1clo - Revision history

OCA at 15:40, 13 March 2024

OCA — Wed, 13 Mar 2024 15:40:41 GMT

←Older revision		Revision as of 15:40, 13 March 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1clo]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CLO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1CLO FirstGlance]. <br>		<table><tr><td colspan='2'>[[1clo]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CLO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1CLO FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1clo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1clo OCA], [https://pdbe.org/1clo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1clo RCSB], [https://www.ebi.ac.uk/pdbsum/1clo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1clo ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.1Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1clo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1clo OCA], [https://pdbe.org/1clo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1clo RCSB], [https://www.ebi.ac.uk/pdbsum/1clo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1clo ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/IGHG1_MOUSE IGHG1_MOUSE]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 16:		Line 19:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1clo ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1clo ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	The crystal structures of two pairs of Fab fragments have been determined. The pairs comprise both a murine and an engineered human form, each derived from the antitumor antibodies A5B7 and CTM01. Although antigen specificity is maintained within the pairs, antigen affinity varies. A comparison of the hypervariable loops for each pair of antibodies shows their structure has been well maintained in grafting, supporting the canonical loop model. Detailed structural analysis of the binding sites and domain arrangements for these antibodies suggests the differences in antigen affinity observed are likely to be due to inherent flexibility of the hypervariable loops and movements at the VL:VH domain interface. The four structures provide the first opportunity to study in detail the effects of protein engineering on specific antibodies.
-
-	VL:VH domain rotations in engineered antibodies: crystal structures of the Fab fragments from two murine antitumor antibodies and their engineered human constructs.,Banfield MJ, King DJ, Mountain A, Brady RL Proteins. 1997 Oct;29(2):161-71. PMID:9329081<ref>PMID:9329081</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 1clo" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
	*[[Monoclonal Antibodies 3D structures\|Monoclonal Antibodies 3D structures]]		*[[Monoclonal Antibodies 3D structures\|Monoclonal Antibodies 3D structures]]
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
-	[[Category: Banfield~~, M J~~]]	+	[[Category: Banfield MJ]]
-	[[Category: Brady~~, R L~~]]	+	[[Category: Brady RL]]
-	[[Category: King~~, D J~~]]	+	[[Category: King DJ]]
-	[[Category: Mountain, A]]	+	[[Category: Mountain A]]
-	~~[[Category: Fab-fragment]]~~	+
-	~~[[Category: Immunoglobulin~~]]	+

OCA at 10:37, 14 July 2021

OCA — Wed, 14 Jul 2021 10:37:48 GMT

←Older revision		Revision as of 10:37, 14 July 2021
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	<StructureSection load='1clo' size='340' side='right'caption='[[1clo]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='1clo' size='340' side='right'caption='[[1clo]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1clo]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CLO OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1CLO FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1clo]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CLO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1CLO FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1clo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1clo OCA], [~~http~~://pdbe.org/1clo PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1clo RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1clo PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1clo ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1clo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1clo OCA], [https://pdbe.org/1clo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1clo RCSB], [https://www.ebi.ac.uk/pdbsum/1clo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1clo ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 07:07, 10 October 2019

OCA — Thu, 10 Oct 2019 07:07:06 GMT

←Older revision		Revision as of 07:07, 10 October 2019
Line 1:		Line 1:

	==ANTI-CARCINOEMBRYONIC ANTIGEN MONOCLONAL ANTIBODY A5B7==		==ANTI-CARCINOEMBRYONIC ANTIGEN MONOCLONAL ANTIBODY A5B7==
-	<StructureSection load='1clo' size='340' side='right' caption='[[1clo]], [[Resolution\|resolution]] 2.10Å' scene=''>	+	<StructureSection load='1clo' size='340' side='right'caption='[[1clo]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1clo]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CLO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1CLO FirstGlance]. <br>		<table><tr><td colspan='2'>[[1clo]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CLO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1CLO FirstGlance]. <br>
Line 10:		Line 10:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cl/1clo_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cl/1clo_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 27:		Line 27:

	==See Also==		==See Also==
-	*[[3D structures ~~of monoclonal antibody~~\|3D structures ~~of monoclonal antibody~~]]	+	*[[Monoclonal Antibodies 3D structures\|Monoclonal Antibodies 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Banfield, M J]]		[[Category: Banfield, M J]]

OCA at 08:05, 29 November 2017

OCA — Wed, 29 Nov 2017 08:05:22 GMT

←Older revision		Revision as of 08:05, 29 November 2017
Line 1:		Line 1:
		+
	==ANTI-CARCINOEMBRYONIC ANTIGEN MONOCLONAL ANTIBODY A5B7==		==ANTI-CARCINOEMBRYONIC ANTIGEN MONOCLONAL ANTIBODY A5B7==
	<StructureSection load='1clo' size='340' side='right' caption='[[1clo]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='1clo' size='340' side='right' caption='[[1clo]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1clo]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CLO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1CLO FirstGlance]. <br>		<table><tr><td colspan='2'>[[1clo]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CLO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1CLO FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1clo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1clo OCA], [http://pdbe.org/1clo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1clo RCSB], [http://www.ebi.ac.uk/pdbsum/1clo PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1clo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1clo OCA], [http://pdbe.org/1clo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1clo RCSB], [http://www.ebi.ac.uk/pdbsum/1clo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1clo ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 26:		Line 27:

	==See Also==		==See Also==
-	*[[~~Monoclonal Antibody~~\|~~Monoclonal Antibody~~]]	+	*[[3D structures of monoclonal antibody\|3D structures of monoclonal antibody]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 03:02, 9 February 2016

OCA — Tue, 09 Feb 2016 03:02:24 GMT

←Older revision		Revision as of 03:02, 9 February 2016
Line 13:		Line 13:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1clo ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 17:58, 10 September 2015

OCA — Thu, 10 Sep 2015 17:58:20 GMT

←Older revision		Revision as of 17:58, 10 September 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1clo]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CLO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1CLO FirstGlance]. <br>		<table><tr><td colspan='2'>[[1clo]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CLO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1CLO FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1clo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1clo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1clo RCSB], [http://www.ebi.ac.uk/pdbsum/1clo PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1clo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1clo OCA], [http://pdbe.org/1clo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1clo RCSB], [http://www.ebi.ac.uk/pdbsum/1clo PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 23:		Line 23:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1clo" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Monoclonal Antibody\|Monoclonal Antibody]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 20:31, 22 December 2014

OCA — Mon, 22 Dec 2014 20:31:51 GMT

←Older revision		Revision as of 20:31, 22 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1clo]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CLO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1CLO FirstGlance]. <br>		<table><tr><td colspan='2'>[[1clo]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CLO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1CLO FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1clo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1clo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1clo RCSB], [http://www.ebi.ac.uk/pdbsum/1clo PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1clo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1clo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1clo RCSB], [http://www.ebi.ac.uk/pdbsum/1clo PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 28:		Line 28:
	</StructureSection>		</StructureSection>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
-	[[Category: Banfield, M J.]]	+	[[Category: Banfield, M J]]
-	[[Category: Brady, R L.]]	+	[[Category: Brady, R L]]
-	[[Category: King, D J.]]	+	[[Category: King, D J]]
-	[[Category: Mountain, A.]]	+	[[Category: Mountain, A]]
	[[Category: Fab-fragment]]		[[Category: Fab-fragment]]
	[[Category: Immunoglobulin]]		[[Category: Immunoglobulin]]

OCA at 09:11, 27 August 2014

OCA — Wed, 27 Aug 2014 09:11:19 GMT

←Older revision		Revision as of 09:11, 27 August 2014
Line 1:		Line 1:
-	[[~~Image~~:1clo.~~png\|left~~\|200px]]	+	==ANTI-CARCINOEMBRYONIC ANTIGEN MONOCLONAL ANTIBODY A5B7==
		+	<StructureSection load='1clo' size='340' side='right' caption='[[1clo]], [[Resolution\|resolution]] 2.10Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1clo]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CLO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1CLO FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1clo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1clo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1clo RCSB], [http://www.ebi.ac.uk/pdbsum/1clo PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cl/1clo_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The crystal structures of two pairs of Fab fragments have been determined. The pairs comprise both a murine and an engineered human form, each derived from the antitumor antibodies A5B7 and CTM01. Although antigen specificity is maintained within the pairs, antigen affinity varies. A comparison of the hypervariable loops for each pair of antibodies shows their structure has been well maintained in grafting, supporting the canonical loop model. Detailed structural analysis of the binding sites and domain arrangements for these antibodies suggests the differences in antigen affinity observed are likely to be due to inherent flexibility of the hypervariable loops and movements at the VL:VH domain interface. The four structures provide the first opportunity to study in detail the effects of protein engineering on specific antibodies.

-	~~{{STRUCTURE_1clo\| PDB=1clo \| SCENE= }}~~	+	VL:VH domain rotations in engineered antibodies: crystal structures of the Fab fragments from two murine antitumor antibodies and their engineered human constructs.,Banfield MJ, King DJ, Mountain A, Brady RL Proteins. 1997 Oct;29(2):161-71. PMID:9329081<ref>PMID:9329081</ref>

-	~~===ANTI-CARCINOEMBRYONIC ANTIGEN MONOCLONAL ANTIBODY A5B7===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_9329081}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[1clo]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Mus_musculus Mus musculus]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1CLO OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:009329081<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Banfield, M J.]]		[[Category: Banfield, M J.]]

OCA: Protected "1clo" [edit=sysop:move=sysop]

OCA — Sun, 21 Oct 2012 20:31:01 GMT

Protected "1clo" [edit=sysop:move=sysop]

←Older revision

Revision as of 20:31, 21 October 2012

OCA at 20:31, 21 October 2012

OCA — Sun, 21 Oct 2012 20:31:00 GMT

←Older revision		Revision as of 20:31, 21 October 2012
Line 1:		Line 1:
-	{{Seed}}
	[[Image:1clo.png\|left\|200px]]		[[Image:1clo.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1clo", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1clo\| PDB=1clo \| SCENE= }}		{{STRUCTURE_1clo\| PDB=1clo \| SCENE= }}

	===ANTI-CARCINOEMBRYONIC ANTIGEN MONOCLONAL ANTIBODY A5B7===		===ANTI-CARCINOEMBRYONIC ANTIGEN MONOCLONAL ANTIBODY A5B7===

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	{{ABSTRACT_PUBMED_9329081}}		{{ABSTRACT_PUBMED_9329081}}

	==About this Structure==		==About this Structure==
-	~~1CLO~~ is a 2 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CLO OCA].	+	[[1clo]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CLO OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~9329081~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:009329081</ref><references group="xtra"/>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Banfield, M J.]]		[[Category: Banfield, M J.]]
Line 31:		Line 19:
	[[Category: Fab-fragment]]		[[Category: Fab-fragment]]
	[[Category: Immunoglobulin]]		[[Category: Immunoglobulin]]
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-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 05:56:25 2009''