60 relatively closely related analogues. By probing the structural basis of inhibition, we discovered, using crystallographic methods, a new mode of high-affinity binding in which a Zn2+ ion is tetrahedrally coordinated between two chelating nitrogens of BABIM and two active site residues, His57 and Ser 195. Zn2+, at subphysiological levels, enhances inhibition by over 10(3)-fold. The distinct Zn2+ coordination geometry implies a strong dependence of affinity on substituents. This unique structural paradigm has enabled development of potent, highly selective, Zn2+-dependent inhibitors of several therapeutically important serine proteases, using a physiologically ubiquitous metal ion.

-	~~{{STRUCTURE_1c1p\| PDB=1c1p \| SCENE= }}~~	+	Design of potent selective zinc-mediated serine protease inhibitors.,Katz BA, Clark JM, Finer-Moore JS, Jenkins TE, Johnson CR, Ross MJ, Luong C, Moore WR, Stroud RM Nature. 1998 Feb 5;391(6667):608-12. PMID:9468142<ref>PMID:9468142</ref>

-	~~===RECRUITING ZINC TO MEDIATE POTENT~~, ~~SPECIFIC INHIBITION OF SERINE PROTEASES===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_9468142}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[1c1p]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Bos_taurus Bos taurus]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1C1P OCA].~~	+

	==See Also==		==See Also==
	*[[Trypsin\|Trypsin]]		*[[Trypsin\|Trypsin]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:009468142<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Bos taurus]]		[[Category: Bos taurus]]
	[[Category: Trypsin]]		[[Category: Trypsin]]

OCA at 17:15, 20 October 2012

OCA — Sat, 20 Oct 2012 17:15:15 GMT

←Older revision		Revision as of 17:15, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[1c1p]] is a 1 chain structure ~~of [[Trypsin]]~~ with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C1P OCA].	+	[[1c1p]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C1P OCA].

	==See Also==		==See Also==

OCA: Protected "1c1p" [edit=sysop:move=sysop]

OCA — Fri, 27 Jul 2012 00:19:16 GMT

Protected "1c1p" [edit=sysop:move=sysop]

←Older revision

Revision as of 00:19, 27 July 2012

OCA at 00:19, 27 July 2012

OCA — Fri, 27 Jul 2012 00:19:14 GMT

←Older revision		Revision as of 00:19, 27 July 2012
Line 1:		Line 1:
-	{{Seed}}
	[[Image:1c1p.png\|left\|200px]]		[[Image:1c1p.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1c1p", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1c1p\| PDB=1c1p \| SCENE= }}		{{STRUCTURE_1c1p\| PDB=1c1p \| SCENE= }}

	===RECRUITING ZINC TO MEDIATE POTENT, SPECIFIC INHIBITION OF SERINE PROTEASES===		===RECRUITING ZINC TO MEDIATE POTENT, SPECIFIC INHIBITION OF SERINE PROTEASES===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_9468142}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 9468142 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_9468142}}		{{ABSTRACT_PUBMED_9468142}}

	==About this Structure==		==About this Structure==
-	~~1C1P~~ is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C1P OCA].	+	[[1c1p]] is a 1 chain structure of [[Trypsin]] with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C1P OCA].
		+
		+	==See Also==
		+	*[[Trypsin\|Trypsin]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~9468142~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:009468142</ref><references group="xtra"/>
	[[Category: Bos taurus]]		[[Category: Bos taurus]]
	[[Category: Trypsin]]		[[Category: Trypsin]]
Line 31:		Line 22:
	[[Category: Ph dependence]]		[[Category: Ph dependence]]
	[[Category: Serine protease serine protease/inhibitor]]		[[Category: Serine protease serine protease/inhibitor]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar 3 14:02:37 2010''