1czq - Revision history

OCA at 08:48, 7 December 2022

OCA — Wed, 07 Dec 2022 08:48:21 GMT

←Older revision		Revision as of 08:48, 7 December 2022
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	<StructureSection load='1czq' size='340' side='right'caption='[[1czq]], [[Resolution\|resolution]] 1.50Å' scene=''>		<StructureSection load='1czq' size='340' side='right'caption='[[1czq]], [[Resolution\|resolution]] 1.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1czq]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CZQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1CZQ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1czq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_immunodeficiency_virus Human immunodeficiency virus] and [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CZQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1CZQ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:~~CHLORIDE~~+~~ION~~'>CL</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=DAL:D-ALANINE'>DAL</scene>, <scene name='pdbligand=DAR:D-ARGININE'>DAR</scene>, <scene name='pdbligand=DCY:D-CYSTEINE'>DCY</scene>, <scene name='pdbligand=DGL:D-GLUTAMIC+ACID'>DGL</scene>, <scene name='pdbligand=DHI:D-HISTIDINE'>DHI</scene>, <scene name='pdbligand=DLE:D-LEUCINE'>DLE</scene>, <scene name='pdbligand=DTR:D-TRYPTOPHAN'>DTR</scene></td></tr>
-	~~<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat">~~<scene name='pdbligand=~~ACE~~:~~ACETYL~~+~~GROUP~~'>~~ACE~~</scene>, <scene name='pdbligand=DAL:D-ALANINE'>DAL</scene>, <scene name='pdbligand=DAR:D-ARGININE'>DAR</scene>, <scene name='pdbligand=DCY:D-CYSTEINE'>DCY</scene>, <scene name='pdbligand=DGL:D-GLUTAMIC+ACID'>DGL</scene>, <scene name='pdbligand=DHI:D-HISTIDINE'>DHI</scene>, <scene name='pdbligand=DLE:D-LEUCINE'>DLE</scene>, <scene name='pdbligand=DTR:D-TRYPTOPHAN'>DTR</scene></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1czq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1czq OCA], [https://pdbe.org/1czq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1czq RCSB], [https://www.ebi.ac.uk/pdbsum/1czq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1czq ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1czq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1czq OCA], [https://pdbe.org/1czq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1czq RCSB], [https://www.ebi.ac.uk/pdbsum/1czq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1czq ProSAT]</span></td></tr>
	</table>		</table>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human immunodeficiency virus]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Carr, P A~~]]	+	[[Category: Saccharomyces cerevisiae]]
-	[[Category: ~~Eckert, D M~~]]	+	[[Category: Carr PA]]
-	[[Category: ~~Hong, L H~~]]	+	[[Category: Eckert DM]]
-	[[Category: ~~Kim, P S~~]]	+	[[Category: Hong LH]]
-	[[Category: ~~Malashkevich, V N~~]]	+	[[Category: Kim PS]]
-	[[Category: ~~Envelope glycoprotein]]~~	+	[[Category: Malashkevich VN]]
-	~~[[Category: Viral protein-inhibitor complex~~]]	+

OCA at 15:20, 3 March 2021

OCA — Wed, 03 Mar 2021 15:20:34 GMT

←Older revision		Revision as of 15:20, 3 March 2021
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	<StructureSection load='1czq' size='340' side='right'caption='[[1czq]], [[Resolution\|resolution]] 1.50Å' scene=''>		<StructureSection load='1czq' size='340' side='right'caption='[[1czq]], [[Resolution\|resolution]] 1.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1czq]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CZQ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1CZQ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1czq]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CZQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1CZQ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=DAL:D-ALANINE'>DAL</scene>, <scene name='pdbligand=DAR:D-ARGININE'>DAR</scene>, <scene name='pdbligand=DCY:D-CYSTEINE'>DCY</scene>, <scene name='pdbligand=DGL:D-GLUTAMIC+ACID'>DGL</scene>, <scene name='pdbligand=DHI:D-HISTIDINE'>DHI</scene>, <scene name='pdbligand=DLE:D-LEUCINE'>DLE</scene>, <scene name='pdbligand=DTR:D-TRYPTOPHAN'>DTR</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=DAL:D-ALANINE'>DAL</scene>, <scene name='pdbligand=DAR:D-ARGININE'>DAR</scene>, <scene name='pdbligand=DCY:D-CYSTEINE'>DCY</scene>, <scene name='pdbligand=DGL:D-GLUTAMIC+ACID'>DGL</scene>, <scene name='pdbligand=DHI:D-HISTIDINE'>DHI</scene>, <scene name='pdbligand=DLE:D-LEUCINE'>DLE</scene>, <scene name='pdbligand=DTR:D-TRYPTOPHAN'>DTR</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1czq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1czq OCA], [~~http~~://pdbe.org/1czq PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1czq RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1czq PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1czq ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1czq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1czq OCA], [https://pdbe.org/1czq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1czq RCSB], [https://www.ebi.ac.uk/pdbsum/1czq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1czq ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 07:14, 29 May 2019

OCA — Wed, 29 May 2019 07:14:37 GMT

←Older revision		Revision as of 07:14, 29 May 2019
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	==CRYSTAL STRUCTURE OF THE D10-P1/IQN17 COMPLEX: A D-PEPTIDE INHIBITOR OF HIV-1 ENTRY BOUND TO THE GP41 COILED-COIL POCKET.==		==CRYSTAL STRUCTURE OF THE D10-P1/IQN17 COMPLEX: A D-PEPTIDE INHIBITOR OF HIV-1 ENTRY BOUND TO THE GP41 COILED-COIL POCKET.==
-	<StructureSection load='1czq' size='340' side='right' caption='[[1czq]], [[Resolution\|resolution]] 1.50Å' scene=''>	+	<StructureSection load='1czq' size='340' side='right'caption='[[1czq]], [[Resolution\|resolution]] 1.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1czq]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CZQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1CZQ FirstGlance]. <br>		<table><tr><td colspan='2'>[[1czq]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CZQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1CZQ FirstGlance]. <br>
Line 21:		Line 21:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Carr, P A]]		[[Category: Carr, P A]]
	[[Category: Eckert, D M]]		[[Category: Eckert, D M]]

OCA at 11:22, 24 August 2017

OCA — Thu, 24 Aug 2017 11:22:32 GMT

←Older revision		Revision as of 11:22, 24 August 2017
Line 1:		Line 1:
		+
	==CRYSTAL STRUCTURE OF THE D10-P1/IQN17 COMPLEX: A D-PEPTIDE INHIBITOR OF HIV-1 ENTRY BOUND TO THE GP41 COILED-COIL POCKET.==		==CRYSTAL STRUCTURE OF THE D10-P1/IQN17 COMPLEX: A D-PEPTIDE INHIBITOR OF HIV-1 ENTRY BOUND TO THE GP41 COILED-COIL POCKET.==
	<StructureSection load='1czq' size='340' side='right' caption='[[1czq]], [[Resolution\|resolution]] 1.50Å' scene=''>		<StructureSection load='1czq' size='340' side='right' caption='[[1czq]], [[Resolution\|resolution]] 1.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1czq]] is a 2 chain structure ~~with sequence from [http://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]~~. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CZQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1CZQ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1czq]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CZQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1CZQ FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=DAL:D-ALANINE'>DAL</scene>, <scene name='pdbligand=DAR:D-ARGININE'>DAR</scene>, <scene name='pdbligand=DCY:D-CYSTEINE'>DCY</scene>, <scene name='pdbligand=DGL:D-GLUTAMIC+ACID'>DGL</scene>, <scene name='pdbligand=DHI:D-HISTIDINE'>DHI</scene>, <scene name='pdbligand=DLE:D-LEUCINE'>DLE</scene>, <scene name='pdbligand=DTR:D-TRYPTOPHAN'>DTR</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=DAL:D-ALANINE'>DAL</scene>, <scene name='pdbligand=DAR:D-ARGININE'>DAR</scene>, <scene name='pdbligand=DCY:D-CYSTEINE'>DCY</scene>, <scene name='pdbligand=DGL:D-GLUTAMIC+ACID'>DGL</scene>, <scene name='pdbligand=DHI:D-HISTIDINE'>DHI</scene>, <scene name='pdbligand=DLE:D-LEUCINE'>DLE</scene>, <scene name='pdbligand=DTR:D-TRYPTOPHAN'>DTR</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1czq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1czq OCA], [http://pdbe.org/1czq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1czq RCSB], [http://www.ebi.ac.uk/pdbsum/1czq PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1czq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1czq OCA], [http://pdbe.org/1czq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1czq RCSB], [http://www.ebi.ac.uk/pdbsum/1czq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1czq ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 20:		Line 21:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Atcc 18824]]
	[[Category: Carr, P A]]		[[Category: Carr, P A]]
	[[Category: Eckert, D M]]		[[Category: Eckert, D M]]

OCA at 02:35, 10 September 2015

OCA — Thu, 10 Sep 2015 02:35:42 GMT

←Older revision		Revision as of 02:35, 10 September 2015
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	<StructureSection load='1czq' size='340' side='right' caption='[[1czq]], [[Resolution\|resolution]] 1.50Å' scene=''>		<StructureSection load='1czq' size='340' side='right' caption='[[1czq]], [[Resolution\|resolution]] 1.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1czq]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Human_immunodeficiency_virus Human immunodeficiency virus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CZQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1CZQ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1czq]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CZQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1CZQ FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=DAL:D-ALANINE'>DAL</scene>, <scene name='pdbligand=DAR:D-ARGININE'>DAR</scene>, <scene name='pdbligand=DCY:D-CYSTEINE'>DCY</scene>, <scene name='pdbligand=DGL:D-GLUTAMIC+ACID'>DGL</scene>, <scene name='pdbligand=DHI:D-HISTIDINE'>DHI</scene>, <scene name='pdbligand=DLE:D-LEUCINE'>DLE</scene>, <scene name='pdbligand=DTR:D-TRYPTOPHAN'>DTR</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=DAL:D-ALANINE'>DAL</scene>, <scene name='pdbligand=DAR:D-ARGININE'>DAR</scene>, <scene name='pdbligand=DCY:D-CYSTEINE'>DCY</scene>, <scene name='pdbligand=DGL:D-GLUTAMIC+ACID'>DGL</scene>, <scene name='pdbligand=DHI:D-HISTIDINE'>DHI</scene>, <scene name='pdbligand=DLE:D-LEUCINE'>DLE</scene>, <scene name='pdbligand=DTR:D-TRYPTOPHAN'>DTR</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1czq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1czq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1czq RCSB], [http://www.ebi.ac.uk/pdbsum/1czq PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1czq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1czq OCA], [http://pdbe.org/1czq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1czq RCSB], [http://www.ebi.ac.uk/pdbsum/1czq PDBsum]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 15:		Line 15:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1czq" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human immunodeficiency virus~~]]	+	[[Category: Atcc 18824]]
	[[Category: Carr, P A]]		[[Category: Carr, P A]]
	[[Category: Eckert, D M]]		[[Category: Eckert, D M]]

OCA at 23:40, 22 December 2014

OCA — Mon, 22 Dec 2014 23:40:32 GMT

←Older revision		Revision as of 23:40, 22 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1czq]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus Human immunodeficiency virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CZQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1CZQ FirstGlance]. <br>		<table><tr><td colspan='2'>[[1czq]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus Human immunodeficiency virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CZQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1CZQ FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=DAL:D-ALANINE'>DAL</scene>, <scene name='pdbligand=DAR:D-ARGININE'>DAR</scene>, <scene name='pdbligand=DCY:D-CYSTEINE'>DCY</scene>, <scene name='pdbligand=DGL:D-GLUTAMIC+ACID'>DGL</scene>, <scene name='pdbligand=DHI:D-HISTIDINE'>DHI</scene>, <scene name='pdbligand=DLE:D-LEUCINE'>DLE</scene>, <scene name='pdbligand=DTR:D-TRYPTOPHAN'>DTR</scene></td></tr>	+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=DAL:D-ALANINE'>DAL</scene>, <scene name='pdbligand=DAR:D-ARGININE'>DAR</scene>, <scene name='pdbligand=DCY:D-CYSTEINE'>DCY</scene>, <scene name='pdbligand=DGL:D-GLUTAMIC+ACID'>DGL</scene>, <scene name='pdbligand=DHI:D-HISTIDINE'>DHI</scene>, <scene name='pdbligand=DLE:D-LEUCINE'>DLE</scene>, <scene name='pdbligand=DTR:D-TRYPTOPHAN'>DTR</scene></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1czq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1czq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1czq RCSB], [http://www.ebi.ac.uk/pdbsum/1czq PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1czq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1czq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1czq RCSB], [http://www.ebi.ac.uk/pdbsum/1czq PDBsum]</span></td></tr>
-	<table>	+	</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 20:		Line 20:
	</StructureSection>		</StructureSection>
	[[Category: Human immunodeficiency virus]]		[[Category: Human immunodeficiency virus]]
-	[[Category: Carr, P A.]]	+	[[Category: Carr, P A]]
-	[[Category: Eckert, D M.]]	+	[[Category: Eckert, D M]]
-	[[Category: Hong, L H.]]	+	[[Category: Hong, L H]]
-	[[Category: Kim, P S.]]	+	[[Category: Kim, P S]]
-	[[Category: Malashkevich, V N.]]	+	[[Category: Malashkevich, V N]]
	[[Category: Envelope glycoprotein]]		[[Category: Envelope glycoprotein]]
	[[Category: Viral protein-inhibitor complex]]		[[Category: Viral protein-inhibitor complex]]

OCA at 09:27, 27 August 2014

OCA — Wed, 27 Aug 2014 09:27:05 GMT

←Older revision		Revision as of 09:27, 27 August 2014
Line 1:		Line 1:
-	[[~~Image:~~1czq.~~png~~\|~~left~~\|~~200px~~]]	+	==CRYSTAL STRUCTURE OF THE D10-P1/IQN17 COMPLEX: A D-PEPTIDE INHIBITOR OF HIV-1 ENTRY BOUND TO THE GP41 COILED-COIL POCKET.==
		+	<StructureSection load='1czq' size='340' side='right' caption='[[1czq]], [[Resolution\|resolution]] 1.50Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1czq]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus Human immunodeficiency virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CZQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1CZQ FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=DAL:D-ALANINE'>DAL</scene>, <scene name='pdbligand=DAR:D-ARGININE'>DAR</scene>, <scene name='pdbligand=DCY:D-CYSTEINE'>DCY</scene>, <scene name='pdbligand=DGL:D-GLUTAMIC+ACID'>DGL</scene>, <scene name='pdbligand=DHI:D-HISTIDINE'>DHI</scene>, <scene name='pdbligand=DLE:D-LEUCINE'>DLE</scene>, <scene name='pdbligand=DTR:D-TRYPTOPHAN'>DTR</scene></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1czq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1czq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1czq RCSB], [http://www.ebi.ac.uk/pdbsum/1czq PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The HIV-1 gp41 protein promotes viral entry by mediating the fusion of viral and cellular membranes. A prominent pocket on the surface of a central trimeric coiled coil within gp41 was previously identified as a potential target for drugs that inhibit HIV-1 entry. We designed a peptide, IQN17, which properly presents this pocket. Utilizing IQN17 and mirror-image phage display, we identified cyclic, D-peptide inhibitors of HIV-1 infection that share a sequence motif. A 1.5 A cocrystal structure of IQN17 in complex with a D-peptide, and NMR studies, show that conserved residues of these inhibitors make intimate contact with the gp41 pocket. Our studies validate the pocket per se as a target for drug development. IQN17 and these D-peptide inhibitors are likely to be useful for development and identification of a new class of orally bioavailable anti-HIV drugs.

-	~~{{STRUCTURE_1czq\| PDB=1czq \| SCENE= }}~~	+	Inhibiting HIV-1 entry: discovery of D-peptide inhibitors that target the gp41 coiled-coil pocket.,Eckert DM, Malashkevich VN, Hong LH, Carr PA, Kim PS Cell. 1999 Oct 1;99(1):103-15. PMID:10520998<ref>PMID:10520998</ref>

-	~~===CRYSTAL STRUCTURE OF THE D10-P1~~/~~IQN17 COMPLEX: A D-PEPTIDE INHIBITOR OF HIV-1 ENTRY BOUND TO THE GP41 COILED-COIL POCKET.===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_10520998}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[1czq]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Human_immunodeficiency_virus Human immunodeficiency virus]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1CZQ OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:010520998<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Human immunodeficiency virus]]		[[Category: Human immunodeficiency virus]]
	[[Category: Carr, P A.]]		[[Category: Carr, P A.]]

OCA: Protected "1czq" [edit=sysop:move=sysop]

OCA — Sun, 21 Oct 2012 20:23:47 GMT

Protected "1czq" [edit=sysop:move=sysop]

←Older revision

Revision as of 20:23, 21 October 2012

OCA at 20:23, 21 October 2012

OCA — Sun, 21 Oct 2012 20:23:44 GMT

←Older revision		Revision as of 20:23, 21 October 2012
Line 1:		Line 1:
-	{{Seed}}
	[[Image:1czq.png\|left\|200px]]		[[Image:1czq.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1czq", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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	{{STRUCTURE_1czq\| PDB=1czq \| SCENE= }}		{{STRUCTURE_1czq\| PDB=1czq \| SCENE= }}

	===CRYSTAL STRUCTURE OF THE D10-P1/IQN17 COMPLEX: A D-PEPTIDE INHIBITOR OF HIV-1 ENTRY BOUND TO THE GP41 COILED-COIL POCKET.===		===CRYSTAL STRUCTURE OF THE D10-P1/IQN17 COMPLEX: A D-PEPTIDE INHIBITOR OF HIV-1 ENTRY BOUND TO THE GP41 COILED-COIL POCKET.===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_10520998}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 10520998 is the PubMed ID number.
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	{{ABSTRACT_PUBMED_10520998}}		{{ABSTRACT_PUBMED_10520998}}

	==About this Structure==		==About this Structure==
-	~~1CZQ is a~~ [[~~Single protein~~]] structure of sequence from [http://en.wikipedia.org/wiki/~~Saccharomyces_cerevisiae_and_human_immunodeficiency_virus Saccharomyces cerevisiae and human~~ immunodeficiency virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CZQ OCA].	+	[[1czq]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus Human immunodeficiency virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CZQ OCA].

	==Reference==		==Reference==
-	~~Inhibiting HIV-1 entry: discovery of D-peptide inhibitors that target the gp41 coiled-coil pocket., Eckert DM, Malashkevich VN, Hong LH, Carr PA, Kim PS, Cell. 1999 Oct 1;99(1):103-15.~~ PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/10520998 10520998]~~	+	<ref group="xtra">PMID:010520998</ref><references group="xtra"/>
-	[[Category: ~~Saccharomyces cerevisiae and human~~ immunodeficiency virus]]	+	[[Category: Human immunodeficiency virus]]
-	~~[[Category: Single protein~~]]	+
	[[Category: Carr, P A.]]		[[Category: Carr, P A.]]
	[[Category: Eckert, D M.]]		[[Category: Eckert, D M.]]
Line 31:		Line 18:
	[[Category: Kim, P S.]]		[[Category: Kim, P S.]]
	[[Category: Malashkevich, V N.]]		[[Category: Malashkevich, V N.]]
-	[[Category: Coiled coil]]
	[[Category: Envelope glycoprotein]]		[[Category: Envelope glycoprotein]]
-		+	[[Category: Viral protein-inhibitor complex]]
-	~~''Page seeded by~~ [~~http~~:~~//oca.weizmann.ac.il/oca OCA~~ ] ~~on Mon Jun 30 21:53:17 2008''~~	+

OCA at 18:53, 30 June 2008

OCA — Mon, 30 Jun 2008 18:53:21 GMT

←Older revision		Revision as of 18:53, 30 June 2008
Line 1:		Line 1:
-	[[Image:1czq.~~gif~~\|left\|200px]]	+	{{Seed}}
		+	[[Image:1czq.png\|left\|200px]]

	<!--		<!--
Line 9:		Line 10:
	{{STRUCTURE_1czq\| PDB=1czq \| SCENE= }}		{{STRUCTURE_1czq\| PDB=1czq \| SCENE= }}

-	~~'''~~CRYSTAL STRUCTURE OF THE D10-P1/IQN17 COMPLEX: A D-PEPTIDE INHIBITOR OF HIV-1 ENTRY BOUND TO THE GP41 COILED-COIL POCKET.~~'''~~	+	===CRYSTAL STRUCTURE OF THE D10-P1/IQN17 COMPLEX: A D-PEPTIDE INHIBITOR OF HIV-1 ENTRY BOUND TO THE GP41 COILED-COIL POCKET.===


-	~~==Overview==~~	+	<!--
-	The ~~HIV-1 gp41 protein promotes viral entry by mediating~~ the ~~fusion of viral and cellular membranes. A prominent pocket on~~ the ~~surface of a central trimeric coiled coil within gp41 was previously identified~~ as ~~a potential target for drugs that inhibit HIV-1 entry~~. ~~We designed a peptide, IQN17, which properly presents this pocket~~. Utilizing IQN17 and mirror-image phage display, we identified cyclic, D-peptide inhibitors of HIV-1 infection that share a sequence motif. A 1.5 A cocrystal structure of IQN17 in complex with a D-peptide, and NMR studies, ~~show that conserved residues of these inhibitors make intimate contact with~~ the ~~gp41 pocket~~. ~~Our studies validate the pocket per se as a target for drug development. IQN17 and these D~~-~~peptide inhibitors are likely to be useful for development and identification of a new class of orally bioavailable anti~~-~~HIV drugs.~~	+	The line below this paragraph, {{ABSTRACT_PUBMED_10520998}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 10520998 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_10520998}}

	==About this Structure==		==About this Structure==
Line 29:		Line 33:
	[[Category: Coiled coil]]		[[Category: Coiled coil]]
	[[Category: Envelope glycoprotein]]		[[Category: Envelope glycoprotein]]
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Fri May 2 13~~:17:01 2008''	+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 21:53:17 2008''