1cky - Revision history

OCA at 11:39, 22 November 2023

OCA — Wed, 22 Nov 2023 11:39:39 GMT

←Older revision		Revision as of 11:39, 22 November 2023
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	==CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR: SOLUTION STRUCTURES OF PEPTIDES BASED ON THE PHE508 REGION, THE MOST COMMON SITE OF DISEASE-CAUSING DELTA-F508 MUTATION==		==CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR: SOLUTION STRUCTURES OF PEPTIDES BASED ON THE PHE508 REGION, THE MOST COMMON SITE OF DISEASE-CAUSING DELTA-F508 MUTATION==
-	<StructureSection load='1cky' size='340' side='right'caption='[[1cky~~]], [[NMR_Ensembles_of_Models \| 10 NMR models~~]]' scene=''>	+	<StructureSection load='1cky' size='340' side='right'caption='[[1cky]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1cky]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CKY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1CKY FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1cky]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Ovis_aries Ovis aries]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CKY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1CKY FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1cky FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cky OCA], [https://pdbe.org/1cky PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1cky RCSB], [https://www.ebi.ac.uk/pdbsum/1cky PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1cky ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1cky FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cky OCA], [https://pdbe.org/1cky PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1cky RCSB], [https://www.ebi.ac.uk/pdbsum/1cky PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1cky ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/CFTR_SHEEP CFTR_SHEEP]] Involved in the transport of chloride ions. May regulate bicarbonate secretion and salvage in epithelial cells by regulating the SLC4A7 transporter. Can inhibit the chloride channel activity of ANO1 (By similarity).	+	[https://www.uniprot.org/uniprot/CFTR_SHEEP CFTR_SHEEP] Involved in the transport of chloride ions. May regulate bicarbonate secretion and salvage in epithelial cells by regulating the SLC4A7 transporter. Can inhibit the chloride channel activity of ANO1 (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 25:		Line 26:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Ko, Y H~~]]	+	[[Category: Ovis aries]]
-	[[Category: ~~Massiah, M A~~]]	+	[[Category: Ko YH]]
-	[[Category: ~~Mildvan, A S~~]]	+	[[Category: Massiah MA]]
-	[[Category: ~~Pedersen, P L~~]]	+	[[Category: Mildvan AS]]
-	[[Category: ~~Cystic fibrosis]]~~	+	[[Category: Pedersen PL]]
-	~~[[Category: Metal transport]]~~	+
-	~~[[Category: Peptide~~]]	+

OCA at 15:17, 3 March 2021

OCA — Wed, 03 Mar 2021 15:17:13 GMT

←Older revision		Revision as of 15:17, 3 March 2021
Line 3:		Line 3:
	<StructureSection load='1cky' size='340' side='right'caption='[[1cky]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>		<StructureSection load='1cky' size='340' side='right'caption='[[1cky]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1cky]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CKY OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1CKY FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1cky]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CKY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1CKY FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1cky FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cky OCA], [~~http~~://pdbe.org/1cky PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1cky RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1cky PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1cky ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1cky FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cky OCA], [https://pdbe.org/1cky PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1cky RCSB], [https://www.ebi.ac.uk/pdbsum/1cky PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1cky ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/CFTR_SHEEP CFTR_SHEEP]] Involved in the transport of chloride ions. May regulate bicarbonate secretion and salvage in epithelial cells by regulating the SLC4A7 transporter. Can inhibit the chloride channel activity of ANO1 (By similarity).	+	[[https://www.uniprot.org/uniprot/CFTR_SHEEP CFTR_SHEEP]] Involved in the transport of chloride ions. May regulate bicarbonate secretion and salvage in epithelial cells by regulating the SLC4A7 transporter. Can inhibit the chloride channel activity of ANO1 (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 07:02, 29 May 2019

OCA — Wed, 29 May 2019 07:02:40 GMT

←Older revision		Revision as of 07:02, 29 May 2019
Line 1:		Line 1:

	==CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR: SOLUTION STRUCTURES OF PEPTIDES BASED ON THE PHE508 REGION, THE MOST COMMON SITE OF DISEASE-CAUSING DELTA-F508 MUTATION==		==CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR: SOLUTION STRUCTURES OF PEPTIDES BASED ON THE PHE508 REGION, THE MOST COMMON SITE OF DISEASE-CAUSING DELTA-F508 MUTATION==
-	<StructureSection load='1cky' size='340' side='right' caption='[[1cky]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>	+	<StructureSection load='1cky' size='340' side='right'caption='[[1cky]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1cky]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CKY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1CKY FirstGlance]. <br>		<table><tr><td colspan='2'>[[1cky]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CKY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1CKY FirstGlance]. <br>
Line 19:		Line 19:

	==See Also==		==See Also==
-	*[[ABC transporter\|ABC transporter]]	+	*[[ABC transporter 3D structures\|ABC transporter 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Ko, Y H]]		[[Category: Ko, Y H]]
	[[Category: Massiah, M A]]		[[Category: Massiah, M A]]

OCA at 11:14, 24 August 2017

OCA — Thu, 24 Aug 2017 11:14:23 GMT

←Older revision		Revision as of 11:14, 24 August 2017
Line 1:		Line 1:
		+
	==CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR: SOLUTION STRUCTURES OF PEPTIDES BASED ON THE PHE508 REGION, THE MOST COMMON SITE OF DISEASE-CAUSING DELTA-F508 MUTATION==		==CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR: SOLUTION STRUCTURES OF PEPTIDES BASED ON THE PHE508 REGION, THE MOST COMMON SITE OF DISEASE-CAUSING DELTA-F508 MUTATION==
	<StructureSection load='1cky' size='340' side='right' caption='[[1cky]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>		<StructureSection load='1cky' size='340' side='right' caption='[[1cky]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1cky]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CKY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1CKY FirstGlance]. <br>		<table><tr><td colspan='2'>[[1cky]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CKY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1CKY FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1cky FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cky OCA], [http://pdbe.org/1cky PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1cky RCSB], [http://www.ebi.ac.uk/pdbsum/1cky PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1cky FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cky OCA], [http://pdbe.org/1cky PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1cky RCSB], [http://www.ebi.ac.uk/pdbsum/1cky PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1cky ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 00:31, 12 September 2015

OCA — Sat, 12 Sep 2015 00:31:15 GMT

←Older revision		Revision as of 00:31, 12 September 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1cky]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CKY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1CKY FirstGlance]. <br>		<table><tr><td colspan='2'>[[1cky]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CKY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1CKY FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1cky FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cky OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1cky RCSB], [http://www.ebi.ac.uk/pdbsum/1cky PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1cky FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cky OCA], [http://pdbe.org/1cky PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1cky RCSB], [http://www.ebi.ac.uk/pdbsum/1cky PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 15:		Line 15:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1cky" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 14:55, 15 February 2015

OCA — Sun, 15 Feb 2015 14:55:21 GMT

←Older revision		Revision as of 14:55, 15 February 2015
Line 5:		Line 5:
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1cky FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cky OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1cky RCSB], [http://www.ebi.ac.uk/pdbsum/1cky PDBsum]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1cky FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cky OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1cky RCSB], [http://www.ebi.ac.uk/pdbsum/1cky PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/CFTR_SHEEP CFTR_SHEEP]] Involved in the transport of chloride ions. May regulate bicarbonate secretion and salvage in epithelial cells by regulating the SLC4A7 transporter. Can inhibit the chloride channel activity of ANO1 (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 22:43, 22 December 2014

OCA — Mon, 22 Dec 2014 22:43:38 GMT

←Older revision		Revision as of 22:43, 22 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1cky]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CKY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1CKY FirstGlance]. <br>		<table><tr><td colspan='2'>[[1cky]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CKY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1CKY FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1cky FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cky OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1cky RCSB], [http://www.ebi.ac.uk/pdbsum/1cky PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1cky FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cky OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1cky RCSB], [http://www.ebi.ac.uk/pdbsum/1cky PDBsum]</span></td></tr>
-	<table>	+	</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 20:		Line 20:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Ko, Y H.]]	+	[[Category: Ko, Y H]]
-	[[Category: Massiah, M A.]]	+	[[Category: Massiah, M A]]
-	[[Category: Mildvan, A S.]]	+	[[Category: Mildvan, A S]]
-	[[Category: Pedersen, P L.]]	+	[[Category: Pedersen, P L]]
	[[Category: Cystic fibrosis]]		[[Category: Cystic fibrosis]]
	[[Category: Metal transport]]		[[Category: Metal transport]]
	[[Category: Peptide]]		[[Category: Peptide]]

OCA at 17:04, 20 August 2014

OCA — Wed, 20 Aug 2014 17:04:57 GMT

←Older revision		Revision as of 17:04, 20 August 2014
Line 1:		Line 1:
-	[[~~Image~~:1cky.~~png\|left\|200px~~]]	+	==CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR: SOLUTION STRUCTURES OF PEPTIDES BASED ON THE PHE508 REGION, THE MOST COMMON SITE OF DISEASE-CAUSING DELTA-F508 MUTATION==
		+	<StructureSection load='1cky' size='340' side='right' caption='[[1cky]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1cky]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CKY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1CKY FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1cky FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cky OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1cky RCSB], [http://www.ebi.ac.uk/pdbsum/1cky PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Most cases of cystic fibrosis (CF), a common inherited disease of epithelial cell origin, are caused by the deletion of Phe508 located in the first nucleotide-binding domain (NBF1) of the protein called CFTR (cystic fibrosis transmembrane conductance regulator). To gain greater insight into the structure within the Phe508 region of the wild-type protein and the change in structure that occurs when this residue is deleted, we conducted nuclear magnetic resonance (NMR) studies on representative synthetic 26 and 25 amino acid peptide segments. 2D 1H NMR studies at 600 MHz of the 26-residue peptide consisting of Met498 to Ala523 in 10% DMSO, pH 4.0, at 25 degrees C show a continuous but labile helix from Gly500 to Lys522, based on both NH-NH(i,i+1) and alphaH-NH(i,i+1) NOEs. Phe508 within this helix shows only short-range (i, </=i + 2) NOEs. The corresponding 25-residue peptide lacking Phe508 also forms a labile helix from Gly500 to Lys522. However, the relative intensities of the NH-NH(i, i+1)/alphaH-NH(i,i+1) NOEs, fewer intermediate-range NOEs, and downfield alphaH and NH chemical shifts indicate a lower helical propensity of the 25-mer between residues 505 and 517, surrounding the missing residue, Phe508. 2D 1H NMR studies of both peptides in saturating (43%) TFE reveal stable alpha-helices from Gly500 to Lys522, based on NH-NH(i,i+1,2,3), alphaH-NH(i,i+2,3,4), alphaH-betaH(i,i+3), and weak alphaH-NH(i,i+1) NOEs. However, downfield shifts of the alphaH resonances from residues Gly500 to Ile507 and fewer intermediate-range NOEs suggest a less stable alpha-helix in the 25-mer even in saturating TFE. These findings show that the Phe508-containing region of CFTR has a propensity to form an alpha-helix, which is destabilized by the DeltaF508 mutation found in most patients with CF. These studies have direct relevance to better understanding the CFTR misfolding problem associated with CF and to identifying chemical agents, which correct this problem.

-	~~{{STRUCTURE_1cky\| PDB=1cky \| SCENE= }}~~	+	Cystic fibrosis transmembrane conductance regulator: solution structures of peptides based on the Phe508 region, the most common site of disease-causing DeltaF508 mutation.,Massiah MA, Ko YH, Pedersen PL, Mildvan AS Biochemistry. 1999 Jun 8;38(23):7453-61. PMID:10360942<ref>PMID:10360942</ref>

-	~~===CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR: SOLUTION STRUCTURES OF PEPTIDES BASED ON THE PHE508 REGION~~, ~~THE MOST COMMON SITE OF DISEASE-CAUSING DELTA-F508 MUTATION===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_10360942}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[1cky]] is~~ a ~~1 chain structure~~. ~~Full experimental information is available from [http://oca~~.~~weizmann~~.~~ac.il~~/~~oca-bin/ocashort?id=1CKY OCA].~~	+

	==See Also==		==See Also==
	*[[ABC transporter\|ABC transporter]]		*[[ABC transporter\|ABC transporter]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:010360942<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Ko, Y H.]]		[[Category: Ko, Y H.]]
	[[Category: Massiah, M A.]]		[[Category: Massiah, M A.]]

OCA at 21:51, 20 October 2012

OCA — Sat, 20 Oct 2012 21:51:43 GMT

←Older revision		Revision as of 21:51, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[1cky]] is a 1 chain structure ~~of [[ABC transporter]]~~. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CKY OCA].	+	[[1cky]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CKY OCA].

	==See Also==		==See Also==

OCA at 14:29, 27 July 2012

OCA — Fri, 27 Jul 2012 14:29:52 GMT

←Older revision		Revision as of 14:29, 27 July 2012
Line 1:		Line 1:
	[[Image:1cky.png\|left\|200px]]		[[Image:1cky.png\|left\|200px]]

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-	-->
	{{STRUCTURE_1cky\| PDB=1cky \| SCENE= }}		{{STRUCTURE_1cky\| PDB=1cky \| SCENE= }}

	===CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR: SOLUTION STRUCTURES OF PEPTIDES BASED ON THE PHE508 REGION, THE MOST COMMON SITE OF DISEASE-CAUSING DELTA-F508 MUTATION===		===CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR: SOLUTION STRUCTURES OF PEPTIDES BASED ON THE PHE508 REGION, THE MOST COMMON SITE OF DISEASE-CAUSING DELTA-F508 MUTATION===

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	{{ABSTRACT_PUBMED_10360942}}		{{ABSTRACT_PUBMED_10360942}}

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	==See Also==		==See Also==
-	*[[ABC transporter]]	+	*[[ABC transporter\|ABC transporter]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~10360942~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:010360942</ref><references group="xtra"/>
	[[Category: Ko, Y H.]]		[[Category: Ko, Y H.]]
	[[Category: Massiah, M A.]]		[[Category: Massiah, M A.]]
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	[[Category: Cystic fibrosis]]		[[Category: Cystic fibrosis]]
	[[Category: Metal transport]]		[[Category: Metal transport]]
-	[[Category: Nmr]]
	[[Category: Peptide]]		[[Category: Peptide]]