1c1r - Revision history

OCA at 23:23, 27 December 2023

OCA — Wed, 27 Dec 2023 23:23:08 GMT

←Older revision		Revision as of 23:23, 27 December 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1c1r]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C1R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1C1R FirstGlance]. <br>		<table><tr><td colspan='2'>[[1c1r]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C1R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1C1R FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BAI:(5-AMIDINO-2-BENZIMIDAZOLYL)(2-BENZIMIDAZOLYL)METHANE'>BAI</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.37Å</td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1c2d\|1c2d]], [[1c2f\|1c2f]], [[1c2g\|1c2g]], [[1c2h\|1c2h]], [[1c2i\|1c2i]], [[1c2l\|1c2l]], [[1c2m\|1c2m]], [[1c1n\|1c1n]], [[1c1o\|1c1o]], [[1c1p\|1c1p]], [[1c1q\|1c1q]], [[1c2e\|1c2e]], [[1c1s\|1c1s]], [[1c1t\|1c1t]], [[1c1u\|1c1u]], [[1c1v\|1c1v]], [[1c1w\|1c1w]], [[1c2j\|1c2j]]</div></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BAI:(5-AMIDINO-2-BENZIMIDAZOLYL)(2-BENZIMIDAZOLYL)METHANE'>BAI</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Trypsin Trypsin], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.4 3.4.21.4] </span></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1c1r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1c1r OCA], [https://pdbe.org/1c1r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1c1r RCSB], [https://www.ebi.ac.uk/pdbsum/1c1r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1c1r ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1c1r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1c1r OCA], [https://pdbe.org/1c1r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1c1r RCSB], [https://www.ebi.ac.uk/pdbsum/1c1r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1c1r ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/TRY1_BOVIN TRY1_BOVIN]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 37:		Line 38:
	[[Category: Bos taurus]]		[[Category: Bos taurus]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: Trypsin]]~~	+	[[Category: Katz BA]]
-	[[Category: Katz~~, B A~~]]	+	[[Category: Luong C]]
-	[[Category: Luong, C]]	+
-	~~[[Category: Hydrolase-hydrolase inhibitor complex]]~~	+
-	~~[[Category: Ph dependence]]~~	+
-	~~[[Category: Serine protease serine protease/inhibitor~~]]	+

OCA at 10:32, 14 July 2021

OCA — Wed, 14 Jul 2021 10:32:23 GMT

←Older revision		Revision as of 10:32, 14 July 2021
Line 3:		Line 3:
	<StructureSection load='1c1r' size='340' side='right'caption='[[1c1r]], [[Resolution\|resolution]] 1.37Å' scene=''>		<StructureSection load='1c1r' size='340' side='right'caption='[[1c1r]], [[Resolution\|resolution]] 1.37Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1c1r]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C1R OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1C1R FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1c1r]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C1R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1C1R FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BAI:(5-AMIDINO-2-BENZIMIDAZOLYL)(2-BENZIMIDAZOLYL)METHANE'>BAI</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BAI:(5-AMIDINO-2-BENZIMIDAZOLYL)(2-BENZIMIDAZOLYL)METHANE'>BAI</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1c2d\|1c2d]], [[1c2f\|1c2f]], [[1c2g\|1c2g]], [[1c2h\|1c2h]], [[1c2i\|1c2i]], [[1c2l\|1c2l]], [[1c2m\|1c2m]], [[1c1n\|1c1n]], [[1c1o\|1c1o]], [[1c1p\|1c1p]], [[1c1q\|1c1q]], [[1c2e\|1c2e]], [[1c1s\|1c1s]], [[1c1t\|1c1t]], [[1c1u\|1c1u]], [[1c1v\|1c1v]], [[1c1w\|1c1w]], [[1c2j\|1c2j]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1c2d\|1c2d]], [[1c2f\|1c2f]], [[1c2g\|1c2g]], [[1c2h\|1c2h]], [[1c2i\|1c2i]], [[1c2l\|1c2l]], [[1c2m\|1c2m]], [[1c1n\|1c1n]], [[1c1o\|1c1o]], [[1c1p\|1c1p]], [[1c1q\|1c1q]], [[1c2e\|1c2e]], [[1c1s\|1c1s]], [[1c1t\|1c1t]], [[1c1u\|1c1u]], [[1c1v\|1c1v]], [[1c1w\|1c1w]], [[1c2j\|1c2j]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Trypsin Trypsin], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.4 3.4.21.4] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Trypsin Trypsin], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.4 3.4.21.4] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1c1r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1c1r OCA], [~~http~~://pdbe.org/1c1r PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1c1r RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1c1r PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1c1r ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1c1r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1c1r OCA], [https://pdbe.org/1c1r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1c1r RCSB], [https://www.ebi.ac.uk/pdbsum/1c1r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1c1r ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 30:		Line 30:

	==See Also==		==See Also==
-	*[[Trypsin\|Trypsin]]	+	*[[Trypsin 3D structures\|Trypsin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 07:13, 10 October 2019

OCA — Thu, 10 Oct 2019 07:13:38 GMT

←Older revision		Revision as of 07:13, 10 October 2019
Line 1:		Line 1:

	==RECRUITING ZINC TO MEDIATE POTENT, SPECIFIC INHIBITION OF SERINE PROTEASES==		==RECRUITING ZINC TO MEDIATE POTENT, SPECIFIC INHIBITION OF SERINE PROTEASES==
-	<StructureSection load='1c1r' size='340' side='right' caption='[[1c1r]], [[Resolution\|resolution]] 1.37Å' scene=''>	+	<StructureSection load='1c1r' size='340' side='right'caption='[[1c1r]], [[Resolution\|resolution]] 1.37Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1c1r]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C1R OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1C1R FirstGlance]. <br>		<table><tr><td colspan='2'>[[1c1r]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C1R OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1C1R FirstGlance]. <br>
Line 13:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c1/1c1r_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c1/1c1r_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 28:		Line 28:
	</div>		</div>
	<div class="pdbe-citations 1c1r" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1c1r" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Trypsin\|Trypsin]]
	== References ==		== References ==
	<references/>		<references/>
Line 33:		Line 36:
	</StructureSection>		</StructureSection>
	[[Category: Bos taurus]]		[[Category: Bos taurus]]
		+	[[Category: Large Structures]]
	[[Category: Trypsin]]		[[Category: Trypsin]]
	[[Category: Katz, B A]]		[[Category: Katz, B A]]

OCA at 08:09, 29 November 2017

OCA — Wed, 29 Nov 2017 08:09:03 GMT

←Older revision		Revision as of 08:09, 29 November 2017
Line 1:		Line 1:
		+
	==RECRUITING ZINC TO MEDIATE POTENT, SPECIFIC INHIBITION OF SERINE PROTEASES==		==RECRUITING ZINC TO MEDIATE POTENT, SPECIFIC INHIBITION OF SERINE PROTEASES==
	<StructureSection load='1c1r' size='340' side='right' caption='[[1c1r]], [[Resolution\|resolution]] 1.37Å' scene=''>		<StructureSection load='1c1r' size='340' side='right' caption='[[1c1r]], [[Resolution\|resolution]] 1.37Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1c2d\|1c2d]], [[1c2f\|1c2f]], [[1c2g\|1c2g]], [[1c2h\|1c2h]], [[1c2i\|1c2i]], [[1c2l\|1c2l]], [[1c2m\|1c2m]], [[1c1n\|1c1n]], [[1c1o\|1c1o]], [[1c1p\|1c1p]], [[1c1q\|1c1q]], [[1c2e\|1c2e]], [[1c1s\|1c1s]], [[1c1t\|1c1t]], [[1c1u\|1c1u]], [[1c1v\|1c1v]], [[1c1w\|1c1w]], [[1c2j\|1c2j]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1c2d\|1c2d]], [[1c2f\|1c2f]], [[1c2g\|1c2g]], [[1c2h\|1c2h]], [[1c2i\|1c2i]], [[1c2l\|1c2l]], [[1c2m\|1c2m]], [[1c1n\|1c1n]], [[1c1o\|1c1o]], [[1c1p\|1c1p]], [[1c1q\|1c1q]], [[1c2e\|1c2e]], [[1c1s\|1c1s]], [[1c1t\|1c1t]], [[1c1u\|1c1u]], [[1c1v\|1c1v]], [[1c1w\|1c1w]], [[1c2j\|1c2j]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Trypsin Trypsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.4 3.4.21.4] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Trypsin Trypsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.4 3.4.21.4] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1c1r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1c1r OCA], [http://pdbe.org/1c1r PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1c1r RCSB], [http://www.ebi.ac.uk/pdbsum/1c1r PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1c1r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1c1r OCA], [http://pdbe.org/1c1r PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1c1r RCSB], [http://www.ebi.ac.uk/pdbsum/1c1r PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1c1r ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 27:		Line 28:
	</div>		</div>
	<div class="pdbe-citations 1c1r" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1c1r" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Trypsin\|Trypsin]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 10:01, 9 February 2016

OCA — Tue, 09 Feb 2016 10:01:52 GMT

←Older revision		Revision as of 10:01, 9 February 2016
Line 16:		Line 16:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1c1r ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 21:07, 10 September 2015

OCA — Thu, 10 Sep 2015 21:07:58 GMT

←Older revision		Revision as of 21:07, 10 September 2015
Line 6:		Line 6:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1c2d\|1c2d]], [[1c2f\|1c2f]], [[1c2g\|1c2g]], [[1c2h\|1c2h]], [[1c2i\|1c2i]], [[1c2l\|1c2l]], [[1c2m\|1c2m]], [[1c1n\|1c1n]], [[1c1o\|1c1o]], [[1c1p\|1c1p]], [[1c1q\|1c1q]], [[1c2e\|1c2e]], [[1c1s\|1c1s]], [[1c1t\|1c1t]], [[1c1u\|1c1u]], [[1c1v\|1c1v]], [[1c1w\|1c1w]], [[1c2j\|1c2j]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1c2d\|1c2d]], [[1c2f\|1c2f]], [[1c2g\|1c2g]], [[1c2h\|1c2h]], [[1c2i\|1c2i]], [[1c2l\|1c2l]], [[1c2m\|1c2m]], [[1c1n\|1c1n]], [[1c1o\|1c1o]], [[1c1p\|1c1p]], [[1c1q\|1c1q]], [[1c2e\|1c2e]], [[1c1s\|1c1s]], [[1c1t\|1c1t]], [[1c1u\|1c1u]], [[1c1v\|1c1v]], [[1c1w\|1c1w]], [[1c2j\|1c2j]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Trypsin Trypsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.4 3.4.21.4] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Trypsin Trypsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.4 3.4.21.4] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1c1r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1c1r OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1c1r RCSB], [http://www.ebi.ac.uk/pdbsum/1c1r PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1c1r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1c1r OCA], [http://pdbe.org/1c1r PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1c1r RCSB], [http://www.ebi.ac.uk/pdbsum/1c1r PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 26:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1c1r" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 11:05, 22 December 2014

OCA — Mon, 22 Dec 2014 11:05:59 GMT

←Older revision		Revision as of 11:05, 22 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1c1r]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C1R OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1C1R FirstGlance]. <br>		<table><tr><td colspan='2'>[[1c1r]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C1R OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1C1R FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BAI:(5-AMIDINO-2-BENZIMIDAZOLYL)(2-BENZIMIDAZOLYL)METHANE'>BAI</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BAI:(5-AMIDINO-2-BENZIMIDAZOLYL)(2-BENZIMIDAZOLYL)METHANE'>BAI</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1c2d\|1c2d]], [[1c2f\|1c2f]], [[1c2g\|1c2g]], [[1c2h\|1c2h]], [[1c2i\|1c2i]], [[1c2l\|1c2l]], [[1c2m\|1c2m]], [[1c1n\|1c1n]], [[1c1o\|1c1o]], [[1c1p\|1c1p]], [[1c1q\|1c1q]], [[1c2e\|1c2e]], [[1c1s\|1c1s]], [[1c1t\|1c1t]], [[1c1u\|1c1u]], [[1c1v\|1c1v]], [[1c1w\|1c1w]], [[1c2j\|1c2j]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1c2d\|1c2d]], [[1c2f\|1c2f]], [[1c2g\|1c2g]], [[1c2h\|1c2h]], [[1c2i\|1c2i]], [[1c2l\|1c2l]], [[1c2m\|1c2m]], [[1c1n\|1c1n]], [[1c1o\|1c1o]], [[1c1p\|1c1p]], [[1c1q\|1c1q]], [[1c2e\|1c2e]], [[1c1s\|1c1s]], [[1c1t\|1c1t]], [[1c1u\|1c1u]], [[1c1v\|1c1v]], [[1c1w\|1c1w]], [[1c2j\|1c2j]]</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Trypsin Trypsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.4 3.4.21.4] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Trypsin Trypsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.4 3.4.21.4] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1c1r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1c1r OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1c1r RCSB], [http://www.ebi.ac.uk/pdbsum/1c1r PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1c1r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1c1r OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1c1r RCSB], [http://www.ebi.ac.uk/pdbsum/1c1r PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 35:		Line 35:
	[[Category: Bos taurus]]		[[Category: Bos taurus]]
	[[Category: Trypsin]]		[[Category: Trypsin]]
-	[[Category: Katz, B A.]]	+	[[Category: Katz, B A]]
-	[[Category: Luong, C.]]	+	[[Category: Luong, C]]
	[[Category: Hydrolase-hydrolase inhibitor complex]]		[[Category: Hydrolase-hydrolase inhibitor complex]]
	[[Category: Ph dependence]]		[[Category: Ph dependence]]
	[[Category: Serine protease serine protease/inhibitor]]		[[Category: Serine protease serine protease/inhibitor]]

OCA at 17:02, 20 August 2014

OCA — Wed, 20 Aug 2014 17:02:28 GMT

←Older revision		Revision as of 17:02, 20 August 2014
Line 1:		Line 1:
-	[[~~Image:~~1c1r.~~png~~\|~~left~~\|200px]]	+	==RECRUITING ZINC TO MEDIATE POTENT, SPECIFIC INHIBITION OF SERINE PROTEASES==
		+	<StructureSection load='1c1r' size='340' side='right' caption='[[1c1r]], [[Resolution\|resolution]] 1.37Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1c1r]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C1R OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1C1R FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BAI:(5-AMIDINO-2-BENZIMIDAZOLYL)(2-BENZIMIDAZOLYL)METHANE'>BAI</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1c2d\|1c2d]], [[1c2f\|1c2f]], [[1c2g\|1c2g]], [[1c2h\|1c2h]], [[1c2i\|1c2i]], [[1c2l\|1c2l]], [[1c2m\|1c2m]], [[1c1n\|1c1n]], [[1c1o\|1c1o]], [[1c1p\|1c1p]], [[1c1q\|1c1q]], [[1c2e\|1c2e]], [[1c1s\|1c1s]], [[1c1t\|1c1t]], [[1c1u\|1c1u]], [[1c1v\|1c1v]], [[1c1w\|1c1w]], [[1c2j\|1c2j]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Trypsin Trypsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.4 3.4.21.4] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1c1r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1c1r OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1c1r RCSB], [http://www.ebi.ac.uk/pdbsum/1c1r PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c1/1c1r_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Many serine proteases are targets for therapeutic intervention because they often play key roles in disease. Small molecule inhibitors of serine proteases with high affinity are especially interesting as they could be used as scaffolds from which to develop drugs selective for protease targets. One such inhibitor is bis(5-amidino-2-benzimidazolyl)methane (BABIM), standing out as the best inhibitor of trypsin (by a factor of over 100) in a series of over 60 relatively closely related analogues. By probing the structural basis of inhibition, we discovered, using crystallographic methods, a new mode of high-affinity binding in which a Zn2+ ion is tetrahedrally coordinated between two chelating nitrogens of BABIM and two active site residues, His57 and Ser 195. Zn2+, at subphysiological levels, enhances inhibition by over 10(3)-fold. The distinct Zn2+ coordination geometry implies a strong dependence of affinity on substituents. This unique structural paradigm has enabled development of potent, highly selective, Zn2+-dependent inhibitors of several therapeutically important serine proteases, using a physiologically ubiquitous metal ion.

-	~~{{STRUCTURE_1c1r\| PDB=1c1r \| SCENE= }}~~	+	Design of potent selective zinc-mediated serine protease inhibitors.,Katz BA, Clark JM, Finer-Moore JS, Jenkins TE, Johnson CR, Ross MJ, Luong C, Moore WR, Stroud RM Nature. 1998 Feb 5;391(6667):608-12. PMID:9468142<ref>PMID:9468142</ref>

-	~~===RECRUITING ZINC TO MEDIATE POTENT~~, ~~SPECIFIC INHIBITION OF SERINE PROTEASES===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_9468142}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[1c1r]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Bos_taurus Bos taurus]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1C1R OCA].~~	+

	==See Also==		==See Also==
	*[[Trypsin\|Trypsin]]		*[[Trypsin\|Trypsin]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:009468142<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Bos taurus]]		[[Category: Bos taurus]]
	[[Category: Trypsin]]		[[Category: Trypsin]]

OCA at 13:30, 20 October 2012

OCA — Sat, 20 Oct 2012 13:30:20 GMT

←Older revision		Revision as of 13:30, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[1c1r]] is a 1 chain structure ~~of [[Trypsin]]~~ with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C1R OCA].	+	[[1c1r]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C1R OCA].

	==See Also==		==See Also==

OCA: Protected "1c1r" [edit=sysop:move=sysop]

OCA — Thu, 26 Jul 2012 12:11:33 GMT

Protected "1c1r" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:11, 26 July 2012