1ci1 - Revision history

OCA at 05:52, 9 August 2023

OCA — Wed, 09 Aug 2023 05:52:14 GMT

←Older revision		Revision as of 05:52, 9 August 2023
Line 3:		Line 3:
	<StructureSection load='1ci1' size='340' side='right'caption='[[1ci1]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='1ci1' size='340' side='right'caption='[[1ci1]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1ci1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Trycr Trycr~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CI1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1CI1 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1ci1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Trypanosoma_cruzi Trypanosoma cruzi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CI1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1CI1 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=HEX:HEXANE'>HEX</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2Å</td></tr>
-	<tr id='~~activity~~'><td class="sblockLbl"><b>~~Activity~~:</b></td><td class="sblockDat"><~~span class~~='~~plainlinks~~'>~~[https://en.wikipedia.org/wiki/Triose-phosphate_isomerase Triose-phosphate isomerase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.1.1 5.3.1.1]~~ </~~span~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEX:HEXANE'>HEX</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ci1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ci1 OCA], [https://pdbe.org/1ci1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ci1 RCSB], [https://www.ebi.ac.uk/pdbsum/1ci1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ci1 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ci1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ci1 OCA], [https://pdbe.org/1ci1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ci1 RCSB], [https://www.ebi.ac.uk/pdbsum/1ci1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ci1 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/TPIS_TRYCR TPIS_TRYCR]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Triose-phosphate isomerase]]
-	[[Category: Trycr]]
-	[[Category: Gao, X G]]
-	[[Category: Gomez-Puyou, A]]
-	[[Category: Gomez-Puyou, M T.De]]
-	[[Category: Maldondo, E]]
-	[[Category: Perez-Montfort, R]]
-	[[Category: Rodriguez-Romero, A]]
-	[[Category: Hexane]]
-	[[Category: Oligomeric protein]]
-	[[Category: Organic solvent]]
-	[[Category: Triosephosphate isomerase]]
	[[Category: Trypanosoma cruzi]]		[[Category: Trypanosoma cruzi]]
		+	[[Category: De Gomez-Puyou MT]]
		+	[[Category: Gao X-G]]
		+	[[Category: Gomez-Puyou A]]
		+	[[Category: Maldondo E]]
		+	[[Category: Perez-Montfort R]]
		+	[[Category: Rodriguez-Romero A]]

OCA at 06:48, 25 August 2021

OCA — Wed, 25 Aug 2021 06:48:11 GMT

←Older revision		Revision as of 06:48, 25 August 2021
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	<StructureSection load='1ci1' size='340' side='right'caption='[[1ci1]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='1ci1' size='340' side='right'caption='[[1ci1]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1ci1]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Trycr Trycr]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CI1 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1CI1 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1ci1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Trycr Trycr]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CI1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1CI1 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEX:HEXANE'>HEX</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEX:HEXANE'>HEX</scene></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Triose-phosphate_isomerase Triose-phosphate isomerase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.1.1 5.3.1.1] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Triose-phosphate_isomerase Triose-phosphate isomerase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.1.1 5.3.1.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1ci1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ci1 OCA], [~~http~~://pdbe.org/1ci1 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1ci1 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1ci1 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1ci1 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ci1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ci1 OCA], [https://pdbe.org/1ci1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ci1 RCSB], [https://www.ebi.ac.uk/pdbsum/1ci1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ci1 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 29:		Line 29:

	==See Also==		==See Also==
-	*[[Triose ~~Phosphate Isomerase~~\|Triose ~~Phosphate Isomerase~~]]	+	*[[Triose phosphate isomerase 3D structures\|Triose phosphate isomerase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 15:43, 20 November 2019

OCA — Wed, 20 Nov 2019 15:43:01 GMT

←Older revision		Revision as of 15:43, 20 November 2019
Line 3:		Line 3:
	<StructureSection load='1ci1' size='340' side='right'caption='[[1ci1]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='1ci1' size='340' side='right'caption='[[1ci1]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1ci1]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CI1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1CI1 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1ci1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Trycr Trycr]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CI1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1CI1 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEX:HEXANE'>HEX</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEX:HEXANE'>HEX</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Triose-phosphate_isomerase Triose-phosphate isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.1.1 5.3.1.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Triose-phosphate_isomerase Triose-phosphate isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.1.1 5.3.1.1] </span></td></tr>
Line 36:		Line 36:
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Triose-phosphate isomerase]]		[[Category: Triose-phosphate isomerase]]
		+	[[Category: Trycr]]
	[[Category: Gao, X G]]		[[Category: Gao, X G]]
	[[Category: Gomez-Puyou, A]]		[[Category: Gomez-Puyou, A]]

OCA at 07:25, 29 May 2019

OCA — Wed, 29 May 2019 07:25:08 GMT

←Older revision		Revision as of 07:25, 29 May 2019
Line 1:		Line 1:

	==CRYSTAL STRUCTURE OF TRIOSEPHOSPHATE ISOMERASE FROM TRYPANOSOMA CRUZI IN HEXANE==		==CRYSTAL STRUCTURE OF TRIOSEPHOSPHATE ISOMERASE FROM TRYPANOSOMA CRUZI IN HEXANE==
-	<StructureSection load='1ci1' size='340' side='right' caption='[[1ci1]], [[Resolution\|resolution]] 2.00Å' scene=''>	+	<StructureSection load='1ci1' size='340' side='right'caption='[[1ci1]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1ci1]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CI1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1CI1 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1ci1]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CI1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1CI1 FirstGlance]. <br>
Line 12:		Line 12:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ci/1ci1_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ci/1ci1_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 34:		Line 34:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Triose-phosphate isomerase]]		[[Category: Triose-phosphate isomerase]]
	[[Category: Gao, X G]]		[[Category: Gao, X G]]

OCA at 11:10, 24 August 2017

OCA — Thu, 24 Aug 2017 11:10:59 GMT

←Older revision		Revision as of 11:10, 24 August 2017
Line 1:		Line 1:
		+
	==CRYSTAL STRUCTURE OF TRIOSEPHOSPHATE ISOMERASE FROM TRYPANOSOMA CRUZI IN HEXANE==		==CRYSTAL STRUCTURE OF TRIOSEPHOSPHATE ISOMERASE FROM TRYPANOSOMA CRUZI IN HEXANE==
	<StructureSection load='1ci1' size='340' side='right' caption='[[1ci1]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='1ci1' size='340' side='right' caption='[[1ci1]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1ci1]] is a 2 chain structure ~~with sequence from [http://en.wikipedia.org/wiki/Trycr Trycr]~~. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CI1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1CI1 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1ci1]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CI1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1CI1 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEX:HEXANE'>HEX</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEX:HEXANE'>HEX</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Triose-phosphate_isomerase Triose-phosphate isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.1.1 5.3.1.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Triose-phosphate_isomerase Triose-phosphate isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.1.1 5.3.1.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ci1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ci1 OCA], [http://pdbe.org/1ci1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1ci1 RCSB], [http://www.ebi.ac.uk/pdbsum/1ci1 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ci1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ci1 OCA], [http://pdbe.org/1ci1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1ci1 RCSB], [http://www.ebi.ac.uk/pdbsum/1ci1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1ci1 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 15:		Line 16:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ci1 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 34:		Line 35:
	</StructureSection>		</StructureSection>
	[[Category: Triose-phosphate isomerase]]		[[Category: Triose-phosphate isomerase]]
-	[[Category: Trycr]]
	[[Category: Gao, X G]]		[[Category: Gao, X G]]
	[[Category: Gomez-Puyou, A]]		[[Category: Gomez-Puyou, A]]

OCA at 11:32, 11 September 2015

OCA — Fri, 11 Sep 2015 11:32:25 GMT

←Older revision		Revision as of 11:32, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='1ci1' size='340' side='right' caption='[[1ci1]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='1ci1' size='340' side='right' caption='[[1ci1]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1ci1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Trypanosoma_cruzi Trypanosoma cruzi~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CI1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1CI1 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1ci1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Trycr Trycr]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CI1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1CI1 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEX:HEXANE'>HEX</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEX:HEXANE'>HEX</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Triose-phosphate_isomerase Triose-phosphate isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.1.1 5.3.1.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Triose-phosphate_isomerase Triose-phosphate isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.1.1 5.3.1.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ci1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ci1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ci1 RCSB], [http://www.ebi.ac.uk/pdbsum/1ci1 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ci1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ci1 OCA], [http://pdbe.org/1ci1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1ci1 RCSB], [http://www.ebi.ac.uk/pdbsum/1ci1 PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 25:		Line 25:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1ci1" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 33:		Line 34:
	</StructureSection>		</StructureSection>
	[[Category: Triose-phosphate isomerase]]		[[Category: Triose-phosphate isomerase]]
-	[[Category: ~~Trypanosoma cruzi~~]]	+	[[Category: Trycr]]
	[[Category: Gao, X G]]		[[Category: Gao, X G]]
	[[Category: Gomez-Puyou, A]]		[[Category: Gomez-Puyou, A]]
Line 44:		Line 45:
	[[Category: Organic solvent]]		[[Category: Organic solvent]]
	[[Category: Triosephosphate isomerase]]		[[Category: Triosephosphate isomerase]]
		+	[[Category: Trypanosoma cruzi]]

OCA at 19:42, 22 December 2014

OCA — Mon, 22 Dec 2014 19:42:30 GMT

←Older revision		Revision as of 19:42, 22 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1ci1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Trypanosoma_cruzi Trypanosoma cruzi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CI1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1CI1 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1ci1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Trypanosoma_cruzi Trypanosoma cruzi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CI1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1CI1 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEX:HEXANE'>HEX</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEX:HEXANE'>HEX</scene></td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Triose-phosphate_isomerase Triose-phosphate isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.1.1 5.3.1.1] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Triose-phosphate_isomerase Triose-phosphate isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.1.1 5.3.1.1] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ci1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ci1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ci1 RCSB], [http://www.ebi.ac.uk/pdbsum/1ci1 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ci1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ci1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ci1 RCSB], [http://www.ebi.ac.uk/pdbsum/1ci1 PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 34:		Line 34:
	[[Category: Triose-phosphate isomerase]]		[[Category: Triose-phosphate isomerase]]
	[[Category: Trypanosoma cruzi]]		[[Category: Trypanosoma cruzi]]
-	[[Category: Gao, X G.]]	+	[[Category: Gao, X G]]
-	[[Category: Gomez-Puyou, A.]]	+	[[Category: Gomez-Puyou, A]]
-	[[Category: Gomez-Puyou, M T.De.]]	+	[[Category: Gomez-Puyou, M T.De]]
-	[[Category: Maldondo, E.]]	+	[[Category: Maldondo, E]]
-	[[Category: Perez-Montfort, R.]]	+	[[Category: Perez-Montfort, R]]
-	[[Category: Rodriguez-Romero, A.]]	+	[[Category: Rodriguez-Romero, A]]
	[[Category: Hexane]]		[[Category: Hexane]]
	[[Category: Oligomeric protein]]		[[Category: Oligomeric protein]]
	[[Category: Organic solvent]]		[[Category: Organic solvent]]
	[[Category: Triosephosphate isomerase]]		[[Category: Triosephosphate isomerase]]
-	[[Category: Trypanosoma cruzi]]

OCA at 14:41, 29 September 2014

OCA — Mon, 29 Sep 2014 14:41:46 GMT

←Older revision		Revision as of 14:41, 29 September 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_1ci1\| PDB=1ci1 \| SCENE= }}~~	+	==CRYSTAL STRUCTURE OF TRIOSEPHOSPHATE ISOMERASE FROM TRYPANOSOMA CRUZI IN HEXANE==
-	===CRYSTAL STRUCTURE OF TRIOSEPHOSPHATE ISOMERASE FROM TRYPANOSOMA CRUZI IN HEXANE===	+	<StructureSection load='1ci1' size='340' side='right' caption='[[1ci1]], [[Resolution\|resolution]] 2.00Å' scene=''>
-	~~{{ABSTRACT_PUBMED_10468562}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1ci1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Trypanosoma_cruzi Trypanosoma cruzi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CI1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1CI1 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEX:HEXANE'>HEX</scene><br>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Triose-phosphate_isomerase Triose-phosphate isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.1.1 5.3.1.1] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ci1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ci1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ci1 RCSB], [http://www.ebi.ac.uk/pdbsum/1ci1 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ci/1ci1_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	To gain insight into the mechanisms of enzyme catalysis in organic solvents, the x-ray structure of some monomeric enzymes in organic solvents was determined. However, it remained to be explored whether the structure of oligomeric proteins is also amenable to such analysis. The field acquired new perspectives when it was proposed that the x-ray structure of enzymes in nonaqueous media could reveal binding sites for organic solvents that in principle could represent the starting point for drug design. Here, a crystal of the dimeric enzyme triosephosphate isomerase from the pathogenic parasite Trypanosoma cruzi was soaked and diffracted in hexane and its structure solved at 2-A resolution. Its overall structure and the dimer interface were not altered by hexane. However, there were differences in the orientation of the side chains of several amino acids, including that of the catalytic Glu-168 in one of the monomers. No hexane molecules were detected in the active site or in the dimer interface. However, three hexane molecules were identified on the surface of the protein at sites, which in the native crystal did not have water molecules. The number of water molecules in the hexane structure was higher than in the native crystal. Two hexanes localized at <4 A from residues that form the dimer interface; they were in close proximity to a site that has been considered a potential target for drug design.

-	~~==About this Structure==~~	+	Crystal structure of triosephosphate isomerase from Trypanosoma cruzi in hexane.,Gao XG, Maldonado E, Perez-Montfort R, Garza-Ramos G, de Gomez-Puyou MT, Gomez-Puyou A, Rodriguez-Romero A Proc Natl Acad Sci U S A. 1999 Aug 31;96(18):10062-7. PMID:10468562<ref>PMID:10468562</ref>
-	~~[[1ci1]] is a 2 chain~~ structure ~~with sequence~~ from ~~[http://en.wikipedia.org/wiki/Trypanosoma_cruzi~~ Trypanosoma cruzi]. ~~Full crystallographic information is available from [http~~://~~oca~~.~~weizmann~~.ac.il/~~oca-bin/ocashort?id=1CI1 OCA].~~	+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

	==See Also==		==See Also==
	*[[Triose Phosphate Isomerase\|Triose Phosphate Isomerase]]		*[[Triose Phosphate Isomerase\|Triose Phosphate Isomerase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:010468562<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Triose-phosphate isomerase]]		[[Category: Triose-phosphate isomerase]]
	[[Category: Trypanosoma cruzi]]		[[Category: Trypanosoma cruzi]]

OCA at 10:01, 11 March 2013

OCA — Mon, 11 Mar 2013 10:01:13 GMT

←Older revision		Revision as of 10:01, 11 March 2013
Line 1:		Line 1:
-	[[Image:1ci1.png\|left\|200px]]
-
	{{STRUCTURE_1ci1\| PDB=1ci1 \| SCENE= }}		{{STRUCTURE_1ci1\| PDB=1ci1 \| SCENE= }}
-
	===CRYSTAL STRUCTURE OF TRIOSEPHOSPHATE ISOMERASE FROM TRYPANOSOMA CRUZI IN HEXANE===		===CRYSTAL STRUCTURE OF TRIOSEPHOSPHATE ISOMERASE FROM TRYPANOSOMA CRUZI IN HEXANE===
-
	{{ABSTRACT_PUBMED_10468562}}		{{ABSTRACT_PUBMED_10468562}}

OCA at 18:34, 20 October 2012

OCA — Sat, 20 Oct 2012 18:34:49 GMT

←Older revision		Revision as of 18:34, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[1ci1]] is a 2 chain structure ~~of [[Triose Phosphate Isomerase]]~~ with sequence from [http://en.wikipedia.org/wiki/Trypanosoma_cruzi Trypanosoma cruzi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CI1 OCA].	+	[[1ci1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Trypanosoma_cruzi Trypanosoma cruzi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CI1 OCA].

	==See Also==		==See Also==