1cto - Revision history

OCA at 15:43, 13 March 2024

OCA — Wed, 13 Mar 2024 15:43:11 GMT

←Older revision		Revision as of 15:43, 13 March 2024
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	==NMR STRUCTURE OF THE C-TERMINAL DOMAIN OF THE LIGAND-BINDING REGION OF MURINE GRANULOCYTE COLONY-STIMULATING FACTOR RECEPTOR, MINIMIZED AVERAGE STRUCTURE==		==NMR STRUCTURE OF THE C-TERMINAL DOMAIN OF THE LIGAND-BINDING REGION OF MURINE GRANULOCYTE COLONY-STIMULATING FACTOR RECEPTOR, MINIMIZED AVERAGE STRUCTURE==
-	<StructureSection load='1cto' size='340' side='right'caption='[[1cto~~]], [[NMR_Ensembles_of_Models \| 1 NMR models~~]]' scene=''>	+	<StructureSection load='1cto' size='340' side='right'caption='[[1cto]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1cto]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CTO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1CTO FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1cto]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CTO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1CTO FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1cto FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cto OCA], [https://pdbe.org/1cto PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1cto RCSB], [https://www.ebi.ac.uk/pdbsum/1cto PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1cto ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1cto FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cto OCA], [https://pdbe.org/1cto PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1cto RCSB], [https://www.ebi.ac.uk/pdbsum/1cto PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1cto ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/CSF3R_MOUSE CSF3R_MOUSE]] Receptor for granulocyte colony-stimulating factor (CSF3). In addition it may function in some adhesion or recognition events at the cell surface.	+	[https://www.uniprot.org/uniprot/CSF3R_MOUSE CSF3R_MOUSE] Receptor for granulocyte colony-stimulating factor (CSF3). In addition it may function in some adhesion or recognition events at the cell surface.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 18:		Line 19:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1cto ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1cto ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	We have determined the NMR structure of a ligand-binding domain of the granulocyte colony-stimulating factor (G-CSF) receptor, containing the highly conserved WSxWS motif. The domain consists of seven beta-strands with the fibronectin type III-like topology seen in several cytokine receptors. Comparisons between the spectra of the 15N-labelled domain with and without G-CSF indicate that the major ligand-recognition site is on the FG loop just upstream of the WSxWS sequence, and not on the BC loop which is mainly used in the growth hormone system. The WSxWS residues are suggested to contribute to ligand-recognition and to the protein architecture of the G-CSF receptor.
-
-	Solution structure of an extracellular domain containing the WSxWS motif of the granulocyte colony-stimulating factor receptor and its interaction with ligand.,Yamasaki K, Naito S, Anaguchi H, Ohkubo T, Ota Y Nat Struct Biol. 1997 Jun;4(6):498-504. PMID:9187659<ref>PMID:9187659</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 1cto" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
	*[[Colony-stimulating factor 3D structures\|Colony-stimulating factor 3D structures]]		*[[Colony-stimulating factor 3D structures\|Colony-stimulating factor 3D structures]]
	*[[Colony-stimulating factor receptor 3D structures\|Colony-stimulating factor receptor 3D structures]]		*[[Colony-stimulating factor receptor 3D structures\|Colony-stimulating factor receptor 3D structures]]
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Lk3 transgenic mice~~]]	+	[[Category: Mus musculus]]
-	[[Category: Anaguchi, H]]	+	[[Category: Anaguchi H]]
-	[[Category: Naito, S]]	+	[[Category: Naito S]]
-	[[Category: Ohkubo, T]]	+	[[Category: Ohkubo T]]
-	[[Category: Ota, Y]]	+	[[Category: Ota Y]]
-	[[Category: Yamasaki, K]]	+	[[Category: Yamasaki K]]
-	~~[[Category: Binding protein]]~~	+
-	~~[[Category: Cytokine receptor~~]]	+

OCA at 07:14, 22 September 2021

OCA — Wed, 22 Sep 2021 07:14:37 GMT

←Older revision		Revision as of 07:14, 22 September 2021
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	<StructureSection load='1cto' size='340' side='right'caption='[[1cto]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>		<StructureSection load='1cto' size='340' side='right'caption='[[1cto]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1cto]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CTO OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1CTO FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1cto]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CTO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1CTO FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1cto FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cto OCA], [~~http~~://pdbe.org/1cto PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1cto RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1cto PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1cto ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1cto FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cto OCA], [https://pdbe.org/1cto PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1cto RCSB], [https://www.ebi.ac.uk/pdbsum/1cto PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1cto ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/CSF3R_MOUSE CSF3R_MOUSE]] Receptor for granulocyte colony-stimulating factor (CSF3). In addition it may function in some adhesion or recognition events at the cell surface.	+	[[https://www.uniprot.org/uniprot/CSF3R_MOUSE CSF3R_MOUSE]] Receptor for granulocyte colony-stimulating factor (CSF3). In addition it may function in some adhesion or recognition events at the cell surface.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 13:49, 18 December 2019

OCA — Wed, 18 Dec 2019 13:49:31 GMT

←Older revision		Revision as of 13:49, 18 December 2019
Line 1:		Line 1:

	==NMR STRUCTURE OF THE C-TERMINAL DOMAIN OF THE LIGAND-BINDING REGION OF MURINE GRANULOCYTE COLONY-STIMULATING FACTOR RECEPTOR, MINIMIZED AVERAGE STRUCTURE==		==NMR STRUCTURE OF THE C-TERMINAL DOMAIN OF THE LIGAND-BINDING REGION OF MURINE GRANULOCYTE COLONY-STIMULATING FACTOR RECEPTOR, MINIMIZED AVERAGE STRUCTURE==
-	<StructureSection load='1cto' size='340' side='right' caption='[[1cto]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>	+	<StructureSection load='1cto' size='340' side='right'caption='[[1cto]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1cto]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CTO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1CTO FirstGlance]. <br>		<table><tr><td colspan='2'>[[1cto]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CTO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1CTO FirstGlance]. <br>
Line 27:		Line 27:
	</div>		</div>
	<div class="pdbe-citations 1cto" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1cto" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Colony-stimulating factor 3D structures\|Colony-stimulating factor 3D structures]]
		+	*[[Colony-stimulating factor receptor 3D structures\|Colony-stimulating factor receptor 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Lk3 transgenic mice]]		[[Category: Lk3 transgenic mice]]
	[[Category: Anaguchi, H]]		[[Category: Anaguchi, H]]

OCA at 08:27, 6 December 2017

OCA — Wed, 06 Dec 2017 08:27:47 GMT

←Older revision		Revision as of 08:27, 6 December 2017
Line 1:		Line 1:
		+
	==NMR STRUCTURE OF THE C-TERMINAL DOMAIN OF THE LIGAND-BINDING REGION OF MURINE GRANULOCYTE COLONY-STIMULATING FACTOR RECEPTOR, MINIMIZED AVERAGE STRUCTURE==		==NMR STRUCTURE OF THE C-TERMINAL DOMAIN OF THE LIGAND-BINDING REGION OF MURINE GRANULOCYTE COLONY-STIMULATING FACTOR RECEPTOR, MINIMIZED AVERAGE STRUCTURE==
	<StructureSection load='1cto' size='340' side='right' caption='[[1cto]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>		<StructureSection load='1cto' size='340' side='right' caption='[[1cto]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1cto]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CTO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1CTO FirstGlance]. <br>		<table><tr><td colspan='2'>[[1cto]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CTO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1CTO FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1cto FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cto OCA], [http://pdbe.org/1cto PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1cto RCSB], [http://www.ebi.ac.uk/pdbsum/1cto PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1cto FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cto OCA], [http://pdbe.org/1cto PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1cto RCSB], [http://www.ebi.ac.uk/pdbsum/1cto PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1cto ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 11:		Line 12:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ct/1cto_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ct/1cto_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 16:36, 9 February 2016

OCA — Tue, 09 Feb 2016 16:36:12 GMT

←Older revision		Revision as of 16:36, 9 February 2016
Line 15:		Line 15:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1cto ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 00:07, 11 September 2015

OCA — Fri, 11 Sep 2015 00:07:30 GMT

←Older revision		Revision as of 00:07, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='1cto' size='340' side='right' caption='[[1cto]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>		<StructureSection load='1cto' size='340' side='right' caption='[[1cto]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1cto]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Mus_musculus Mus musculus~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CTO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1CTO FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1cto]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CTO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1CTO FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1cto FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cto OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1cto RCSB], [http://www.ebi.ac.uk/pdbsum/1cto PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1cto FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cto OCA], [http://pdbe.org/1cto PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1cto RCSB], [http://www.ebi.ac.uk/pdbsum/1cto PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1cto" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Mus musculus~~]]	+	[[Category: Lk3 transgenic mice]]
	[[Category: Anaguchi, H]]		[[Category: Anaguchi, H]]
	[[Category: Naito, S]]		[[Category: Naito, S]]

OCA at 08:06, 25 December 2014

OCA — Thu, 25 Dec 2014 08:06:26 GMT

←Older revision		Revision as of 08:06, 25 December 2014
Line 5:		Line 5:
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1cto FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cto OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1cto RCSB], [http://www.ebi.ac.uk/pdbsum/1cto PDBsum]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1cto FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cto OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1cto RCSB], [http://www.ebi.ac.uk/pdbsum/1cto PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/CSF3R_MOUSE CSF3R_MOUSE]] Receptor for granulocyte colony-stimulating factor (CSF3). In addition it may function in some adhesion or recognition events at the cell surface.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 20:16, 22 December 2014

OCA — Mon, 22 Dec 2014 20:16:07 GMT

←Older revision		Revision as of 20:16, 22 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1cto]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CTO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1CTO FirstGlance]. <br>		<table><tr><td colspan='2'>[[1cto]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CTO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1CTO FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1cto FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cto OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1cto RCSB], [http://www.ebi.ac.uk/pdbsum/1cto PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1cto FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cto OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1cto RCSB], [http://www.ebi.ac.uk/pdbsum/1cto PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
-	[[Category: Anaguchi, H.]]	+	[[Category: Anaguchi, H]]
-	[[Category: Naito, S.]]	+	[[Category: Naito, S]]
-	[[Category: Ohkubo, T.]]	+	[[Category: Ohkubo, T]]
-	[[Category: Ota, Y.]]	+	[[Category: Ota, Y]]
-	[[Category: Yamasaki, K.]]	+	[[Category: Yamasaki, K]]
	[[Category: Binding protein]]		[[Category: Binding protein]]
	[[Category: Cytokine receptor]]		[[Category: Cytokine receptor]]

OCA at 09:18, 27 August 2014

OCA — Wed, 27 Aug 2014 09:18:13 GMT

←Older revision		Revision as of 09:18, 27 August 2014
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-	[[~~Image~~:1cto.~~png\|left~~\|200px]]	+	==NMR STRUCTURE OF THE C-TERMINAL DOMAIN OF THE LIGAND-BINDING REGION OF MURINE GRANULOCYTE COLONY-STIMULATING FACTOR RECEPTOR, MINIMIZED AVERAGE STRUCTURE==
		+	<StructureSection load='1cto' size='340' side='right' caption='[[1cto]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1cto]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CTO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1CTO FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1cto FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cto OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1cto RCSB], [http://www.ebi.ac.uk/pdbsum/1cto PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ct/1cto_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	We have determined the NMR structure of a ligand-binding domain of the granulocyte colony-stimulating factor (G-CSF) receptor, containing the highly conserved WSxWS motif. The domain consists of seven beta-strands with the fibronectin type III-like topology seen in several cytokine receptors. Comparisons between the spectra of the 15N-labelled domain with and without G-CSF indicate that the major ligand-recognition site is on the FG loop just upstream of the WSxWS sequence, and not on the BC loop which is mainly used in the growth hormone system. The WSxWS residues are suggested to contribute to ligand-recognition and to the protein architecture of the G-CSF receptor.

-	~~{{STRUCTURE_1cto\| PDB=1cto \| SCENE= }}~~	+	Solution structure of an extracellular domain containing the WSxWS motif of the granulocyte colony-stimulating factor receptor and its interaction with ligand.,Yamasaki K, Naito S, Anaguchi H, Ohkubo T, Ota Y Nat Struct Biol. 1997 Jun;4(6):498-504. PMID:9187659<ref>PMID:9187659</ref>

-	~~===NMR STRUCTURE OF THE C-TERMINAL DOMAIN OF THE LIGAND-BINDING REGION OF MURINE GRANULOCYTE COLONY-STIMULATING FACTOR RECEPTOR~~, ~~MINIMIZED AVERAGE STRUCTURE===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_9187659}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[1cto]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Mus_musculus Mus musculus]~~. ~~Full experimental information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1CTO OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:009187659<~~/~~ref~~><~~ref group="xtra">PMID:010656800</ref><references group="xtra"~~/>	+
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Anaguchi, H.]]		[[Category: Anaguchi, H.]]

OCA: Protected "1cto" [edit=sysop:move=sysop]

OCA — Sun, 21 Oct 2012 20:12:23 GMT

Protected "1cto" [edit=sysop:move=sysop]

←Older revision

Revision as of 20:12, 21 October 2012