1cr9 - Revision history

OCA at 15:41, 13 March 2024

OCA — Wed, 13 Mar 2024 15:41:57 GMT

←Older revision		Revision as of 15:41, 13 March 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1cr9]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CR9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1CR9 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1cr9]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CR9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1CR9 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1cr9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cr9 OCA], [https://pdbe.org/1cr9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1cr9 RCSB], [https://www.ebi.ac.uk/pdbsum/1cr9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1cr9 ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1cr9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cr9 OCA], [https://pdbe.org/1cr9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1cr9 RCSB], [https://www.ebi.ac.uk/pdbsum/1cr9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1cr9 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 16:		Line 17:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1cr9 ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1cr9 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	The X-ray crystallographic structures of the anti-Syrian hamster prion protein (SHaPrP) monoclonal Fab 3F4 alone, as well as the complex with its cognate peptide epitope (SHaPrP 104-113), have been determined to atomic resolution. The conformation of the decapeptide is an Omega-loop. There are substantial alterations in the antibody combining region upon epitope binding. The peptide binds in a U-shaped groove on the Fab surface, with the two specificity determinants, Met109 and Met112, penetrating deeply into separate hydrophobic cavities formed by the heavy and light chain complementarity-determining regions. In addition to the numerous contacts between the Fab and the peptide, two intrapeptide hydrogen bonds are observed, perhaps indicating the structure bound to the Fab exists transiently in solution. This provides the first structural information on a portion of the PrP N-terminal region observed to be flexible in the NMR studies of SHPrP 90-231, SHaPrP 29-231 and mouse PrP 23-231. Antibody characterization of the antigenic surfaces of PrPC and PrPSc identifies this flexible region as a component of the conformational rearrangement that is an essential feature of prion disease.
-
-	Antibody binding defines a structure for an epitope that participates in the PrPC-->PrPSc conformational change.,Kanyo ZF, Pan KM, Williamson RA, Burton DR, Prusiner SB, Fletterick RJ, Cohen FE J Mol Biol. 1999 Nov 5;293(4):855-63. PMID:10543972<ref>PMID:10543972</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 1cr9" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 30:		Line 22:
	*[[Sandbox 20009\|Sandbox 20009]]		*[[Sandbox 20009\|Sandbox 20009]]
	*[[3D structures of non-human antibody\|3D structures of non-human antibody]]		*[[3D structures of non-human antibody\|3D structures of non-human antibody]]
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
-	[[Category: Burton~~, D R~~]]	+	[[Category: Burton DR]]
-	[[Category: Cohen~~, F E~~]]	+	[[Category: Cohen FE]]
-	[[Category: Fletterick~~, R J~~]]	+	[[Category: Fletterick RJ]]
-	[[Category: Kanyo~~, Z F~~]]	+	[[Category: Kanyo ZF]]
-	[[Category: Pan~~, K M~~]]	+	[[Category: Pan KM]]
-	[[Category: Prusiner~~, S B~~]]	+	[[Category: Prusiner SB]]
-	[[Category: Williamson~~, R A]]~~	+	[[Category: Williamson RA]]
-	~~[[Category: Anti-prion antibody]]~~	+
-	~~[[Category: Fab 3f4]]~~	+
-	~~[[Category: Immune system~~]]	+

OCA at 13:10, 13 October 2021

OCA — Wed, 13 Oct 2021 13:10:27 GMT

←Older revision		Revision as of 13:10, 13 October 2021
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	<StructureSection load='1cr9' size='340' side='right'caption='[[1cr9]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='1cr9' size='340' side='right'caption='[[1cr9]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1cr9]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CR9 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1CR9 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1cr9]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CR9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1CR9 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1cr9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cr9 OCA], [~~http~~://pdbe.org/1cr9 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1cr9 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1cr9 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1cr9 ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1cr9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cr9 OCA], [https://pdbe.org/1cr9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1cr9 RCSB], [https://www.ebi.ac.uk/pdbsum/1cr9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1cr9 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 28:		Line 28:
	==See Also==		==See Also==
	*[[Antibody 3D structures\|Antibody 3D structures]]		*[[Antibody 3D structures\|Antibody 3D structures]]
		+	*[[Sandbox 20009\|Sandbox 20009]]
		+	*[[3D structures of non-human antibody\|3D structures of non-human antibody]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 10:17, 8 January 2020

OCA — Wed, 08 Jan 2020 10:17:08 GMT

←Older revision		Revision as of 10:17, 8 January 2020
Line 1:		Line 1:

	==CRYSTAL STRUCTURE OF THE ANTI-PRION FAB 3F4==		==CRYSTAL STRUCTURE OF THE ANTI-PRION FAB 3F4==
-	<StructureSection load='1cr9' size='340' side='right' caption='[[1cr9]], [[Resolution\|resolution]] 2.00Å' scene=''>	+	<StructureSection load='1cr9' size='340' side='right'caption='[[1cr9]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1cr9]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CR9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1CR9 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1cr9]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CR9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1CR9 FirstGlance]. <br>
Line 32:		Line 32:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Burton, D R]]		[[Category: Burton, D R]]

OCA at 06:08, 4 April 2018

OCA — Wed, 04 Apr 2018 06:08:15 GMT

←Older revision		Revision as of 06:08, 4 April 2018
Line 27:		Line 27:

	==See Also==		==See Also==
-	*[[3D structures ~~of antibody~~\|3D structures ~~of antibody~~]]	+	*[[Antibody 3D structures\|Antibody 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 08:31, 6 December 2017

OCA — Wed, 06 Dec 2017 08:31:16 GMT

←Older revision		Revision as of 08:31, 6 December 2017
Line 1:		Line 1:
		+
	==CRYSTAL STRUCTURE OF THE ANTI-PRION FAB 3F4==		==CRYSTAL STRUCTURE OF THE ANTI-PRION FAB 3F4==
	<StructureSection load='1cr9' size='340' side='right' caption='[[1cr9]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='1cr9' size='340' side='right' caption='[[1cr9]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1cr9]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CR9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1CR9 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1cr9]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CR9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1CR9 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1cr9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cr9 OCA], [http://pdbe.org/1cr9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1cr9 RCSB], [http://www.ebi.ac.uk/pdbsum/1cr9 PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1cr9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cr9 OCA], [http://pdbe.org/1cr9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1cr9 RCSB], [http://www.ebi.ac.uk/pdbsum/1cr9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1cr9 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 9:		Line 10:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cr/1cr9_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cr/1cr9_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 26:		Line 27:

	==See Also==		==See Also==
-	*[[~~Antibody~~\|~~Antibody~~]]	+	*[[3D structures of antibody\|3D structures of antibody]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 21:36, 8 February 2016

OCA — Mon, 08 Feb 2016 21:36:59 GMT

←Older revision		Revision as of 21:36, 8 February 2016
Line 13:		Line 13:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1cr9 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 15:36, 10 September 2015

OCA — Thu, 10 Sep 2015 15:36:32 GMT

←Older revision		Revision as of 15:36, 10 September 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1cr9]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CR9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1CR9 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1cr9]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CR9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1CR9 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1cr9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cr9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1cr9 RCSB], [http://www.ebi.ac.uk/pdbsum/1cr9 PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1cr9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cr9 OCA], [http://pdbe.org/1cr9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1cr9 RCSB], [http://www.ebi.ac.uk/pdbsum/1cr9 PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 23:		Line 23:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1cr9" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 00:18, 23 December 2014

OCA — Tue, 23 Dec 2014 00:18:55 GMT

←Older revision		Revision as of 00:18, 23 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1cr9]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CR9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1CR9 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1cr9]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CR9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1CR9 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1cr9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cr9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1cr9 RCSB], [http://www.ebi.ac.uk/pdbsum/1cr9 PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1cr9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cr9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1cr9 RCSB], [http://www.ebi.ac.uk/pdbsum/1cr9 PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 31:		Line 31:
	</StructureSection>		</StructureSection>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
-	[[Category: Burton, D R.]]	+	[[Category: Burton, D R]]
-	[[Category: Cohen, F E.]]	+	[[Category: Cohen, F E]]
-	[[Category: Fletterick, R J.]]	+	[[Category: Fletterick, R J]]
-	[[Category: Kanyo, Z F.]]	+	[[Category: Kanyo, Z F]]
-	[[Category: Pan, K M.]]	+	[[Category: Pan, K M]]
-	[[Category: Prusiner, S B.]]	+	[[Category: Prusiner, S B]]
-	[[Category: Williamson, R A.]]	+	[[Category: Williamson, R A]]
	[[Category: Anti-prion antibody]]		[[Category: Anti-prion antibody]]
	[[Category: Fab 3f4]]		[[Category: Fab 3f4]]
	[[Category: Immune system]]		[[Category: Immune system]]

OCA at 09:21, 27 August 2014

OCA — Wed, 27 Aug 2014 09:21:22 GMT

←Older revision		Revision as of 09:21, 27 August 2014
Line 1:		Line 1:
-	[[~~Image~~:1cr9.~~png\|left~~\|200px]]	+	==CRYSTAL STRUCTURE OF THE ANTI-PRION FAB 3F4==
		+	<StructureSection load='1cr9' size='340' side='right' caption='[[1cr9]], [[Resolution\|resolution]] 2.00Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1cr9]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CR9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1CR9 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1cr9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cr9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1cr9 RCSB], [http://www.ebi.ac.uk/pdbsum/1cr9 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cr/1cr9_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The X-ray crystallographic structures of the anti-Syrian hamster prion protein (SHaPrP) monoclonal Fab 3F4 alone, as well as the complex with its cognate peptide epitope (SHaPrP 104-113), have been determined to atomic resolution. The conformation of the decapeptide is an Omega-loop. There are substantial alterations in the antibody combining region upon epitope binding. The peptide binds in a U-shaped groove on the Fab surface, with the two specificity determinants, Met109 and Met112, penetrating deeply into separate hydrophobic cavities formed by the heavy and light chain complementarity-determining regions. In addition to the numerous contacts between the Fab and the peptide, two intrapeptide hydrogen bonds are observed, perhaps indicating the structure bound to the Fab exists transiently in solution. This provides the first structural information on a portion of the PrP N-terminal region observed to be flexible in the NMR studies of SHPrP 90-231, SHaPrP 29-231 and mouse PrP 23-231. Antibody characterization of the antigenic surfaces of PrPC and PrPSc identifies this flexible region as a component of the conformational rearrangement that is an essential feature of prion disease.

-	~~{{STRUCTURE_1cr9\| PDB=1cr9 \| SCENE= }}~~	+	Antibody binding defines a structure for an epitope that participates in the PrPC-->PrPSc conformational change.,Kanyo ZF, Pan KM, Williamson RA, Burton DR, Prusiner SB, Fletterick RJ, Cohen FE J Mol Biol. 1999 Nov 5;293(4):855-63. PMID:10543972<ref>PMID:10543972</ref>

-	~~===CRYSTAL STRUCTURE OF THE ANTI-PRION FAB 3F4===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_10543972}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[1cr9]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Mus_musculus Mus musculus]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1CR9 OCA].~~	+

	==See Also==		==See Also==
	*[[Antibody\|Antibody]]		*[[Antibody\|Antibody]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:010543972<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Burton, D R.]]		[[Category: Burton, D R.]]

OCA at 11:33, 20 October 2012

OCA — Sat, 20 Oct 2012 11:33:16 GMT

←Older revision		Revision as of 11:33, 20 October 2012
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	==About this Structure==		==About this Structure==
-	[[1cr9]] is a 2 chain structure ~~of [[Antibody]]~~ with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CR9 OCA].	+	[[1cr9]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CR9 OCA].

	==See Also==		==See Also==