1coe - Revision history

OCA at 15:41, 13 March 2024

OCA — Wed, 13 Mar 2024 15:41:09 GMT

←Older revision		Revision as of 15:41, 13 March 2024
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	==SOLUTION CONFORMATION OF COBROTOXIN: A NUCLEAR MAGNETIC RESONANCE AND HYBRID DISTANCE GEOMETRY-DYNAMICAL SIMULATED ANNEALING STUDY==		==SOLUTION CONFORMATION OF COBROTOXIN: A NUCLEAR MAGNETIC RESONANCE AND HYBRID DISTANCE GEOMETRY-DYNAMICAL SIMULATED ANNEALING STUDY==
-	<StructureSection load='1coe' size='340' side='right'caption='[[1coe~~]], [[NMR_Ensembles_of_Models \| 11 NMR models~~]]' scene=''>	+	<StructureSection load='1coe' size='340' side='right'caption='[[1coe]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1coe]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Ansp_6988 Ansp 6988~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1COE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1COE FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1coe]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Naja_atra Naja atra]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1COE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1COE FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style~~=~~'overflow: auto; max-height: 3em;'>[[1cod\|1cod]]</div~~></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1coe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1coe OCA], [https://pdbe.org/1coe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1coe RCSB], [https://www.ebi.ac.uk/pdbsum/1coe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1coe ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1coe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1coe OCA], [https://pdbe.org/1coe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1coe RCSB], [https://www.ebi.ac.uk/pdbsum/1coe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1coe ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/3S1CB_NAJAT 3S1CB_NAJAT]] Binds to muscle nicotinic acetylcholine receptor (nAChR) and inhibit acetylcholine from binding to the receptor, thereby impairing neuromuscular transmission. Has a higher toxicity than cobrotoxin-b.	+	[https://www.uniprot.org/uniprot/3S1CB_NAJAT 3S1CB_NAJAT] Binds to muscle nicotinic acetylcholine receptor (nAChR) and inhibit acetylcholine from binding to the receptor, thereby impairing neuromuscular transmission. Has a higher toxicity than cobrotoxin-b.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1coe ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1coe ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	The solution conformation of cobrotoxin has been determined by using proton nuclear magnetic resonance spectroscopy. With the combination of various two-dimensional NMR techniques, the 1H-NMR spectrum of cobrotoxin was completely assigned (Yu et al., 1990). A set of 435 approximate interproton distance restraints was derived from nuclear Overhauser enhancement (NOE) measurements. These NOE constraints, in addition to the 29 dihedral angle constraints (from coupling constant measurements) and 26 hydrogen bonding restraints (from the pattern of short-range NOEs), form the basis of 3-D structure determination by the hybrid distance geometry-dynamical simulated annealing method. The 23 structures that were obtained satisfy the experimental restraints, display small deviation from idealized covalent geometry, and possess good nonbonded contacts. Analysis of converged structures indicated that there are two antiparallel beta sheets (double and triple stranded), duly confirming our earlier observations. These are well defined in terms of both atomic root mean square (RMS) differences and backbone torsional angles. The average backbone RMS deviation between the calculated structures and the mean structure, for the beta-sheet regions, is 0.92 A. The mean solution structure was compared with the X-ray crystal structure of erabutoxin b, the homologous protein. This yielded information that both structures resemble each other except at the exposed loop/surface regions, where the solution structure seems to possess more flexibility.
-
-	Solution conformation of cobrotoxin: a nuclear magnetic resonance and hybrid distance geometry-dynamical simulated annealing study.,Yu C, Bhaskaran R, Chuang LC, Yang CC Biochemistry. 1993 Mar 9;32(9):2131-6. PMID:8443154<ref>PMID:8443154</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 1coe" style="background-color:#fffaf0;"></div>
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Ansp 6988]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Bhaskaran, R~~]]	+	[[Category: Naja atra]]
-	[[Category: ~~Yang, C C~~]]	+	[[Category: Bhaskaran R]]
-	[[Category: ~~Yu, C~~]]	+	[[Category: Yang CC]]
-	[[Category: ~~Short neurotoxin~~]]	+	[[Category: Yu C]]

OCA at 10:44, 19 May 2021

OCA — Wed, 19 May 2021 10:44:06 GMT

←Older revision		Revision as of 10:44, 19 May 2021
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	<StructureSection load='1coe' size='340' side='right'caption='[[1coe]], [[NMR_Ensembles_of_Models \| 11 NMR models]]' scene=''>		<StructureSection load='1coe' size='340' side='right'caption='[[1coe]], [[NMR_Ensembles_of_Models \| 11 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1coe]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Ansp_6988 Ansp 6988]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1COE OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1COE FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1coe]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Ansp_6988 Ansp 6988]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1COE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1COE FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1cod\|1cod]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1cod\|1cod]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1coe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1coe OCA], [~~http~~://pdbe.org/1coe PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1coe RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1coe PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1coe ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1coe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1coe OCA], [https://pdbe.org/1coe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1coe RCSB], [https://www.ebi.ac.uk/pdbsum/1coe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1coe ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/3S1CB_NAJAT 3S1CB_NAJAT]] Binds to muscle nicotinic acetylcholine receptor (nAChR) and inhibit acetylcholine from binding to the receptor, thereby impairing neuromuscular transmission. Has a higher toxicity than cobrotoxin-b.	+	[[https://www.uniprot.org/uniprot/3S1CB_NAJAT 3S1CB_NAJAT]] Binds to muscle nicotinic acetylcholine receptor (nAChR) and inhibit acetylcholine from binding to the receptor, thereby impairing neuromuscular transmission. Has a higher toxicity than cobrotoxin-b.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 18:05, 14 August 2019

OCA — Wed, 14 Aug 2019 18:05:53 GMT

←Older revision		Revision as of 18:05, 14 August 2019
Line 1:		Line 1:

	==SOLUTION CONFORMATION OF COBROTOXIN: A NUCLEAR MAGNETIC RESONANCE AND HYBRID DISTANCE GEOMETRY-DYNAMICAL SIMULATED ANNEALING STUDY==		==SOLUTION CONFORMATION OF COBROTOXIN: A NUCLEAR MAGNETIC RESONANCE AND HYBRID DISTANCE GEOMETRY-DYNAMICAL SIMULATED ANNEALING STUDY==
-	<StructureSection load='1coe' size='340' side='right' caption='[[1coe]], [[NMR_Ensembles_of_Models \| 11 NMR models]]' scene=''>	+	<StructureSection load='1coe' size='340' side='right'caption='[[1coe]], [[NMR_Ensembles_of_Models \| 11 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1coe]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Ansp_6988 Ansp 6988]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1COE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1COE FirstGlance]. <br>		<table><tr><td colspan='2'>[[1coe]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Ansp_6988 Ansp 6988]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1COE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1COE FirstGlance]. <br>
Line 13:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/co/1coe_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/co/1coe_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 33:		Line 33:
	</StructureSection>		</StructureSection>
	[[Category: Ansp 6988]]		[[Category: Ansp 6988]]
		+	[[Category: Large Structures]]
	[[Category: Bhaskaran, R]]		[[Category: Bhaskaran, R]]
	[[Category: Yang, C C]]		[[Category: Yang, C C]]
	[[Category: Yu, C]]		[[Category: Yu, C]]
	[[Category: Short neurotoxin]]		[[Category: Short neurotoxin]]

OCA at 10:45, 8 November 2017

OCA — Wed, 08 Nov 2017 10:45:48 GMT

←Older revision		Revision as of 10:45, 8 November 2017
Line 1:		Line 1:
		+
	==SOLUTION CONFORMATION OF COBROTOXIN: A NUCLEAR MAGNETIC RESONANCE AND HYBRID DISTANCE GEOMETRY-DYNAMICAL SIMULATED ANNEALING STUDY==		==SOLUTION CONFORMATION OF COBROTOXIN: A NUCLEAR MAGNETIC RESONANCE AND HYBRID DISTANCE GEOMETRY-DYNAMICAL SIMULATED ANNEALING STUDY==
	<StructureSection load='1coe' size='340' side='right' caption='[[1coe]], [[NMR_Ensembles_of_Models \| 11 NMR models]]' scene=''>		<StructureSection load='1coe' size='340' side='right' caption='[[1coe]], [[NMR_Ensembles_of_Models \| 11 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1coe]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Chinese_cobra Chinese cobra~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1COE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1COE FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1coe]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Ansp_6988 Ansp 6988]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1COE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1COE FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1cod\|1cod]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1cod\|1cod]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1coe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1coe OCA], [http://pdbe.org/1coe PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1coe RCSB], [http://www.ebi.ac.uk/pdbsum/1coe PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1coe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1coe OCA], [http://pdbe.org/1coe PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1coe RCSB], [http://www.ebi.ac.uk/pdbsum/1coe PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1coe ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Chinese cobra~~]]	+	[[Category: Ansp 6988]]
	[[Category: Bhaskaran, R]]		[[Category: Bhaskaran, R]]
	[[Category: Yang, C C]]		[[Category: Yang, C C]]
	[[Category: Yu, C]]		[[Category: Yu, C]]
	[[Category: Short neurotoxin]]		[[Category: Short neurotoxin]]

OCA at 09:17, 7 February 2016

OCA — Sun, 07 Feb 2016 09:17:36 GMT

←Older revision		Revision as of 09:17, 7 February 2016
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	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1coe ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 23:58, 9 September 2015

OCA — Wed, 09 Sep 2015 23:58:18 GMT

←Older revision		Revision as of 23:58, 9 September 2015
Line 2:		Line 2:
	<StructureSection load='1coe' size='340' side='right' caption='[[1coe]], [[NMR_Ensembles_of_Models \| 11 NMR models]]' scene=''>		<StructureSection load='1coe' size='340' side='right' caption='[[1coe]], [[NMR_Ensembles_of_Models \| 11 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1coe]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Naja_atra Naja atra~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1COE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1COE FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1coe]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Chinese_cobra Chinese cobra]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1COE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1COE FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1cod\|1cod]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1cod\|1cod]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1coe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1coe OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1coe RCSB], [http://www.ebi.ac.uk/pdbsum/1coe PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1coe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1coe OCA], [http://pdbe.org/1coe PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1coe RCSB], [http://www.ebi.ac.uk/pdbsum/1coe PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/3S1CB_NAJAT 3S1CB_NAJAT]] Binds to muscle nicotinic acetylcholine receptor (nAChR) and inhibit acetylcholine from binding to the receptor, thereby impairing neuromuscular transmission. Has a higher toxicity than cobrotoxin-b.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 24:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1coe" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Naja atra~~]]	+	[[Category: Chinese cobra]]
	[[Category: Bhaskaran, R]]		[[Category: Bhaskaran, R]]
	[[Category: Yang, C C]]		[[Category: Yang, C C]]
	[[Category: Yu, C]]		[[Category: Yu, C]]
	[[Category: Short neurotoxin]]		[[Category: Short neurotoxin]]

OCA at 21:26, 22 December 2014

OCA — Mon, 22 Dec 2014 21:26:59 GMT

←Older revision		Revision as of 21:26, 22 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1coe]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Naja_atra Naja atra]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1COE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1COE FirstGlance]. <br>		<table><tr><td colspan='2'>[[1coe]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Naja_atra Naja atra]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1COE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1COE FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1cod\|1cod]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1cod\|1cod]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1coe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1coe OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1coe RCSB], [http://www.ebi.ac.uk/pdbsum/1coe PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1coe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1coe OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1coe RCSB], [http://www.ebi.ac.uk/pdbsum/1coe PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Naja atra]]		[[Category: Naja atra]]
-	[[Category: Bhaskaran, R.]]	+	[[Category: Bhaskaran, R]]
-	[[Category: Yang, C C.]]	+	[[Category: Yang, C C]]
-	[[Category: Yu, C.]]	+	[[Category: Yu, C]]
	[[Category: Short neurotoxin]]		[[Category: Short neurotoxin]]

OCA at 09:13, 27 August 2014

OCA — Wed, 27 Aug 2014 09:13:50 GMT

←Older revision		Revision as of 09:13, 27 August 2014
Line 1:		Line 1:
-	[[~~Image:~~1coe.~~png~~\|~~left~~\|200px]]	+	==SOLUTION CONFORMATION OF COBROTOXIN: A NUCLEAR MAGNETIC RESONANCE AND HYBRID DISTANCE GEOMETRY-DYNAMICAL SIMULATED ANNEALING STUDY==
		+	<StructureSection load='1coe' size='340' side='right' caption='[[1coe]], [[NMR_Ensembles_of_Models \| 11 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1coe]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Naja_atra Naja atra]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1COE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1COE FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1cod\|1cod]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1coe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1coe OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1coe RCSB], [http://www.ebi.ac.uk/pdbsum/1coe PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/co/1coe_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The solution conformation of cobrotoxin has been determined by using proton nuclear magnetic resonance spectroscopy. With the combination of various two-dimensional NMR techniques, the 1H-NMR spectrum of cobrotoxin was completely assigned (Yu et al., 1990). A set of 435 approximate interproton distance restraints was derived from nuclear Overhauser enhancement (NOE) measurements. These NOE constraints, in addition to the 29 dihedral angle constraints (from coupling constant measurements) and 26 hydrogen bonding restraints (from the pattern of short-range NOEs), form the basis of 3-D structure determination by the hybrid distance geometry-dynamical simulated annealing method. The 23 structures that were obtained satisfy the experimental restraints, display small deviation from idealized covalent geometry, and possess good nonbonded contacts. Analysis of converged structures indicated that there are two antiparallel beta sheets (double and triple stranded), duly confirming our earlier observations. These are well defined in terms of both atomic root mean square (RMS) differences and backbone torsional angles. The average backbone RMS deviation between the calculated structures and the mean structure, for the beta-sheet regions, is 0.92 A. The mean solution structure was compared with the X-ray crystal structure of erabutoxin b, the homologous protein. This yielded information that both structures resemble each other except at the exposed loop/surface regions, where the solution structure seems to possess more flexibility.

-	~~{{STRUCTURE_1coe\| PDB=1coe \| SCENE= }}~~	+	Solution conformation of cobrotoxin: a nuclear magnetic resonance and hybrid distance geometry-dynamical simulated annealing study.,Yu C, Bhaskaran R, Chuang LC, Yang CC Biochemistry. 1993 Mar 9;32(9):2131-6. PMID:8443154<ref>PMID:8443154</ref>

-	~~===SOLUTION CONFORMATION OF COBROTOXIN: A NUCLEAR MAGNETIC RESONANCE AND HYBRID DISTANCE GEOMETRY-DYNAMICAL SIMULATED ANNEALING STUDY===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_8443154}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[1coe]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Naja_atra Naja atra]~~. ~~Full experimental information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1COE OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:008443154<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Naja atra]]		[[Category: Naja atra]]
	[[Category: Bhaskaran, R.]]		[[Category: Bhaskaran, R.]]

OCA: Protected "1coe" [edit=sysop:move=sysop]

OCA — Sun, 21 Oct 2012 20:34:25 GMT

Protected "1coe" [edit=sysop:move=sysop]

←Older revision

Revision as of 20:34, 21 October 2012

OCA at 20:34, 21 October 2012

OCA — Sun, 21 Oct 2012 20:34:23 GMT

←Older revision		Revision as of 20:34, 21 October 2012
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-	{{Seed}}
	[[Image:1coe.png\|left\|200px]]		[[Image:1coe.png\|left\|200px]]

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	{{STRUCTURE_1coe\| PDB=1coe \| SCENE= }}		{{STRUCTURE_1coe\| PDB=1coe \| SCENE= }}

	===SOLUTION CONFORMATION OF COBROTOXIN: A NUCLEAR MAGNETIC RESONANCE AND HYBRID DISTANCE GEOMETRY-DYNAMICAL SIMULATED ANNEALING STUDY===		===SOLUTION CONFORMATION OF COBROTOXIN: A NUCLEAR MAGNETIC RESONANCE AND HYBRID DISTANCE GEOMETRY-DYNAMICAL SIMULATED ANNEALING STUDY===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_8443154}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 8443154 is the PubMed ID number.
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	{{ABSTRACT_PUBMED_8443154}}		{{ABSTRACT_PUBMED_8443154}}

	==About this Structure==		==About this Structure==
-	~~1COE~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Naja_atra Naja atra]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1COE OCA].	+	[[1coe]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Naja_atra Naja atra]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1COE OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~8443154~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:008443154</ref><references group="xtra"/>
	[[Category: Naja atra]]		[[Category: Naja atra]]
	[[Category: Bhaskaran, R.]]		[[Category: Bhaskaran, R.]]
Line 29:		Line 17:
	[[Category: Yu, C.]]		[[Category: Yu, C.]]
	[[Category: Short neurotoxin]]		[[Category: Short neurotoxin]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 12:50:24 2009''