1c5d - Revision history

OCA at 05:48, 9 August 2023

OCA — Wed, 09 Aug 2023 05:48:02 GMT

←Older revision		Revision as of 05:48, 9 August 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1c5d]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C5D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1C5D FirstGlance]. <br>		<table><tr><td colspan='2'>[[1c5d]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C5D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1C5D FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1c5d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1c5d OCA], [https://pdbe.org/1c5d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1c5d RCSB], [https://www.ebi.ac.uk/pdbsum/1c5d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1c5d ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.4Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1c5d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1c5d OCA], [https://pdbe.org/1c5d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1c5d RCSB], [https://www.ebi.ac.uk/pdbsum/1c5d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1c5d ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/KACB_RAT KACB_RAT]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Rattus norvegicus]]		[[Category: Rattus norvegicus]]
-	[[Category: Acharya~~, K R~~]]	+	[[Category: Acharya KR]]
-	[[Category: Kontou, M]]	+	[[Category: Kontou M]]
-	[[Category: Leonidas~~, D D~~]]	+	[[Category: Leonidas DD]]
-	[[Category: Mamalaki, A]]	+	[[Category: Mamalaki A]]
-	[[Category: Oikonomakos~~, N G~~]]	+	[[Category: Oikonomakos NG]]
-	[[Category: Tsantili, P]]	+	[[Category: Tsantili P]]
-	[[Category: Tzartos~~, S J~~]]	+	[[Category: Tzartos SJ]]
-	[[Category: Vatzaki~~, E H]]~~	+	[[Category: Vatzaki EH]]
-	~~[[Category: Immune system]]~~	+
-	~~[[Category: Immunoglobulin~~]]	+

OCA at 10:33, 14 July 2021

OCA — Wed, 14 Jul 2021 10:33:15 GMT

←Older revision		Revision as of 10:33, 14 July 2021
Line 3:		Line 3:
	<StructureSection load='1c5d' size='340' side='right'caption='[[1c5d]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='1c5d' size='340' side='right'caption='[[1c5d]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1c5d]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C5D OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1C5D FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1c5d]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C5D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1C5D FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1c5d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1c5d OCA], [~~http~~://pdbe.org/1c5d PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1c5d RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1c5d PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1c5d ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1c5d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1c5d OCA], [https://pdbe.org/1c5d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1c5d RCSB], [https://www.ebi.ac.uk/pdbsum/1c5d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1c5d ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 07:20, 10 October 2019

OCA — Thu, 10 Oct 2019 07:20:14 GMT

←Older revision		Revision as of 07:20, 10 October 2019
Line 1:		Line 1:

	==THE CRYSTAL STRUCTURE OF THE FAB FRAGMENT OF A RAT MONOCLONAL ANTIBODY AGAINST THE MAIN IMMUNOGENIC REGION OF THE HUMAN MUSCLE ACETYLCHOLINE RECEPTOR==		==THE CRYSTAL STRUCTURE OF THE FAB FRAGMENT OF A RAT MONOCLONAL ANTIBODY AGAINST THE MAIN IMMUNOGENIC REGION OF THE HUMAN MUSCLE ACETYLCHOLINE RECEPTOR==
-	<StructureSection load='1c5d' size='340' side='right' caption='[[1c5d]], [[Resolution\|resolution]] 2.40Å' scene=''>	+	<StructureSection load='1c5d' size='340' side='right'caption='[[1c5d]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1c5d]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C5D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1C5D FirstGlance]. <br>		<table><tr><td colspan='2'>[[1c5d]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C5D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1C5D FirstGlance]. <br>
Line 10:		Line 10:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c5/1c5d_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c5/1c5d_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 27:		Line 27:

	==See Also==		==See Also==
-	*[[3D structures ~~of monoclonal antibody~~\|3D structures ~~of monoclonal antibody~~]]	+	*[[Monoclonal Antibodies 3D structures\|Monoclonal Antibodies 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Rattus norvegicus]]		[[Category: Rattus norvegicus]]
	[[Category: Acharya, K R]]		[[Category: Acharya, K R]]

OCA at 08:13, 29 November 2017

OCA — Wed, 29 Nov 2017 08:13:19 GMT

←Older revision		Revision as of 08:13, 29 November 2017
Line 1:		Line 1:
		+
	==THE CRYSTAL STRUCTURE OF THE FAB FRAGMENT OF A RAT MONOCLONAL ANTIBODY AGAINST THE MAIN IMMUNOGENIC REGION OF THE HUMAN MUSCLE ACETYLCHOLINE RECEPTOR==		==THE CRYSTAL STRUCTURE OF THE FAB FRAGMENT OF A RAT MONOCLONAL ANTIBODY AGAINST THE MAIN IMMUNOGENIC REGION OF THE HUMAN MUSCLE ACETYLCHOLINE RECEPTOR==
	<StructureSection load='1c5d' size='340' side='right' caption='[[1c5d]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='1c5d' size='340' side='right' caption='[[1c5d]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1c5d]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C5D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1C5D FirstGlance]. <br>		<table><tr><td colspan='2'>[[1c5d]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C5D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1C5D FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1c5d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1c5d OCA], [http://pdbe.org/1c5d PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1c5d RCSB], [http://www.ebi.ac.uk/pdbsum/1c5d PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1c5d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1c5d OCA], [http://pdbe.org/1c5d PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1c5d RCSB], [http://www.ebi.ac.uk/pdbsum/1c5d PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1c5d ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 26:		Line 27:

	==See Also==		==See Also==
-	*[[~~Monoclonal Antibody~~\|~~Monoclonal Antibody~~]]	+	*[[3D structures of monoclonal antibody\|3D structures of monoclonal antibody]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 02:05, 10 February 2016

OCA — Wed, 10 Feb 2016 02:05:54 GMT

←Older revision		Revision as of 02:05, 10 February 2016
Line 13:		Line 13:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1c5d ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 04:18, 11 September 2015

OCA — Fri, 11 Sep 2015 04:18:23 GMT

←Older revision		Revision as of 04:18, 11 September 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1c5d]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C5D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1C5D FirstGlance]. <br>		<table><tr><td colspan='2'>[[1c5d]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C5D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1C5D FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1c5d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1c5d OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1c5d RCSB], [http://www.ebi.ac.uk/pdbsum/1c5d PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1c5d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1c5d OCA], [http://pdbe.org/1c5d PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1c5d RCSB], [http://www.ebi.ac.uk/pdbsum/1c5d PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 23:		Line 23:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1c5d" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Monoclonal Antibody\|Monoclonal Antibody]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 12:03, 22 December 2014

OCA — Mon, 22 Dec 2014 12:03:15 GMT

←Older revision		Revision as of 12:03, 22 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1c5d]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C5D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1C5D FirstGlance]. <br>		<table><tr><td colspan='2'>[[1c5d]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C5D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1C5D FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1c5d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1c5d OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1c5d RCSB], [http://www.ebi.ac.uk/pdbsum/1c5d PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1c5d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1c5d OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1c5d RCSB], [http://www.ebi.ac.uk/pdbsum/1c5d PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 28:		Line 28:
	</StructureSection>		</StructureSection>
	[[Category: Rattus norvegicus]]		[[Category: Rattus norvegicus]]
-	[[Category: Acharya, K R.]]	+	[[Category: Acharya, K R]]
-	[[Category: Kontou, M.]]	+	[[Category: Kontou, M]]
-	[[Category: Leonidas, D D.]]	+	[[Category: Leonidas, D D]]
-	[[Category: Mamalaki, A.]]	+	[[Category: Mamalaki, A]]
-	[[Category: Oikonomakos, N G.]]	+	[[Category: Oikonomakos, N G]]
-	[[Category: Tsantili, P.]]	+	[[Category: Tsantili, P]]
-	[[Category: Tzartos, S J.]]	+	[[Category: Tzartos, S J]]
-	[[Category: Vatzaki, E H.]]	+	[[Category: Vatzaki, E H]]
	[[Category: Immune system]]		[[Category: Immune system]]
	[[Category: Immunoglobulin]]		[[Category: Immunoglobulin]]

OCA at 17:08, 20 August 2014

OCA — Wed, 20 Aug 2014 17:08:07 GMT

←Older revision		Revision as of 17:08, 20 August 2014
Line 1:		Line 1:
-	[[~~Image~~:1c5d.~~png\|left~~\|200px]]	+	==THE CRYSTAL STRUCTURE OF THE FAB FRAGMENT OF A RAT MONOCLONAL ANTIBODY AGAINST THE MAIN IMMUNOGENIC REGION OF THE HUMAN MUSCLE ACETYLCHOLINE RECEPTOR==
		+	<StructureSection load='1c5d' size='340' side='right' caption='[[1c5d]], [[Resolution\|resolution]] 2.40Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1c5d]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C5D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1C5D FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1c5d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1c5d OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1c5d RCSB], [http://www.ebi.ac.uk/pdbsum/1c5d PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c5/1c5d_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The crystal structure of the Fab fragment of a rat monoclonal antibody, number 192, with a very high affinity (Kd = 0.05 nM) for the main immunogenic region of the human muscle acetylcholine receptor (AChR), has been determined and refined to 2.4 A resolution by X-ray crystallographic methods. The overall structure is similar to a Fab (NC6.8) from a murine antibody, used as a search model in molecular replacement. Structural comparisons with known antibody structures showed that the conformations of the hypervariable regions H1, H2, L1, L2, L3 of Fab192 adopt the canonical structures 1, 1, 2, 1, and 1, respectively. The surface of the antigen-binding site is relatively planar, as expected for an antibody against a large protein antigen, with an accessible area of 2865 A2. Analysis of the electrostatic surface potential of the antigen-binding site shows that the bottom of the cleft formed in the center of the site appears to be negatively charged. The structure will be useful in the rational design of very high affinity humanized mutants of Fab192, appropriate for therapeutic approaches of the model autoimmune disease myasthenia gravis.

-	~~{{STRUCTURE_1c5d\| PDB=1c5d \| SCENE= }}~~	+	The crystal structure of the Fab fragment of a rat monoclonal antibody against the main immunogenic region of the human muscle acetylcholine receptor.,Kontou M, Leonidas DD, Vatzaki EH, Tsantili P, Mamalaki A, Oikonomakos NG, Acharya KR, Tzartos SJ Eur J Biochem. 2000 Apr;267(8):2389-97. PMID:10759865<ref>PMID:10759865</ref>

-	~~===THE CRYSTAL STRUCTURE OF THE FAB FRAGMENT OF A RAT MONOCLONAL ANTIBODY AGAINST THE MAIN IMMUNOGENIC REGION OF THE HUMAN MUSCLE ACETYLCHOLINE RECEPTOR===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_10759865}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[1c5d]] is~~ a ~~4 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Rattus_norvegicus Rattus norvegicus]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1C5D OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:010759865<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Rattus norvegicus]]		[[Category: Rattus norvegicus]]
	[[Category: Acharya, K R.]]		[[Category: Acharya, K R.]]

OCA: Protected "1c5d" [edit=sysop:move=sysop]

OCA — Sun, 21 Oct 2012 20:44:54 GMT

Protected "1c5d" [edit=sysop:move=sysop]

←Older revision

Revision as of 20:44, 21 October 2012

OCA at 20:44, 21 October 2012

OCA — Sun, 21 Oct 2012 20:44:51 GMT

←Older revision		Revision as of 20:44, 21 October 2012
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-	{{Seed}}
	[[Image:1c5d.png\|left\|200px]]		[[Image:1c5d.png\|left\|200px]]

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	{{STRUCTURE_1c5d\| PDB=1c5d \| SCENE= }}		{{STRUCTURE_1c5d\| PDB=1c5d \| SCENE= }}

	===THE CRYSTAL STRUCTURE OF THE FAB FRAGMENT OF A RAT MONOCLONAL ANTIBODY AGAINST THE MAIN IMMUNOGENIC REGION OF THE HUMAN MUSCLE ACETYLCHOLINE RECEPTOR===		===THE CRYSTAL STRUCTURE OF THE FAB FRAGMENT OF A RAT MONOCLONAL ANTIBODY AGAINST THE MAIN IMMUNOGENIC REGION OF THE HUMAN MUSCLE ACETYLCHOLINE RECEPTOR===

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	{{ABSTRACT_PUBMED_10759865}}		{{ABSTRACT_PUBMED_10759865}}

	==About this Structure==		==About this Structure==
-	~~1C5D~~ is a 4 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C5D OCA].	+	[[1c5d]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C5D OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~10759865~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:010759865</ref><references group="xtra"/>
	[[Category: Rattus norvegicus]]		[[Category: Rattus norvegicus]]
	[[Category: Acharya, K R.]]		[[Category: Acharya, K R.]]
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	[[Category: Tzartos, S J.]]		[[Category: Tzartos, S J.]]
	[[Category: Vatzaki, E H.]]		[[Category: Vatzaki, E H.]]
		+	[[Category: Immune system]]
	[[Category: Immunoglobulin]]		[[Category: Immunoglobulin]]
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-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 14:32:55 2009''