1cvz - Revision history

OCA at 09:34, 21 December 2022

OCA — Wed, 21 Dec 2022 09:34:19 GMT

←Older revision		Revision as of 09:34, 21 December 2022
Line 5:		Line 5:
	<table><tr><td colspan='2'>[[1cvz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Carica_papaya Carica papaya]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CVZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1CVZ FirstGlance]. <br>		<table><tr><td colspan='2'>[[1cvz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Carica_papaya Carica papaya]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CVZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1CVZ FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=C48:N1-(1-DIMETHYLCARBAMOYL-2-PHENYL-ETHYL)-2-OXO-N4-(2-PYRIDIN-2-YL-ETHYL)-SUCCINAMIDE'>C48</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=C48:N1-(1-DIMETHYLCARBAMOYL-2-PHENYL-ETHYL)-2-OXO-N4-(2-PYRIDIN-2-YL-ETHYL)-SUCCINAMIDE'>C48</scene></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Papain Papain], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.2 3.4.22.2] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1cvz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cvz OCA], [https://pdbe.org/1cvz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1cvz RCSB], [https://www.ebi.ac.uk/pdbsum/1cvz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1cvz ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1cvz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cvz OCA], [https://pdbe.org/1cvz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1cvz RCSB], [https://www.ebi.ac.uk/pdbsum/1cvz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1cvz ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/PAPA1_CARPA PAPA1_CARPA]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 36:		Line 37:
	[[Category: Carica papaya]]		[[Category: Carica papaya]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: Papain]]~~	+	[[Category: Tsuge H]]
-	[[Category: Tsuge, H]]	+
-	~~[[Category: Cathepsin l inhibitor]]~~	+
-	~~[[Category: Clik148]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Sulfhydryl proteinase~~]]	+

OCA at 15:19, 3 March 2021

OCA — Wed, 03 Mar 2021 15:19:31 GMT

←Older revision		Revision as of 15:19, 3 March 2021
Line 3:		Line 3:
	<StructureSection load='1cvz' size='340' side='right'caption='[[1cvz]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='1cvz' size='340' side='right'caption='[[1cvz]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1cvz]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Carica_papaya Carica papaya]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CVZ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1CVZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1cvz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Carica_papaya Carica papaya]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CVZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1CVZ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=C48:N1-(1-DIMETHYLCARBAMOYL-2-PHENYL-ETHYL)-2-OXO-N4-(2-PYRIDIN-2-YL-ETHYL)-SUCCINAMIDE'>C48</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=C48:N1-(1-DIMETHYLCARBAMOYL-2-PHENYL-ETHYL)-2-OXO-N4-(2-PYRIDIN-2-YL-ETHYL)-SUCCINAMIDE'>C48</scene></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Papain Papain], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.2 3.4.22.2] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Papain Papain], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.2 3.4.22.2] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1cvz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cvz OCA], [~~http~~://pdbe.org/1cvz PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1cvz RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1cvz PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1cvz ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1cvz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cvz OCA], [https://pdbe.org/1cvz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1cvz RCSB], [https://www.ebi.ac.uk/pdbsum/1cvz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1cvz ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 07:15, 29 May 2019

OCA — Wed, 29 May 2019 07:15:11 GMT

←Older revision		Revision as of 07:15, 29 May 2019
Line 1:		Line 1:

	==CRYSTAL STRUCTURE ANALYSIS OF PAPAIN WITH CLIK148(CATHEPSIN L SPECIFIC INHIBITOR)==		==CRYSTAL STRUCTURE ANALYSIS OF PAPAIN WITH CLIK148(CATHEPSIN L SPECIFIC INHIBITOR)==
-	<StructureSection load='1cvz' size='340' side='right' caption='[[1cvz]], [[Resolution\|resolution]] 1.70Å' scene=''>	+	<StructureSection load='1cvz' size='340' side='right'caption='[[1cvz]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1cvz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Carica_papaya Carica papaya]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CVZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1CVZ FirstGlance]. <br>		<table><tr><td colspan='2'>[[1cvz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Carica_papaya Carica papaya]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CVZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1CVZ FirstGlance]. <br>
Line 12:		Line 12:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cv/1cvz_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cv/1cvz_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 35:		Line 35:
	</StructureSection>		</StructureSection>
	[[Category: Carica papaya]]		[[Category: Carica papaya]]
		+	[[Category: Large Structures]]
	[[Category: Papain]]		[[Category: Papain]]
	[[Category: Tsuge, H]]		[[Category: Tsuge, H]]

OCA at 11:22, 24 August 2017

OCA — Thu, 24 Aug 2017 11:22:45 GMT

←Older revision		Revision as of 11:22, 24 August 2017
Line 1:		Line 1:
		+
	==CRYSTAL STRUCTURE ANALYSIS OF PAPAIN WITH CLIK148(CATHEPSIN L SPECIFIC INHIBITOR)==		==CRYSTAL STRUCTURE ANALYSIS OF PAPAIN WITH CLIK148(CATHEPSIN L SPECIFIC INHIBITOR)==
	<StructureSection load='1cvz' size='340' side='right' caption='[[1cvz]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='1cvz' size='340' side='right' caption='[[1cvz]], [[Resolution\|resolution]] 1.70Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=C48:N1-(1-DIMETHYLCARBAMOYL-2-PHENYL-ETHYL)-2-OXO-N4-(2-PYRIDIN-2-YL-ETHYL)-SUCCINAMIDE'>C48</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=C48:N1-(1-DIMETHYLCARBAMOYL-2-PHENYL-ETHYL)-2-OXO-N4-(2-PYRIDIN-2-YL-ETHYL)-SUCCINAMIDE'>C48</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Papain Papain], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.2 3.4.22.2] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Papain Papain], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.2 3.4.22.2] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1cvz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cvz OCA], [http://pdbe.org/1cvz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1cvz RCSB], [http://www.ebi.ac.uk/pdbsum/1cvz PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1cvz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cvz OCA], [http://pdbe.org/1cvz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1cvz RCSB], [http://www.ebi.ac.uk/pdbsum/1cvz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1cvz ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 15:		Line 16:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1cvz ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 13:47, 11 September 2015

OCA — Fri, 11 Sep 2015 13:47:57 GMT

←Older revision		Revision as of 13:47, 11 September 2015
Line 5:		Line 5:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=C48:N1-(1-DIMETHYLCARBAMOYL-2-PHENYL-ETHYL)-2-OXO-N4-(2-PYRIDIN-2-YL-ETHYL)-SUCCINAMIDE'>C48</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=C48:N1-(1-DIMETHYLCARBAMOYL-2-PHENYL-ETHYL)-2-OXO-N4-(2-PYRIDIN-2-YL-ETHYL)-SUCCINAMIDE'>C48</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Papain Papain], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.2 3.4.22.2] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Papain Papain], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.2 3.4.22.2] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1cvz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cvz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1cvz RCSB], [http://www.ebi.ac.uk/pdbsum/1cvz PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1cvz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cvz OCA], [http://pdbe.org/1cvz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1cvz RCSB], [http://www.ebi.ac.uk/pdbsum/1cvz PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 25:		Line 25:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1cvz" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 22:04, 22 December 2014

OCA — Mon, 22 Dec 2014 22:04:42 GMT

←Older revision		Revision as of 22:04, 22 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1cvz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Carica_papaya Carica papaya]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CVZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1CVZ FirstGlance]. <br>		<table><tr><td colspan='2'>[[1cvz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Carica_papaya Carica papaya]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CVZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1CVZ FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=C48:N1-(1-DIMETHYLCARBAMOYL-2-PHENYL-ETHYL)-2-OXO-N4-(2-PYRIDIN-2-YL-ETHYL)-SUCCINAMIDE'>C48</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=C48:N1-(1-DIMETHYLCARBAMOYL-2-PHENYL-ETHYL)-2-OXO-N4-(2-PYRIDIN-2-YL-ETHYL)-SUCCINAMIDE'>C48</scene></td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Papain Papain], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.2 3.4.22.2] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Papain Papain], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.2 3.4.22.2] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1cvz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cvz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1cvz RCSB], [http://www.ebi.ac.uk/pdbsum/1cvz PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1cvz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cvz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1cvz RCSB], [http://www.ebi.ac.uk/pdbsum/1cvz PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 34:		Line 34:
	[[Category: Carica papaya]]		[[Category: Carica papaya]]
	[[Category: Papain]]		[[Category: Papain]]
-	[[Category: Tsuge, H.]]	+	[[Category: Tsuge, H]]
	[[Category: Cathepsin l inhibitor]]		[[Category: Cathepsin l inhibitor]]
	[[Category: Clik148]]		[[Category: Clik148]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
-	[[Category: Papain]]
	[[Category: Sulfhydryl proteinase]]		[[Category: Sulfhydryl proteinase]]

OCA at 09:27, 27 August 2014

OCA — Wed, 27 Aug 2014 09:27:17 GMT

←Older revision		Revision as of 09:27, 27 August 2014
Line 1:		Line 1:
-	[[~~Image~~:1cvz.~~png\|left~~\|200px]]	+	==CRYSTAL STRUCTURE ANALYSIS OF PAPAIN WITH CLIK148(CATHEPSIN L SPECIFIC INHIBITOR)==
		+	<StructureSection load='1cvz' size='340' side='right' caption='[[1cvz]], [[Resolution\|resolution]] 1.70Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1cvz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Carica_papaya Carica papaya]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CVZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1CVZ FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=C48:N1-(1-DIMETHYLCARBAMOYL-2-PHENYL-ETHYL)-2-OXO-N4-(2-PYRIDIN-2-YL-ETHYL)-SUCCINAMIDE'>C48</scene><br>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Papain Papain], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.2 3.4.22.2] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1cvz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cvz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1cvz RCSB], [http://www.ebi.ac.uk/pdbsum/1cvz PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cv/1cvz_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Papain was used as an experimental model structure to understand the inhibition mechanism of newly developed specific inhibitors of cathepsin L, the papain superfamily. Recently, we developed a series of cathepsin L-specific inhibitors which are called the CLIK series [(1999) FEBS Lett. 458, 6-10]. Here, we report the complex structure of papain with CLIK148, which is a representative inhibitor from the CLIK series. The inhibitor complex structure was solved at 1.7 A resolution with conventional R 0.177. Unlike other epoxisuccinate inhibitors (E64, CA030, and CA074), CLIK148 uses both prime and nonprime sites, which are important for the specific inhibitory effect on cathepsin L. Also, the specificity for cathepsin L could be explained by the existence of Phe in the P2 site and hydrophobic interaction of N-terminal pyridine ring.

-	~~{{STRUCTURE_1cvz\| PDB=1cvz \| SCENE= }}~~	+	Inhibition mechanism of cathepsin L-specific inhibitors based on the crystal structure of papain-CLIK148 complex.,Tsuge H, Nishimura T, Tada Y, Asao T, Turk D, Turk V, Katunuma N Biochem Biophys Res Commun. 1999 Dec 20;266(2):411-6. PMID:10600517<ref>PMID:10600517</ref>

-	~~===CRYSTAL STRUCTURE ANALYSIS OF PAPAIN WITH CLIK148(CATHEPSIN L SPECIFIC INHIBITOR)===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_10600517}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[1cvz]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Carica_papaya Carica papaya]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1CVZ OCA].~~	+

	==See Also==		==See Also==
	*[[Papain\|Papain]]		*[[Papain\|Papain]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:010600517<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Carica papaya]]		[[Category: Carica papaya]]
	[[Category: Papain]]		[[Category: Papain]]

OCA at 19:21, 20 October 2012

OCA — Sat, 20 Oct 2012 19:21:32 GMT

←Older revision		Revision as of 19:21, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[1cvz]] is a 1 chain structure ~~of [[Papain]]~~ with sequence from [http://en.wikipedia.org/wiki/Carica_papaya Carica papaya]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CVZ OCA].	+	[[1cvz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Carica_papaya Carica papaya]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CVZ OCA].

	==See Also==		==See Also==

OCA: Protected "1cvz" [edit=sysop:move=sysop]

OCA — Fri, 27 Jul 2012 07:05:56 GMT

Protected "1cvz" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:05, 27 July 2012

OCA at 07:05, 27 July 2012

OCA — Fri, 27 Jul 2012 07:05:55 GMT

←Older revision		Revision as of 07:05, 27 July 2012
Line 1:		Line 1:
-	{{Seed}}
	[[Image:1cvz.png\|left\|200px]]		[[Image:1cvz.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1cvz", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1cvz\| PDB=1cvz \| SCENE= }}		{{STRUCTURE_1cvz\| PDB=1cvz \| SCENE= }}

	===CRYSTAL STRUCTURE ANALYSIS OF PAPAIN WITH CLIK148(CATHEPSIN L SPECIFIC INHIBITOR)===		===CRYSTAL STRUCTURE ANALYSIS OF PAPAIN WITH CLIK148(CATHEPSIN L SPECIFIC INHIBITOR)===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_10600517}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 10600517 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_10600517}}		{{ABSTRACT_PUBMED_10600517}}

	==About this Structure==		==About this Structure==
-	~~1CVZ~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Carica_papaya Carica papaya]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CVZ OCA].	+	[[1cvz]] is a 1 chain structure of [[Papain]] with sequence from [http://en.wikipedia.org/wiki/Carica_papaya Carica papaya]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CVZ OCA].
		+
		+	==See Also==
		+	*[[Papain\|Papain]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~10600517~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:010600517</ref><references group="xtra"/>
	[[Category: Carica papaya]]		[[Category: Carica papaya]]
	[[Category: Papain]]		[[Category: Papain]]
Line 29:		Line 20:
	[[Category: Cathepsin l inhibitor]]		[[Category: Cathepsin l inhibitor]]
	[[Category: Clik148]]		[[Category: Clik148]]
		+	[[Category: Hydrolase]]
	[[Category: Papain]]		[[Category: Papain]]
	[[Category: Sulfhydryl proteinase]]		[[Category: Sulfhydryl proteinase]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 23:58:26 2009''