1cja - Revision history

OCA at 06:43, 7 February 2024

OCA — Wed, 07 Feb 2024 06:43:29 GMT

←Older revision		Revision as of 06:43, 7 February 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1cja]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Physarum_polycephalum Physarum polycephalum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CJA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1CJA FirstGlance]. <br>		<table><tr><td colspan='2'>[[1cja]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Physarum_polycephalum Physarum polycephalum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CJA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1CJA FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.9Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1cja FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cja OCA], [https://pdbe.org/1cja PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1cja RCSB], [https://www.ebi.ac.uk/pdbsum/1cja PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1cja ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1cja FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cja OCA], [https://pdbe.org/1cja PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1cja RCSB], [https://www.ebi.ac.uk/pdbsum/1cja PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1cja ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/AFK_PHYPO AFK_PHYPO] Has a role in the regulation of microfilament formation. Phosphorylates the actin-fragmin complex on threonine residues, in vitro.<ref>PMID:8896448</ref> <ref>PMID:1587799</ref> <ref>PMID:1315751</ref>		[https://www.uniprot.org/uniprot/AFK_PHYPO AFK_PHYPO] Has a role in the regulation of microfilament formation. Phosphorylates the actin-fragmin complex on threonine residues, in vitro.<ref>PMID:8896448</ref> <ref>PMID:1587799</ref> <ref>PMID:1315751</ref>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	Coordinated temporal and spatial regulation of the actin cytoskeleton is essential for diverse cellular processes such as cell division, cell motility and the formation and maintenance of specialized structures in differentiated cells. In plasmodia of Physarum polycephalum, the F-actin capping activity of the actin-fragmin complex is regulated by the phosphorylation of actin. This is mediated by a novel type of protein kinase with no sequence homology to eukaryotic-type protein kinases. Here we present the crystal structure of the catalytic domain of the first cloned actin kinase in complex with AMP at 2.9 A resolution. The three-dimensional fold reveals a catalytic module of approximately 160 residues, in common with the eukaryotic protein kinase superfamily, which harbours the nucleotide binding site and the catalytic apparatus in an inter-lobe cleft. Several kinases that share this catalytic module differ in the overall architecture of their substrate recognition domain. The actin-fragmin kinase has acquired a unique flat substrate recognition domain which is supposed to confer stringent substrate specificity.
-
-	The crystal structure of the Physarum polycephalum actin-fragmin kinase: an atypical protein kinase with a specialized substrate-binding domain.,Steinbacher S, Hof P, Eichinger L, Schleicher M, Gettemans J, Vandekerckhove J, Huber R, Benz J EMBO J. 1999 Jun 1;18(11):2923-9. PMID:10357805<ref>PMID:10357805</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 1cja" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 08:47, 7 December 2022

OCA — Wed, 07 Dec 2022 08:47:03 GMT

←Older revision		Revision as of 08:47, 7 December 2022
Line 3:		Line 3:
	<StructureSection load='1cja' size='340' side='right'caption='[[1cja]], [[Resolution\|resolution]] 2.90Å' scene=''>		<StructureSection load='1cja' size='340' side='right'caption='[[1cja]], [[Resolution\|resolution]] 2.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1cja]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CJA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1CJA FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1cja]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Physarum_polycephalum Physarum polycephalum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CJA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1CJA FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1cja FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cja OCA], [https://pdbe.org/1cja PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1cja RCSB], [https://www.ebi.ac.uk/pdbsum/1cja PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1cja ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1cja FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cja OCA], [https://pdbe.org/1cja PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1cja RCSB], [https://www.ebi.ac.uk/pdbsum/1cja PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1cja ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/AFK_PHYPO AFK_PHYPO]] Has a role in the regulation of microfilament formation. Phosphorylates the actin-fragmin complex on threonine residues, in vitro.<ref>PMID:8896448</ref> <ref>PMID:1587799</ref> <ref>PMID:1315751</ref>	+	[https://www.uniprot.org/uniprot/AFK_PHYPO AFK_PHYPO] Has a role in the regulation of microfilament formation. Phosphorylates the actin-fragmin complex on threonine residues, in vitro.<ref>PMID:8896448</ref> <ref>PMID:1587799</ref> <ref>PMID:1315751</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Benz, J]]	+	[[Category: Physarum polycephalum]]
-	[[Category: Eichinger, L]]	+	[[Category: Benz J]]
-	[[Category: Gettemans, J]]	+	[[Category: Eichinger L]]
-	[[Category: Hof, P]]	+	[[Category: Gettemans J]]
-	[[Category: Huber, R]]	+	[[Category: Hof P]]
-	[[Category: Schleicher, M]]	+	[[Category: Huber R]]
-	[[Category: Steinbacher, S]]	+	[[Category: Schleicher M]]
-	[[Category: Vandekerckhove, J]]	+	[[Category: Steinbacher S]]
-	~~[[Category: Actin]]~~	+	[[Category: Vandekerckhove J]]
-	~~[[Category: Kinase]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 15:16, 3 March 2021

OCA — Wed, 03 Mar 2021 15:16:54 GMT

←Older revision		Revision as of 15:16, 3 March 2021
Line 3:		Line 3:
	<StructureSection load='1cja' size='340' side='right'caption='[[1cja]], [[Resolution\|resolution]] 2.90Å' scene=''>		<StructureSection load='1cja' size='340' side='right'caption='[[1cja]], [[Resolution\|resolution]] 2.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1cja]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CJA OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1CJA FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1cja]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CJA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1CJA FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1cja FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cja OCA], [~~http~~://pdbe.org/1cja PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1cja RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1cja PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1cja ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1cja FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cja OCA], [https://pdbe.org/1cja PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1cja RCSB], [https://www.ebi.ac.uk/pdbsum/1cja PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1cja ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/AFK_PHYPO AFK_PHYPO]] Has a role in the regulation of microfilament formation. Phosphorylates the actin-fragmin complex on threonine residues, in vitro.<ref>PMID:8896448</ref> <ref>PMID:1587799</ref> <ref>PMID:1315751</ref>	+	[[https://www.uniprot.org/uniprot/AFK_PHYPO AFK_PHYPO]] Has a role in the regulation of microfilament formation. Phosphorylates the actin-fragmin complex on threonine residues, in vitro.<ref>PMID:8896448</ref> <ref>PMID:1587799</ref> <ref>PMID:1315751</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 07:24, 29 May 2019

OCA — Wed, 29 May 2019 07:24:00 GMT

←Older revision		Revision as of 07:24, 29 May 2019
Line 1:		Line 1:

	==ACTIN-FRAGMIN KINASE, CATALYTIC DOMAIN FROM PHYSARUM POLYCEPHALUM==		==ACTIN-FRAGMIN KINASE, CATALYTIC DOMAIN FROM PHYSARUM POLYCEPHALUM==
-	<StructureSection load='1cja' size='340' side='right' caption='[[1cja]], [[Resolution\|resolution]] 2.90Å' scene=''>	+	<StructureSection load='1cja' size='340' side='right'caption='[[1cja]], [[Resolution\|resolution]] 2.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1cja]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CJA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1CJA FirstGlance]. <br>		<table><tr><td colspan='2'>[[1cja]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CJA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1CJA FirstGlance]. <br>
Line 22:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Benz, J]]		[[Category: Benz, J]]
	[[Category: Eichinger, L]]		[[Category: Eichinger, L]]

OCA at 11:10, 24 August 2017

OCA — Thu, 24 Aug 2017 11:10:02 GMT

←Older revision		Revision as of 11:10, 24 August 2017
Line 1:		Line 1:
		+
	==ACTIN-FRAGMIN KINASE, CATALYTIC DOMAIN FROM PHYSARUM POLYCEPHALUM==		==ACTIN-FRAGMIN KINASE, CATALYTIC DOMAIN FROM PHYSARUM POLYCEPHALUM==
	<StructureSection load='1cja' size='340' side='right' caption='[[1cja]], [[Resolution\|resolution]] 2.90Å' scene=''>		<StructureSection load='1cja' size='340' side='right' caption='[[1cja]], [[Resolution\|resolution]] 2.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1cja]] is a 2 chain structure ~~with sequence from [http://en.wikipedia.org/wiki/Phypo Phypo]~~. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CJA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1CJA FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1cja]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CJA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1CJA FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1cja FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cja OCA], [http://pdbe.org/1cja PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1cja RCSB], [http://www.ebi.ac.uk/pdbsum/1cja PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1cja FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cja OCA], [http://pdbe.org/1cja PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1cja RCSB], [http://www.ebi.ac.uk/pdbsum/1cja PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1cja ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 21:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Phypo]]
	[[Category: Benz, J]]		[[Category: Benz, J]]
	[[Category: Eichinger, L]]		[[Category: Eichinger, L]]

OCA at 15:07, 10 September 2015

OCA — Thu, 10 Sep 2015 15:07:44 GMT

←Older revision		Revision as of 15:07, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='1cja' size='340' side='right' caption='[[1cja]], [[Resolution\|resolution]] 2.90Å' scene=''>		<StructureSection load='1cja' size='340' side='right' caption='[[1cja]], [[Resolution\|resolution]] 2.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1cja]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Physarum_polycephalum Physarum polycephalum~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CJA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1CJA FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1cja]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Phypo Phypo]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CJA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1CJA FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1cja FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cja OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1cja RCSB], [http://www.ebi.ac.uk/pdbsum/1cja PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1cja FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cja OCA], [http://pdbe.org/1cja PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1cja RCSB], [http://www.ebi.ac.uk/pdbsum/1cja PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 16:		Line 16:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1cja" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Physarum polycephalum~~]]	+	[[Category: Phypo]]
	[[Category: Benz, J]]		[[Category: Benz, J]]
	[[Category: Eichinger, L]]		[[Category: Eichinger, L]]

OCA at 01:56, 25 December 2014

OCA — Thu, 25 Dec 2014 01:56:42 GMT

←Older revision		Revision as of 01:56, 25 December 2014
Line 6:		Line 6:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1cja FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cja OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1cja RCSB], [http://www.ebi.ac.uk/pdbsum/1cja PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1cja FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cja OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1cja RCSB], [http://www.ebi.ac.uk/pdbsum/1cja PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/AFK_PHYPO AFK_PHYPO]] Has a role in the regulation of microfilament formation. Phosphorylates the actin-fragmin complex on threonine residues, in vitro.<ref>PMID:8896448</ref> <ref>PMID:1587799</ref> <ref>PMID:1315751</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 23:47, 22 December 2014

OCA — Mon, 22 Dec 2014 23:47:39 GMT

←Older revision		Revision as of 23:47, 22 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1cja]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Physarum_polycephalum Physarum polycephalum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CJA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1CJA FirstGlance]. <br>		<table><tr><td colspan='2'>[[1cja]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Physarum_polycephalum Physarum polycephalum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CJA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1CJA FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1cja FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cja OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1cja RCSB], [http://www.ebi.ac.uk/pdbsum/1cja PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1cja FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cja OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1cja RCSB], [http://www.ebi.ac.uk/pdbsum/1cja PDBsum]</span></td></tr>
-	<table>	+	</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 19:		Line 19:
	</StructureSection>		</StructureSection>
	[[Category: Physarum polycephalum]]		[[Category: Physarum polycephalum]]
-	[[Category: Benz, J.]]	+	[[Category: Benz, J]]
-	[[Category: Eichinger, L.]]	+	[[Category: Eichinger, L]]
-	[[Category: Gettemans, J.]]	+	[[Category: Gettemans, J]]
-	[[Category: Hof, P.]]	+	[[Category: Hof, P]]
-	[[Category: Huber, R.]]	+	[[Category: Huber, R]]
-	[[Category: Schleicher, M.]]	+	[[Category: Schleicher, M]]
-	[[Category: Steinbacher, S.]]	+	[[Category: Steinbacher, S]]
-	[[Category: Vandekerckhove, J.]]	+	[[Category: Vandekerckhove, J]]
	[[Category: Actin]]		[[Category: Actin]]
	[[Category: Kinase]]		[[Category: Kinase]]
	[[Category: Transferase]]		[[Category: Transferase]]

OCA at 16:59, 20 August 2014

OCA — Wed, 20 Aug 2014 16:59:12 GMT

←Older revision		Revision as of 16:59, 20 August 2014
Line 1:		Line 1:
-	[[~~Image:~~1cja.~~png~~\|~~left\|200px~~]]	+	==ACTIN-FRAGMIN KINASE, CATALYTIC DOMAIN FROM PHYSARUM POLYCEPHALUM==
		+	<StructureSection load='1cja' size='340' side='right' caption='[[1cja]], [[Resolution\|resolution]] 2.90Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1cja]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Physarum_polycephalum Physarum polycephalum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CJA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1CJA FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene><br>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1cja FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cja OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1cja RCSB], [http://www.ebi.ac.uk/pdbsum/1cja PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Coordinated temporal and spatial regulation of the actin cytoskeleton is essential for diverse cellular processes such as cell division, cell motility and the formation and maintenance of specialized structures in differentiated cells. In plasmodia of Physarum polycephalum, the F-actin capping activity of the actin-fragmin complex is regulated by the phosphorylation of actin. This is mediated by a novel type of protein kinase with no sequence homology to eukaryotic-type protein kinases. Here we present the crystal structure of the catalytic domain of the first cloned actin kinase in complex with AMP at 2.9 A resolution. The three-dimensional fold reveals a catalytic module of approximately 160 residues, in common with the eukaryotic protein kinase superfamily, which harbours the nucleotide binding site and the catalytic apparatus in an inter-lobe cleft. Several kinases that share this catalytic module differ in the overall architecture of their substrate recognition domain. The actin-fragmin kinase has acquired a unique flat substrate recognition domain which is supposed to confer stringent substrate specificity.

-	~~{{STRUCTURE_1cja\| PDB=1cja \| SCENE= }}~~	+	The crystal structure of the Physarum polycephalum actin-fragmin kinase: an atypical protein kinase with a specialized substrate-binding domain.,Steinbacher S, Hof P, Eichinger L, Schleicher M, Gettemans J, Vandekerckhove J, Huber R, Benz J EMBO J. 1999 Jun 1;18(11):2923-9. PMID:10357805<ref>PMID:10357805</ref>

-	~~===ACTIN-FRAGMIN KINASE~~, ~~CATALYTIC DOMAIN FROM PHYSARUM POLYCEPHALUM===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_10357805}}~~	+	== References ==
-		+	<references/>
-	==~~About this Structure~~==	+	__TOC__
-	~~[[1cja]] is a 2 chain structure with sequence from [http:~~//~~en.wikipedia.org/wiki/Physarum_polycephalum Physarum polycephalum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CJA OCA].~~	+	</StructureSection>
	[[Category: Physarum polycephalum]]		[[Category: Physarum polycephalum]]
	[[Category: Benz, J.]]		[[Category: Benz, J.]]

OCA: Protected "1cja" [edit=sysop:move=sysop]

OCA — Sun, 21 Oct 2012 20:33:44 GMT

Protected "1cja" [edit=sysop:move=sysop]

←Older revision

Revision as of 20:33, 21 October 2012