1ckr - Revision history

OCA at 23:27, 27 December 2023

OCA — Wed, 27 Dec 2023 23:27:16 GMT

←Older revision		Revision as of 23:27, 27 December 2023
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	==HIGH RESOLUTION SOLUTION STRUCTURE OF THE HEAT SHOCK COGNATE-70 KD SUBSTRATE BINDING DOMAIN OBTAINED BY MULTIDIMENSIONAL NMR TECHNIQUES==		==HIGH RESOLUTION SOLUTION STRUCTURE OF THE HEAT SHOCK COGNATE-70 KD SUBSTRATE BINDING DOMAIN OBTAINED BY MULTIDIMENSIONAL NMR TECHNIQUES==
-	<StructureSection load='1ckr' size='340' side='right'caption='[[1ckr~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>	+	<StructureSection load='1ckr' size='340' side='right'caption='[[1ckr]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1ckr]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Buffalo_rat Buffalo rat~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CKR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1CKR FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1ckr]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CKR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1CKR FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ckr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ckr OCA], [https://pdbe.org/1ckr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ckr RCSB], [https://www.ebi.ac.uk/pdbsum/1ckr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ckr ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ckr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ckr OCA], [https://pdbe.org/1ckr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ckr RCSB], [https://www.ebi.ac.uk/pdbsum/1ckr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ckr ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/HSP7C_RAT HSP7C_RAT]] Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Chaperone. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex (By similarity).	+	[https://www.uniprot.org/uniprot/HSP7C_RAT HSP7C_RAT] Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Chaperone. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Buffalo rat]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Flynn~~, G C~~]]	+	[[Category: Rattus norvegicus]]
-	[[Category: Hu, W]]	+	[[Category: Flynn GC]]
-	[[Category: Morshauser~~, R C~~]]	+	[[Category: Hu W]]
-	[[Category: Pang, Y]]	+	[[Category: Morshauser RC]]
-	[[Category: Wang, H]]	+	[[Category: Pang Y]]
-	[[Category: Zuiderweg~~, E R.P]]~~	+	[[Category: Wang H]]
-	~~[[Category: Chaperone]]~~	+	[[Category: Zuiderweg ERP]]
-	~~[[Category: Hsp70]]~~	+
-	~~[[Category: Molecular chaperone]]~~	+
-	~~[[Category: Peptide binding]]~~	+
-	~~[[Category: Protein folding~~]]	+

OCA at 10:33, 16 February 2022

OCA — Wed, 16 Feb 2022 10:33:04 GMT

←Older revision		Revision as of 10:33, 16 February 2022
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	<StructureSection load='1ckr' size='340' side='right'caption='[[1ckr]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='1ckr' size='340' side='right'caption='[[1ckr]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1ckr]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CKR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1CKR FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1ckr]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CKR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1CKR FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ckr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ckr OCA], [https://pdbe.org/1ckr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ckr RCSB], [https://www.ebi.ac.uk/pdbsum/1ckr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ckr ProSAT]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ckr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ckr OCA], [https://pdbe.org/1ckr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ckr RCSB], [https://www.ebi.ac.uk/pdbsum/1ckr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ckr ProSAT]</span></td></tr>
	</table>		</table>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Buffalo rat]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Flynn, G C]]		[[Category: Flynn, G C]]

OCA at 15:17, 3 March 2021

OCA — Wed, 03 Mar 2021 15:17:06 GMT

←Older revision		Revision as of 15:17, 3 March 2021
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	<StructureSection load='1ckr' size='340' side='right'caption='[[1ckr]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='1ckr' size='340' side='right'caption='[[1ckr]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1ckr]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CKR OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1CKR FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1ckr]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CKR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1CKR FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1ckr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ckr OCA], [~~http~~://pdbe.org/1ckr PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1ckr RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1ckr PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1ckr ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ckr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ckr OCA], [https://pdbe.org/1ckr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ckr RCSB], [https://www.ebi.ac.uk/pdbsum/1ckr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ckr ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/HSP7C_RAT HSP7C_RAT]] Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Chaperone. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex (By similarity).	+	[[https://www.uniprot.org/uniprot/HSP7C_RAT HSP7C_RAT]] Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Chaperone. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 29:		Line 29:

	==See Also==		==See Also==
-	*[[Heat Shock ~~Proteins~~\|Heat Shock ~~Proteins~~]]	+	*[[Heat Shock Protein structures\|Heat Shock Protein structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 07:19, 29 May 2019

OCA — Wed, 29 May 2019 07:19:14 GMT

←Older revision		Revision as of 07:19, 29 May 2019
Line 1:		Line 1:

	==HIGH RESOLUTION SOLUTION STRUCTURE OF THE HEAT SHOCK COGNATE-70 KD SUBSTRATE BINDING DOMAIN OBTAINED BY MULTIDIMENSIONAL NMR TECHNIQUES==		==HIGH RESOLUTION SOLUTION STRUCTURE OF THE HEAT SHOCK COGNATE-70 KD SUBSTRATE BINDING DOMAIN OBTAINED BY MULTIDIMENSIONAL NMR TECHNIQUES==
-	<StructureSection load='1ckr' size='340' side='right' caption='[[1ckr]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>	+	<StructureSection load='1ckr' size='340' side='right'caption='[[1ckr]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1ckr]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CKR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1CKR FirstGlance]. <br>		<table><tr><td colspan='2'>[[1ckr]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CKR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1CKR FirstGlance]. <br>
Line 12:		Line 12:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ck/1ckr_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ck/1ckr_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 34:		Line 34:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Flynn, G C]]		[[Category: Flynn, G C]]
	[[Category: Hu, W]]		[[Category: Hu, W]]

OCA at 11:07, 24 August 2017

OCA — Thu, 24 Aug 2017 11:07:07 GMT

←Older revision		Revision as of 11:07, 24 August 2017
Line 1:		Line 1:
		+
	==HIGH RESOLUTION SOLUTION STRUCTURE OF THE HEAT SHOCK COGNATE-70 KD SUBSTRATE BINDING DOMAIN OBTAINED BY MULTIDIMENSIONAL NMR TECHNIQUES==		==HIGH RESOLUTION SOLUTION STRUCTURE OF THE HEAT SHOCK COGNATE-70 KD SUBSTRATE BINDING DOMAIN OBTAINED BY MULTIDIMENSIONAL NMR TECHNIQUES==
	<StructureSection load='1ckr' size='340' side='right' caption='[[1ckr]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='1ckr' size='340' side='right' caption='[[1ckr]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1ckr]] is a 1 chain structure ~~with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]~~. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CKR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1CKR FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1ckr]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CKR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1CKR FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ckr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ckr OCA], [http://pdbe.org/1ckr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1ckr RCSB], [http://www.ebi.ac.uk/pdbsum/1ckr PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ckr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ckr OCA], [http://pdbe.org/1ckr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1ckr RCSB], [http://www.ebi.ac.uk/pdbsum/1ckr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1ckr ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ckr ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Buffalo rat]]
	[[Category: Flynn, G C]]		[[Category: Flynn, G C]]
	[[Category: Hu, W]]		[[Category: Hu, W]]

OCA at 17:43, 11 September 2015

OCA — Fri, 11 Sep 2015 17:43:15 GMT

←Older revision		Revision as of 17:43, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='1ckr' size='340' side='right' caption='[[1ckr]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='1ckr' size='340' side='right' caption='[[1ckr]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1ckr]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Rattus_norvegicus Rattus norvegicus~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CKR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1CKR FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1ckr]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CKR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1CKR FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ckr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ckr OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ckr RCSB], [http://www.ebi.ac.uk/pdbsum/1ckr PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ckr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ckr OCA], [http://pdbe.org/1ckr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1ckr RCSB], [http://www.ebi.ac.uk/pdbsum/1ckr PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 25:		Line 25:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1ckr" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 32:		Line 33:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Rattus norvegicus~~]]	+	[[Category: Buffalo rat]]
	[[Category: Flynn, G C]]		[[Category: Flynn, G C]]
	[[Category: Hu, W]]		[[Category: Hu, W]]

OCA at 19:44, 25 December 2014

OCA — Thu, 25 Dec 2014 19:44:56 GMT

←Older revision		Revision as of 19:44, 25 December 2014
Line 5:		Line 5:
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ckr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ckr OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ckr RCSB], [http://www.ebi.ac.uk/pdbsum/1ckr PDBsum]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ckr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ckr OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ckr RCSB], [http://www.ebi.ac.uk/pdbsum/1ckr PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/HSP7C_RAT HSP7C_RAT]] Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Chaperone. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 19:35, 22 December 2014

OCA — Mon, 22 Dec 2014 19:35:39 GMT

←Older revision		Revision as of 19:35, 22 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1ckr]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CKR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1CKR FirstGlance]. <br>		<table><tr><td colspan='2'>[[1ckr]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CKR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1CKR FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ckr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ckr OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ckr RCSB], [http://www.ebi.ac.uk/pdbsum/1ckr PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ckr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ckr OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ckr RCSB], [http://www.ebi.ac.uk/pdbsum/1ckr PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 31:		Line 31:
	</StructureSection>		</StructureSection>
	[[Category: Rattus norvegicus]]		[[Category: Rattus norvegicus]]
-	[[Category: Flynn, G C.]]	+	[[Category: Flynn, G C]]
-	[[Category: Hu, W.]]	+	[[Category: Hu, W]]
-	[[Category: Morshauser, R C.]]	+	[[Category: Morshauser, R C]]
-	[[Category: Pang, Y.]]	+	[[Category: Pang, Y]]
-	[[Category: Wang, H.]]	+	[[Category: Wang, H]]
-	[[Category: Zuiderweg, E R.P.]]	+	[[Category: Zuiderweg, E R.P]]
	[[Category: Chaperone]]		[[Category: Chaperone]]
	[[Category: Hsp70]]		[[Category: Hsp70]]

OCA at 16:55, 20 August 2014

OCA — Wed, 20 Aug 2014 16:55:05 GMT

←Older revision		Revision as of 16:55, 20 August 2014
Line 1:		Line 1:
-	[[~~Image~~:1ckr.~~png\|left~~\|200px]]	+	==HIGH RESOLUTION SOLUTION STRUCTURE OF THE HEAT SHOCK COGNATE-70 KD SUBSTRATE BINDING DOMAIN OBTAINED BY MULTIDIMENSIONAL NMR TECHNIQUES==
		+	<StructureSection load='1ckr' size='340' side='right' caption='[[1ckr]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1ckr]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CKR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1CKR FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ckr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ckr OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ckr RCSB], [http://www.ebi.ac.uk/pdbsum/1ckr PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ck/1ckr_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The three-dimensional structure for the substrate-binding domain of the mammalian chaperone protein Hsc70 of the 70 kDa heat shock class (HSP70) is presented. This domain includes residues 383-540 (18 kDa) and is necessary for the binding of the chaperone with substrate proteins and peptides. The high-resolution NMR solution structure is based on 4150 experimental distance constraints leading to an average root-mean-square precision of 0.38 A for the backbone atoms and 0.76 A for all atoms in the beta-sandwich sub-domain. The protein is observed to bind residue Leu539 in its hydrophobic substrate-binding groove by intramolecular interaction. The position of a helical latch differs dramatically from what is observed in the crystal and solution structures of the homologous prokaryotic chaperone DnaK. In the Hsc70 structure, the helix lies in a hydrophobic groove and is anchored by a buried salt-bridge. Residues involved in this salt-bridge appear to be important for the allosteric functioning of the protein. A mechanism for interdomain allosteric modulation of substrate-binding is proposed. It involves large-scale movements of the helical domain, redefining the location of the hinge area that enables such motions.

-	~~{{STRUCTURE_1ckr\| PDB=1ckr \| SCENE= }}~~	+	High-resolution solution structure of the 18 kDa substrate-binding domain of the mammalian chaperone protein Hsc70.,Morshauser RC, Hu W, Wang H, Pang Y, Flynn GC, Zuiderweg ER J Mol Biol. 1999 Jun 25;289(5):1387-403. PMID:10373374<ref>PMID:10373374</ref>

-	~~===HIGH RESOLUTION SOLUTION STRUCTURE OF THE HEAT SHOCK COGNATE-70 KD SUBSTRATE BINDING DOMAIN OBTAINED BY MULTIDIMENSIONAL NMR TECHNIQUES===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_10373374}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[1ckr]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Rattus_norvegicus Rattus norvegicus]~~. ~~Full experimental information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1CKR OCA].~~	+

	==See Also==		==See Also==
	*[[Heat Shock Proteins\|Heat Shock Proteins]]		*[[Heat Shock Proteins\|Heat Shock Proteins]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:010373374<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Rattus norvegicus]]		[[Category: Rattus norvegicus]]
	[[Category: Flynn, G C.]]		[[Category: Flynn, G C.]]

OCA at 20:42, 20 October 2012

OCA — Sat, 20 Oct 2012 20:42:25 GMT

←Older revision		Revision as of 20:42, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[1ckr]] is a 1 chain structure ~~of [[Heat Shock Proteins]]~~ with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CKR OCA].	+	[[1ckr]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CKR OCA].

	==See Also==		==See Also==