1ccd - Revision history

OCA at 15:38, 13 March 2024

OCA — Wed, 13 Mar 2024 15:38:56 GMT

←Older revision		Revision as of 15:38, 13 March 2024
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	<StructureSection load='1ccd' size='340' side='right'caption='[[1ccd]], [[Resolution\|resolution]] 3.00Å' scene=''>		<StructureSection load='1ccd' size='340' side='right'caption='[[1ccd]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1ccd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Black_rat Black rat~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CCD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1CCD FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1ccd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_rattus Rattus rattus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CCD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1CCD FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ccd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ccd OCA], [https://pdbe.org/1ccd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ccd RCSB], [https://www.ebi.ac.uk/pdbsum/1ccd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ccd ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ccd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ccd OCA], [https://pdbe.org/1ccd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ccd RCSB], [https://www.ebi.ac.uk/pdbsum/1ccd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ccd ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/UTER_RAT UTER_RAT]] Binds phosphatidylcholine, phosphatidylinositol, polychlorinated biphenyls (PCB) and weakly progesterone, potent inhibitor of phospholipase A2.	+	[https://www.uniprot.org/uniprot/UTER_RAT UTER_RAT] Binds phosphatidylcholine, phosphatidylinositol, polychlorinated biphenyls (PCB) and weakly progesterone, potent inhibitor of phospholipase A2.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 19:		Line 20:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ccd ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ccd ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	The rat Clara cell 17 kDa protein (previously referred to as the rat Clara cell 10 kDa protein) has been reported to inhibit phospholipase A2 and papain, and to also bind progesterone. It has been isolated from rat lung lavage fluid and crystallized in the space group P6(5)22. The structure has been determined to 3.0 A resolution using the molecular replacement method. Uteroglobin, whose amino acid sequence is 55.7% identical, was used as the search model. The structure was then refined using restrained least-squares and simulated annealing methods. The R-factor is 22.5%. The protein is a covalently bound dimer. Two disulfide bonds join the monomers together in an antiparallel manner such that the dimer encloses a large internal hydrophobic cavity. The hydrophobic cavity is large enough to serve as the progesterone binding site, but access to the cavity is limited. Each monomer is composed of four alpha-helices. The main-chain structure of the Clara cell protein closely resembles that of uteroglobin, but the nature of many of the exposed side-chains differ. This is true, particularly in a hypervariable region between residues 23 and 36, and in the H1H4 pocket.
-
-	Refined structure of rat Clara cell 17 kDa protein at 3.0 A resolution.,Umland TC, Swaminathan S, Furey W, Singh G, Pletcher J, Sax M J Mol Biol. 1992 Mar 20;224(2):441-8. PMID:1560460<ref>PMID:1560460</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 1ccd" style="background-color:#fffaf0;"></div>
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Black rat]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Furey, W]]	+	[[Category: Rattus rattus]]
-	[[Category: Pletcher, J]]	+	[[Category: Furey W]]
-	[[Category: Sax, M]]	+	[[Category: Pletcher J]]
-	[[Category: Singh, G]]	+	[[Category: Sax M]]
-	[[Category: Swaminathan, S]]	+	[[Category: Singh G]]
-	[[Category: Umland~~, T C]]~~	+	[[Category: Swaminathan S]]
-	~~[[Category: Phospholipase a2 inhibitor~~]]	+	[[Category: Umland TC]]

OCA at 10:35, 14 July 2021

OCA — Wed, 14 Jul 2021 10:35:27 GMT

←Older revision		Revision as of 10:35, 14 July 2021
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	<StructureSection load='1ccd' size='340' side='right'caption='[[1ccd]], [[Resolution\|resolution]] 3.00Å' scene=''>		<StructureSection load='1ccd' size='340' side='right'caption='[[1ccd]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1ccd]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Black_rat Black rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CCD OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1CCD FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1ccd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Black_rat Black rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CCD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1CCD FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1ccd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ccd OCA], [~~http~~://pdbe.org/1ccd PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1ccd RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1ccd PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1ccd ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ccd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ccd OCA], [https://pdbe.org/1ccd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ccd RCSB], [https://www.ebi.ac.uk/pdbsum/1ccd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ccd ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/UTER_RAT UTER_RAT]] Binds phosphatidylcholine, phosphatidylinositol, polychlorinated biphenyls (PCB) and weakly progesterone, potent inhibitor of phospholipase A2.	+	[[https://www.uniprot.org/uniprot/UTER_RAT UTER_RAT]] Binds phosphatidylcholine, phosphatidylinositol, polychlorinated biphenyls (PCB) and weakly progesterone, potent inhibitor of phospholipase A2.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 07:31, 10 October 2019

OCA — Thu, 10 Oct 2019 07:31:31 GMT

←Older revision		Revision as of 07:31, 10 October 2019
Line 1:		Line 1:

	==REFINED STRUCTURE OF RAT CLARA CELL 17 KDA PROTEIN AT 3.0 ANGSTROMS RESOLUTION==		==REFINED STRUCTURE OF RAT CLARA CELL 17 KDA PROTEIN AT 3.0 ANGSTROMS RESOLUTION==
-	<StructureSection load='1ccd' size='340' side='right' caption='[[1ccd]], [[Resolution\|resolution]] 3.00Å' scene=''>	+	<StructureSection load='1ccd' size='340' side='right'caption='[[1ccd]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1ccd]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Black_rat Black rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CCD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1CCD FirstGlance]. <br>		<table><tr><td colspan='2'>[[1ccd]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Black_rat Black rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CCD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1CCD FirstGlance]. <br>
Line 13:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cc/1ccd_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cc/1ccd_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 33:		Line 33:
	</StructureSection>		</StructureSection>
	[[Category: Black rat]]		[[Category: Black rat]]
		+	[[Category: Large Structures]]
	[[Category: Furey, W]]		[[Category: Furey, W]]
	[[Category: Pletcher, J]]		[[Category: Pletcher, J]]

OCA at 06:27, 29 November 2017

OCA — Wed, 29 Nov 2017 06:27:47 GMT

←Older revision		Revision as of 06:27, 29 November 2017
Line 1:		Line 1:
		+
	==REFINED STRUCTURE OF RAT CLARA CELL 17 KDA PROTEIN AT 3.0 ANGSTROMS RESOLUTION==		==REFINED STRUCTURE OF RAT CLARA CELL 17 KDA PROTEIN AT 3.0 ANGSTROMS RESOLUTION==
	<StructureSection load='1ccd' size='340' side='right' caption='[[1ccd]], [[Resolution\|resolution]] 3.00Å' scene=''>		<StructureSection load='1ccd' size='340' side='right' caption='[[1ccd]], [[Resolution\|resolution]] 3.00Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[1ccd]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Black_rat Black rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CCD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1CCD FirstGlance]. <br>		<table><tr><td colspan='2'>[[1ccd]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Black_rat Black rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CCD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1CCD FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ccd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ccd OCA], [http://pdbe.org/1ccd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1ccd RCSB], [http://www.ebi.ac.uk/pdbsum/1ccd PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ccd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ccd OCA], [http://pdbe.org/1ccd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1ccd RCSB], [http://www.ebi.ac.uk/pdbsum/1ccd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1ccd ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 08:44, 8 February 2016

OCA — Mon, 08 Feb 2016 08:44:50 GMT

←Older revision		Revision as of 08:44, 8 February 2016
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	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ccd ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 09:50, 10 September 2015

OCA — Thu, 10 Sep 2015 09:50:51 GMT

←Older revision		Revision as of 09:50, 10 September 2015
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	<StructureSection load='1ccd' size='340' side='right' caption='[[1ccd]], [[Resolution\|resolution]] 3.00Å' scene=''>		<StructureSection load='1ccd' size='340' side='right' caption='[[1ccd]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1ccd]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Rattus_rattus Rattus rattus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CCD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1CCD FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1ccd]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Black_rat Black rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CCD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1CCD FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ccd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ccd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ccd RCSB], [http://www.ebi.ac.uk/pdbsum/1ccd PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ccd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ccd OCA], [http://pdbe.org/1ccd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1ccd RCSB], [http://www.ebi.ac.uk/pdbsum/1ccd PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 26:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1ccd" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Rattus rattus~~]]	+	[[Category: Black rat]]
	[[Category: Furey, W]]		[[Category: Furey, W]]
	[[Category: Pletcher, J]]		[[Category: Pletcher, J]]

OCA at 22:03, 24 December 2014

OCA — Wed, 24 Dec 2014 22:03:02 GMT

←Older revision		Revision as of 22:03, 24 December 2014
Line 6:		Line 6:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ccd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ccd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ccd RCSB], [http://www.ebi.ac.uk/pdbsum/1ccd PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ccd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ccd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ccd RCSB], [http://www.ebi.ac.uk/pdbsum/1ccd PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/UTER_RAT UTER_RAT]] Binds phosphatidylcholine, phosphatidylinositol, polychlorinated biphenyls (PCB) and weakly progesterone, potent inhibitor of phospholipase A2.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 12:12, 22 December 2014

OCA — Mon, 22 Dec 2014 12:12:08 GMT

←Older revision		Revision as of 12:12, 22 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1ccd]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_rattus Rattus rattus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CCD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1CCD FirstGlance]. <br>		<table><tr><td colspan='2'>[[1ccd]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_rattus Rattus rattus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CCD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1CCD FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ccd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ccd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ccd RCSB], [http://www.ebi.ac.uk/pdbsum/1ccd PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ccd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ccd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ccd RCSB], [http://www.ebi.ac.uk/pdbsum/1ccd PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Rattus rattus]]		[[Category: Rattus rattus]]
-	[[Category: Furey, W.]]	+	[[Category: Furey, W]]
-	[[Category: Pletcher, J.]]	+	[[Category: Pletcher, J]]
-	[[Category: Sax, M.]]	+	[[Category: Sax, M]]
-	[[Category: Singh, G.]]	+	[[Category: Singh, G]]
-	[[Category: Swaminathan, S.]]	+	[[Category: Swaminathan, S]]
-	[[Category: Umland, T C.]]	+	[[Category: Umland, T C]]
	[[Category: Phospholipase a2 inhibitor]]		[[Category: Phospholipase a2 inhibitor]]

OCA at 17:14, 20 August 2014

OCA — Wed, 20 Aug 2014 17:14:58 GMT

←Older revision		Revision as of 17:14, 20 August 2014
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-	[[~~Image~~:1ccd.~~png\|left~~\|200px]]	+	==REFINED STRUCTURE OF RAT CLARA CELL 17 KDA PROTEIN AT 3.0 ANGSTROMS RESOLUTION==
		+	<StructureSection load='1ccd' size='340' side='right' caption='[[1ccd]], [[Resolution\|resolution]] 3.00Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1ccd]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_rattus Rattus rattus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CCD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1CCD FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ccd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ccd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ccd RCSB], [http://www.ebi.ac.uk/pdbsum/1ccd PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cc/1ccd_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The rat Clara cell 17 kDa protein (previously referred to as the rat Clara cell 10 kDa protein) has been reported to inhibit phospholipase A2 and papain, and to also bind progesterone. It has been isolated from rat lung lavage fluid and crystallized in the space group P6(5)22. The structure has been determined to 3.0 A resolution using the molecular replacement method. Uteroglobin, whose amino acid sequence is 55.7% identical, was used as the search model. The structure was then refined using restrained least-squares and simulated annealing methods. The R-factor is 22.5%. The protein is a covalently bound dimer. Two disulfide bonds join the monomers together in an antiparallel manner such that the dimer encloses a large internal hydrophobic cavity. The hydrophobic cavity is large enough to serve as the progesterone binding site, but access to the cavity is limited. Each monomer is composed of four alpha-helices. The main-chain structure of the Clara cell protein closely resembles that of uteroglobin, but the nature of many of the exposed side-chains differ. This is true, particularly in a hypervariable region between residues 23 and 36, and in the H1H4 pocket.

-	~~{{STRUCTURE_1ccd\| PDB=1ccd \| SCENE= }}~~	+	Refined structure of rat Clara cell 17 kDa protein at 3.0 A resolution.,Umland TC, Swaminathan S, Furey W, Singh G, Pletcher J, Sax M J Mol Biol. 1992 Mar 20;224(2):441-8. PMID:1560460<ref>PMID:1560460</ref>

-	~~===REFINED STRUCTURE OF RAT CLARA CELL 17 KDA PROTEIN AT 3.0 ANGSTROMS RESOLUTION===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_1560460}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[1ccd]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Rattus_rattus Rattus rattus]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1CCD OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:001560460<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Rattus rattus]]		[[Category: Rattus rattus]]
	[[Category: Furey, W.]]		[[Category: Furey, W.]]

OCA: Protected "1ccd" [edit=sysop:move=sysop]

OCA — Sun, 21 Oct 2012 20:56:06 GMT

Protected "1ccd" [edit=sysop:move=sysop]

←Older revision

Revision as of 20:56, 21 October 2012