1co8 - Revision history

OCA at 05:54, 9 August 2023

OCA — Wed, 09 Aug 2023 05:54:11 GMT

←Older revision		Revision as of 05:54, 9 August 2023
Line 3:		Line 3:
	<StructureSection load='1co8' size='340' side='right'caption='[[1co8]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='1co8' size='340' side='right'caption='[[1co8]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1co8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Phymc Phymc~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CO8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1CO8 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1co8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Physeter_catodon Physeter catodon]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CO8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1CO8 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.8Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1co8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1co8 OCA], [https://pdbe.org/1co8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1co8 RCSB], [https://www.ebi.ac.uk/pdbsum/1co8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1co8 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1co8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1co8 OCA], [https://pdbe.org/1co8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1co8 RCSB], [https://www.ebi.ac.uk/pdbsum/1co8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1co8 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/MYG_PHYMC MYG_PHYMC]] Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles.	+	[https://www.uniprot.org/uniprot/MYG_PHYMC MYG_PHYMC] Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 36:		Line 37:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Phymc~~]]	+	[[Category: Physeter catodon]]
-	[[Category: Liong~~, E C~~]]	+	[[Category: Liong EC]]
-	[[Category: Phillips~~, G N]]~~	+	[[Category: Phillips Jr GN]]
-	~~[[Category: Heme]]~~	+
-	~~[[Category: Muscle protein]]~~	+
-	~~[[Category: Oxygen transport~~]]	+

OCA at 14:54, 3 November 2021

OCA — Wed, 03 Nov 2021 14:54:17 GMT

←Older revision		Revision as of 14:54, 3 November 2021
Line 3:		Line 3:
	<StructureSection load='1co8' size='340' side='right'caption='[[1co8]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='1co8' size='340' side='right'caption='[[1co8]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1co8]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CO8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1CO8 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1co8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Phymc Phymc]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CO8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1CO8 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1co8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1co8 OCA], [https://pdbe.org/1co8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1co8 RCSB], [https://www.ebi.ac.uk/pdbsum/1co8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1co8 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1co8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1co8 OCA], [https://pdbe.org/1co8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1co8 RCSB], [https://www.ebi.ac.uk/pdbsum/1co8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1co8 ProSAT]</span></td></tr>
Line 36:		Line 36:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
		+	[[Category: Phymc]]
	[[Category: Liong, E C]]		[[Category: Liong, E C]]
	[[Category: Phillips, G N]]		[[Category: Phillips, G N]]

OCA at 15:17, 3 March 2021

OCA — Wed, 03 Mar 2021 15:17:54 GMT

←Older revision		Revision as of 15:17, 3 March 2021
Line 3:		Line 3:
	<StructureSection load='1co8' size='340' side='right'caption='[[1co8]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='1co8' size='340' side='right'caption='[[1co8]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1co8]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CO8 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1CO8 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1co8]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CO8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1CO8 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1co8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1co8 OCA], [~~http~~://pdbe.org/1co8 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1co8 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1co8 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1co8 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1co8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1co8 OCA], [https://pdbe.org/1co8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1co8 RCSB], [https://www.ebi.ac.uk/pdbsum/1co8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1co8 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/MYG_PHYMC MYG_PHYMC]] Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles.	+	[[https://www.uniprot.org/uniprot/MYG_PHYMC MYG_PHYMC]] Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 30:		Line 30:

	==See Also==		==See Also==
-	*[[Myoglobin\|Myoglobin]]	+	*[[Myoglobin 3D structures\|Myoglobin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 07:11, 29 May 2019

OCA — Wed, 29 May 2019 07:11:29 GMT

←Older revision		Revision as of 07:11, 29 May 2019
Line 1:		Line 1:

	==RECOMBINANT SPERM WHALE MYOGLOBIN L104A MUTANT (MET)==		==RECOMBINANT SPERM WHALE MYOGLOBIN L104A MUTANT (MET)==
-	<StructureSection load='1co8' size='340' side='right' caption='[[1co8]], [[Resolution\|resolution]] 1.80Å' scene=''>	+	<StructureSection load='1co8' size='340' side='right'caption='[[1co8]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1co8]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CO8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1CO8 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1co8]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CO8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1CO8 FirstGlance]. <br>
Line 13:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/co/1co8_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/co/1co8_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 35:		Line 35:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Liong, E C]]		[[Category: Liong, E C]]
	[[Category: Phillips, G N]]		[[Category: Phillips, G N]]

OCA at 11:20, 24 August 2017

OCA — Thu, 24 Aug 2017 11:20:00 GMT

←Older revision		Revision as of 11:20, 24 August 2017
Line 1:		Line 1:
		+
	==RECOMBINANT SPERM WHALE MYOGLOBIN L104A MUTANT (MET)==		==RECOMBINANT SPERM WHALE MYOGLOBIN L104A MUTANT (MET)==
	<StructureSection load='1co8' size='340' side='right' caption='[[1co8]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='1co8' size='340' side='right' caption='[[1co8]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1co8]] is a 1 chain structure ~~with sequence from [http://en.wikipedia.org/wiki/Phycd Phycd]~~. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CO8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1CO8 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1co8]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CO8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1CO8 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1co8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1co8 OCA], [http://pdbe.org/1co8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1co8 RCSB], [http://www.ebi.ac.uk/pdbsum/1co8 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1co8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1co8 OCA], [http://pdbe.org/1co8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1co8 RCSB], [http://www.ebi.ac.uk/pdbsum/1co8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1co8 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 16:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1co8 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 34:		Line 35:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Phycd]]
	[[Category: Liong, E C]]		[[Category: Liong, E C]]
	[[Category: Phillips, G N]]		[[Category: Phillips, G N]]

OCA at 08:27, 11 September 2015

OCA — Fri, 11 Sep 2015 08:27:28 GMT

←Older revision		Revision as of 08:27, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='1co8' size='340' side='right' caption='[[1co8]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='1co8' size='340' side='right' caption='[[1co8]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1co8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Physeter_catodon Physeter catodon~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CO8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1CO8 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1co8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Phycd Phycd]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CO8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1CO8 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1co8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1co8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1co8 RCSB], [http://www.ebi.ac.uk/pdbsum/1co8 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1co8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1co8 OCA], [http://pdbe.org/1co8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1co8 RCSB], [http://www.ebi.ac.uk/pdbsum/1co8 PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 26:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1co8" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 33:		Line 34:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Physeter catodon~~]]	+	[[Category: Phycd]]
	[[Category: Liong, E C]]		[[Category: Liong, E C]]
	[[Category: Phillips, G N]]		[[Category: Phillips, G N]]

OCA at 13:52, 25 December 2014

OCA — Thu, 25 Dec 2014 13:52:21 GMT

←Older revision		Revision as of 13:52, 25 December 2014
Line 6:		Line 6:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1co8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1co8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1co8 RCSB], [http://www.ebi.ac.uk/pdbsum/1co8 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1co8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1co8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1co8 RCSB], [http://www.ebi.ac.uk/pdbsum/1co8 PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/MYG_PHYMC MYG_PHYMC]] Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 22:50, 22 December 2014

OCA — Mon, 22 Dec 2014 22:50:35 GMT

←Older revision		Revision as of 22:50, 22 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1co8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Physeter_catodon Physeter catodon]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CO8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1CO8 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1co8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Physeter_catodon Physeter catodon]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CO8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1CO8 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1co8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1co8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1co8 RCSB], [http://www.ebi.ac.uk/pdbsum/1co8 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1co8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1co8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1co8 RCSB], [http://www.ebi.ac.uk/pdbsum/1co8 PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 32:		Line 32:
	</StructureSection>		</StructureSection>
	[[Category: Physeter catodon]]		[[Category: Physeter catodon]]
-	[[Category: Liong, E C.]]	+	[[Category: Liong, E C]]
-	[[Category: Phillips, G N.]]	+	[[Category: Phillips, G N]]
	[[Category: Heme]]		[[Category: Heme]]
	[[Category: Muscle protein]]		[[Category: Muscle protein]]
	[[Category: Oxygen transport]]		[[Category: Oxygen transport]]

OCA at 09:24, 27 August 2014

OCA — Wed, 27 Aug 2014 09:24:30 GMT

←Older revision		Revision as of 09:24, 27 August 2014
Line 1:		Line 1:
-	[[~~Image~~:1co8.~~png\|left~~\|200px]]	+	==RECOMBINANT SPERM WHALE MYOGLOBIN L104A MUTANT (MET)==
		+	<StructureSection load='1co8' size='340' side='right' caption='[[1co8]], [[Resolution\|resolution]] 1.80Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1co8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Physeter_catodon Physeter catodon]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CO8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1CO8 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1co8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1co8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1co8 RCSB], [http://www.ebi.ac.uk/pdbsum/1co8 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/co/1co8_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The ability of myoglobin to bind oxygen reversibly depends critically on retention of the heme prosthetic group. Globin side chains at the Leu(89)(F4), His(97)(FG3), Ile(99)(FG5), and Leu(104)(G5) positions on the proximal side of the heme pocket strongly influence heme affinity. The roles of these amino acids in preventing heme loss have been examined by determining high resolution structures of 14 different mutants at these positions using x-ray crystallography. Leu(89) and His(97) are important surface amino acids that interact either sterically or electrostatically with the edges of the porphyrin ring. Ile(99) and Leu(104) are located in the interior region of the proximal pocket beneath ring C of the heme prosthetic group. The apolar amino acids Leu(89), Ile(99), and Leu(104) "waterproof" the heme pocket by forming a barrier to solvent penetration, minimizing the size of the proximal cavity, and maintaining a hydrophobic environment. Substitutions with smaller or polar side chains at these positions result in exposure of the heme to solvent, the appearance of crystallographically defined water molecules in or near the proximal pocket, and large increases in the rate of hemin loss. Thus, the naturally occurring amino acid side chains at these positions serve to prevent hydration of the His(93)-Fe(III) bond and are highly conserved in all known myoglobins and hemoglobins.

-	~~{{STRUCTURE_1co8\| PDB=1co8 \| SCENE= }}~~	+	Waterproofing the heme pocket. Role of proximal amino acid side chains in preventing hemin loss from myoglobin.,Liong EC, Dou Y, Scott EE, Olson JS, Phillips GN Jr J Biol Chem. 2001 Mar 23;276(12):9093-100. Epub 2000 Nov 17. PMID:11084036<ref>PMID:11084036</ref>

-	~~===RECOMBINANT SPERM WHALE MYOGLOBIN L104A MUTANT (MET)===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_11084036}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[1co8]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Physeter_catodon Physeter catodon]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1CO8 OCA].~~	+

	==See Also==		==See Also==
	*[[Myoglobin\|Myoglobin]]		*[[Myoglobin\|Myoglobin]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:011084036<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Physeter catodon]]		[[Category: Physeter catodon]]
	[[Category: Liong, E C.]]		[[Category: Liong, E C.]]

OCA at 17:28, 20 October 2012

OCA — Sat, 20 Oct 2012 17:28:15 GMT

←Older revision		Revision as of 17:28, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[1co8]] is a 1 chain structure ~~of [[Myoglobin]]~~ with sequence from [http://en.wikipedia.org/wiki/Physeter_catodon Physeter catodon]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CO8 OCA].	+	[[1co8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Physeter_catodon Physeter catodon]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CO8 OCA].

	==See Also==		==See Also==